CN102844317B - 作为Janus激酶抑制剂的环丁烷和甲基环丁烷衍生物 - Google Patents

作为Janus激酶抑制剂的环丁烷和甲基环丁烷衍生物 Download PDF

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CN102844317B
CN102844317B CN201180019267.XA CN201180019267A CN102844317B CN 102844317 B CN102844317 B CN 102844317B CN 201180019267 A CN201180019267 A CN 201180019267A CN 102844317 B CN102844317 B CN 102844317B
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compound
acceptable salt
pyrrolo
pyrazol
pharmacy acceptable
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CN102844317A (zh
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Y-L·李
J·D·罗杰斯
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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  • Health & Medical Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180019267.XA 2010-02-18 2011-02-18 作为Janus激酶抑制剂的环丁烷和甲基环丁烷衍生物 Active CN102844317B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30563010P 2010-02-18 2010-02-18
US61/305,630 2010-02-18
PCT/US2011/025433 WO2011103423A1 (en) 2010-02-18 2011-02-18 Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors

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CN102844317A CN102844317A (zh) 2012-12-26
CN102844317B true CN102844317B (zh) 2015-06-03

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US (2) US20110207754A1 (enExample)
EP (1) EP2536729A1 (enExample)
JP (1) JP5858434B2 (enExample)
KR (1) KR101836538B1 (enExample)
CN (1) CN102844317B (enExample)
AU (1) AU2011217961B2 (enExample)
BR (1) BR112012020693B1 (enExample)
CA (1) CA2790070C (enExample)
EA (1) EA023444B1 (enExample)
MX (1) MX2012009541A (enExample)
WO (1) WO2011103423A1 (enExample)

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