CN102869356A - 治疗癌症中的植物大麻素 - Google Patents

治疗癌症中的植物大麻素 Download PDF

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Publication number
CN102869356A
CN102869356A CN2011800236521A CN201180023652A CN102869356A CN 102869356 A CN102869356 A CN 102869356A CN 2011800236521 A CN2011800236521 A CN 2011800236521A CN 201180023652 A CN201180023652 A CN 201180023652A CN 102869356 A CN102869356 A CN 102869356A
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CN
China
Prior art keywords
phytocannabinoids
phytocannabinoid
plant extract
cannabis plant
bds
Prior art date
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Pending
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CN2011800236521A
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English (en)
Chinese (zh)
Inventor
D.帕罗拉罗
P.马西
A.A.伊佐
F.博雷利
G.阿韦洛
V.迪马尔佐
L.德佩特罗塞利斯
A.S.莫列洛
A.利格雷斯蒂
R.A.罗斯
L.A.福特
S.阿纳维-戈弗
M.古茨曼
G.维拉斯科
M.洛伦特
S.托雷斯
T.基库奇
G.盖伊
C.斯托特
S.怀特
A.苏顿
D.波特
E.德梅杰
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GW Pharma Ltd
Otsuka Pharmaceutical Co Ltd
Original Assignee
GW Pharma Ltd
Otsuka Pharmaceutical Co Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42261478&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102869356(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by GW Pharma Ltd, Otsuka Pharmaceutical Co Ltd filed Critical GW Pharma Ltd
Publication of CN102869356A publication Critical patent/CN102869356A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3482—Cannabis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800236521A 2010-03-12 2011-03-11 治疗癌症中的植物大麻素 Pending CN102869356A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1004137.4 2010-03-12
GB1004137.4A GB2478595B (en) 2010-03-12 2010-03-12 Phytocannabinoids in the treatment of glioma
PCT/GB2011/050487 WO2011110866A1 (en) 2010-03-12 2011-03-11 Phytocannabinoids in the treatment of cancer

Publications (1)

Publication Number Publication Date
CN102869356A true CN102869356A (zh) 2013-01-09

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ID=42261478

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CN2011800236521A Pending CN102869356A (zh) 2010-03-12 2011-03-11 治疗癌症中的植物大麻素

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US (3) US8790719B2 (enExample)
EP (1) EP2544682B1 (enExample)
JP (1) JP5785569B2 (enExample)
KR (1) KR20130067248A (enExample)
CN (1) CN102869356A (enExample)
AR (1) AR080454A1 (enExample)
AU (3) AU2011225837A1 (enExample)
BR (1) BR112012023017A8 (enExample)
CA (1) CA2792722A1 (enExample)
CO (1) CO6630103A2 (enExample)
CY (1) CY1117451T1 (enExample)
DK (1) DK2544682T3 (enExample)
EA (1) EA201290901A1 (enExample)
ES (1) ES2569669T3 (enExample)
GB (1) GB2478595B (enExample)
HR (1) HRP20160427T1 (enExample)
HU (1) HUE029817T2 (enExample)
IL (1) IL221871A (enExample)
MX (1) MX2012010512A (enExample)
NZ (2) NZ629136A (enExample)
PH (1) PH12012501782A1 (enExample)
PL (1) PL2544682T3 (enExample)
SG (1) SG184016A1 (enExample)
SI (1) SI2544682T1 (enExample)
TW (1) TWI461205B (enExample)
UA (1) UA109271C2 (enExample)
WO (1) WO2011110866A1 (enExample)
ZA (1) ZA201207574B (enExample)

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CN104277917A (zh) * 2014-10-24 2015-01-14 汉康(云南)生物科技有限公司 一种富含大麻二酚的工业大麻精油提取方法及其提取设备
CN107405314A (zh) * 2015-02-27 2017-11-28 埃布公司 包含纯化的大麻素与至少一种类黄酮、萜或矿物质的组合的组合物
CN107735086A (zh) * 2015-05-07 2018-02-23 马克·安德鲁·夏尔多内 大麻油的氢化
CN109789123A (zh) * 2016-08-03 2019-05-21 塞尔达治疗手术有限公司 大麻属组合物
CN109789124A (zh) * 2016-08-03 2019-05-21 塞尔达治疗手术有限公司 大麻属组合物
CN109843287A (zh) * 2016-08-03 2019-06-04 塞尔达治疗手术有限公司 大麻属组合物
CN110621312A (zh) * 2017-03-05 2019-12-27 以色列国家农业部、农村发展农业研究组织·沃尔卡尼中心 用于治疗癌症的组合物和方法
CN111184710A (zh) * 2020-03-02 2020-05-22 福建省中科生物股份有限公司 一种环酚的应用和制备方法
US10722490B2 (en) 2016-08-29 2020-07-28 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
CN111773390A (zh) * 2020-07-01 2020-10-16 南京大学 一种药物在制备治疗脑转移瘤及其相关疾病的药品中的应用
US10821147B2 (en) 2015-02-27 2020-11-03 Canopy Growth Corporation Printable cannabinoid and terpene compositions
CN113264914A (zh) * 2018-02-20 2021-08-17 麦姆德制药(佛罗里达)公司 用于治疗物质成瘾和其它障碍的遗传修饰的大麻植物和修饰的大麻素化合物
CN115583933A (zh) * 2022-10-31 2023-01-10 暨明医药科技（苏州）有限公司 一种高纯度四氢大麻素同系物的制备方法
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