CN102731333A - 一种丁卡因的制备方法 - Google Patents
一种丁卡因的制备方法 Download PDFInfo
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- CN102731333A CN102731333A CN2012102425967A CN201210242596A CN102731333A CN 102731333 A CN102731333 A CN 102731333A CN 2012102425967 A CN2012102425967 A CN 2012102425967A CN 201210242596 A CN201210242596 A CN 201210242596A CN 102731333 A CN102731333 A CN 102731333A
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CN201210242596.7A CN102731333B (zh) | 2012-07-13 | 2012-07-13 | 一种丁卡因的制备方法 |
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CN102731333A true CN102731333A (zh) | 2012-10-17 |
CN102731333B CN102731333B (zh) | 2014-12-03 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105646259A (zh) * | 2014-11-18 | 2016-06-08 | 上海朝晖药业有限公司 | 高纯度4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯盐酸盐的制备方法 |
CN106518697A (zh) * | 2016-09-20 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种制备盐酸丁卡因的方法 |
CN109180511A (zh) * | 2018-08-22 | 2019-01-11 | 辽宁东科药业有限公司 | 一种盐酸丁卡因的制备方法 |
CN109761835A (zh) * | 2018-12-29 | 2019-05-17 | 江苏尚莱特医药化工材料有限公司 | 盐酸丁卡因的制备方法 |
CN115466190A (zh) * | 2021-10-13 | 2022-12-13 | 浙江孚诺医药股份有限公司 | 一种丁卡因的制备方法及其应用 |
-
2012
- 2012-07-13 CN CN201210242596.7A patent/CN102731333B/zh active Active
Non-Patent Citations (3)
Title |
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ADRIANA L. ANDRADE ET AL.: "Cyclic Nucleotide-Gated Channel Block by Hydrolysis-Resistant Tetracaine Derivatives", 《JOURNAL OF MEDICINAL CHEMISTRY》 * |
M. G. ABDULLAEV: "A NEW METHOD OF DICAINE SYNTHESIS FROM p-NITROBENZOIC ACID ETHYLATE", 《PHARMACEUTICAL CHEMISTRY JOURNAL》 * |
TIMOTHY STRASSMAIER ET AL.: "Block of cyclic nucleotide-gated channels by tetracaine derivatives: Role of apolar interactions at two distinct locations", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105646259A (zh) * | 2014-11-18 | 2016-06-08 | 上海朝晖药业有限公司 | 高纯度4-(丁氨基)-苯甲酸-2-(二甲氨基)乙酯盐酸盐的制备方法 |
CN106518697A (zh) * | 2016-09-20 | 2017-03-22 | 北京万全德众医药生物技术有限公司 | 一种制备盐酸丁卡因的方法 |
CN109180511A (zh) * | 2018-08-22 | 2019-01-11 | 辽宁东科药业有限公司 | 一种盐酸丁卡因的制备方法 |
CN109761835A (zh) * | 2018-12-29 | 2019-05-17 | 江苏尚莱特医药化工材料有限公司 | 盐酸丁卡因的制备方法 |
CN109761835B (zh) * | 2018-12-29 | 2021-10-15 | 常州市阳光药业有限公司 | 盐酸丁卡因的制备方法 |
CN115466190A (zh) * | 2021-10-13 | 2022-12-13 | 浙江孚诺医药股份有限公司 | 一种丁卡因的制备方法及其应用 |
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CN102731333B (zh) | 2014-12-03 |
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Effective date of registration: 20190222 Address after: 253100 North Second Ring Road, West First Road, Dezhou Plain Economic Development Zone, Shandong Province Patentee after: Shandong Yunjia Pharmaceutical Co. Ltd. Address before: 250101 2350 development road, hi tech Development Zone, Ji'nan, Shandong Patentee before: Jinan Chenghui Shuangda Chemical Co., Ltd. |
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Denomination of invention: A preparation method of tetracaine Effective date of registration: 20220616 Granted publication date: 20141203 Pledgee: Shandong Pingyuan Rural Commercial Bank Co.,Ltd. Pledgor: SHANDONG CHENGHUI SHUANGDA PHARMACEUTICAL CO.,LTD. Registration number: Y2022980007784 |
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