CN105770813A - Medicine for treating rheumatoid arthritis, gout and osteonecrosis and preparation method thereof - Google Patents

Medicine for treating rheumatoid arthritis, gout and osteonecrosis and preparation method thereof Download PDF

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CN105770813A
CN105770813A CN201610212503.4A CN201610212503A CN105770813A CN 105770813 A CN105770813 A CN 105770813A CN 201610212503 A CN201610212503 A CN 201610212503A CN 105770813 A CN105770813 A CN 105770813A
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parts
rhizoma
radix
medicine
osteonecrosis
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陈明华
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
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    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses medicine for treating rheumatoid arthritis, gout and osteonecrosis and a preparation method thereof.The preparation method comprises the steps that semen sapindi mukorossi (pipal tree seeds), fiveleaf gynostemma herb, pericarpium citri reticulatae, licorice roots, climbing groundsel herb, roots and rhizomes of rohdea japonica, scandent schefflera stems and leaves, poria cocos, rhizoma polygoni cuspidate, rhizoma zingiberis, eucommia bark, herba agrimoniae, radix angelica sinensis, kadsura longipedunculata finet et gagn, fruit of cubeb litsea trees, radix angelicae, herb of urtica macrorrhiza Hand.-Mazz, botrychium ternatum leaves, rhizoma paridis, ramulus uncariae cum uncis, rhizoma paridis, cinnamomum camphora presl, rhizoma acori graminei, rhizoma valerianae jatamansi, radix polygonati officinalis and radix aucklandiae are taken as raw materials, all the bulk drugs are smashed and screened with a 50-80-mesh screen or smashed into granules with the size of a rice grain, the smashed materials are wrapped by a white cloth, boiled by adding 4000-6000 parts of water and then continuously decocted for 10-15 minutes, a water decoction is taken, and then the medicine is obtained.The medicine is low in price and free of side effects, and the preparation method is simple and easy to operate.Two thousands of cases are clinically treated, the total efficiency rate is 83%, and no adverse reaction is generated in all the cases.

Description

A kind of medicine treating rheumatoid arthritis, gout, osteonecrosis and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field, relate in particular to a kind of medicine treating rheumatoid arthritis, gout, osteonecrosis, also relate to its preparation method.
Background technology
Rheumatoid arthritis (RA) is chronic, the systemic disease based on inflammatory synovitis that a kind of cause of disease is the brightest. it is characterized in that hands, the foot multi-joint of Minor articulus, symmetry, aggressive arthritis, it is often accompanied by organ outside joint and is involved the serum rheumatoid factor (SRF) positive, joint deformity and afunction can be caused.
Gout is that purine metabolic disturbance causes uric acid to synthesize the metabolic disease increased and cause.Clinical manifestation: show as the serious pain of affected joints, swelling, erythema, stiff, heating, and symptom during gouty attack,acute and occur suddenly.Though this quasi drugs is many currently on the market, but most pain relieving is of short duration, and effect is slow and unstable.
Osteonecrosis, refers to that skeleton living tissue composition is downright bad.Motherland's medical science is referred to as osteomyelitis disease osteonecrosis.The a lot of position of human body, all can cause osteonecrosis, and the reason of osteonecrosis is a lot, often the most common with femur head necrosis in clinic, concentrates on greatly and introduces the reason of femur head necrosis, symptom, treats, exercises, puts prevention first.And for osteonecrosis, human body is likely at any position occur, only having been found that more than 40 locate with regard to ischemic necrosis, and femur head necrosis incidence rate is the highest, this is mainly determined by the feature of biomechanics and anatomical terms.Because femoral head is that end blood vessel is that fan-shaped 20--25 is propped up eventually, having a common boundary at head and neck forms dynamic and static circulus venosus, and it derives from and revolves tremulous pulse inside and outside stock.At present, activating blood circulation to dissipate blood stasis simple in terms of the traditional Chinese medical science, dredging collateral hemostasis can not cure osteonecrosis, simply alleviate and.Some scholars think massage, external application, acupuncture, add heat energy treatment osteonecrosis, actually this is not so, " have takes effect " be alleviating pain and, osteonecrosis can not be given treatment at all, and utilize artificial femoral head replacement costly.
Summary of the invention
It is an object of the invention to provide a kind of cheap, effect is notable, and treatment rheumatoid arthritis, gout, the medicine of osteonecrosis having no side effect.
Another object of the present invention is to provide the preparation method of the medicine of this treatment rheumatoid arthritis, gout, osteonecrosis.
A kind of medicine treating rheumatoid arthritis, gout, osteonecrosis of the present invention, each raw material components consumption is for all having a good therapeutic effect in following weight scope:
Fructus Sapindi Mukouossi (Fructus Sapindi Mukouossi) 10-20 part, Herb Gynostemmae Pentaphylli 30-50 part, Pericarpium Citri Reticulatae 10-20 part, Radix Glycyrrhizae 2-5 part, Herba Senecionis Scandentis 10-20 part, Rohdea japonica Roth 5-15 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2-4 part, Poria 8-16 part, Rhizoma Polygoni Cuspidati 10-20 part, Rhizoma Zingiberis 10-20 part, Cortex Eucommiae 4-8 part, Herba Agrimoniae 5-20 part, Radix Angelicae Sinensis 5-10 part, Caulis Kadsurae Longipedunculatae 5-12 part, Fructus Litseae 4-10 part, Radix Angelicae Dahuricae 3-10 part, blue or green fiber crops 2-6 part of living, Folium Pittospori Glabrati 4-8 part, Rhizoma Paridis 2-4 part, Ramulus Uncariae Cum Uncis 5-10 part, Lignum cinnamomi camphorae 2-15 part, Rhizoma Acori Graminei 3-8 part, Rhizoma valerianae latifoliae 3-8 part, Rhizoma Polygonati Odorati 2-4 part, Radix Aucklandiae 5-10 part.
Above-mentioned a kind of medicine treating rheumatoid arthritis, gout, osteonecrosis, by weight, including following raw material:
Fructus Sapindi Mukouossi 15 parts, Herb Gynostemmae Pentaphylli 40 parts, Pericarpium Citri Reticulatae 15 parts, 3 parts of Radix Glycyrrhizae, Herba Senecionis Scandentis 15 parts, Rohdea japonica Roth 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 3 parts, 12 parts of Poria, Rhizoma Polygoni Cuspidati 15 parts, Rhizoma Zingiberis 15 parts, the Cortex Eucommiae 6 parts, Herba Agrimoniae 12 parts, Radix Angelicae Sinensis 8 parts, Caulis Kadsurae Longipedunculatae 8 parts, Fructus Litseae 7 parts, the Radix Angelicae Dahuricae 6 parts, blue or green fiber crops 4 parts, Folium Pittospori Glabrati 6 parts, Rhizoma Paridis 3 parts, Ramulus Uncariae Cum Uncis 7 parts, Lignum cinnamomi camphorae 8 parts, Rhizoma Acori Graminei 5 parts, Rhizoma valerianae latifoliae 5 parts, Rhizoma Polygonati Odorati 3 parts, the Radix Aucklandiae 7 parts of living.
The preparation method of a kind of medicine treating rheumatoid arthritis, gout, osteonecrosis of the present invention, comprises the following steps:
(1) sample by following weight portion: Fructus Sapindi Mukouossi 10-20 part, Herb Gynostemmae Pentaphylli 30-50 part, Pericarpium Citri Reticulatae 10-20 part, Radix Glycyrrhizae 2-5 part, Herba Senecionis Scandentis 10-20 part, Rohdea japonica Roth 5-15 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2-4 part, Poria 8-16 part, Rhizoma Polygoni Cuspidati 10-20 part, Rhizoma Zingiberis 10-20 part, Cortex Eucommiae 4-8 part, Herba Agrimoniae 5-20 part, Radix Angelicae Sinensis 5-10 part, Caulis Kadsurae Longipedunculatae 5-12 part, Fructus Litseae 4-10 part, Radix Angelicae Dahuricae 3-10 part, blue or green fiber crops 2-6 part of living, Folium Pittospori Glabrati 4-8 part, Rhizoma Paridis 2-4 part, Ramulus Uncariae Cum Uncis 5-10 part, Lignum cinnamomi camphorae 2-15 part, Rhizoma Acori Graminei 3-8 part, Rhizoma valerianae latifoliae 3-8 part, Rhizoma Polygonati Odorati 2-4 part, Radix Aucklandiae 5-10 part；
(2) each crude drug pulverized 50-80 mesh sieve or was ground into grain of rice size, and wrapping up with calico, add 4000-6000 part water, and after boiling, continuing to decoct 10-15 minute, decocting liquid of fetching water, to obtain final product.
The present invention is compared with prior art, there is obvious beneficial effect, as can be known from the above technical solutions: the present invention selects Fructus Sapindi Mukouossi (Fructus Sapindi Mukouossi), Herb Gynostemmae Pentaphylli, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Herba Senecionis Scandentis, Rohdea japonica Roth, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Poria, Rhizoma Polygoni Cuspidati, Rhizoma Zingiberis, the Cortex Eucommiae, Herba Agrimoniae, Radix Angelicae Sinensis, Caulis Kadsurae Longipedunculatae, Fructus Litseae, the Radix Angelicae Dahuricae, the blue or green fiber crops that live, Folium Pittospori Glabrati, Rhizoma Paridis, Ramulus Uncariae Cum Uncis, Lignum cinnamomi camphorae, Rhizoma Acori Graminei, Rhizoma valerianae latifoliae, Rhizoma Polygonati Odorati, the Radix Aucklandiae to be raw material, consolidated by the synergism performance kidney tonifying of each medicine, the effect such as blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness dredging collateral, hard masses softening and resolving.There is good curative effect for diseases such as treatment rheumatoid arthritis, gout, osteonecrosis, prolapse of lumbar intervertebral disc, hyperosteogenys, have the effect of repair cell, anti-inflammation detumescence.Medicine source is abundant, cheap, have no side effect, and preparation method is simple, easily operated.Clinical treatment case 2000 example, total obvious effective rate 83%, all cases all have no adverse reaction.
Detailed description of the invention
The beneficial effect of of the present invention medicine is expanded on further below by way of test example.
Test example:The clinical observation of medicine of the present invention
1. case selection
Treatment case 2000 example, wherein: the age 8-80 year, male 980 people, female 1200 people.
2. diagnostic criteria:
" disease of tcm Standardization of diagnosis and curative effect ".
3. Therapeutic Method
Taking the medicine prepared by the embodiment of the present invention, three times a day, with the medicinal liquid moistening towel wiping health 10 minutes of heat, wash tiptoe from shoulder, medicinal liquid is reused.One auxiliary medicine can wash two days.Medication 10 days to two months.
4. curative effect determinate standard
With the improvement degree such as symptom, body card as curative effect determinate standard, it is divided into:
Effective: symptom has clear improvement；
Effective: symptom has certain improvement.
Invalid: to compare with before medication, each side is unchanged.
5. therapeutic effect
Effective 1660 examples, effective 320 examples, invalid 20 examples, total obvious effective rate 83%, total effective rate 99%.It is invalid for only having 20 examples in treatment, and all cases all have no adverse reaction.
The preparation method of this medicine is illustrated by following example.
Embodiment 1:
The preparation method of a kind of medicine treating rheumatoid arthritis, gout, osteonecrosis, comprises the following steps:
(1) weigh: Fructus Sapindi Mukouossi 10g, Herb Gynostemmae Pentaphylli 50g, Pericarpium Citri Reticulatae 10g, Radix Glycyrrhizae 5g, Herba Senecionis Scandentis 10g, Rohdea japonica Roth 15g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2g, Poria 16g, Rhizoma Polygoni Cuspidati 10g, Rhizoma Zingiberis 20g, Cortex Eucommiae 4g, Herba Agrimoniae 20g, Radix Angelicae Sinensis 5g, Caulis Kadsurae Longipedunculatae 12g, Fructus Litseae 4g, Radix Angelicae Dahuricae 10g, blue or green fiber crops 2g, Folium Pittospori Glabrati 8g, Rhizoma Paridis 2g, Ramulus Uncariae Cum Uncis 10g, Lignum cinnamomi camphorae 2g, Rhizoma Acori Graminei 8g, Rhizoma valerianae latifoliae 3g, Rhizoma Polygonati Odorati 4g, the Radix Aucklandiae 5g of living；
(2) each crude drug pulverized 50 mesh sieves or was ground into grain of rice size, and wrapping up with calico, add 6kg water, and after boiling, continuing to decoct 15 minutes, decocting liquid of fetching water, to obtain final product.
Embodiment 2 :
The preparation method of a kind of medicine treating rheumatoid arthritis, gout, osteonecrosis, comprises the following steps:
(1) weigh: Fructus Sapindi Mukouossi 15g, Herb Gynostemmae Pentaphylli 40g, Pericarpium Citri Reticulatae 15g, Radix Glycyrrhizae 3g, Herba Senecionis Scandentis 15g, Rohdea japonica Roth 10g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 3g, Poria 12g, Rhizoma Polygoni Cuspidati 15g, Rhizoma Zingiberis 15g, Cortex Eucommiae 6g, Herba Agrimoniae 12g, Radix Angelicae Sinensis 8g, Caulis Kadsurae Longipedunculatae 8g, Fructus Litseae 7g, Radix Angelicae Dahuricae 6g, blue or green fiber crops 4g, Folium Pittospori Glabrati 6g, Rhizoma Paridis 3g, Ramulus Uncariae Cum Uncis 7g, Lignum cinnamomi camphorae 8g, Rhizoma Acori Graminei 5g, Rhizoma valerianae latifoliae 5g, Rhizoma Polygonati Odorati 3g, the Radix Aucklandiae 7g of living；
(2) each crude drug pulverized 60 mesh sieves or was ground into grain of rice size, and wrapping up with calico, add 5kg water, and after boiling, continuing to decoct 12 minutes, decocting liquid of fetching water, to obtain final product.
Embodiment 3 :
A kind of preparation method of the medicine treating rheumatoid arthritis, gout, osteonecrosis, comprise the following steps:
(1) weigh: Fructus Sapindi Mukouossi 20g, Herb Gynostemmae Pentaphylli 30g, Pericarpium Citri Reticulatae 20g, Radix Glycyrrhizae 2g, Herba Senecionis Scandentis 20g, Rohdea japonica Roth 5g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 4g, Poria 8g, Rhizoma Polygoni Cuspidati 20g, Rhizoma Zingiberis 10g, Cortex Eucommiae 8g, Herba Agrimoniae 5g, Radix Angelicae Sinensis 10g, Caulis Kadsurae Longipedunculatae 5g, Fructus Litseae 10g, Radix Angelicae Dahuricae 3g, blue or green fiber crops 6g, Folium Pittospori Glabrati 4g, Rhizoma Paridis 4g, Ramulus Uncariae Cum Uncis 5g, Lignum cinnamomi camphorae 15g, Rhizoma Acori Graminei 3g, Rhizoma valerianae latifoliae 8g, Rhizoma Polygonati Odorati 2g, the Radix Aucklandiae 10g of living；
(2) each crude drug pulverized 80 mesh sieves or was ground into grain of rice size, and wrapping up with calico, add 4kg water, and after boiling, continuing to decoct 10 minutes, decocting liquid of fetching water, to obtain final product.
The above, it it is only presently preferred embodiments of the present invention, not the present invention is made any pro forma restriction, any without departing from technical solution of the present invention content, any simple modification, equivalent variations and the modification made above example according to the technical spirit of the present invention, all still falls within the range of technical solution of the present invention.

Claims (3)

1. treat a medicine for rheumatoid arthritis, gout, osteonecrosis, by weight, including following raw material:
Fructus Sapindi Mukouossi 10-20 part, Herb Gynostemmae Pentaphylli 30-50 part, Pericarpium Citri Reticulatae 10-20 part, Radix Glycyrrhizae 2-5 part, Herba Senecionis Scandentis 10-20 part, Rohdea japonica Roth 5-15 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2-4 part, Poria 8-16 part, Rhizoma Polygoni Cuspidati 10-20 part, Rhizoma Zingiberis 10-20 part, Cortex Eucommiae 4-8 part, Herba Agrimoniae 5-20 part, Radix Angelicae Sinensis 5-10 part, Caulis Kadsurae Longipedunculatae 5-12 part, Fructus Litseae 4-10 part, Radix Angelicae Dahuricae 3-10 part, blue or green fiber crops 2-6 part of living, Folium Pittospori Glabrati 4-8 part, Rhizoma Paridis 2-4 part, Ramulus Uncariae Cum Uncis 5-10 part, Lignum cinnamomi camphorae 2-15 part, Rhizoma Acori Graminei 3-8 part, Rhizoma valerianae latifoliae 3-8 part, Rhizoma Polygonati Odorati 2-4 part, Radix Aucklandiae 5-10 part.
Treat the medicine of rheumatoid arthritis, gout, osteonecrosis the most as claimed in claim 1, by weight, including following raw material:
Fructus Sapindi Mukouossi 15 parts, Herb Gynostemmae Pentaphylli 40 parts, Pericarpium Citri Reticulatae 15 parts, 3 parts of Radix Glycyrrhizae, Herba Senecionis Scandentis 15 parts, Rohdea japonica Roth 10 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 3 parts, 12 parts of Poria, Rhizoma Polygoni Cuspidati 15 parts, Rhizoma Zingiberis 15 parts, the Cortex Eucommiae 6 parts, Herba Agrimoniae 12 parts, Radix Angelicae Sinensis 8 parts, Caulis Kadsurae Longipedunculatae 8 parts, Fructus Litseae 7 parts, the Radix Angelicae Dahuricae 6 parts, blue or green fiber crops 4 parts, Folium Pittospori Glabrati 6 parts, Rhizoma Paridis 3 parts, Ramulus Uncariae Cum Uncis 7 parts, Lignum cinnamomi camphorae 8 parts, Rhizoma Acori Graminei 5 parts, Rhizoma valerianae latifoliae 5 parts, Rhizoma Polygonati Odorati 3 parts, the Radix Aucklandiae 7 parts of living.
3. treat a preparation method for the medicine of rheumatoid arthritis, gout, osteonecrosis, comprise the following steps:
(1) sample by following weight portion: Fructus Sapindi Mukouossi 10-20 part, Herb Gynostemmae Pentaphylli 30-50 part, Pericarpium Citri Reticulatae 10-20 part, Radix Glycyrrhizae 2-5 part, Herba Senecionis Scandentis 10-20 part, Rohdea japonica Roth 5-15 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 2-4 part, Poria 8-16 part, Rhizoma Polygoni Cuspidati 10-20 part, Rhizoma Zingiberis 10-20 part, Cortex Eucommiae 4-8 part, Herba Agrimoniae 5-20 part, Radix Angelicae Sinensis 5-10 part, Caulis Kadsurae Longipedunculatae 5-12 part, Fructus Litseae 4-10 part, Radix Angelicae Dahuricae 3-10 part, blue or green fiber crops 2-6 part of living, Folium Pittospori Glabrati 4-8 part, Rhizoma Paridis 2-4 part, Ramulus Uncariae Cum Uncis 5-10 part, Lignum cinnamomi camphorae 2-15 part, Rhizoma Acori Graminei 3-8 part, Rhizoma valerianae latifoliae 3-8 part, Rhizoma Polygonati Odorati 2-4 part, Radix Aucklandiae 5-10 part；
(2) each crude drug pulverized 50-80 mesh sieve or was ground into grain of rice size, and wrapping up with calico, add 4000-6000 part water, and after boiling, continuing to decoct 10-15 minute, decocting liquid of fetching water, to obtain final product.
CN201610212503.4A 2016-04-07 2016-04-07 Medicine for treating rheumatoid arthritis, gout and osteonecrosis and preparation method thereof Pending CN105770813A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1350852A (en) * 2000-10-30 2002-05-29 兰州三极生物资源技术公司 Medicine for treating rheumatic or rheumatoid arthritis, osteoarthropathy and gout
CN101264160A (en) * 2008-05-13 2008-09-17 刘裕志 Bone-setting and pain-relieving Chinese medicine composition and preparation thereof
CN102793829A (en) * 2011-10-02 2012-11-28 莫寿科 Medicine for external application used for treating gout and preparation method
CN102805817A (en) * 2012-08-27 2012-12-05 李克金 Medicine for treating rheumatism and rheumatoid diseases
CN103768531A (en) * 2014-02-14 2014-05-07 谭维勇 Traditional Chinese medicinal composition for treating rheumatoid arthritis and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1350852A (en) * 2000-10-30 2002-05-29 兰州三极生物资源技术公司 Medicine for treating rheumatic or rheumatoid arthritis, osteoarthropathy and gout
CN101264160A (en) * 2008-05-13 2008-09-17 刘裕志 Bone-setting and pain-relieving Chinese medicine composition and preparation thereof
CN102793829A (en) * 2011-10-02 2012-11-28 莫寿科 Medicine for external application used for treating gout and preparation method
CN102805817A (en) * 2012-08-27 2012-12-05 李克金 Medicine for treating rheumatism and rheumatoid diseases
CN103768531A (en) * 2014-02-14 2014-05-07 谭维勇 Traditional Chinese medicinal composition for treating rheumatoid arthritis and preparation method thereof

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Application publication date: 20160720