CN102812354A - 色谱分析柱及其制造方法、以及分析装置 - Google Patents

色谱分析柱及其制造方法、以及分析装置 Download PDF

Info

Publication number
CN102812354A
CN102812354A CN2010800647168A CN201080064716A CN102812354A CN 102812354 A CN102812354 A CN 102812354A CN 2010800647168 A CN2010800647168 A CN 2010800647168A CN 201080064716 A CN201080064716 A CN 201080064716A CN 102812354 A CN102812354 A CN 102812354A
Authority
CN
China
Prior art keywords
column
side wall
mobile phase
flow path
side walls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800647168A
Other languages
English (en)
Chinese (zh)
Inventor
洪锡亨
清元智文
小林宏资
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Electron Ltd
Shinwa Chemical Industries Ltd
Original Assignee
Tokyo Electron Ltd
Shinwa Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Electron Ltd, Shinwa Chemical Industries Ltd filed Critical Tokyo Electron Ltd
Publication of CN102812354A publication Critical patent/CN102812354A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
CN2010800647168A 2010-02-25 2010-12-24 色谱分析柱及其制造方法、以及分析装置 Pending CN102812354A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010040077A JP2011174856A (ja) 2010-02-25 2010-02-25 クロマトグラフィー用カラム、その製造方法、および分析装置
JP2010-040077 2010-02-25
PCT/JP2010/073369 WO2011104990A1 (ja) 2010-02-25 2010-12-24 クロマトグラフィー用カラム、その製造方法、および分析装置

Publications (1)

Publication Number Publication Date
CN102812354A true CN102812354A (zh) 2012-12-05

Family

ID=44506425

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800647168A Pending CN102812354A (zh) 2010-02-25 2010-12-24 色谱分析柱及其制造方法、以及分析装置

Country Status (6)

Country Link
US (1) US20120318049A1 (enExample)
EP (1) EP2541245A4 (enExample)
JP (1) JP2011174856A (enExample)
CN (1) CN102812354A (enExample)
TW (1) TWI421493B (enExample)
WO (1) WO2011104990A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105102113A (zh) * 2013-02-05 2015-11-25 制药流体股份有限公司 化学反应器装置
CN106062551A (zh) * 2013-09-18 2016-10-26 安捷伦科技有限公司 具有结构壁的液相色谱柱
CN108333283A (zh) * 2017-01-20 2018-07-27 中国科学院上海微系统与信息技术研究所 一种含有流线型椭圆微柱阵列的微色谱柱及其制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1024344B1 (nl) 2016-07-04 2018-02-02 PharmaFluidics N.V. Productie van chemische reactoren
BE1026910B1 (nl) * 2018-12-21 2020-07-22 Pharmafluidics N V Chemische reactoren
BE1028976B1 (nl) * 2020-12-30 2022-08-01 Pharmafluidics N V Pilaarstructuren

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720438A (zh) * 2002-11-29 2006-01-11 日本电气株式会社 分离设备和分离方法
WO2008020593A1 (en) * 2006-08-14 2008-02-21 Tokyo Electron Limited Column for chromatography and method for producing the same
WO2009028238A1 (ja) * 2007-08-24 2009-03-05 Tokyo Electron Limited クロマト検出装置
WO2009128294A1 (ja) * 2008-04-19 2009-10-22 ブラザー工業株式会社 検査対象受体及び当該検査対象受体を備えた検査装置
CN101585507A (zh) * 2009-06-23 2009-11-25 中国科学院上海微系统与信息技术研究所 一种pdms微流控芯片中通孔结构的制作方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07120450A (ja) * 1993-10-22 1995-05-12 Sumika Bunseki Center:Kk 多孔質体クロマトグラフィー用カラム
US6156273A (en) * 1997-05-27 2000-12-05 Purdue Research Corporation Separation columns and methods for manufacturing the improved separation columns
JP2002301367A (ja) * 2001-04-05 2002-10-15 Gl Sciences Inc クロマトグラフィー用多孔質体の製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720438A (zh) * 2002-11-29 2006-01-11 日本电气株式会社 分离设备和分离方法
WO2008020593A1 (en) * 2006-08-14 2008-02-21 Tokyo Electron Limited Column for chromatography and method for producing the same
WO2009028238A1 (ja) * 2007-08-24 2009-03-05 Tokyo Electron Limited クロマト検出装置
WO2009128294A1 (ja) * 2008-04-19 2009-10-22 ブラザー工業株式会社 検査対象受体及び当該検査対象受体を備えた検査装置
CN101585507A (zh) * 2009-06-23 2009-11-25 中国科学院上海微系统与信息技术研究所 一种pdms微流控芯片中通孔结构的制作方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BING HE ET AL.: "Microfabricated liquid chromatography columns based on collocated monolith support structures", 《ANALYSIS》, vol. 17, no. 67, 1 September 1998 (1998-09-01), pages 925 - 932, XP002255566, DOI: doi:10.1016/S0731-7085(98)00060-0 *
M.DE PRA ET AL.: "Experimental Study on Band Dispersion in Channels Structured with Micropillars", 《ANAL.CHEM.》, vol. 78, no. 18, 15 September 2006 (2006-09-15), pages 6519 - 6525, XP002496764, DOI: doi:10.1021/ac060915h *
NICO VERVOORT ET AL.: "Importance and Reduction of the Sidewall-Induced Band-Broadening Effect in Pressure-Driven Microfabricated Columns", 《ANAL.CHEM.》, vol. 76, no. 15, 1 August 2004 (2004-08-01), pages 4501 - 4507, XP055087346, DOI: doi:10.1021/ac049930h *
姚波等: "微全分析系统中的电色谱分离技术", 《分析化学》, vol. 32, no. 12, 31 December 2004 (2004-12-31), pages 1673 - 1676 *
方肇伦: "微流控分析芯片发展与展望", 《大学化学》, vol. 16, no. 2, 30 April 2001 (2001-04-30), pages 1 - 6 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105102113A (zh) * 2013-02-05 2015-11-25 制药流体股份有限公司 化学反应器装置
CN105102113B (zh) * 2013-02-05 2018-05-29 制药流体股份有限公司 化学反应器装置
CN106062551A (zh) * 2013-09-18 2016-10-26 安捷伦科技有限公司 具有结构壁的液相色谱柱
US10073068B2 (en) 2013-09-18 2018-09-11 Agilent Technologies, Inc. Liquid chromatography columns with structured walls
US10718743B2 (en) 2013-09-18 2020-07-21 Agilent Technologies, Inc. Liquid chromatography columns with structured walls
CN108333283A (zh) * 2017-01-20 2018-07-27 中国科学院上海微系统与信息技术研究所 一种含有流线型椭圆微柱阵列的微色谱柱及其制备方法
CN108333283B (zh) * 2017-01-20 2024-07-19 中国科学院上海微系统与信息技术研究所 一种含有流线型椭圆微柱阵列的微色谱柱及其制备方法

Also Published As

Publication number Publication date
EP2541245A4 (en) 2013-12-18
US20120318049A1 (en) 2012-12-20
TW201142281A (en) 2011-12-01
EP2541245A1 (en) 2013-01-02
WO2011104990A1 (ja) 2011-09-01
TWI421493B (zh) 2014-01-01
JP2011174856A (ja) 2011-09-08

Similar Documents

Publication Publication Date Title
CN102812354A (zh) 色谱分析柱及其制造方法、以及分析装置
US9726636B2 (en) Single particle analyzer and single particle analysis method
US20100032357A1 (en) Chromatography column and manufacturing method of the same
CN105102113B (zh) 化学反应器装置
CN101571535A (zh) 具有三维金属纳米线电极形成沟道的生物传感器及其制造方法及具有该传感器的生物盘系统
CN110506201B (zh) 粒子检测装置和粒子检测方法
CN102119321A (zh) 测量流体通道中流动的液体的流速的方法以及实现设备
Vangelooven et al. Design and evaluation of flow distributors for microfabricated pillar array columns
Slentz et al. Geometric effects of collocated monolithic support structures on separation performance in microfabricated systems
US20140256028A1 (en) Semiconductor micro-analysis chip and manufacturing method thereof
KR101584083B1 (ko) 미소입자의 변형성 및 피로 특성 분석 장치
CN112816608B (zh) 微色谱柱及制备方法
JP2014519611A (ja) 平面状マイクロ流体分離装置のヴィアに起因する分散の低減
JP2023525994A (ja) 倒壊のない高アスペクト比ナノ構造のナノファブリケーション
CN103718019A (zh) 用于流动细胞计量的流体力学细胞导引装置
CN111398496B (zh) 一种交错阵列布置的微气相色谱柱
CN1118623A (zh) 具有一个阻挡体的涡流检测器
JP2001091497A (ja) フリーフロー電気泳動装置
JP5331798B2 (ja) 検査対象受体及び当該検査対象受体を備えた検査装置
JP2019117064A (ja) 粒子検出装置及び粒子検出方法
JP2022514346A (ja) 化学反応器
JP2015004540A (ja) 流速測定方法および装置ならびに測定チップおよびプログラム
CN1168953C (zh) 整流装置
JP2021120620A (ja) 粒子検出用流体
TW201242659A (en) Micro-mixer and micro-fluid chip

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121205