CN102524539A - Animal health preserver composition and preparation process for animal health preserver composition - Google Patents
Animal health preserver composition and preparation process for animal health preserver composition Download PDFInfo
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Abstract
The invention relates to an animal health agent composition and a preparation process for the animal health agent composition, in particular to an animal health agent composition for improving the immunities of young companion animals (particularly dogs and cats), promoting and keeping the function normality of intestinal tracts and improving the digestion capacity and the preparation process for the animal health agent composition. Astragalus polysaccharides, alpha-mannatide, fructo-oligosaccharide and yucca are mixed according to a scientific formula, so that the animal health agent composition has functional complementation and exact effect, is aimed at better improving the immune constitutions of animals, especially the companion animals, enhancing the immunities and digestions of the intestinal tracts, keeping the normal functions of the intestinal tracts and reducing the occurrence of animal diseases. The preparation process in the invention is realized by tablets, premixed preparations, paste, powder, granules and the like and any preparations which can be made according with the requirements of pharmaceutics and animal food additives. The preparation process has easy acquirement of raw materials and mature process and is suitable for batch production of modern industries.
Description
Affiliated technical field
The present invention relates to a kind of animal health agent composition and preparation technology thereof, particularly a kind of raising children companion animals in age (especially dog cat) immunity improves the health-care agent composition and the preparation technology thereof of digestion power with promoting with to keep function of intestinal canal normal.Belong to animal health article field.
Background technology
Veterinary science expert is through discovering, companion animals (especially dog cat) not only can enrich human life, can also change one's mood, and regulates people's internal system, blood pressure, and heart rate tends to be steady, and effectively improves and strengthen physical function and mental health.Current, the purchase volume of companion animals increases severely day by day, and renews environment at children's companion animals in age, changes under the effect of stressors such as food, causes companion animals self resistance to descend easily, easily the scabies secondary infection various diseases.Statistics finds that communicable diseases such as canine parvovirus (cardinal symptom is diarrhoea, vomits), canine distemper infect up to 40% when concluding the business between 1-4 month such as young dog.Also become " week dog ", refer to purchase and just fall ill or dead this phenomenon less than a week.Find after deliberation; The companion animals in young age at 1-4 monthly age, maternal immunity albumen is in the peak and falls the stage after rise in the body, and the new antibody that produces of vaccinate is not enough; Under the effect of various comprehensive stressors, cause the young animal immunity of organisms to lower and the infection various diseases more easily.Prevention children's companion animals in age or vulnerable method of sick phase are not only being taked etiological treatment, and will to improve immunity of organisms also be very important.Other there are some researches show, children's age and sick during its maintenance of companion animals and promote that function of intestinal canal is normal, it also is very important improving nutrient absorption.After the companion animals wean, the beneficial bacteria of intestinal tract crowd is in the unsettled stage of propagation, keeps and strengthen the growth rate of gut flora, reduces the generation of harmful substance in the enteron aisle, 1-4 stage at monthly age, is to promote the normal critical period of function of intestinal canal.Improve immunity and promote that the composition that improves digestion power combines with to keep function of intestinal canal normal, when improving companion animals immunity, promote and keep normal function of intestinal canal, improve the absorption of nutrition, could the whole physique of enhancing body, improve survival rate.Improve companion animals immunity and promote that the health-care agent that improves digestion power is less with to keep function of intestinal canal normal with tool at present.
In recent years, the Radix Astragali is as holding up this solid positive type Chinese herb feed additive to begin to be used to the disease prevention and cure of animal.The main component astragalus polyose is a kind of interferon inducer, its antiviral principle: stimulate the function of macrophage and T cell, making the E ring form cell number increases; Induce cell factor; Promote that interleukins induces, and make animal body produce endogenous interferon, thereby reach antiviral purpose.Prove after deliberation; Astragalus polyose antibacterial action mechanism is many-sided; On the one hand being medicine looses and directly pressing down of toxic product kills and detoxication to thin, and main on the other hand is, and to wave strengthening vital QI to eliminate pathogenic factors antibacterial through transferring the immunity of organism defense function, bactericidal action.Astragalus polyose can significantly strengthen non-specific immune function and humoral immune function; Significantly strengthen the phagocytic function of mouse macrophage; Promote serum hemolysin to form, raising plaque forming cells's haemolysis function and tangible carbon are from effect of cleaning up and obvious increase spleen weight.
The a-mannatide is a kind of glycoprotein, and it is the multiple bioactive material that has that from a-hemolytic streptococcus (Alpha-hemilyticstreptococci) 33# strain cultured solution, extracts.In alimentary canal; It is broken down into mannosan (Oligomeric manna sugar) and basic polypeptide two parts; And mannosan produces manna oligosacchride (MOS) through the incomplete hydrolysis of corresponding enzyme, and the a-mannatide is many in people's application study, has confirmed to strengthen people's immunity; Discovered in recent years, it has important growth promoting function and the effect of enhance immunity power equally to animal.(1) α-mannatide is to the growth promoting function of animal body: the a-mannatide gets into enteron aisle and is hydrolyzed to two parts later on, i.e. mannosan (Oligomeric manna sugar) and basic polypeptide.Because Oligomeric manna sugar is difficult to absorbed and can promote by stomach and intestine the growth and breeding of beneficial bacterium in the enteron aisle (Bifidobacterium and lactic acid bacteria), so the Oligomeric manna sugar that generates after the hydrolysis can directly get into large intestine by the beneficial bacterium utilization.(2) for beneficial bacterium nutrition is provided: contain distinctive glycosidic bond (a-1 in the structure of Oligomeric manna sugar; 4 sugared sweet keys) can not be by animal digestive ferment digestibility and utilization, and the beneficial bacterium (Bifidobacterium and lactic acid bacteria) in the enteron aisle can finely utilize Oligomeric manna sugar and can breed in a large number; On the contrary, harmful bacterium such as Escherichia coli, salmonella then can not utilize Oligomeric manna sugar, finally can cause these harmful bacterium nutrition for want of and death.Through the variation of these two different aspects, the ratio of beneficial bacterium increases greatly, can produce dissolving and absorption that more SCFA (SCFA) quickens mineral element, thereby produces growth enhancing effect.(3) improve digesting and assimilating of nutriment: thus Oligomeric manna sugar can be produced SCFA by the profitable strain fermentation in large intestine, and then reduce the pH value of large intestine, so just suppressed harmful bacteria growing, the wriggling that also stimulates digestion simultaneously.The adding of Oligomeric manna sugar has changed the microbiota in the large intestine, and these change the change that has finally caused enteron aisle form (intestinal villus height, the gland nest degree of depth), so just helps digesting and assimilating of nutriment more.New-man etc. (1993) report, when in the milk of 1～35 age in days calf, adding Oligomeric manna sugar, the speed of growth improves 8%, and feed intake improves 10%.In addition, Oligomeric manna sugar is a kind of oligosaccharides, can regulate the thyroxine and growth hormone (GH) secretion of body, the collaborative growth of animal that promotes.(4) to the effect of pathogen: could field planting in alimentary canal after the pathogen in the enteron aisle must at first be attached on the intestinal mucosa, thus begin to adhere to-breed-approach that causes a disease.Discover; Oligomeric manna sugar can competitively combine with the lectin that pathogen produces, and combines (Oyafo, 1989) thereby suppress pathogen with the intestinal mucosa surface; It can combine pathogen; Even make and be attached to epithelial Escherichia coli and split away off (Wu Shilin etc., 2000), excrete with ight soil together.(5) repair enteron aisle: Oligomeric manna sugar can improve the inside and outside biologically active of cell after getting into enteron aisle; The transmembrane signal system is produced specific influence, have facilitation for the propagation differentiation of T, bone-marrow-derived lymphocyte, a large amount of simultaneously secretion various types of cells growth-stimulating factors and immune molecule (IgA, IgM, IgG, IgD etc.) activate the normal tissues genes; Suppress unusual mutator; Both can improve material concentrations such as local mucous membrane tissue SIgA, IgM, can increase a large amount of Porcine HGFs again, thereby promote the active reparation of mucous membrane tissue damage; Play the enhancing function of intestinal canal, promote the effect of growth of animal.(6) regulate immunity function: the evidence Oligomeric manna sugar is had a liking for cell and monocyte has positive impact to huge, strengthens its phagocytosis; Improve lysozyme level in the serum; Stimulating TNF to keep (TNF), interleukins (IL), interferon (IFN) and NO level raises.TNF can suppress tumour cell; IL and IFN have immunocompetent endogenous peptide, and the both can activate or regulate the immune response center; NO has a liking for the effect that cell has the direct killing tumour cell by huge.(7) immunosuppressive action of reduction mycotoxin: mycotoxin is produced by aerobic bacteria; Can produce very strong toxic and side effect; It is one of zootrophic ultimate challenge; And the material that can produce Oligomeric manna sugar after Oligomeric manna sugar or the decomposition can well combine mycotoxin, thereby reduces the toxic and side effect of moldin to humans and animals, reduces the immunosuppressive action of moldin.(7) function of basic polypeptide: peptide is not only the substrate of body protein metabolism, but also has other important biological actions.The basic polypeptide that a-mannosan hydrolase polypeptide produces can act on gram-positive bacteria cell composition-peptide glycan, cuts off the polysaccharide chains of edge joint N-second peptide Portugal's amine and N-second peptide muramic acid, loses its toughness, and the cracking of hyposmosis type takes place bacterium, thereby kills and wounds bacterium.Peptide promotes huge cytophilic phagocytosis in addition, promotes the proliferation function of lymphocyte and splenocyte, thus enhancing body immunity.The a-mannatide is a kind of effective immunopotentiator on human body, but the research report on aspect the animal health is very few.Mannatide has good development prospect, particularly disease pilosity and the cub of hypoimmunity, young fowl and sick during animal on.And the source of a-mannatide is also simpler, and the microbial fermentation through special bacterial classification can obtain.But its effect, economic benefit etc. await more more deep researchs.
The effect of FOS mainly is through regulating animal
Enteron aisleMiddle microbiota balance realizes.FOS greatly can both be smoothly through stomach and small intestine and the utilization that is not degraded, but the Bacillus acidi lactici in the large intestine, Bifidobacterium Bifidum,
ClostridiumCan produce a series of fructosidases, make these beneficial bacteriums obtain nutrient and breed.Can secrete this enzyme and harmful bacterium is individual, after the beneficial bacterium propagation, can suppress by all means to be harmful to bacterium, thereby make simultaneously
The intestinal microecology systemAdjust to normal condition.Promote intestines peristalsis, remove enteron aisle rubbish, improve constipation, prevent diarrhoea, improve functions of intestines and stomach.(1) in intestines, optionally act on Bifidobacterium,
Lactic acid bacteriaDeng beneficial bacterium, and make its a large amount of propagation.Can make the harmful bacterium breeding of Bifidobacterium fast breeding, inhibition in the enteron aisle; Reduce the generation of toxin, and promote intestines peristalsis to discharge harmful substance in the body, acetate that produces in the Bifidobacterium breeding and lactic acid can strengthen the harmony of intestinal motive force and enterocinesia; Promote the contractile motion of intestines wall; Regulate intestinal microecology, correct bowel dysfunction, the effect that improves constipation and maintenance enteron aisle is arranged.(2) biological barrier on the reparation intestinal mucosa improves function of intestinal canal, promotes peristalsis of the digest tract.Promote that the B family vitamin is synthetic in the human body, improve the body metabolism, enhance immunity power and premunition promote mineral matters such as calcium, magnesium, iron to absorb simultaneously.
Comprise four kinds of main active components in the pure powder of yucca plant: saponin, glucosides, the pure and mild yucca polyphenol of Bai Lilu.1) saponin Saponins: yucca is rich in natural steroids saponin, has both comprised water soluble group, has fat-soluble group again, is natural clean agent or surfactant.The steroids saponin is because its special chemical structure; Be difficult to through gastrointestinal epithelial cells, so can in enteron aisle, bring into play its special physiological properties: have the surface-active effect, change the form of gastrointestinal epithelial cells film; Reduce the surface tension of cell membrane, promote the absorption of nutriment; Can combine the cholesterol on the cell membrane, form irreversible compound and excrete, thereby can improve the permeability of small intestinal cell, more help nutriment and absorb through the intestines wall; Germ is had certain inhibitory action, can optimize the gut flora structure.Activity (influencing the permeability of pathogenic cell film) with inhibition protozoon (comprising coccidia etc.), fungi and nematode; Saponin also has good immunostimulatory properties, can increase immunity function of animal.2) glucosides: being also referred to as oligosaccharides (Oligosaccharides) is a kind of important activity composition in the yucca.Thisly connect the functional oligosaccharide forms straight or branched through glycosidic bond, have and do not receive the digestive ferment of animal self secretion to influence or digest, decomposed by beneficial bacteria of intestinal tract such as Bifidobacterium, lactobacillus and utilize but can be used as nutriment at entering enteron aisle back segment by a plurality of monose; Promote that a large amount of breedings of beneficial bacteria are long; Be the high efficiently multiplying factor of beneficial bacterium, and can significantly suppress the breeding of harmful germ, effectively adjust the intestinal tract normal flora group structure; Promote the pet intestinal health; Help digesting and assimilating and utilizing of nutriment (amino acid, vitamin, mineral matter etc.).3) the pure and mild yucca polyphenol of Bai Lilu: this is the polyphenol of two kinds of uniquenesses; As everyone knows; Polyphenol has and combines amino ability in the middle of the amino acid, so scientist infers that these the two kinds of compositions in the yucca also have strong combination ammonia effect, reduce pernicious gas and promote pet fast the effect aspect the growth to get well; It is (trans that scientist has successfully separated the polyhydroxy stilbene that suppresses the urine enzyme simultaneously; Tetrahydroxy-methoxyl group stilbene), this is identical with Bai Lilu alcohol structure, so it has the effect that suppresses the urine enzyme again.Can combine with ammonia, can suppress urease again, reduce the generation of ammonia from two links.Current research shows that these two polyphenol substances also have good anti-inflammatory effect and natural anti-oxidation efficacy, and aspect people's health care and disease treatment, uses quite successful.The pure powder of yucca plant can significantly reduce ammonia; Possibly also exist these two kinds of compositions of oligosaccharides (or glucosides glycocomponents) and polyphenol; Have good synergy (suppress the urine enzyme and directly combine ammonia) aspect the control ammonia, thereby improving the function of enteron aisle.
Improve at present children's companion animals in age (especially dog cat) immunity and promote with to keep function of intestinal canal normal, the health product of dual regulation function that improves digestion power is less, and the present invention is through scientific composition, with astragalus polyose; The a-mannatide, FOS, yucca carries out compatibility, and it has complementary functions; Definite effect is intended to better improve animal, companion animals immunity physique; Strengthen enteron aisle resistance and eupepsy, keep the enteron aisle normal function, reduce the generation of Animal diseases.
Summary of the invention
The objective of the invention is to disclose a kind of raising animal (especially dog cat) immunity and improve the health-care agent composition of digestion power with to keep function of intestinal canal normal with promoting.The present invention also aims to disclose this health-care agent preparation of compositions technology
The objective of the invention is to a kind of raising animal (especially dog cat) immunity and promotion and keep function of intestinal canal normal; Improve the health-care agent composition of digestion power; The preparation technology of said composition is a tablet, pre-mixing agent, paste; Any formulation that meets pharmacy and animal food additive that powder, granule etc. can be made into.
Technical scheme of the present invention is following the realization:
A kind of raising animal provided by the present invention (especially dog cat) immunity with promote with to keep function of intestinal canal normal; Improve the health-care agent composition of digestion power; It is by raw material etc. by with the following weight parts proportioning, by astragalus polyose 1-100 weight portion, a-mannatide 1-100 weight portion; FOS 1-100 weight portion, the pure powder 1-100 of yucca plant weight portion is formed.
A kind of raising animal provided by the present invention (especially dog cat) immunity with promote with to keep function of intestinal canal normal; Improve the health-care agent composition of digestion power; It is to be made for tablet, pre-mixing agent, paste, powder, granule etc. by preparation process thereof, and can be made into meet pharmacy and animal food additive any formulation realized.
Technical scheme of the present invention can be the astragalus polyose 5-80 weight portion that comprises following weight parts, a-mannatide 5-80 weight portion, and FOS 5-80 weight portion, the pure powder 5-80 of yucca plant weight portion is formed.
The preferred technical scheme of technical scheme of the present invention is: astragalus polyose 30 weight portions, and a-mannatide 20 weight portions, FOS 20 weight portions, pure powder 30 weight portions of yucca plant are formed.
The preparation technology that the present invention adopts, equipment is prone to purchase, and raw material is easy to get, and produces easily, and constant product quality is fit to modern industrialization production.
The specific embodiment
Embodiment 1
Prescription: astragalus polyose 30 weight portions, a-mannatide 20 weight portions, FOS 20 weight portions, pure powder 30 weight portions of yucca plant, auxiliary material powdered glucose and skimmed milk power are processed 20% pulvis in right amount.For testing its effect, select dog field, Beijing, 60 pups are divided into three groups of A, B, C at random, 20 every group, wherein the A group is control group, and the B group is added 5% pulvis in pup grain, and the C group is added 10% pulvis in pup grain.Observe to open in its 20 days and eat disease incident between 60 days, essential record catches several, suffer from diarrhoea number and the variation of observation ight soil.
From experiment, analyze: A control group and B, C interpolation group significant difference, but B 5% pulvis group and C 10% pulvis group difference are not obvious, need further description of test.
Embodiment 2
Prescription: astragalus polyose 10 weight portions, a-mannatide 10 weight portions, FOS 35 weight portions, pure powder 45 weight portions of yucca plant, auxiliary material meat meal tankage and skimmed milk power are processed 50% deodorizing prescription type pre-mixing agent in right amount.Being its effect of experiment, select 40 the adult bitches in dog field, Tongzhou, Beijing to be divided into 2 groups of A control groups, 5% pre-mixing agent is organized in the B interpolation, continues to feed 6 months, and its experimental result is following:
| The contrast project | The A control group | B 5% pulvis group |
| Ill sum | 2 | 0 |
| The diarrhoea number | 1 | 0 |
| Ight soil changes | Amount is many, and it is smelly big to distinguish the flavor of | Amount is few, and stink obviously alleviates |
| The color and luster of hair | Coarse, lackluster degree | Submissive, glossiness is high |
| Body weight | Average weight changes little | Average weight weightening finish 1.86Kg |
| The number of oestrusing | 8 | 14 |
| Conceived number | 5 | 13 |
According to the experimental data assessment, deodorizing prescription type pre-mixing agent of the present invention, deodorizing effect is more remarkable, promotes that simultaneously nutrient absorption also is apparent in view.
A kind of raising animal provided by the present invention (especially dog cat) immunity with promote with to keep function of intestinal canal normal; The health-care agent composition that improves digestion power is not limited only to above-mentioned prescription and preparation process; It can also be to be made for tablet, pre-mixing agent, paste, powder, granule etc. by preparation process thereof, and can be made into meet pharmacy and animal food additive any formulation realized.
Claims (4)
1. animal health agent composition and preparation technology thereof; It is characterized in that: it be by raw material etc. by with the following weight parts proportioning, by astragalus polyose 1-100 weight portion, a-mannatide 1-100 weight portion; FOS 1-100 weight portion, the pure powder 1-100 of yucca plant weight portion is formed.
2. a kind of animal health agent composition according to claim 1 and preparation technology thereof; Its characteristic also is: by the astragalus polyose 5-80 weight portion of parts by weight of raw materials; A-mannatide 5-80 weight portion, FOS 5-80 weight portion, the pure powder 5-80 of yucca plant weight portion is formed.
3. a kind of animal health agent composition according to claim 1 and preparation technology thereof; Its characteristic also is: optimized technical scheme is astragalus polyose 30 weight portions; A-mannatide 20 weight portions, FOS 20 weight portions, pure powder 30 weight portions of yucca plant are formed.
4. according to described a kind of animal health agent composition of claim 1-3 and preparation technology thereof; Its characteristic also is: be a kind of raising animal (especially dog cat) immunity and promote with to keep function of intestinal canal normal; The health-care agent composition that improves digestion power is not limited only to above-mentioned prescription and preparation process; It is to be made for tablet, pre-mixing agent, paste, powder, granule etc. by preparation process thereof, and can be made into meet pharmacy and animal food additive any formulation realized.
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| CN103127304A (en) * | 2013-03-12 | 2013-06-05 | 丁国成 | Composition for enhancing immunity and preparation process of composition |
| CN103783290A (en) * | 2014-01-27 | 2014-05-14 | 湖南农业大学 | High-efficiency feed additive capable of reducing cholesterol of bird eggs and preparation method thereof |
| CN104207151A (en) * | 2014-09-05 | 2014-12-17 | 浙江汇能动物药品有限公司 | Nutritional agent capable of promoting recovery of canine-feline intestinal function as well as preparation method and application of nutritional agent |
| GB2526242A (en) * | 2014-01-08 | 2015-11-25 | Leander Internat Pet Foods Ltd | Nutritional composition |
| CN107232424A (en) * | 2017-06-28 | 2017-10-10 | 深圳市红瑞生物科技有限公司 | Pet is from emulsifiable paste and preparation method thereof |
| CN107691349A (en) * | 2017-09-27 | 2018-02-16 | 广州动物园 | A kind of brave human assistance mating system |
| CN108936030A (en) * | 2018-05-21 | 2018-12-07 | 沂南帅克宠物用品有限公司 | A kind of pet nutrition composition reducing pet kenosis peculiar smell containing probiotics |
| CN110464791A (en) * | 2019-09-04 | 2019-11-19 | 湖南宇山玉月农业科技有限公司 | A kind of application of yucca spp in prevention chicken necrotizing enterocolitis |
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Cited By (9)
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| CN103127304A (en) * | 2013-03-12 | 2013-06-05 | 丁国成 | Composition for enhancing immunity and preparation process of composition |
| GB2526242A (en) * | 2014-01-08 | 2015-11-25 | Leander Internat Pet Foods Ltd | Nutritional composition |
| CN103783290A (en) * | 2014-01-27 | 2014-05-14 | 湖南农业大学 | High-efficiency feed additive capable of reducing cholesterol of bird eggs and preparation method thereof |
| CN103783290B (en) * | 2014-01-27 | 2016-04-27 | 湖南农业大学 | A kind of reduction cholesterol of poultry egg heavy duty detergent feed addictive and preparation method |
| CN104207151A (en) * | 2014-09-05 | 2014-12-17 | 浙江汇能动物药品有限公司 | Nutritional agent capable of promoting recovery of canine-feline intestinal function as well as preparation method and application of nutritional agent |
| CN107232424A (en) * | 2017-06-28 | 2017-10-10 | 深圳市红瑞生物科技有限公司 | Pet is from emulsifiable paste and preparation method thereof |
| CN107691349A (en) * | 2017-09-27 | 2018-02-16 | 广州动物园 | A kind of brave human assistance mating system |
| CN108936030A (en) * | 2018-05-21 | 2018-12-07 | 沂南帅克宠物用品有限公司 | A kind of pet nutrition composition reducing pet kenosis peculiar smell containing probiotics |
| CN110464791A (en) * | 2019-09-04 | 2019-11-19 | 湖南宇山玉月农业科技有限公司 | A kind of application of yucca spp in prevention chicken necrotizing enterocolitis |
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