JP5775874B2 - 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 - Google Patents
腎損傷および腎不全の診断および予後診断のための方法ならびに組成物 Download PDFInfo
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| CN104569417B (zh) * | 2013-10-12 | 2016-06-01 | 广州瑞博奥生物科技有限公司 | 一种用于早期诊断急性肾损伤的抗体芯片试剂盒 |
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| US5824799A (en) | 1993-09-24 | 1998-10-20 | Biosite Diagnostics Incorporated | Hybrid phthalocyanine derivatives and their uses |
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| WO2002048329A2 (en) * | 2000-11-20 | 2002-06-20 | Idun Pharmaceuticals, Inc. | Membrane derived caspase-3, compositions comprising the same and methods of use therefor |
| JPWO2002081515A1 (ja) * | 2001-04-03 | 2004-07-29 | 協和醗酵工業株式会社 | インスリン様増殖因子結合蛋白質 |
| US20030003588A1 (en) * | 2001-06-28 | 2003-01-02 | Comper Wayne D. | Method for kidney disease detection by protein profiling |
| CN1791797A (zh) * | 2003-03-27 | 2006-06-21 | 儿童医院医疗中心 | 用于检测肾小管细胞损伤的早发的方法和试剂盒 |
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| US7416854B2 (en) * | 2004-01-22 | 2008-08-26 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US20090215046A1 (en) * | 2004-01-27 | 2009-08-27 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and assays methods of use thereof for diagnosis of colon cancer |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| AU2005288522B2 (en) * | 2004-09-28 | 2012-06-28 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| US7141382B1 (en) * | 2004-10-12 | 2006-11-28 | Parikh Chirag R | Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality |
| ES2818028T3 (es) * | 2004-12-20 | 2021-04-09 | Antibodyshop As | Determinación de lipocalina asociada a gelatinasa de neutrófilos (NGAL) como marcador diagnóstico para trastornos renales |
| WO2006102979A2 (de) * | 2005-03-31 | 2006-10-05 | Johannes Gutenberg-Universität Mainz | Entzündungsmarker und kombinationen davon als biochemische marker bei kardiovaskulären erkrankungen |
| WO2006116622A2 (en) * | 2005-04-27 | 2006-11-02 | Emiliem | Novel methods and devices for evaluating poisons |
| TW200716764A (en) * | 2005-05-02 | 2007-05-01 | Genenews Inc | Bladder cancer biomarkers and uses thereof |
| JP4800384B2 (ja) * | 2005-06-08 | 2011-10-26 | ヒタチ ケミカル リサーチ センター インコーポレイテッド | 腫瘍細胞及び刺激された白血球におけるｍＲＮＡの発現プロファイルに基づく腫瘍性疾患に対する免疫応答を予測する方法 |
| US7662578B2 (en) * | 2006-04-21 | 2010-02-16 | Children's Hospital Medical Center | Method and kit for the early detection of impaired renal status |
| ATE473448T1 (de) * | 2006-04-24 | 2010-07-15 | Univ Wien Med | Verfahren zur diagnose von herz-kreislauf- krankheiten |
| CN106908603B (zh) * | 2007-01-25 | 2019-04-02 | 霍夫曼-拉罗奇有限公司 | Igfbp-7在心力衰竭评估中的用途 |
| EP2134866A2 (en) * | 2007-04-10 | 2009-12-23 | Integragen | Human diabetes susceptibility tnfrsf10b gene |
| WO2009091556A2 (en) * | 2008-01-17 | 2009-07-23 | The General Hospital Corporation | Diagnostic methods and kits using fibroblast growth factor-23 |
| WO2010048347A2 (en) * | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
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- 2010-08-27 JP JP2012527009A patent/JP5775874B2/ja not_active Expired - Fee Related
- 2010-08-27 WO PCT/US2010/046910 patent/WO2011025917A1/en not_active Ceased
- 2010-08-27 EP EP10812639.2A patent/EP2470905B1/en not_active Not-in-force
- 2010-08-27 US US13/393,075 patent/US20120315649A1/en not_active Abandoned
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|---|---|
| NZ598712A (en) | 2014-05-30 |
| WO2011025917A1 (en) | 2011-03-03 |
| US20150204892A1 (en) | 2015-07-23 |
| JP6054481B2 (ja) | 2016-12-27 |
| CN102792161A (zh) | 2012-11-21 |
| JP2015212704A (ja) | 2015-11-26 |
| HK1208074A1 (en) | 2016-02-19 |
| EP2894473A1 (en) | 2015-07-15 |
| CN104483488A (zh) | 2015-04-01 |
| EP2470905A4 (en) | 2013-08-14 |
| JP2013503344A (ja) | 2013-01-31 |
| EP2894473B1 (en) | 2016-09-21 |
| NZ624609A (en) | 2015-12-24 |
| HK1172691A1 (en) | 2013-04-26 |
| US20120315649A1 (en) | 2012-12-13 |
| CN102792161B (zh) | 2014-11-12 |
| EP2470905B1 (en) | 2015-01-07 |
| EP3151005A1 (en) | 2017-04-05 |
| AU2010286559A1 (en) | 2012-04-05 |
| CA2772336A1 (en) | 2011-03-03 |
| EP2470905A1 (en) | 2012-07-04 |
| AU2010286559B2 (en) | 2015-01-22 |
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