CN102792161B - 肾损伤和肾衰竭的诊断及预后的方法及组合物 - Google Patents
肾损伤和肾衰竭的诊断及预后的方法及组合物 Download PDFInfo
- Publication number
- CN102792161B CN102792161B CN201080045575.5A CN201080045575A CN102792161B CN 102792161 B CN102792161 B CN 102792161B CN 201080045575 A CN201080045575 A CN 201080045575A CN 102792161 B CN102792161 B CN 102792161B
- Authority
- CN
- China
- Prior art keywords
- urine
- measuring
- plasma concentration
- concentration
- experimenter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4748—Details p53
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/775—Apolipopeptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23811509P | 2009-08-28 | 2009-08-28 | |
| US23813409P | 2009-08-28 | 2009-08-28 | |
| US23812809P | 2009-08-28 | 2009-08-28 | |
| US23812509P | 2009-08-28 | 2009-08-28 | |
| US23811809P | 2009-08-28 | 2009-08-28 | |
| US23812109P | 2009-08-28 | 2009-08-28 | |
| US23812909P | 2009-08-28 | 2009-08-28 | |
| US23812709P | 2009-08-28 | 2009-08-28 | |
| US23812309P | 2009-08-28 | 2009-08-28 | |
| US23812009P | 2009-08-28 | 2009-08-28 | |
| US61/238,120 | 2009-08-28 | ||
| US61/238,118 | 2009-08-28 | ||
| US61/238,123 | 2009-08-28 | ||
| US61/238,115 | 2009-08-28 | ||
| US61/238,128 | 2009-08-28 | ||
| US61/238,125 | 2009-08-28 | ||
| US61/238,134 | 2009-08-28 | ||
| US61/238,121 | 2009-08-28 | ||
| US61/238,129 | 2009-08-28 | ||
| US61/238,127 | 2009-08-28 | ||
| US24399309P | 2009-09-18 | 2009-09-18 | |
| US24400209P | 2009-09-18 | 2009-09-18 | |
| US24399709P | 2009-09-18 | 2009-09-18 | |
| US24399109P | 2009-09-18 | 2009-09-18 | |
| US61/243,993 | 2009-09-18 | ||
| US61/244,002 | 2009-09-18 | ||
| US61/243,991 | 2009-09-18 | ||
| US61/243,997 | 2009-09-18 | ||
| PCT/US2010/046910 WO2011025917A1 (en) | 2009-08-28 | 2010-08-27 | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410573713.7A Division CN104483488A (zh) | 2009-08-28 | 2010-08-27 | 肾损伤和肾衰竭的诊断及预后的方法及组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102792161A CN102792161A (zh) | 2012-11-21 |
| CN102792161B true CN102792161B (zh) | 2014-11-12 |
Family
ID=43628398
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080045575.5A Expired - Fee Related CN102792161B (zh) | 2009-08-28 | 2010-08-27 | 肾损伤和肾衰竭的诊断及预后的方法及组合物 |
| CN201410573713.7A Pending CN104483488A (zh) | 2009-08-28 | 2010-08-27 | 肾损伤和肾衰竭的诊断及预后的方法及组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410573713.7A Pending CN104483488A (zh) | 2009-08-28 | 2010-08-27 | 肾损伤和肾衰竭的诊断及预后的方法及组合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20120315649A1 (https=) |
| EP (3) | EP2470905B1 (https=) |
| JP (2) | JP5775874B2 (https=) |
| CN (2) | CN102792161B (https=) |
| AU (1) | AU2010286559B2 (https=) |
| CA (1) | CA2772336A1 (https=) |
| HK (1) | HK1208074A1 (https=) |
| NZ (2) | NZ598712A (https=) |
| WO (1) | WO2011025917A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5763098B2 (ja) | 2009-12-20 | 2015-08-12 | アスチュート メディカル,インコーポレイテッド | 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 |
| PT2666872T (pt) | 2010-02-05 | 2016-07-08 | Astute Medical Inc | Processos e composições para o diagnóstico e o prognóstico de lesões renais e de insuficiência renal |
| IN2012MN02812A (https=) | 2010-06-23 | 2015-05-22 | Astute Medical Inc | |
| EP2899545B1 (en) * | 2010-06-23 | 2018-08-22 | Astute Medical, Inc. | Methods for diagnosis and prognosis of renal injury and renal failure |
| US10557856B2 (en) * | 2010-09-24 | 2020-02-11 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Biomarkers of renal injury |
| EP2668497B1 (en) * | 2011-01-26 | 2020-03-25 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Urine biomarkers for prediction of recovery after acute kidney injury : proteomics |
| EP2503340A1 (en) * | 2011-03-22 | 2012-09-26 | Fundació Institut de Recerca Hospital Universitari Vall d'Hebron, Fundació Privada | Diagnostic marker for relapsing primary idiopathic focal segmental glomerulosclerosis |
| TW201250248A (en) * | 2011-04-25 | 2012-12-16 | Kyowa Medex Co Ltd | Prognostication method of renal failure |
| WO2012155123A2 (en) * | 2011-05-12 | 2012-11-15 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| ES2734494T3 (es) | 2011-12-08 | 2019-12-10 | Astute Medical Inc | Métodos y usos para el diagnóstico de una lesión renal y de una insuficiencia renal |
| EP2834638B1 (en) * | 2012-04-02 | 2020-02-12 | Astute Medical, Inc. | Methods for diagnosis and prognosis of sepsis |
| TR201807542T4 (tr) | 2013-01-17 | 2018-06-21 | Astute Medical Inc | Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler. |
| CN104569417B (zh) * | 2013-10-12 | 2016-06-01 | 广州瑞博奥生物科技有限公司 | 一种用于早期诊断急性肾损伤的抗体芯片试剂盒 |
| US10300108B2 (en) | 2013-12-03 | 2019-05-28 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US11243202B2 (en) | 2015-04-09 | 2022-02-08 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| HK1249467A1 (zh) | 2015-05-12 | 2018-11-02 | 阿斯图特医药公司 | 用於肾损伤和肾衰竭的诊断和预後的方法和组合物 |
| EP3465201A4 (en) | 2016-06-06 | 2020-08-26 | Astute Medical, Inc. | MANAGEMENT OF ACUTE KIDNEY DAMAGE USING INSULINOMIMETIC GROWTH FACTOR BINDING PROTEIN 7 AND TISSUE METALLOPROTEINASE 2 INHIBITOR |
| KR20210019459A (ko) | 2018-05-24 | 2021-02-22 | 레니버스 테라퓨틱스, 인크. | 신장 손상 및 신부전 위험이 있는 환자를 치료하는 방법 |
| CN117825674A (zh) * | 2023-12-28 | 2024-04-05 | 南方医科大学南方医院 | 用于评估肝病预后的分子标志物及诊断试剂盒 |
| CN121186383B (zh) * | 2025-11-24 | 2026-03-13 | 华中科技大学 | 慢性肾病的蛋白质标志物的筛选及应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006102979A2 (de) * | 2005-03-31 | 2006-10-05 | Johannes Gutenberg-Universität Mainz | Entzündungsmarker und kombinationen davon als biochemische marker bei kardiovaskulären erkrankungen |
| US7141382B1 (en) * | 2004-10-12 | 2006-11-28 | Parikh Chirag R | Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality |
| CN101084437A (zh) * | 2004-01-22 | 2007-12-05 | 普罗美加公司 | 发光和不发光多重检测 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5939272A (en) | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
| US5028535A (en) | 1989-01-10 | 1991-07-02 | Biosite Diagnostics, Inc. | Threshold ligand-receptor assay |
| US5922615A (en) | 1990-03-12 | 1999-07-13 | Biosite Diagnostics Incorporated | Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network |
| CA2072758A1 (en) | 1990-09-14 | 1992-03-15 | Kenneth Francis Buechler | Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays |
| US5955377A (en) | 1991-02-11 | 1999-09-21 | Biostar, Inc. | Methods and kits for the amplification of thin film based assays |
| CA2107894C (en) | 1991-04-10 | 2003-10-14 | Kenneth F. Buechler | Crosstalk inhibitors and their uses |
| EP0579767B1 (en) | 1991-04-11 | 2000-08-23 | Biosite Diagnostics Inc. | Novel conjugates and assays for simultaneous detection of multiple ligands |
| US6019944A (en) | 1992-05-21 | 2000-02-01 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
| US6143576A (en) | 1992-05-21 | 2000-11-07 | Biosite Diagnostics, Inc. | Non-porous diagnostic devices for the controlled movement of reagents |
| US5494829A (en) | 1992-07-31 | 1996-02-27 | Biostar, Inc. | Devices and methods for detection of an analyte based upon light interference |
| US5824799A (en) | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
| US6113855A (en) | 1996-11-15 | 2000-09-05 | Biosite Diagnostics, Inc. | Devices comprising multiple capillarity inducing surfaces |
| US5947124A (en) | 1997-03-11 | 1999-09-07 | Biosite Diagnostics Incorporated | Diagnostic for determining the time of a heart attack |
| US6057098A (en) | 1997-04-04 | 2000-05-02 | Biosite Diagnostics, Inc. | Polyvalent display libraries |
| CA2356174A1 (en) * | 1998-12-21 | 2000-06-29 | Monash University | Kidney disease detection and treatment |
| WO2002048329A2 (en) * | 2000-11-20 | 2002-06-20 | Idun Pharmaceuticals, Inc. | Membrane derived caspase-3, compositions comprising the same and methods of use therefor |
| JPWO2002081515A1 (ja) * | 2001-04-03 | 2004-07-29 | 協和醗酵工業株式会社 | インスリン様増殖因子結合蛋白質 |
| US20030003588A1 (en) * | 2001-06-28 | 2003-01-02 | Comper Wayne D. | Method for kidney disease detection by protein profiling |
| CN1791797A (zh) * | 2003-03-27 | 2006-06-21 | 儿童医院医疗中心 | 用于检测肾小管细胞损伤的早发的方法和试剂盒 |
| DE602004022150D1 (de) * | 2003-03-27 | 2009-09-03 | Childrens Hosp Medical Center | Verfahren und kit zum nachweis des frühstadiums einer nierentubuluszellenverletzung |
| US20090215046A1 (en) * | 2004-01-27 | 2009-08-27 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and assays methods of use thereof for diagnosis of colon cancer |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| AU2005288522B2 (en) * | 2004-09-28 | 2012-06-28 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| ES2818028T3 (es) * | 2004-12-20 | 2021-04-09 | Antibodyshop As | Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales |
| WO2006116622A2 (en) * | 2005-04-27 | 2006-11-02 | Emiliem | Novel methods and devices for evaluating poisons |
| TW200716764A (en) * | 2005-05-02 | 2007-05-01 | Genenews Inc | Bladder cancer biomarkers and uses thereof |
| JP4800384B2 (ja) * | 2005-06-08 | 2011-10-26 | ヒタチ ケミカル リサーチ センター インコーポレイテッド | 腫瘍細胞及び刺激された白血球におけるmRNAの発現プロファイルに基づく腫瘍性疾患に対する免疫応答を予測する方法 |
| US7662578B2 (en) * | 2006-04-21 | 2010-02-16 | Children's Hospital Medical Center | Method and kit for the early detection of impaired renal status |
| ATE473448T1 (de) * | 2006-04-24 | 2010-07-15 | Univ Wien Med | Verfahren zur diagnose von herz-kreislauf- krankheiten |
| CN106908603B (zh) * | 2007-01-25 | 2019-04-02 | 霍夫曼-拉罗奇有限公司 | Igfbp-7在心力衰竭评估中的用途 |
| EP2134866A2 (en) * | 2007-04-10 | 2009-12-23 | Integragen | Human diabetes susceptibility tnfrsf10b gene |
| WO2009091556A2 (en) * | 2008-01-17 | 2009-07-23 | The General Hospital Corporation | Diagnostic methods and kits using fibroblast growth factor-23 |
| WO2010048347A2 (en) * | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
-
2010
- 2010-08-27 NZ NZ598712A patent/NZ598712A/en not_active IP Right Cessation
- 2010-08-27 JP JP2012527009A patent/JP5775874B2/ja not_active Expired - Fee Related
- 2010-08-27 WO PCT/US2010/046910 patent/WO2011025917A1/en not_active Ceased
- 2010-08-27 EP EP10812639.2A patent/EP2470905B1/en not_active Not-in-force
- 2010-08-27 US US13/393,075 patent/US20120315649A1/en not_active Abandoned
- 2010-08-27 CN CN201080045575.5A patent/CN102792161B/zh not_active Expired - Fee Related
- 2010-08-27 AU AU2010286559A patent/AU2010286559B2/en not_active Ceased
- 2010-08-27 EP EP15150059.2A patent/EP2894473B1/en not_active Not-in-force
- 2010-08-27 NZ NZ624609A patent/NZ624609A/en not_active IP Right Cessation
- 2010-08-27 CA CA2772336A patent/CA2772336A1/en not_active Abandoned
- 2010-08-27 EP EP16189562.8A patent/EP3151005A1/en not_active Withdrawn
- 2010-08-27 CN CN201410573713.7A patent/CN104483488A/zh active Pending
-
2015
- 2015-03-31 US US14/675,344 patent/US20150204892A1/en not_active Abandoned
- 2015-07-06 JP JP2015135079A patent/JP6054481B2/ja not_active Expired - Fee Related
- 2015-09-04 HK HK15108654.3A patent/HK1208074A1/xx unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084437A (zh) * | 2004-01-22 | 2007-12-05 | 普罗美加公司 | 发光和不发光多重检测 |
| US7141382B1 (en) * | 2004-10-12 | 2006-11-28 | Parikh Chirag R | Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality |
| WO2006102979A2 (de) * | 2005-03-31 | 2006-10-05 | Johannes Gutenberg-Universität Mainz | Entzündungsmarker und kombinationen davon als biochemische marker bei kardiovaskulären erkrankungen |
Non-Patent Citations (6)
| Title |
|---|
| 《Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review》;COCA et al.;《Kidney Internat》;20081231;第73卷(第9期);1008-1016 * |
| Acute Kidney Injury.;Kellum;《Crit. Care. Med.》;20081231;第36卷(第4期);S141-S145 * |
| Comprehensiv analysis of the renal transcriptional response to acute uranyl nitrate exposure.;Taulan et al.;《BMC Genomics》;20060111;第7卷(第2期);1-14 * |
| Impaired IL-18 processing protects caspase-1deficient mice from ischemic acute renal failure.;Melnikov et al.;《J. Clin. Invest.》;20011231;第107卷(第9期);1145-1152 * |
| Urinary IL-18 is an early predictive biomarker of acue kidney injury after cardiac surgery.;Parik et al.;《Kidney Internat》;20061231;第70卷(第1期);199-203 * |
| 急性缺血-再灌注肾损伤小鼠肾组织Caspase-1蛋白表达及酶活性变化;刘付捷等;《中国血液净化》;20071112;第6卷(第11期);601-603 * |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ598712A (en) | 2014-05-30 |
| WO2011025917A1 (en) | 2011-03-03 |
| US20150204892A1 (en) | 2015-07-23 |
| JP6054481B2 (ja) | 2016-12-27 |
| CN102792161A (zh) | 2012-11-21 |
| JP2015212704A (ja) | 2015-11-26 |
| HK1208074A1 (en) | 2016-02-19 |
| EP2894473A1 (en) | 2015-07-15 |
| CN104483488A (zh) | 2015-04-01 |
| EP2470905A4 (en) | 2013-08-14 |
| JP2013503344A (ja) | 2013-01-31 |
| EP2894473B1 (en) | 2016-09-21 |
| NZ624609A (en) | 2015-12-24 |
| HK1172691A1 (en) | 2013-04-26 |
| US20120315649A1 (en) | 2012-12-13 |
| EP2470905B1 (en) | 2015-01-07 |
| EP3151005A1 (en) | 2017-04-05 |
| AU2010286559A1 (en) | 2012-04-05 |
| CA2772336A1 (en) | 2011-03-03 |
| EP2470905A1 (en) | 2012-07-04 |
| JP5775874B2 (ja) | 2015-09-09 |
| AU2010286559B2 (en) | 2015-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102792161B (zh) | 肾损伤和肾衰竭的诊断及预后的方法及组合物 | |
| CN105074466B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN102791885B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN103874923B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN102439441B (zh) | 用于肾损伤和肾衰竭的诊断及预后方法和组合物 | |
| CN102725636B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| JP7217796B2 (ja) | 腎障害および腎不全の診断および予後のための方法および組成物 | |
| CN102369293B (zh) | 肾损伤和肾衰竭的诊断及预后 | |
| CN102711827B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN103080743B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN102597258B (zh) | 肾损伤和肾衰竭的诊断及预后 | |
| CN102576011B (zh) | 用于肾损伤和肾衰竭的诊断及预后的组合物和方法 | |
| CN103238068B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN103858008B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN102725635B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN102884205B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN102576012B (zh) | 用于肾损伤和肾衰竭的诊断及预后方法和组合物 | |
| CN107003325A (zh) | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 | |
| CN104379758A (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN104335045B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN104583774A (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN105209914B (zh) | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 | |
| CN107735147A (zh) | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 | |
| CN107709993A (zh) | 用于肾损伤和肾衰竭的诊断和预后的方法和组合物 | |
| HK1162617B (zh) | 腎損傷和腎衰竭的診斷和預後 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1172691 Country of ref document: HK |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141112 Termination date: 20210827 |