CN102869372B - 经修饰的结核抗原 - Google Patents

经修饰的结核抗原 Download PDF

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Publication number
CN102869372B
CN102869372B CN201180014803.7A CN201180014803A CN102869372B CN 102869372 B CN102869372 B CN 102869372B CN 201180014803 A CN201180014803 A CN 201180014803A CN 102869372 B CN102869372 B CN 102869372B
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CN
China
Prior art keywords
seq
polypeptide
residues
sequence
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201180014803.7A
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English (en)
Chinese (zh)
Other versions
CN102869372A (zh
Inventor
N.布莱斯
J.布朗
A-M.格利纳斯
P.梅滕斯
D.墨菲
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GlaxoSmithKline Biologicals SA
Glaxo Group Ltd
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GlaxoSmithKline Biologicals SA
Glaxo Group Ltd
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201180014803.7A 2010-01-27 2011-01-27 经修饰的结核抗原 Expired - Fee Related CN102869372B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29871010P 2010-01-27 2010-01-27
US61/298710 2010-01-27
US61/298,710 2010-01-27
PCT/EP2011/051158 WO2011092253A1 (en) 2010-01-27 2011-01-27 Modified tuberculosis antigens

Publications (2)

Publication Number Publication Date
CN102869372A CN102869372A (zh) 2013-01-09
CN102869372B true CN102869372B (zh) 2016-01-20

Family

ID=44318698

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180014803.7A Expired - Fee Related CN102869372B (zh) 2010-01-27 2011-01-27 经修饰的结核抗原

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US (2) US8932600B2 (https=)
EP (1) EP2528621B1 (https=)
JP (2) JP6010463B2 (https=)
KR (1) KR20120129927A (https=)
CN (1) CN102869372B (https=)
AU (1) AU2011209399B2 (https=)
BR (1) BR112012018669A2 (https=)
CA (1) CA2786969C (https=)
CO (1) CO6650338A2 (https=)
CY (1) CY1119518T1 (https=)
DK (1) DK2528621T3 (https=)
EA (1) EA201290590A1 (https=)
ES (1) ES2614266T3 (https=)
HR (1) HRP20161608T1 (https=)
HU (1) HUE031184T2 (https=)
LT (1) LT2528621T (https=)
MX (1) MX2012008790A (https=)
MY (1) MY156697A (https=)
PH (1) PH12012501550A1 (https=)
PL (1) PL2528621T3 (https=)
PT (1) PT2528621T (https=)
SG (1) SG182573A1 (https=)
SI (1) SI2528621T1 (https=)
UA (1) UA110103C2 (https=)
WO (1) WO2011092253A1 (https=)

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PT2315773T (pt) 2008-07-25 2016-11-23 Glaxosmithkline Biologicals Sa Polipéptidos, polinucleótidos e composições para utilização no tratamento de tuberculose latente
HUE037121T2 (hu) 2008-07-25 2018-08-28 Glaxosmithkline Biologicals Sa Új készítmények és eljárások
MX2011000982A (es) 2008-07-25 2011-03-02 Glaxosmithkline Biolog Sa La proteina de tuberculosis rv2386c, composiciones y usos de la misma.
SI2528621T1 (sl) * 2010-01-27 2017-01-31 Glaxosmithkline Biologicals S.A., Modificirani tuberkolozni antigeni
GB201116248D0 (en) 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
WO2013123579A1 (en) * 2012-02-24 2013-08-29 Mcmaster University Adenovirus-based tuberculosis vaccine and its use
CN103467582A (zh) * 2012-06-08 2013-12-25 同济大学 结核杆菌重要抗原的高通量筛选及其在结核病诊断中的应用
CN105431166B (zh) 2013-06-25 2020-09-18 国际艾滋病疫苗行动组织公司 结核病组合物和其使用方法
US10857219B2 (en) 2014-03-28 2020-12-08 The Board Of Regents Of The University Of Oklahoma Compositions comprising soluble HLA/M. tuberculosis-specific ligand complexes and methods of production and use thereof
GB201405921D0 (en) * 2014-04-02 2014-05-14 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
GB201513176D0 (en) * 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
CN105675863B (zh) * 2016-02-17 2017-10-20 遵义医学院附属医院 一组耐多药结核病诊断标志物及其用途
US10428122B2 (en) 2016-06-16 2019-10-01 International Aids Vaccine Initiative, Inc. Tuberculosis compositions and methods of treating or preventing tuberculosis
CN106546737A (zh) * 2016-10-24 2017-03-29 广州迪澳医疗科技有限公司 一种体外检测活动性结核的方法
GB201618432D0 (en) * 2016-11-01 2016-12-14 Matn Scient Ltd Detection and treatment of demyelinating diseases
BR112019011286A2 (pt) 2016-12-07 2019-10-15 Glaxosmithkline Biologicals S.A. métodos para produzir uma composição de lipossoma, para preparar uma composição de vacina e para preparar um kit de vacina.
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
GB201707700D0 (en) 2017-05-12 2017-06-28 Glaxosmithkline Biologicals Sa Dried composition
CA3063954A1 (en) 2017-05-30 2018-12-06 Glaxosmithline Biologicals S.A. Methods for manufacturing an adjuvant
BR112020010790A2 (pt) 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. purificação da saponina
CN109966170B (zh) * 2018-02-13 2022-04-15 深圳高尚科美生物科技有限公司 包含生物大分子的柔性脂质体化妆品及其制备方法
JP7640473B2 (ja) 2019-06-05 2025-03-05 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サポニン精製
EP4192429A4 (en) * 2020-08-05 2024-10-09 The Administrators of The Tulane Educational Fund METHOD FOR DETECTING TB IN BODY FLUID SAMPLES
GB202318595D0 (en) * 2023-12-05 2024-01-17 Sec Dep For Environment Food And Rural Affairs Acting Through Animal And Plant Health Agency Diagnostic proteins and reagents

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Also Published As

Publication number Publication date
DK2528621T3 (da) 2017-01-02
JP6503309B2 (ja) 2019-04-17
ES2614266T3 (es) 2017-05-30
US8932600B2 (en) 2015-01-13
JP2013517783A (ja) 2013-05-20
PL2528621T3 (pl) 2017-07-31
MY156697A (en) 2016-03-15
CA2786969C (en) 2018-07-24
EP2528621B1 (en) 2016-09-21
CO6650338A2 (es) 2013-04-15
MX2012008790A (es) 2012-08-17
PH12012501550A1 (en) 2012-10-22
EA201290590A1 (ru) 2013-03-29
HRP20161608T1 (hr) 2017-01-13
CN102869372A (zh) 2013-01-09
JP2016166193A (ja) 2016-09-15
SG182573A1 (en) 2012-08-30
KR20120129927A (ko) 2012-11-28
AU2011209399B2 (en) 2014-04-10
LT2528621T (lt) 2016-12-12
SI2528621T1 (sl) 2017-01-31
EP2528621A1 (en) 2012-12-05
US20120294882A1 (en) 2012-11-22
HUE031184T2 (en) 2017-06-28
US9200044B2 (en) 2015-12-01
JP6010463B2 (ja) 2016-10-19
PT2528621T (pt) 2016-12-20
UA110103C2 (uk) 2015-11-25
WO2011092253A1 (en) 2011-08-04
CA2786969A1 (en) 2011-08-04
BR112012018669A2 (pt) 2017-09-05
CY1119518T1 (el) 2018-03-07
US20150093414A1 (en) 2015-04-02
AU2011209399A1 (en) 2012-08-23

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