CN102740889A - 用于预防或抑制艰难梭菌感染的疗法 - Google Patents

用于预防或抑制艰难梭菌感染的疗法 Download PDF

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Publication number
CN102740889A
CN102740889A CN2010800537789A CN201080053778A CN102740889A CN 102740889 A CN102740889 A CN 102740889A CN 2010800537789 A CN2010800537789 A CN 2010800537789A CN 201080053778 A CN201080053778 A CN 201080053778A CN 102740889 A CN102740889 A CN 102740889A
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CN
China
Prior art keywords
toxin
antibody
trypsin
clostridium difficile
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800537789A
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English (en)
Chinese (zh)
Inventor
克利福德·肖恩
埃普丽尔·罗伯茨
约翰·兰登
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Department Of Health And Social Security
Mccrofom Co Ltd
Original Assignee
Wei Shengfanghujigou
Micropharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2010/050288 external-priority patent/WO2010094970A1/en
Application filed by Wei Shengfanghujigou, Micropharm Ltd filed Critical Wei Shengfanghujigou
Publication of CN102740889A publication Critical patent/CN102740889A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1282—Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2010800537789A 2009-12-04 2010-12-06 用于预防或抑制艰难梭菌感染的疗法 Pending CN102740889A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0921288.7A GB0921288D0 (en) 2009-12-04 2009-12-04 Therapies for preventing or suppressing clostridium difficile infection
GB0921288.7 2009-12-04
PCT/GB2010/050288 WO2010094970A1 (en) 2009-02-20 2010-02-19 Antibodies to clostridium difficile toxins
GBPCT/GB2010/050288 2010-02-19
PCT/GB2010/052035 WO2011067616A1 (en) 2009-12-04 2010-12-06 Therapies for preventing or suppressing clostridium difficile infection

Publications (1)

Publication Number Publication Date
CN102740889A true CN102740889A (zh) 2012-10-17

Family

ID=41641956

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800537789A Pending CN102740889A (zh) 2009-12-04 2010-12-06 用于预防或抑制艰难梭菌感染的疗法

Country Status (10)

Country Link
US (1) US8921529B2 (enExample)
EP (1) EP2506877B1 (enExample)
JP (1) JP5877161B2 (enExample)
CN (1) CN102740889A (enExample)
BR (1) BR112012013496A2 (enExample)
CA (1) CA2782639C (enExample)
GB (1) GB0921288D0 (enExample)
MY (1) MY158712A (enExample)
SG (1) SG181127A1 (enExample)
WO (1) WO2011067616A1 (enExample)

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CN113846079A (zh) * 2015-07-24 2021-12-28 酶公司 新型胰蛋白酶同功异型物和其用途
CN115704021A (zh) * 2021-08-17 2023-02-17 上海宝济药业有限公司 一种人糜蛋白酶原及其制备方法和应用
WO2026036320A1 (zh) * 2024-08-15 2026-02-19 中国科学院上海有机化学研究所 一种靶向酶蛋白药物及其设计方法

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US8709428B2 (en) 2009-02-20 2014-04-29 Health Protection Agency Antibodies to Clostridium difficile toxins
GB0921288D0 (en) 2009-12-04 2010-01-20 Health Prot Agency Therapies for preventing or suppressing clostridium difficile infection
KR101907434B1 (ko) 2010-09-03 2018-10-12 발네바 오스트리아 게엠베하 C. 디피실의 a 독소 및 b 독소 단백질의 분리된 폴리펩타이드 및 이의 용도
GB201016742D0 (en) 2010-10-05 2010-11-17 Health Prot Agency Clostridium difficile antigens
AR086199A1 (es) 2011-04-22 2013-11-27 Wyeth Llc Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos
US9505847B2 (en) 2011-08-22 2016-11-29 Cnj Holdings Inc Clostridium difficile antibodies
AU2012349753A1 (en) 2011-12-08 2014-06-19 Novartis Ag Clostridium difficile toxin-based vaccine
DE102011121237A1 (de) * 2011-12-14 2013-06-20 Universitätsklinikum Hamburg-Eppendorf Einzeldomänen-Antikörper gegen Clostridium difficile Toxin CDTa
AR089797A1 (es) * 2012-01-27 2014-09-17 Merck Sharp & Dohme Vacunas contra clostridum difficile que comprenden toxinas recombinantes
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
US20160002278A1 (en) 2013-03-08 2016-01-07 Cipla Limited Pharmaceutical Compositions for Rectal Administration
HK1213917A1 (zh) * 2013-03-15 2016-07-15 Sanofi Pasteur, Inc. 類霉素、組合物及相關方法
CN105451762A (zh) * 2013-04-22 2016-03-30 俄克拉荷马州大学评议会 艰难梭菌疫苗及使用方法
SG11201510166YA (en) 2013-06-14 2016-01-28 Sanofi Pasteur Inc Compositions and methods of immunizing against c. difficile
US10513552B2 (en) 2014-06-20 2019-12-24 Immunimed Inc. Use of polyclonal antibodies against clostridium difficile for treatment of inflammatory bowel disease
EP2957570B1 (en) * 2014-06-20 2019-04-17 Immunimed Inc. Polyclonal antibodies against clostridium difficile and uses thereof
CN106659799B (zh) * 2014-07-25 2020-07-17 碧奥辛斯有限责任公司 用于制备针对因肠致病性细菌引起的感染的广谱疫苗的包含表达内置的多个表位的分子构建体的基本单元的糖缀合物疫苗
US20190111001A1 (en) * 2016-03-30 2019-04-18 University Of Maryland, Baltimore Microparticulate system for colonic drug delivery
GB201701404D0 (en) 2017-01-27 2017-03-15 Micropharm Ltd Therapies for treating inflammatory disorders
WO2021255690A2 (en) 2020-06-19 2021-12-23 Pfizer Inc. Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof
GB202019817D0 (en) * 2020-12-15 2021-01-27 Univ Oxford Innovation Ltd Ligand-binding polypeptides and uses thereof
WO2026085370A2 (en) * 2024-10-16 2026-04-23 Triveni Bio, Inc. Dual inhibitor trypsin antibodies and uses thereof

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WO2002043767A1 (en) * 2000-11-30 2002-06-06 Unigene Laboratories Inc. Improved oral delivery of peptides using enzyme-cleavable membrane translocators

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US6096310A (en) 1997-04-15 2000-08-01 Bier; Milan Oral immunotherapy of bacterial overgrowth
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US6074689A (en) 1998-03-10 2000-06-13 Immucell Corporation Colonic delivery of protein or peptide compositions
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US8709428B2 (en) 2009-02-20 2014-04-29 Health Protection Agency Antibodies to Clostridium difficile toxins
GB0921288D0 (en) 2009-12-04 2010-01-20 Health Prot Agency Therapies for preventing or suppressing clostridium difficile infection

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US5601823A (en) * 1989-10-31 1997-02-11 Ophidian Pharmaceuticals, Inc. Avian antitoxins to clostridium difficle toxin A
CN1176658A (zh) * 1994-10-24 1998-03-18 蛇药制品有限公司 治疗和预防艰难梭菌疾病的疫苗和抗毒素
WO2002043767A1 (en) * 2000-11-30 2002-06-06 Unigene Laboratories Inc. Improved oral delivery of peptides using enzyme-cleavable membrane translocators

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113846079A (zh) * 2015-07-24 2021-12-28 酶公司 新型胰蛋白酶同功异型物和其用途
CN113846079B (zh) * 2015-07-24 2024-12-03 酶公司 新型胰蛋白酶同功异型物和其用途
CN115704021A (zh) * 2021-08-17 2023-02-17 上海宝济药业有限公司 一种人糜蛋白酶原及其制备方法和应用
WO2026036320A1 (zh) * 2024-08-15 2026-02-19 中国科学院上海有机化学研究所 一种靶向酶蛋白药物及其设计方法

Also Published As

Publication number Publication date
JP2013512889A (ja) 2013-04-18
GB0921288D0 (en) 2010-01-20
US20130004561A1 (en) 2013-01-03
AU2010325764A1 (en) 2012-06-07
MY158712A (en) 2016-11-15
EP2506877B1 (en) 2021-08-04
BR112012013496A2 (pt) 2016-08-16
WO2011067616A1 (en) 2011-06-09
JP5877161B2 (ja) 2016-03-02
EP2506877A1 (en) 2012-10-10
US8921529B2 (en) 2014-12-30
CA2782639C (en) 2019-02-26
SG181127A1 (en) 2012-07-30
CA2782639A1 (en) 2011-06-09

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TA01 Transfer of patent application right

Effective date of registration: 20161128

Address after: London, England

Applicant after: BMH

Applicant after: Micropharm Limited

Address before: Wiltshire

Applicant before: Health Protection Agency

Applicant before: Micropharm Limited

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Application publication date: 20121017

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Applicant after: Department of health and social security

Applicant after: Mccrofom Co., Ltd

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Applicant before: Mccrofom Co., Ltd

TA01 Transfer of patent application right