CN102793829A - Medicine for external application used for treating gout and preparation method - Google Patents
Medicine for external application used for treating gout and preparation method Download PDFInfo
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- CN102793829A CN102793829A CN2012102878257A CN201210287825A CN102793829A CN 102793829 A CN102793829 A CN 102793829A CN 2012102878257 A CN2012102878257 A CN 2012102878257A CN 201210287825 A CN201210287825 A CN 201210287825A CN 102793829 A CN102793829 A CN 102793829A
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Abstract
The invention relates to a medicine for external application used for treating gout and a preparation method, the medicine for external application comprises the following traditional Chinese medicines: smallflower galinsoga flower, buckwheat root, philippine flemingia root, glabrousleaf pittosporum leaf and Paris polyphylla Smith; the above traditional Chinese medicines are respectively immersed in a boiled rice vinegar, and are inoculated to Acetobactersp. GLYSM66CCTCC NO: M2011238, after fermenting through different fermentation times, and then a fermentation broth is blended to prepare the medicine. The medicine for external application has the function of dredging the channel and activating meridian, can rapidly reduce the uric acid level in blood of the gout patients, and has the advantages of fast pain relieving effect, good curative effect, low cost, no toxic and side effects and simple preparation method.
Description
Technical field
The present invention relates to application compress, specifically is a kind of application compress of treating gout and preparation method thereof.
Background technology
Gout is claimed " hyperuricemia " again, the purine metabolism obstacle, and it is a kind of to belong to arthritis.Gout is that the metabolism of the material of purine in the body gets muddled; The synthetic increase of uric acid or discharge reduce, and cause hyperuricemia, during the blood uric acid excessive concentration; Uric acid is deposited in joint, cartilage and the kidney with the form of sodium salt; Cause and organize the foreign body inflammatory reaction, i.e. gout, general outbreak part is thumb joint, ankle joint, knee joint etc.That the gouty attack,acute position occurs is red, swollen, hot, have an intense pain, general many in midnight's outbreak, and the people is waken up with a start from sleep, and at the gout initial stage, shows effect and is more common in lower limb.
At present for gout; Doctor trained in Western medicine mainly adopts analgesia and anti-inflammatory type medicine respite pain; Side effect is big, and it is main that Chinese medicine adopts clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, promotes the drainage of uric acid; Because the processing procedure of most of Chinese medicines is through boiling, extracting the method for the effective ingredient in the Chinese crude drug with decocting in water.But this method has following shortcoming: 1, owing to boil time, temperature, pressure and can not unify, the effective ingredient in the Chinese crude drug is difficult to be extracted out fully; 2, it is very high to boil in the process temperature, might destroy the effective ingredient of those heat sensitivitys; 3, be the intermediate of effective ingredient mostly through boiling the Chinese medicine ingredients that lixiviate goes out merely; Must transform through the intravital probiotic bacteria of people, finally become acting effective ingredient, get into blood; Because human body probiotic bacteria situation is different; Thereby produce the situation such as slow or ineffective that takes effect, therapeutic effect is unsatisfactory, develop nontoxic, anti-gout novel medical is the vital task that gout is prevented and treated efficiently.
Summary of the invention
The objective of the invention is the deficiency to prior art, and provide a kind of pain relieving fast, have dredging the meridian, reduce the application compress of uric acid content in the blood, evident in efficacy, the treatment gout that has no side effect fast.
Another object of the present invention provides the method for preparing of these application compress.
The technical scheme that realizes the object of the invention is:
A kind of application compress of treating gout; It is to be immersed in respectively in the rice vinegar of boiling by Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, Radix Flemingiae Philippinensis, Folium Pittospori Glabrati and Rhizoma Paridis Chinese medicine of the five flavours material; Inoculate acetobacter, when different fermentations, behind the indirect fermentation, its fermentation liquid is blent processed again.
Described acetobacter is acetobacter (Acetobacter sp.) GLYSM66 CCTCC NO:M2011238; Be called for short acetobacter GLYSM66; Be that the inventor screens from common acetobacter; In on July 5th, 2011 be deposited in Chinese Wuhan University China typical culture collection center (be called for short: CCTCC), depositary institution address: Chinese Wuhan Wuhan University, preservation date: on July 12nd, 2011; The classification name: acetobacter GLYSM66 Acetobacter sp.GLYSM66, deposit number is CCTCC NO:M2011238.This acetobacter has the function of degraded several kinds of Chinese medicinal materials or composite Chinese crude drug.
The method for preparing of application compress of the present invention comprises the steps:
(1) Chinese crude drug Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, Radix Flemingiae Philippinensis, Folium Pittospori Glabrati, Rhizoma Paridis pulverize separately are crossed 100 orders, and autoclaving 30 minutes, subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, subsequent use;
(3) five kinds of Chinese crude drugs step (1) being handled well are immersed in respectively in the rice vinegar after step (2) sterilization, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, its inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Flos Galinsogae Parviflorae 145-155 days; Semen Fagopyri Esculenti root 145-155 days; Radix Flemingiae Philippinensis 115-130 days; Folium Pittospori Glabrati 85-100 days; Rhizoma Paridis 175-185 days, subsequent use;
(6) blend: the fermentation liquid of getting above-mentioned each medicine is blent, and its weight part ratio is: Xiang ︰ (2.5-3.5) ︰ (1.5-2.5) ︰ (the 0.4-0.6) ︰ (0.25-0.4) of Yang Hua ︰ Semen Fagopyri Esculenti Gen ︰ Qian Jin Ba ︰ YIDUOYUN Ye ︰ Rhizoma Paridis=(0.8-1.5);
(7) seal up for safekeeping again after blending more than 3 months.
The animal experiment of this medicinal liquid: on JIUYUE 19,2010 1 day to 2010 JIUYUE in; Entrust Guangxi Zhuang Autonomous Region Medicine Research Academy to carry out; The experimental study content: clinical application method (external) is in dermatologic acute toxicity and acute skin irritation property/corrosivity; Test shows: have no effect with behavioral activity, fur gloss, diet and the body weight etc. of 5210.81mg crude drug in whole/kg percutaneous dosing to intact skin and damaged skin rabbit; Do not see dead and any acute toxic reaction; Show that the meridians regulator is used on intact skin and the damaged skin, does not all cause acute toxic reaction to rabbit, in acute skin irritation property/corrosion test outward; Do not find that with 5210.81mg crude drug in whole/kg percutaneous multiple dosing the situation such as tissue injury of erythema, edema and reversible or irreversibility appear in rabbit skin, show this medicinal liquid to the intact skin of rabbit and damaged skin all non-stimulated/corrosiveness.
The method for using of this medicine has two kinds, can use wherein a kind of, also can two kinds of combinations:
First method is:
(1) take a shower earlier, patient's pore is fully opened after, with this medicinal liquid fumigation 30 minutes to 1 hour;
(2) put on the clothes that soaked with this medicinal liquid, the parcel health;
(3) toast whole body with infrared ray;
(4) carry out channels and network vessels regulation.
10 days is a course of treatment.
Second method is: external application, suction medicinal liquid with absorbent paper, and apply at the gout position, the external preservative film encases, and fixes with adhesive tape, and applied 6 hours every day at least, and 7 days is a course of treatment.
The record of the pharmacological action of each medical material certificate " Chinese medicine voluminous dictionary " and books such as " national Chinese herbal medicine compilations " in these application compress: Flos Galinsogae Parviflorae is the flower of feverfew Herba galinsogae parviflorae, has the function of liver heat removing and eyesight improving; Semen Fagopyri Esculenti root, Folium Pittospori Glabrati are leaf, the Rhizoma Paridis of Pittosporaceae plant Pittosporum glabratum Lindl, another name: Typhonium divaricatum (L.) Decne, ferrum lamp lotus all have heat-clearing and toxic substances removing, a function of the eliminating carbuncle of invigorating blood circulation, expelling wind and removing dampness sore; Radix Flemingiae Philippinensis is the root of the climing property of leguminous plant Radix Flemingiae Philippinensis, has the function of expelling wind and removing dampness, pain relieving, pathogenic wind expelling and blood circulation promoting.These medicines by the fermentation of Acetobacter invention, the decomposition and transformation of the Chinese herbal medicine, the active ingredient is fully released, enhanced potency, and acetic acid bacteria and the presence of strong acids, enhances the oxidation resistance of the active ingredient, a more Strong blood circulation, Shujin, carminative dehumidification, gas line anti-inflammatory analgesic function, clinical treatment results showed that the drug can significantly reduce gout uric acid levels in the blood, pain fast, the effect is significant, and the low cost of treatment, preparation method is simple.
Clinical this medicine of usefulness treatment gout 12 examples are wherein cured 5 examples fully, significant curative effect 5 examples, and effective 2 examples are to the non-stimulated corrosiveness of skin.
The specific embodiment
Below through embodiment the present invention is described.
Used acetobacter GLYSM66 obtains through the screening technique that comprises the steps in the present embodiment:
(1) gets Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, very heavy group, Folium Pittospori Glabrati or five kinds of Chinese crude drugs of Rhizoma Paridis, pulverize, cross 100 mesh sieves, autoclaving 30 minutes respectively afterwards, five kinds of Chinese crude drug mixed in equal amounts or deposit subsequent use separately;
(2) use the soaking in rice vinegar medical material, medical material compares public jin ︰ liter with the mass and size of rice vinegar) 1 ︰ (5-10), soaking temperature 20-35 ℃, the soaking fermentation different time;
(3) get the fermentation liquid of different fermentations time; Measure effective ingredient--total flavones and total saponins; Simultaneously through 1000 power microscope microscopies; Total flavones and the total saponin content in the sample of five kinds of Chinese crude drug mixed in equal amounts and the five kinds of single samples of Chinese crude drug relatively, the result finds: biased sample is total flavones and total saponin content height not only, and only has single microorganism in the fermentation liquid; Microbe species in latter's liquid is many.Separation screening is carried out in microorganism to biased sample, and successive transfer culture obtains the acetobacter of the several kinds of Chinese medicinal materials of degrading of the present invention.
The used LB culture medium of the amplification culture of acetobacter described in the present embodiment is by sodium chloride 10g, and peptone 10g, yeast extract 5g add water and be settled to 1L and process.
Embodiment 1
A kind of method for preparing of treating the application compress of gout comprises the steps:
(1) Chinese crude drug Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, Radix Flemingiae Philippinensis, Folium Pittospori Glabrati, Rhizoma Paridis pulverize separately are crossed 100 orders, all autoclaving is 30 minutes, and is subsequent use;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature, subsequent use;
(3) the described five kinds of Chinese crude drugs of step (1) are immersed in respectively in step (2) the disinfectant rice vinegar, solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, each single medical material fermentation time is: Flos Galinsogae Parviflorae 150 days; Semen Fagopyri Esculenti root 150 days; Radix Flemingiae Philippinensis 120 days; Folium Pittospori Glabrati 90 days; Rhizoma Paridis 180 days;
(6) blend: get each medicine fermentation liquid and blend: pull out ︰ YIDUOYUN leaf ︰ Rhizoma Paridis=1 ︰, 3 ︰, 2 ︰, 0.5 ︰ 0.3 for thousand jin to sun flower ︰ Semen Fagopyri Esculenti root ︰ by following weight part ratio (kilogram);
(7) seal the application compress of promptly processing the treatment gout in 90 days after blending again up for safekeeping.
Embodiment 2
Method step according to embodiment 1 carries out; Different is: the weight part ratio (kilogram) that said each the medicine fermentation liquid of step (6) is blent is: Xiang Yang Hua ︰ Semen Fagopyri Esculenti Gen ︰ Qian Jin Ba ︰ YIDUOYUN Ye ︰ Rhizoma Paridis=0.8 ︰, 2.5 ︰, 1.5 ︰, 0.6 ︰ 0.4, sealed up for safekeeping after blending 110 days.
Embodiment 3
Use these application compress treatment shank gout instance:
1, patient: deep certain, man, 45 years old, Guilin city people from Pingyue County; Gout is treated preceding symptom for many years: uric acid is up to 745 μ mol/L, and both feet can not land during pain; After the Therapeutic Method that adopts this medicine is treated three days, can slightly walk down, medication was fully recovered after two courses of treatment; Uric acid returns to normal value basically, does not see recurrence so far, and therapeutic effect is seen table one.
Table one: uric acid conventional sense in the blood
| Before and after the medication | Check result | Reference value (μ mol/L) | Inspection hospital | Review time |
| Before the medication | 745 | 124-416 | The People's Hospital, Pingyue County | 2011.04.24 |
| After the medication | 488 | 87-418 | Guilin City Pok Oi Hospital | 2011.05.19 |
| After the medication | 436 | 124-416 | The People's Hospital, Pingyue County | 2011.05.27 |
2, patient: Liu, man, 26 years old, Guilin people from city, certain college sports teacher is that pain the first time after higher appears in uric acid; Before the treatment, sore spot is red and swollen, and foot can not land, and pain unbearably; After the drug of topical application 6 hours, pain alleviates gradually, and the next morning, foot can slightly land, continuous use; Cooperate artificial auxiliary massage conditioning, recovery from illness after seven days, rehabilitation is as usual, does not see recurrence so far more than a year.
Claims (4)
1. application compress of treating gout; It is characterized in that: it is to be immersed in respectively in the rice vinegar of boiling by Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, Radix Flemingiae Philippinensis, Folium Pittospori Glabrati, Rhizoma Paridis Chinese crude drug, inoculates acetobacter, when different fermentations behind the indirect fermentation; Again its fermentation liquid is blent and processed, wherein:
Described acetobacter is acetobacter (Acetobacter sp.) GLYSM66 CCTCC NO:M2011238;
The solid-liquid ratio of said each medical material and rice vinegar is 1 ︰ (8-10);
Said fermentation time is respectively: Flos Galinsogae Parviflorae 145-155 days; Semen Fagopyri Esculenti root 145-155 days; Radix Flemingiae Philippinensis 115-130 days; Folium Pittospori Glabrati 85-100 days; Rhizoma Paridis 175-185 days;
The weight part ratio that said each fermentation liquid is blent is: Xiang ︰ (2.5-3.5) ︰ (1.5-2.5) ︰ (the 0.4-0.6) ︰ (0.25-0.4) of Yang Hua ︰ Semen Fagopyri Esculenti Gen ︰ Qian Jin Ba ︰ Yi Duo Yun ︰ Rhizoma Paridis=(0.8-1.5).
2. a method for preparing of treating the application compress of gout is characterized in that: comprise the steps:
(1) Chinese crude drug Flos Galinsogae Parviflorae, Semen Fagopyri Esculenti root, Radix Flemingiae Philippinensis, Folium Pittospori Glabrati, Rhizoma Paridis pulverize separately are crossed 100 orders, and autoclaving 30 minutes;
(2) rice vinegar is boiled with warm fire, naturally cool to room temperature;
(3) five kinds of Chinese crude drugs step (1) being handled well are immersed in respectively in step (2) the disinfectant rice vinegar, and solid-liquid ratio is 1 ︰ (8-10);
(4) with acetobacter GLYSM66 with LB culture medium amplification culture after, be inoculated into respectively in each medical material soak, inoculum concentration is: medical material soaks the ︰ 1 of the volume ratio of Ye ︰ strain=(20-50);
(5) ferment at normal temperatures, fermentation time is respectively: Flos Galinsogae Parviflorae 145-155 days; Semen Fagopyri Esculenti root 145-155 days; Radix Flemingiae Philippinensis 115-130 days; Folium Pittospori Glabrati 85-100 days; Rhizoma Paridis 175-185 days;
(6) blend: get above-mentioned each medicine fermentation liquid and blend, its weight part ratio is: Xiang ︰ (2.5-3.5) ︰ (1.5-2.5) ︰ (the 0.4-0.6) ︰ (0.25-0.4) of Yang Hua ︰ Semen Fagopyri Esculenti Gen ︰ Qian Jin Ba ︰ YIDUOYUN Ye ︰ Rhizoma Paridis=(0.8-1.5);
(7) seal up for safekeeping again after blending more than 3 months.
3. method for preparing according to claim 2 is characterized in that: the weight part ratio that said each the medicine fermentation liquid of step (6) is blent is: Xiang Yang Hua ︰ Semen Fagopyri Esculenti Gen ︰ Qian Jin Ba ︰ YIDUOYUN Ye ︰ Rhizoma Paridis=1 ︰, 3 ︰, 2 ︰, 0.5 ︰ 0.3.
4. the said a kind of method for using of treating the application compress of gout of claim 1 is characterized in that: comprise the steps:
(1) take a shower earlier, patient's pore is fully opened after, with this medicinal liquid fumigation 30 minutes to 1 hour;
(2) put on the clothes that soaked with this medicinal liquid, the parcel health;
(3) toast whole body with infrared ray;
(4) carry out channels and network vessels regulation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735488A (en) * | 2014-01-10 | 2014-04-23 | 王胜文 | Herbal medicine-containing skin moisturizer and preparation method thereof |
| CN105770813A (en) * | 2016-04-07 | 2016-07-20 | 陈明华 | Medicine for treating rheumatoid arthritis, gout and osteonecrosis and preparation method thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160051596A1 (en) * | 2014-08-21 | 2016-02-25 | Food Industry Research And Development Institute | Novel acetobacter and gluconacetobacter strains and their metabolites for use in inhibiting xanthine oxidase |
| US9867857B2 (en) | 2014-08-21 | 2018-01-16 | Food Industry Research And Development Institute | Acetobacter and gluconacetobacter strains and their metabolites for use in inhibiting xanthine oxidase |
| US9636368B2 (en) | 2014-08-22 | 2017-05-02 | Food Industry Research And Development Institute | Strain of Lactobacillus rhamnosus and its metabolites for use in inhibiting xanthine oxidase and treating gout |
| CN104337989A (en) * | 2014-11-07 | 2015-02-11 | 成都华熹科技有限公司 | Traditional Chinese medicine composition containing centipeda minima and frankincense for treating gout |
| CN108743869A (en) * | 2018-07-03 | 2018-11-06 | 广东楷铭生物科技有限公司 | A kind of arthritic Chinese medicine composition vinegar extracting solution of compound for treating gout swelling and pain |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214366A (en) * | 2008-01-04 | 2008-07-09 | 胡祥福 | Chinese medicine preparation for treating gout and rheumatism |
| CN101991811A (en) * | 2009-08-26 | 2011-03-30 | 广西玉林制药有限责任公司 | Traditional Chinese medicine composition for treating rheumatism arthralgia, cold headache, abdominal cavity pain and chilblain and preparation method thereof |
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2011
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214366A (en) * | 2008-01-04 | 2008-07-09 | 胡祥福 | Chinese medicine preparation for treating gout and rheumatism |
| CN101991811A (en) * | 2009-08-26 | 2011-03-30 | 广西玉林制药有限责任公司 | Traditional Chinese medicine composition for treating rheumatism arthralgia, cold headache, abdominal cavity pain and chilblain and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735488A (en) * | 2014-01-10 | 2014-04-23 | 王胜文 | Herbal medicine-containing skin moisturizer and preparation method thereof |
| CN103735488B (en) * | 2014-01-10 | 2015-07-15 | 王胜文 | Herbal medicine-containing skin moisturizer and preparation method thereof |
| CN105770813A (en) * | 2016-04-07 | 2016-07-20 | 陈明华 | Medicine for treating rheumatoid arthritis, gout and osteonecrosis and preparation method thereof |
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| CN102793829B (en) | 2013-11-06 |
| CN102370859A (en) | 2012-03-14 |
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