CN102885206A - Natural animal feed additive - Google Patents
Natural animal feed additive Download PDFInfo
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- CN102885206A CN102885206A CN2012104208226A CN201210420822A CN102885206A CN 102885206 A CN102885206 A CN 102885206A CN 2012104208226 A CN2012104208226 A CN 2012104208226A CN 201210420822 A CN201210420822 A CN 201210420822A CN 102885206 A CN102885206 A CN 102885206A
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Abstract
The invention discloses a natural animal feed additive which comprises the following components in mass percentage: 10-25% of allicin, 1-5% of beta-glucanase, 20-40% of diatomaceous earth, 5-15% of potassium sorbate, 25-50% of beer yeast cell wall and 0.5-1% of vitamin C. Mixing materials which are 0.01-5% of the dry weight of the natural animal feed additive is added in the natural animal feed additive; and by carrying out oral feeding every day, the natural animal feed additive can be used for preventing and treating the infection from causative agents such as fungus, bacterium and virus causative agents to the animals, so that the immunity and the adversity resistance of various farmed animals are strengthened, the antibiotic used multi-component complex formula products are decreased, the inborn and acquired immunities of the animals can be strengthened, the response of the organism to various vaccines is remarkably improved so as to strengthen the comprehensive immunological competence of the organism for diseases, the death rate can be remarkably reduced at the paedomorphosis stage of the animals and the weight increment capability and other production capabilities of the animals can be improved at the adult growth state.
Description
Technical field
The invention belongs to the animal-breeding technical field, relate in particular to a kind of natural animal feed addictive.
Background technology
In recent years, the extensive illness of aquaculture often has generation, and concrete needs are often ignored arbitrarily and heavy dose of use antibiotic for guaranteeing income by animal doctor or raising specialist.Abuse of antibiotics can cause following adverse consequences: germ is developed immunity to drugs, form the resistance germ.2) destroy animal the normal flora structure should be arranged.Use unreasonably antibiotic that normal flora is destroyed, affect the normal activities of animal body, pathogen then seizes the opportunity amount reproduction, causes the generation of disease.3) make animal produce toxic reaction.Unreasonable use antibiotic often can cause drug poisoning, and the lighter affects growth and the feed conversion rate of animal, and severe patient causes the death of animal.The excessive animal nerve muscle impulse conduction that causes of antibiotic application dose blocks, and brings out the breathing muscular paralysis, respiration inhibition, and quadriplegia, in addition dead.4) in follow-up edible crowd, cause poisoning or irritated serious consequence.Use antibiotic for a long time or in a large number, cause in the consumable products such as livestock and poultry meat, milk a large amount of antibiotic residues being arranged, cause edible crowd's poisoning or allergy.5) affect the production performance of animal.Medicines such as sulfamido, furans can affect laying rate, rate of fertilization, incubation rate etc. when being applied to laying hen, if with being intended to upper these medicines that use of laying hen, will affect the production performance of chicken, cause unnecessary production loss.
Immunosupress is quite common and often be the ill main cause of animal in cultivated animals.Cultivated animals generally is that growth is rapid, product meat is many, the strain of the high of giving milk or lay eggs, but the breeding result often causes this type of strain easily to suffer from metabolic disease.Simultaneously, the cultivated animals with above-mentioned good production traits is usually also very responsive to various stress factors, so the often also easier infection that is subject to all kinds of pathogenic factors.
The effect of animal immune system is to protect various pathogen that the host avoids existing in the environment and the infringement of other harmful substances.Immune system can be told the dissident's material that is different from host's self component at any time.Immune system can be divided into two classes difference but the interactional system that is closely connected: 1) innate immune system; 2) acquired immunity system is comprising antibody-mediated immune response.Two type systematics all have many haematogenous factors (such as complement, antibody, cell factor etc.) and the different cell of plurality of classes to participate in.For example, main housing construction, cell and the factor of the reaction of participation congenital immunity comprise: the epithelial cell or epithelial tissue, hydrochloric acid in gastric juice and all kinds of digestive ferment that 1) play direct physics or chemical barrier effect in the invasion of antagonism cause of disease; 2) can engulf and digest the cell of invading cause of disease, such as the neutrophil leucocyte in the blood; 3) but the surface receptor of the above-mentioned various types of cells of mentioning of identification and affine absorption pathogen; 4) in immune response, play the information conduct factors of communication and control of related gene expression, such as chemotactic factor (CF) and cell factor etc.
Along with modern biology especially cell and molecular biological development, the understanding of Animal nutrition and animal immune mechanism has been deep into molecular level.In the animal-breeding industry, develop hundreds of and promoted all kinds of feed addictives of Animal nutrition, raising immunity with different mechanism, various in style, wide material sources comprise the trace element of all kinds of polysaccharide of allicin, polysaccharides of traditional Chinese medicine, microbial source of plant origin even viable bacteria probiotics, mineral source and traditional vitamin(e) supplement etc.
Allicin (Allicin) is the bioactive ingredients that has in the Liliaceae allium garlic.Allicin can strengthen cellular metabolism, promotes a large amount of releases of animal body lysozyme, strengthens the non-specific immune function of body, promotes the hyperplasia of lymphocyte, macrophage, stimulates lymphocytic emiocytosis interferon, TNF, interleukins etc.Allicin is made the palatability that feed addictive can obviously improve feed, improves animal feed intake, avoids behavior particular about food, and can promote growing of animal, improves Abwehrkraft des Koepers; Improve each system organization function in the animal body, promote the wriggling of stomach and intestine and the secretion of various digestive ferments, improve animal to the digestibility and utilization of feed, allicin also has the functions such as sterilization, expelling parasite, detoxifcation, and have no side effect, noresidue is not developed immunity to drugs, be a kind of natural green additive, have aborning the function of substitute antibiotics.In addition, allicin becomes the garlic bulblet element under the effect of enzyme, discharges with the form of fecaluria, can stop the Growth and Reproduction of germ and insect in the breeding environment, improves whole breeding environment, reduce animal to environment stress.
Yeast cell wall is the key component of saccharomycete moderate stimulation animal immune function, and its active component mainly is comprised of beta glucan (57.0%), manna oligosacchride (MOS, 6.6%), glycoprotein (22.0%) and chitin.Research finds that the performance Main Function is beta glucan and manna oligosacchride in these active components.Link to each other with β-1,3 key and β-1,6 key between the monose in the beta glucan, its molecular structure has the immune function of stimulating animal twist.But beta glucan is activating macrophage after the Macrophage Surface glycoprotein receptor is combined.After macrophage was activated, all kinds of pathogen that will invade by phagocytosis on the one hand directly comprised that the harmful and noxious substance of self metabolism generation kills removing; On the other hand, in the initial stage of immune response, macrophage can be given other lymphocytes with the antigen degraded and with the antigen signals submission, starts the acquired immune response reaction.Macrophage can produce multiple different bioactivator under the stimulation of different material, such as interleukins, interferon, complement, clotting factor, tumor growth inhibiting factor etc., strengthen the immunity function of animal by their synergy.The oligosaccharides that manna oligosacchride in the yeast cell wall (MOS) manna oligosacchride is comprised of mannose and glucose, because its bonding mode is special, animal self can not directly be degraded, but can be fermented by enteric microorganism, produce organic acid, methane, carbon dioxide and hydrogen etc., the pH value of downward modulation intestinal environment, thereby the growth of inhibition harmful bacteria.In addition, manna oligosacchride can also the field planting of emulative prevention pathogen on the intestines wall, reduces pathogen adhering at the intestines inwall.
Vitamin C is one of necessary nutritional labeling of growth of animal, and, mineral absorption synthetic with hormone, metabolism have substantial connection, and can strengthen immunity of organisms, prevention scurvy, protection capilary, promotes wound healing.
Enzyme Preparations Used for Feeds is a kind of green feed additive that saves grain, environment-friendly type, is used widely in the cultivation industry in recent years.The enzyme Preparations Used for Feeds digestive ferment is in the majority, comprising amylase, protease, 1,4 beta-glucanase, pectase, cellulase etc.Its effect is: 1) direct decomposition nutrition matter, improve efficiency of feed utilization; 2) eliminate anti-nutrient molecule, improve digestive function.3) secretion of activation endogenous enzyme improves digestive ferment concentration; 4) also can reduce the generation of nitrogen, phosphorus etc. in letting animals feed excrement, the urine, reduce the pollution to environment from the source, help animal husbandry to realize sustainable development.Enzyme Preparations Used for Feeds can enlarge the scope of feedstuff, help to slow down the increasingly serious people, animal of China and strive grain contradiction, and enzyme Preparations Used for Feeds residual, have no side effect, progressively substitute the conventional medicine feed addictive.
The characteristics such as diatomite has porous, density is little, specific area is large, excellent adsorption.In recent years as preventing the feed agllutination, going mouldy and the additive of insect pest is used widely at feedstuff industry.Owing to the mineral source feature, examples of such additives can also be replenished some required micro-element nutrition of animal, helps lend some impetus to growth of animals or poultry simultaneously.
Different classes of feed addictive can by different physiological mechanism promote animal to utilization and the absorption of nutrition, strengthen its immunity, reduce stress reaction, composite feed additive also progressively obtains exploitation in recent years.Yet in research and development, usually run into bottleneck former because of the complicated component that sets out, the staggered even mutual antagonism of the mechanism of action etc. thereby that cause, therefore, an approach that solves the research and development bottleneck can be, further understand component mechanism in depth at molecular level, the Selecting Mechanism and Procedure complement components, on the basis of maximization each individual components effectiveness own, utilize animal self to degraded, digestion and the absorption of feed, by its physiological metabolism so that the cooperative effect of compound compatibility component also can give full play to.
Summary of the invention
The invention provides a kind of natural animal feed addictive, be intended to improve the animal autoimmune function by performance compounding ingredients cooperative effect in animal body, promote animal to digestion and the absorption of feed nutrition, promote on the whole animal health, comprehensively promote productivity effect.
Natural animal feed addictive provided by the invention, constituent and mass percent thereof are: the diatomite of the allicin of 10-25%, the 1,4 beta-glucanase of 1-5%, 20-40%, the potassium sorbate of 5-15%, the beer yeast cells wall of 25-50%, the vitamin C of 0.5-1%, the 0.01%-5% that this natural animal feed addictive is pressed the feed dry weight adds spice, and every day is individual by oral feeding animals.
This feed addictive can strengthen the congenital of all kinds of cultivated animals and acquired immunity function, significantly improve animal body to the responsing reaction of all kinds of vaccines, and then the comprehensive immunocompetence of enhancing body opposing disease, can be used for preventing and treating pathogen and comprise fungi, bacterium and viral pathogen infect animal, this feed addictive also can strengthen the degeneration-resistant of animal, anti-stress ability, promote the nutrition condition of animal, the application of this multicomponent compound prescription product in producing cultivation. can significantly reduce its death rate in the animal paedomorphosis stage, improve gaining ability and other production capacity of animal at its adult growth phase.，
Description of drawings
Fig. 1 is control group and the body weight gain curve comparison schematic diagram of experimental group animal within whole growth period in the embodiment of the invention 1;
Fig. 2 is control group and the death rate comparison schematic diagram of experimental group animal within whole growth period in the embodiment of the invention 1;
Fig. 3 is the mrna expression amount schematic diagram relatively of control group and experimental group animal MIP-1 β in the embodiment of the invention 1;
Fig. 4 is the comparison schematic diagram that control group and experimental group animal produce peroxide concentrations in the embodiment of the invention 1;
Fig. 5 is the comparison schematic diagram that control group and experimental group animal neutrophil cell are removed the Escherichia coli ability in the embodiment of the invention 1;
Fig. 6 is the comparison schematic diagram of IFN γ concentration in control group and the experimental group animal blood serum in the embodiment of the invention 1;
Fig. 7 is the comparison schematic diagram of cell surface CD4+/CD8+ ratio in control group and the experimental group animal blood serum in the embodiment of the invention 1;
Fig. 8 is control group and the experimental group animal comparison schematic diagram of antibody titer of ND in the serum in growth course in the embodiment of the invention 1.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further described in detail.Should be appreciated that specific embodiment described herein only in order to explaining the present invention, and be not used in and limit invention.
The object of the present invention is to provide a kind of natural animal feed addictive, the composition of this natural animal feed addictive and mass percent thereof are: the diatomite of the allicin of 10-25%, the 1,4 beta-glucanase of 1-5%, 20-40%, the potassium sorbate of 5-15%, the beer yeast cells wall of 25-50%, the vitamin C of 0.5-1%.
In embodiments of the present invention, this natural animal feed addictive is individual by oral feeding animals every day.。
In embodiments of the present invention, this natural animal feed addictive is pressed the 0.01%-5% interpolation spice of feed dry weight.
For estimating the invention additive product to the feeding effect of animal, organized serial experiment to examine or check the impact of product on immunity, upgrowth situation and the raising economic well-being of workers and staff of this most common poultry animal of cultivation chicken group.
Embodiment 1:
The experimental group composition
The used additive of embodiment 1 experimental group is product of the present invention, accompanies into daily ration in 0.5% ratio.
Animal used as test:
Select 180 of the healthy broiler chicken of 1 age in days (without remarkable body weight difference, P value＞0.05), adopt the one factor factorial experiment with complete randomization design design, be divided at random two groups, every group three repetition, 30 of every repetitions.The control group product of the present invention of not feeding;
Experimental result:
1. the invention product is on the impact of growth of animal weightening finish and survival rate
The result shows, compares with control group, and additive experimental group chicken group increases weight in 1 to 45 day obviously (Fig. 1, P value＜0.05), more is remarkable to the later stage more, and the different also contrast of the individual method of double differences group in the group is little simultaneously.In addition, additive experimental group chicken group's the death rate also has remarkable reduction (Fig. 2, P value＜0.05) than control group chicken group.
2. the invention product is on the impact of chicken congenital immunity
2.1 the animal immunizing power index is estimated with the mrna expression amount of macrophage inflammatory protein (MIP).MIP albumen has two kinds of hypotypes, MIP-1 α and MIP-1 β.Fig. 3 shows the examination result of the latter 14 days chicken ages.Data show, the mrna expression amount of the MIP-1 β of experimental group is significantly higher than control group (P＜0.01), this result shows that the experimental chicken group is using product of the present invention after 14 days, its congenital immunity power has obtained remarkable enhancing, and the homogeneity of MIP-1 β mrna expression amount also is better than control group in the group simultaneously.
2.2 pathogen after by complement factor (C3b and C3bi) or antibody sandwich, is modified through conditioning, activable neutrophil leucocyte and the identification of other immunocytes cause and engulf reaction.Fig. 4 and Fig. 5 show that respectively the experimental chicken group's who has eaten product of the present invention neutrophil cell has the colibacillary ability of killing of remarkable enhancing, are embodied in the enhancing of phagocytic activity and the increase (P＜0.05) of activating oxide (ROS) expression.The homogeneity of desired value also is better than control group in the group.
3. the invention product is on the impact of chicken acquired immunity
3.1 Fig. 6 shows the serum-concentration of one of acquired immunity indication IFN-γ all be significantly increased (P＜0.05) in the experimental chicken group.
3.2 Fig. 7 shows that the ratio of one of acquired immunity indication CD4/CD8 all is significantly increased (P＜0.05) in the experimental chicken group, the homogeneity of desired value is better than control group in the group simultaneously.
3.3 Fig. 8 shows that the experimental chicken group ate additive of the present invention after 28 days, its immune response ability to vaccine obviously is better than control group, and the internal antibody titre is high, longer duration (P＜0.05).The vaccine inoculation time was respectively the 7th, 14 and 27 day.Ewcastle disease is most popular avian viral communicable disease; use at present the vaccine immunity poultry and be still the most effective safeguard measure; but in 7 days or longer a little time, the antibody of its generation also is difficult to antiviral invasion and attack chick, the immune empty window phase namely occurs after immunity inoculation.In addition should virus to various factors in the environment tolerance of height be arranged, very easily cause early infection, and cause immuning failure and cause the outburst of this disease.Product of the present invention promotes to produce in its body the antibody of higher concentration by improving the immune response ability of animal, reaches the effect that strengthens premunition.
Above-mentioned only is preferred embodiment of the present invention, not in order to limiting the present invention, all any modifications of doing within the spirit and principles in the present invention, is equal to and replaces and improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. natural animal feed addictive, it is characterized in that the composition of this natural animal feed addictive and mass percent thereof are: the diatomite of the allicin of 10-25%, the 1,4 beta-glucanase of 1-5%, 20-40%, the potassium sorbate of 5-15%, the beer yeast cells wall of 25-50%, the vitamin C of 0.5-1%.
2. natural animal feed addictive as claimed in claim 1 is characterized in that, this natural animal feed addictive is individual by oral feeding animals every day.
3. natural animal feed addictive as claimed in claim 1 is characterized in that, the 0.01%-5% that this natural animal feed addictive is pressed the feed dry weight adds spice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201210420822 CN102885206B (en) | 2012-10-29 | 2012-10-29 | Natural animal feed additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 201210420822 CN102885206B (en) | 2012-10-29 | 2012-10-29 | Natural animal feed additive |
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| CN102885206B CN102885206B (en) | 2013-10-30 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2642444C1 (en) * | 2016-12-20 | 2018-01-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") | Dysbiosis correction method of young farm livestock |
| CN110592056A (en) * | 2019-09-19 | 2019-12-20 | 昆明理工大学 | Phage lyase composite powder and preparation method and application thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2570393C2 (en) * | 2014-05-05 | 2015-12-10 | Федеральное государственное бюджетное учреждение "Федеральный Центр токсикологической, радиационной и биологической безопасности" (ФГБУ "ФЦТРБ-ВНИВИ") | Method of producing preparation to improve resistance of newborn young farm animals and method of increasing resistance |
| WO2018049243A1 (en) * | 2016-09-09 | 2018-03-15 | Omnigen Research, Llc | Feed additive comprising allicin |
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| CN1714670A (en) * | 2004-06-29 | 2006-01-04 | 韩克朴 | Tortoise and turtle feedstuff and preparing method |
| WO2008049437A1 (en) * | 2006-10-26 | 2008-05-02 | Biofiber-Damino A/S | Composition comprising lignin and antidi arrheal component |
| CN101828647A (en) * | 2010-06-03 | 2010-09-15 | 程永发 | Health care feedstuff additive for animals |
| CN101836700A (en) * | 2010-04-16 | 2010-09-22 | 上海市奶牛研究所 | Concentrate supplement for high-producing dairy cows applying TMR |
| CN102326677A (en) * | 2011-10-21 | 2012-01-25 | 北京大北农科技集团股份有限公司 | Composite micro-ecological feed additive and preparation method and premix thereof |
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2012
- 2012-10-29 CN CN 201210420822 patent/CN102885206B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1714670A (en) * | 2004-06-29 | 2006-01-04 | 韩克朴 | Tortoise and turtle feedstuff and preparing method |
| WO2008049437A1 (en) * | 2006-10-26 | 2008-05-02 | Biofiber-Damino A/S | Composition comprising lignin and antidi arrheal component |
| CN101836700A (en) * | 2010-04-16 | 2010-09-22 | 上海市奶牛研究所 | Concentrate supplement for high-producing dairy cows applying TMR |
| CN101828647A (en) * | 2010-06-03 | 2010-09-15 | 程永发 | Health care feedstuff additive for animals |
| CN102326677A (en) * | 2011-10-21 | 2012-01-25 | 北京大北农科技集团股份有限公司 | Composite micro-ecological feed additive and preparation method and premix thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2642444C1 (en) * | 2016-12-20 | 2018-01-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет инженерных технологий" (ФГБОУ ВО "ВГУИТ") | Dysbiosis correction method of young farm livestock |
| CN110592056A (en) * | 2019-09-19 | 2019-12-20 | 昆明理工大学 | Phage lyase composite powder and preparation method and application thereof |
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| CN102885206B (en) | 2013-10-30 |
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Effective date of registration: 20160928 Address after: 214000 Jiangsu province Wuxi Yanqiao Huishan Economic Development Zone, supporting the District Yan Feng Road 28 Building No. 3 Patentee after: Jiangsu inscription Biotechnology Development Co., Ltd. Address before: 361000 room 227, Nanshan Road, Huli District, Fujian, Xiamen, 402 Patentee before: Zeng Wei Patentee before: Zheng Yan Patentee before: Chen Liangcheng Patentee before: Li Yu |
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