CN102716339A - Chinese medicinal composition for treating uremia, and preparation method and application thereof - Google Patents
Chinese medicinal composition for treating uremia, and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition which is combined with hemodialysis to treat uremia. The Chinese medicinal composition comprises herba cissampelotis, coastal glehnia root, common bletilla pseudobulb, white paeony root, oyster, yerbadetajo herb, cortex dictamni, prepared rehmannia root, chrysanthemum, ligusticum wallichii, plantain herb, pyrrosia leaf, dwarf lilyturf root, medlar, epimedium herb, rhubarb, fineleaf schizonepeta herb, mirabilite, suberect spatholobus stem and sealwort. The Chinese medicinal composition can reduce the frequency of hemodialysis; and when combined with hemodialysis to treat uremia, the Chinese medicinal composition has the advantages of small side effect, good curative effect, low cost and high cure rate, and a patient does not develop medicine tolerance.
Description
Technical field
The present invention relates to the Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used to treat uremia's complication of hemodialysis.
Background technology
Chronic renal insufficiency develops into uremia's phase kidney forfeiture and drains and regulatory function; Cause Water-Electrolyte, acid base imbalance and nitrogen matter metabolite to be put aside in vivo; Finally develop into uremia; Uremia is not an independently disease, but the total clinical syndrome of the nephropathy in various late periods, is that chronic renal failure gets into the syndrome that a series of clinical manifestation that end eventually occurs during the stage is formed.
The first-selected hemodialysis of modern medicine treatment uremia, its purpose one is to prolong patient's life, improves patients ' life quality; The 2nd, for renal transplantation provides favourable opportunity, but conventional hemodialysis is each 3 hours, 2～3 times weekly; Frequent dialysis brings a lot of complication to the patient, and the dialysis expensive, and a lot of patients can't bear; And hemodialysis can only take stopgap measures; Can not effect a permanent cure, chronic renal insufficiency develops into uremia's phase, abnormalities of sugar/lipid metabolism, anemia to be increased the weight of, and these all are that hemodialysis cann't be solved; Simultaneously because the non-physiologic of dialysis can produce multiple untoward reaction in dialysis procedure or after the dialysis.
Chinese medicine uremia, but relieve clinical symptoms, the protection residual renal function delays PD, postpones the time of necessary dialysis and renal transplantation, more and more receives the attention of domestic and international medical circle.Uremia belongs to Chinese medicine obstruction and rejection, edema, the categories such as poison, asthenia of drowning, and Chinese medicine thinks that with the passing of time this disease delays or the exopathogen invasion and attack, the overstrain internal injury; Cause function deficient, turbid damp is stopped over, and three warmers are jammed; Ascending or descending movement of vital Qi is not normal; Though the state of an illness is critical, syndrome is complicated, and deficiency in origin and excess in superficiality is to run through the course of disease main pathogenesis all the time.Deficiency in origin is main with spleen kidney yang (gas) void, and mark is real to be main with turbid damp, noxious water, blood stasis, and strengthening vital QI to eliminate pathogenic factors is answered in treatment.
Adopt Chinese traditional treatment uremia, not only can before uremia takes place, play the effect of checking the state of an illness, also can reduce the dialysis number of times fully even the patient has developed into the uremic stage.Different with patient's dialysis treatment is, though dialysis treatment can not damage kidney, can not fundamentally improve renal function, and adopts Chinese traditional treatment can improve renal function to a certain extent, and this is that doctor trained in Western medicine is incomparable.
But uremic patient can not rely on Chinese traditional treatment merely, but must be by the technology of modern medicine doctor trained in Western medicine.In the face of the middle and advanced stage uremic patient time, the effect that simple Chinese traditional treatment can be brought into play is just more and more limited.This time, the dialysis treatment and the kidney transfer operation of doctor trained in Western medicine still were important.
Therefore the present invention provides a kind of cooperation hemodialysis uremic Chinese medicine composition; It focuses on and effects a permanent cure, and is the Therapeutic Principle with purging FU-organs the turbid descending, invigorating spleen to remove dampness, activating blood circulation to dissipate blood stasis, can start with from adjustment internal organs negative and positive of qi and blood; Improve the function of human body state; Effectively improve immunity, make remaining glomerule function be able to protection to greatest extent, improve symptom comprehensively.
Summary of the invention
Technical problem to be solved by this invention is; A kind of uremic Chinese medicine composition of hemodialysis that is used to cooperate is provided; Adopt this Chinese medicine composition can alleviate the number of times of hemodialysis, cooperate that hemodialysis uremia has that side effect is little, good effect, cost is low, cure rate is high, the advantage that has no drug resistance.
Ask in order to solve above-mentioned technology; The invention provides the uremic Chinese medicine composition of a kind of cooperation hemodialysis, it comprises: Herba Cissampelotis pareiae, Radix Glehniae, Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, Concha Ostreae, Herba Ecliptae, Cortex Dictamni, Radix Rehmanniae Preparata, Flos Chrysanthemi, Rhizoma Chuanxiong, Herba Plantaginis, Folium Pyrrosiae, Radix Ophiopogonis, Fructus Lycii, Herba Epimedii, Radix Et Rhizoma Rhei, Herba Schizonepetae, Natrii Sulfas, Caulis Spatholobi and Rhizoma Polygonati.
Wherein, the ratio of weight and number of each component is in the said Chinese medicine composition:
Herba Cissampelotis pareiae 10～20 weight portions; Radix Glehniae 20～30 weight portions; Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 weight portions; The Radix Paeoniae Alba 25～35 weight portions; Concha Ostreae 10～20 weight portions; Herba Ecliptae 30～40 weight portions; Cortex Dictamni 10～20 weight portions; Radix Rehmanniae Preparata 20～30 weight portions; Flos Chrysanthemi 15～25 weight portions; Rhizoma Chuanxiong 20～30 weight portions; Herba Plantaginis 10～20 weight portions; Folium Pyrrosiae 10～20 weight portions; Radix Ophiopogonis 30～40 weight portion; Fructus Lycii 25～35 weight portions; Herba Epimedii 10～20 weight portions; Radix Et Rhizoma Rhei 60～70 weight portions; Herba Schizonepetae 10～20 weight portions; Natrii Sulfas 15～25 weight portions; Caulis Spatholobi 25～35 weight portions and Rhizoma Polygonati 30～40 weight portions.
Wherein, in the said Chinese medicine composition weight fraction of each component than further being preferably:
Herba Cissampelotis pareiae 15～20 weight portions; Radix Glehniae 25～30 weight portions; Pseudobulbus Bletillae (Rhizoma Bletillae) 15～20 weight portions; The Radix Paeoniae Alba 30～35 weight portions; Concha Ostreae 15～20 weight portions; Herba Ecliptae 35～40 weight portions; Cortex Dictamni 15～20 weight portions; Radix Rehmanniae Preparata 25～30 weight portions; Flos Chrysanthemi 20～25 weight portions; Rhizoma Chuanxiong 25～30 weight portions; Herba Plantaginis 15～20 weight portions; Folium Pyrrosiae 15～20 weight portions; Radix Ophiopogonis 35～40 weight portion; Fructus Lycii 30～35 weight portions; Herba Epimedii 15～20 weight portions; Radix Et Rhizoma Rhei 65～70 weight portions; Herba Schizonepetae 15～20 weight portions; Natrii Sulfas 20～25 weight portions; Caulis Spatholobi 30～35 weight portions and Rhizoma Polygonati 35～40 weight portions.
Wherein, Can also further add Herba Agrimoniae and Rhizoma Imperatae in the said Chinese medicine composition; Said Herba Agrimoniae and the Rhizoma Imperatae parts by weight in said Chinese medicine composition are Herba Agrimoniae 15～25 weight portions and Rhizoma Imperatae 10～20 weight portions, further are preferably Herba Agrimoniae 20～25 weight portions and Rhizoma Imperatae 15～20 weight portions.
Wherein, Can also further add Rhizoma Coptidis and Caulis Bambusae In Taenia in the said Chinese medicine composition; Said Rhizoma Coptidis and the Caulis Bambusae In Taenia weight fraction in said Chinese medicine composition is Rhizoma Coptidis 10～20 weight portions and Caulis Bambusae In Taenia 5～15 weight portions, further is preferably Rhizoma Coptidis 15～20 weight portions and Caulis Bambusae In Taenia 10～15 weight portions.
Wherein, said composition of medicine dosage form is decoct, powder, honey refining pill, hydration pill, and tablet, capsule, oral liquid, granule, colloid or syrup further are preferably syrup and capsule.
The invention provides the method for preparing of above-mentioned Chinese medicine composition, it comprises:
The first step with each component proportional mixing in the said Chinese medicine composition, is ground into 100 orders～200 purpose powder;
In second step, the determining alcohol that adds 2～4 times of the powder qualities that obtain with respect to the first step is 80～90% ethanol, and reflux 1～3 hour is extracted; Obtain extracting solution, filter and obtain first alcohol extract, filtering the medicinal residues that obtain, to add determining alcohol with respect to 1～2 times of filtering residue quality again be 70～80% ethanol, reflux 1～3 hour; Extract, obtain extracting solution, filter and obtain second alcohol extract, first filtrate and second filtrate are mixed; Concentrating under reduced pressure removes and to desolvate, and drying obtains and gets dry extract;
The 3rd step was broken into 200 orders～400 purpose powder with said dried cream powder, added various auxiliary additives and prepared needed various dosage form.
Wherein, When the dosage form of said Chinese medicine composition is syrup; Said the 3rd step is for adding the water dissolution with respect to 2～3 times of powder qualities in the powder after pulverizing; Regulate pH value to 7.0 with 40% sodium hydroxide solution; Add correctives sucrose, antiseptic mix homogeneously subsequently, promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
Wherein, when the dosage form of said Chinese medicine composition was capsule, said the 3rd step was for adding 5～7 weight portion carboxymethyl starch sodium, 5～50 weight portion starch mix homogeneously in the powder after pulverizing; 3～5 weight portion magnesium stearate; 150～200 weight portion determining alcohols are 80%～90% alcohol granulation, drying, granulate; Pack into then in the gelatine capsule, process capsule.
The present invention also provides above-mentioned Chinese medicine composition, and it is in the application that is used for cooperating the uremic medicine of hemodialysis of the various dosage forms of preparation.
Beneficial effect of the present invention:
Adopt this Chinese medicine composition can alleviate the number of times of hemodialysis, cooperate that hemodialysis uremia has that side effect is little, good effect, cost is low, cure rate is high, the advantage that has no drug resistance.
The specific embodiment
The invention provides the uremic Chinese medicine composition of a kind of cooperation hemodialysis, it comprises: Herba Cissampelotis pareiae, Radix Glehniae, Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, Concha Ostreae, Herba Ecliptae, Cortex Dictamni, Radix Rehmanniae Preparata, Flos Chrysanthemi, Rhizoma Chuanxiong, Herba Plantaginis, Folium Pyrrosiae, Radix Ophiopogonis, Fructus Lycii, Herba Epimedii, Radix Et Rhizoma Rhei, Herba Schizonepetae, Natrii Sulfas, Caulis Spatholobi and Rhizoma Polygonati.
Herba Cissampelotis pareiae: latin name Cissampelotis Herba, sweet in the mouth, hardship, warm in nature, return liver, spleen channel, have reducing swelling and alleviating pain, the effect of hemostasia and promoting granulation cures mainly traumatic injury, and wound swells and ache, wound hemorrhage, rheumatic arthralgia, cards such as arthralgia.
Radix Glehniae: latin name Glehniae Radix, sweet in the mouth, little hardship, cold nature is gone into lung, spleen channel, has nourishing YIN and clearing away lung-heat, and the effect of reinforcing stomach reg fluid cures mainly nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough.Control lung-heat type cough, chronic consumptive disease chronic cough, the moon are hindered dry pharynx, card such as thirsty.
Pseudobulbus Bletillae (Rhizoma Bletillae): latin name Bletillac Rhizoma, bitter in the mouth, sweet, puckery, cold nature is returned lung, liver, stomach warp, has the tonifying the lung hemostasis; Detumescence and promoting granulation is held back the effect of skin ulcer, and cure mainly lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage; Swollen ulcer drug, ulcer pain, the soup fire is burnt, cards such as rhagadia manus et pedis.
The Radix Paeoniae Alba: latin name Paeoniae Radix Alba, bitter in the mouth, acid, cool in nature, go into liver, spleen channel; Have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the effect of antiperspirant, cures mainly the breast abdomen pain over the hypochondriac region; Dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia; Metrorrhagia, cards such as leukorrhagia, the Radix Paeoniae Alba has good liver-protective effect.
Concha Ostreae: latin name Ostreae Concha, to distinguish the flavor of, cold nature is returned liver, gallbladder, kidney channel, has suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion; Hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect, cures mainly vertigo and tinnitus, brothers' chatter, palpitation and insomnia; Dysphoria, infantile convulsion is demented, scrofula goiter, breast caking, spontaneous sweating; The seminal emission frequent micturition, bleeding not during menses, the acid regurgitation stomachache, cards such as eczema skin infection, Concha Ostreae polysaccharide has blood fat reducing, anticoagulation, anti thrombotic action.
Herba Ecliptae: latin name Ecliptae Herba, sweet in the mouth, acid, cold in nature, return liver, kidney channel, play liver and kidney tonifying, the effect of cooling blood for hemostasis, cure mainly have a dizzy spell due to the hepatic and renal YIN deficiency, blurring of vision, soreness of the waist and knees; Being suitable for the deficiency of YIN has hot person, the haematemesis of long-pending heat in the stomach, and cards such as the hemoptysis of injury of blood vessel of the lung by heat, Herba Ecliptae has inhibitory action to staphylococcus aureus, Bacillus typhi, Song Shi dysentery bacterium, bacillus pyocyaneus, obviously enhancing non-specific immunity and cellular immune function.
Cortex Dictamni: latin name Dictamni Cortex, bitter in the mouth becomes, and is cold in nature, returns spleen channel; Lung meridian; Small intestine meridian; The stomach warp; Urinary bladder channel has heat clearing and damp drying; Dispelling wind for relieving itching; The antidotal effect cures mainly the rubella due to the wind heat noxious dampness; Eczema; Scabies; Jaundice; Cards such as damp and hot arthralgia pain.
Radix Rehmanniae Preparata: latin name Rehmanniae Radix Praeparata, sweet in the mouth, slightly warm in nature is gone into liver, kidney channel, has the YIN nourishing of enriching blood, and beneficial essence is filled out the effect of marrow, cures mainly blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia is collapsed more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; The seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; The cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Flos Chrysanthemi: latin name Chrysanthemi Flos, acrid in the mouth, sweet, bitter, cold nature is returned lung, Liver Channel; Have that dispelling wind liver heat removing, suppressing the hyperactive liver make eye bright, the effect of removing toxic substances and promoting subsidence of swelling, cure mainly affection due to external wind and heat and epidemic febrile disease from the beginning of, have a dizzy spell; Blurring of vision, conjunctival congestion and swelling pain, cards such as pyretic toxicity carbuncle.
Rhizoma Chuanxiong: latin name Chuanxiong Rhizoma, acrid in the mouth, warm in nature, go into liver, gallbladder, pericardium channel, have blood-activating and qi-promoting, the effect of wind-expelling pain-stopping cures mainly stagnation of QI and blood, headache, rheumatic arthralgia, cards such as traumatic injury.
Herba Plantaginis: latin name Plantaginis Herba, sweet in the mouth; Light; Cold nature is returned lung meridian; Liver Channel; Kidney channel; Urinary bladder channel has clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; The expectorant effect that makes eye bright cures mainly dysuria; The stranguria with turbid discharge leukorrhagia; The edema distension; The heat-damp in summer dysentery; Conjunctival congestion is hidden from view; The expectorant heat syndrome cough such as breathes heavily at card.
Folium Pyrrosiae: latin name Pyrrosiae Folium, sweet in the mouth, hardship, cold nature is returned lung, urinary bladder channel, has relieving stranguria by diuresis, and the effect that lung heat clearing expels the heat-evil cures mainly and drenches pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, cards such as carbuncle.
Radix Ophiopogonis: latin name Ophiopogonis Radix, sweet in the mouth, little hardship, cold nature is gone into the heart, lung, stomach warp; Have the effect that nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away nourish heart, curing mainly pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN has the dry cough expectorant of heat glutinous, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity; Dry mouth and throat due to the lung abscess, thermal burn stomach-Yin or deficiency of stomach-Yin, the few tongue of red tongue, vague epigastralgia; Interior-heat is quenched one's thirst, constipation due to dry stool, and deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and do and wait card.
Fructus Lycii: latin name Lycii Fructus; Sweet in the mouth, property are put down; Go into liver, kidney channel, have liver and kidney tonifying, nourish blood enrich blood, the effect of replenishing vital essence to improve eyesight, nourishing the lung to arrest cough, cure mainly soreness of the waist and knees, dizziness and tinnitus, seminal emission tinnitus, the unconsciously sweat and tire of Liver and kidney two void, asthenia of essence and blood; The sexual impotence of insufficiency of kidney-YANG, sterile; Cards such as the dim-sighted and deficiency of YIN chronic cough of the eyes of deficiency of YIN-essence, deficiency of liver-blood, Fructus Lycii can promote liver cell regeneration, the effect of enhancing non-specific immunity function.
Herba Epimedii: latin name Epimedii Folium, acrid in the mouth, sweet, warm in nature, go into liver, kidney channel, have kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling cures mainly impotence due to deficiency of the kidney, seminal emission premature ejaculation, soft, the cold extremities with aversion to cold of waist knee joint flaccidity; Cards such as arthralgia due to cold-dampnes or spasm of the limbs numbness, Herba Epimedii is traditional kidney invigorating and YANG supporting Chinese medicine, is rich in flavone compound, has gonadotropic Effect, directly suppresses bone resorption and promotes bone formation, makes organism metabolism be in the positive balance state of bone formation greater than bone resorption.
Radix Et Rhizoma Rhei: latin name Rhei Radix et Rhizoma, bitter in the mouth, cold in nature, return the stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The antidotal effect cures mainly the excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; The edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Cards such as scald.
Herba Schizonepetae: latin name Schizonepetae Herba, acrid in the mouth, slightly warm in nature is gone into lung, Liver Channel, and relieving the exterior syndrome by diaphoresis is arranged, and declares malicious rash and blood hemostatic effect, cures mainly the fever and headache due to the affection of exogenous wind-cold wind heat, no matter has antiperspirant lossless, all can use; The headache of attacking on the wind heat is dizzy, and rash goes out not pass through; The puerperal blood faints apoplexy, cards such as discharging fresh blood stool.
Natrii Sulfas: latin name NAtrii Sulfas, distinguish the flavor of, hardship, cold in nature, return the stomach warp; Lung meridian; Spleen channel; Kidney channel; Small intestine meridian; Tri-jiao channel; Large intestine channel is used for the excess-heat constipation, constipation due to dry stool, and stagnant stomachache, acute appendicitis swells and ache; The external treatment acute mastitis, cards such as swelling and pain of hemorrhoid also contain the multiple composition down that rushes down in the Natrii Sulfas, can promote noxious substances such as carbamide, creatinine from intestinal, to drain, and renal blood flow increasing and glomerular filtration rate improve the hypercoagulability effect in addition, thereby nephrocyte is had protective effect.
Caulis Spatholobi: latin name Spatholobi Caulis, bitter in the mouth, sweet, warm in nature, go into liver, kidney channel; Blood vessel dilating is arranged, enrich blood and invigorate blood circulation, regulating menstruation; The effect of relaxing muscles and tendons and activating QI and blood in the collateral has the obvious suppression effect to platelet aggregation, promotes animal kidney and the total phosphorus metabolism in uterus; Be mainly used in and treat the menoxenia that blood deficiency has silt, limbs pain is meciless, cards such as soreness of the waist and knees, pain.
Rhizoma Polygonati: latin name Polygonati Rhizoma, sweet in the mouth, property is flat, goes into lung, spleen, kidney channel; Has the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence; Be used for the taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN; The few expectorant of dry cough, interior-heat caused by deficiency of YIN quench one's thirst cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.
The ratio of weight and number of each component is in the said Chinese medicine composition:
Herba Cissampelotis pareiae 10～20 weight portions; Radix Glehniae 20～30 weight portions; Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 weight portions; The Radix Paeoniae Alba 25～35 weight portions; Concha Ostreae 10～20 weight portions; Herba Ecliptae 30～40 weight portions; Cortex Dictamni 10～20 weight portions; Radix Rehmanniae Preparata 20～30 weight portions; Flos Chrysanthemi 15～25 weight portions; Rhizoma Chuanxiong 20～30 weight portions; Herba Plantaginis 10～20 weight portions; Folium Pyrrosiae 10～20 weight portions; Radix Ophiopogonis 30～40 weight portion; Fructus Lycii 25～35 weight portions; Herba Epimedii 10～20 weight portions; Radix Et Rhizoma Rhei 60～70 weight portions; Herba Schizonepetae 10～20 weight portions; Natrii Sulfas 15～25 weight portions; Caulis Spatholobi 25～35 weight portions and Rhizoma Polygonati 30～40 weight portions.
The weight fraction of each component is than further being preferably in the said Chinese medicine composition:
Herba Cissampelotis pareiae 15～20 weight portions; Radix Glehniae 25～30 weight portions; Pseudobulbus Bletillae (Rhizoma Bletillae) 15～20 weight portions; The Radix Paeoniae Alba 30～35 weight portions; Concha Ostreae 15～20 weight portions; Herba Ecliptae 35～40 weight portions; Cortex Dictamni 15～20 weight portions; Radix Rehmanniae Preparata 25～30 weight portions; Flos Chrysanthemi 20～25 weight portions; Rhizoma Chuanxiong 25～30 weight portions; Herba Plantaginis 15～20 weight portions; Folium Pyrrosiae 15～20 weight portions; Radix Ophiopogonis 35～40 weight portion; Fructus Lycii 30～35 weight portions; Herba Epimedii 15～20 weight portions; Radix Et Rhizoma Rhei 65～70 weight portions; Herba Schizonepetae 15～20 weight portions; Natrii Sulfas 20～25 weight portions; Caulis Spatholobi 30～35 weight portions and Rhizoma Polygonati 35～40 weight portions.
Further, said Chinese medicine composition only is made up of said components.
For the hematuria patient; Can also further add Herba Agrimoniae and Rhizoma Imperatae in the said Chinese medicine composition; Said Herba Agrimoniae and the Rhizoma Imperatae parts by weight in said Chinese medicine composition are Herba Agrimoniae 15～25 weight portions and Rhizoma Imperatae 10～20 weight portions, further are preferably Herba Agrimoniae 20～25 weight portions and Rhizoma Imperatae 15～20 weight portions.
Herba Agrimoniae: latin name Agrimoniae Herba, bitter in the mouth, puckery, property is flat, GUIXIN, Liver Channel; Have astringing to arrest bleeding, the parasiticidal effect of dysentery relieving cures mainly various hemorrhage cards; For example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain is taken off power; Carbuncle, traumatic injury, cards such as wound hemorrhage.
Rhizoma Imperatae: latin name Imperatae Rhizoma, sweet in the mouth, cold in nature is gone into lung, stomach, small intestine meridian, has cooling blood for hemostasis, clearing away heat and promoting production of body fluid; The effect of inducing diuresis for treating stranguria syndrome cures mainly heat in blood and spits blood, epistaxis spitting of blood, hematuria; Metrorrhagia, purpura, calentura excessive thirst, gastric heat vomiting; Dyspnea and cough due to lung-heat, the puckery pain of dribbling urination, edema, cards such as jaundice.
For the serious patient of nausea and vomiting; Can also further add Rhizoma Coptidis and Caulis Bambusae In Taenia in the said Chinese medicine composition; Said Rhizoma Coptidis and the Caulis Bambusae In Taenia weight fraction in said Chinese medicine composition is Rhizoma Coptidis 10～20 weight portions and Caulis Bambusae In Taenia 5～15 weight portions, further is preferably Rhizoma Coptidis 15～20 weight portions and Caulis Bambusae In Taenia 10～15 weight portions.
Rhizoma Coptidis: latin name Coptidis Rhizoma, bitter in the mouth, cold in nature, go into the heart, lung, gallbladder, stomach, large intestine channel; Heat clearing and damp drying is arranged, eliminating fire and detoxication, the effect of cooling blood for improving eyesight; Be usually used in treating the fire of removing pathogen in the heart warp, the dysphoria and insomnia that heart-fire is prosperous, and the high fever coma of epidemic febrile disease, symptom such as vexed, thirsty; Also can be used for treating symptoms such as dysentery due to damp and hot, tenesmus.
Caulis Bambusae In Taenia: latin name Bambusae Caulis In Taenias, sweet in the mouth, cold nature is gone into lung, stomach warp, the effect that removing heat-phlegm is arranged, relieves restlessness and prevents vomiting, being mainly used in lung meridian has heat, the cough ant phlegm of expectorant and accumulation of heat; The gallbladder fire is held expectorant under the arm, violates lung and disturbs the vexed of the heart, the palpitation with fear insomnia; Middle wind-phlegm fan, insufficiency of stomach is held the cards such as vomiting of heat under the arm.
Said composition of medicine dosage form is decoct, powder, honey refining pill, hydration pill, and tablet, capsule, oral liquid, granule, colloid or syrup further are preferably syrup and capsule.
The invention provides the method for preparing of above-mentioned Chinese medicine composition, it comprises:
The first step with each component proportional mixing in the said Chinese medicine composition, is ground into 100 orders～200 purpose powder;
In second step, the determining alcohol that adds 2～4 times of the powder qualities that obtain with respect to the first step is 80～90% ethanol, and reflux 1～3 hour is extracted; Obtain extracting solution, filter and obtain first alcohol extract, filtering the medicinal residues that obtain, to add determining alcohol with respect to 1～2 times of filtering residue quality again be 70～80% ethanol, reflux 1～3 hour; Extract, obtain extracting solution, filter and obtain second alcohol extract, first filtrate and second filtrate are mixed; Concentrating under reduced pressure removes and to desolvate, and drying obtains and gets dry extract;
The 3rd step was broken into 200 orders～400 purpose powder with said dried cream powder, added various auxiliary additives and prepared needed various dosage form.
Wherein, When the dosage form of said Chinese medicine composition is syrup; Said the 3rd step is for adding the water dissolution with respect to 2～3 times of powder qualities in the powder after pulverizing; Regulate pH value to 7.0 with 40% sodium hydroxide solution; Add correctives sucrose, antiseptic mix homogeneously subsequently, promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
Wherein, when the dosage form of said Chinese medicine composition was capsule, said the 3rd step was for adding 5～7 weight portion carboxymethyl starch sodium, 5～50 weight portion starch mix homogeneously in the powder after pulverizing; 3～5 weight portion magnesium stearate; 150～200 weight portion determining alcohols are 80%～90% alcohol granulation, drying, granulate; Pack into then in the gelatine capsule, process capsule.
The present invention also provides above-mentioned Chinese medicine composition, and it is in the application that is used for cooperating the uremic medicine of hemodialysis of the various dosage forms of preparation.
Below adopt embodiment to specify embodiment of the present invention, how the application technology means solve technical problem to the present invention whereby, and the implementation procedure of reaching technique effect can make much of and implement according to this.
The syrup 1 of embodiment 1 the present invention preparation
30g, Fructus Lycii 25g, Herba Epimedii 10g, Radix Et Rhizoma Rhei 60g, Herba Schizonepetae 10g, Natrii Sulfas 15g, Caulis Spatholobi 25g and Rhizoma Polygonati 30g mix with Herba Cissampelotis pareiae 10g, Radix Glehniae 20g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Paeoniae Alba 25g, Concha Ostreae 10g, Herba Ecliptae 30g, Cortex Dictamni 10g, Radix Rehmanniae Preparata 20g, Flos Chrysanthemi 15g, Rhizoma Chuanxiong 20g, Herba Plantaginis 10g, Folium Pyrrosiae 10g, Radix Ophiopogonis, are ground into 100 purpose powder, in the powder that obtains, add determining alcohol and be 90% ethanol 1200g; Reflux 2 hours is extracted, and obtains extracting solution; Filter to obtain first alcohol extract, filtering the medicinal residues that obtain, to add determining alcohol again be 80% ethanol 400g, reflux 2 hours; Extract, obtain extracting solution, filter and obtain second alcohol extract; First filtrate and second filtrate are mixed, and concentrating under reduced pressure removes and desolvates; Drying obtains and gets dry extract, and said dried cream powder is broken into 300 purpose powder; The water dissolution that adds 800g in the powder after pulverizing; Regulate pH value to 7.0 with 40% sodium hydroxide solution, add correctives 300g sucrose, potassium sorbate 2g mix homogeneously subsequently, promptly get syrup 1.
Toxicity test
Use 60 of NIH mices, the SPF level, male and female half and half, body weight 18～22g carries out acute toxicity testing.Mice is divided into two groups at random, and promptly matched group and administration group are tested preceding fasting 12 hours, and the Chinese medicine composition syrup 1 that embodiments of the invention 1 are prepared is dissolved in the water; (concentration is 6.28g crude drug/ml, maximum concentration) irritated stomach, and irritating the stomach volume and be 5ml/kg (is that single-dose dosage is 31.4g crude drug/kg); Matched group gives the equivalent normal saline, administration in 1 day 2 times, delivery time 6 hours; Observed 14 days continuously after the administration, and toxic reaction and the death toll of record mice, specifically see table 1 for details.Experimental result shows: with matched group relatively, mice does not see notable difference after the administration, experiment was observed 14 days continuously, the mice overall health of patients, ingest, drinking-water, body weight gain is all normal.Mice oral administration gavage capsule LD of the present invention
50＞31.4g crude drug/kg, every day, maximum dosage-feeding was 62.8g crude drug/kg/ day.Chinese medicine composition clinical application amount of the present invention is 2.1g crude drug/day/people, becomes body weight for humans in 60kg, and average dosage is 0.035g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine composition of the present invention is 897 times of clinical consumption.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.
The syrup 2 of embodiment 2 the present invention preparation
40g, Fructus Lycii 35g, Herba Epimedii 12g, Radix Et Rhizoma Rhei 70g, Herba Schizonepetae 15g, Natrii Sulfas 12g, Caulis Spatholobi 35g and Rhizoma Polygonati 40g mix with Herba Cissampelotis pareiae 12g, Radix Glehniae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Paeoniae Alba 35g, Concha Ostreae 18g, Herba Ecliptae 38g, Cortex Dictamni 12g, Radix Rehmanniae Preparata 29g, Flos Chrysanthemi 18g, Rhizoma Chuanxiong 30g, Herba Plantaginis 20g, Folium Pyrrosiae 10g, Radix Ophiopogonis, are ground into 100 purpose powder, in the powder that obtains, add determining alcohol and be 90% ethanol 1200g; Reflux 2 hours is extracted, and obtains extracting solution; Filter to obtain first alcohol extract, filtering the medicinal residues that obtain, to add determining alcohol again be 80% ethanol 400g, reflux 2 hours; Extract, obtain extracting solution, filter and obtain second alcohol extract; First filtrate and second filtrate are mixed, and concentrating under reduced pressure removes and desolvates; Drying obtains and gets dry extract, and said dried cream powder is broken into 300 purpose powder; The water dissolution that adds 800g in the powder after pulverizing; Regulate pH value to 7.0 with 40% sodium hydroxide solution, add correctives 300g sucrose, potassium sorbate 2g mix homogeneously subsequently, promptly get syrup 2.
The capsule of embodiment 3 the present invention preparation
40g, Fructus Lycii 35g, Herba Epimedii 20g, Radix Et Rhizoma Rhei 70g, Herba Schizonepetae 20g, Natrii Sulfas 25g, Caulis Spatholobi 35g and Rhizoma Polygonati 40g mix with Herba Cissampelotis pareiae 20g, Radix Glehniae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 20g, Radix Paeoniae Alba 35g, Concha Ostreae 20g, Herba Ecliptae 40g, Cortex Dictamni 20g, Radix Rehmanniae Preparata 30g, Flos Chrysanthemi 25g, Rhizoma Chuanxiong 30g, Herba Plantaginis 20g, Folium Pyrrosiae 20g, Radix Ophiopogonis, are ground into 100 purpose powder, in the powder that obtains, add determining alcohol and be 90% ethanol 1200g, reflux 2 hours; Extract, obtain extracting solution, filter and obtain first alcohol extract; It is 80% ethanol 400g that the medicinal residues that filter to obtain add determining alcohol again, and reflux 2 hours is extracted; Obtain extracting solution, filter and obtain second alcohol extract, first filtrate and second filtrate are mixed; Concentrating under reduced pressure removes and desolvates drying; Obtain and get dry extract, said dried cream powder is broken into 300 purpose powder, add 50g carboxymethyl starch sodium, 400g starch mix homogeneously in the powder after pulverizing; 15g magnesium stearate, determining alcohol are that 90% ethanol 2000g granulates drying; Granulate is packed in the gelatine capsule then, processes capsule.
Embodiment 2 clinical experiments
Patient's data
187 routine cases are my institute's inpatient, wherein male 98 examples, women 89 examples; 42.8 years old mean age; Sick time 2～10 years, average 4 years; Pathogenic factor: chronic glomerulonephritis 103 examples, diabetic nephropathy 65 examples, hypertensive nephropathy 19 examples.The serum creatinine average was at (830 ± 242) μ mol/L when the patient was admitted to hospital, carbamide average (38.9 ± 11.1) mmol/L, and creatinine clearance rate average (12.1 ± 4.5) mL/min all meets the indication of hemodialysis.Above-mentioned 187 routine patients are divided into 2 groups at random, and 105 examples are organized in treatment, matched group 82 examples, and clinical data such as 2 groups of patient's sexes, age, pathogenic factor is compared difference not statistically significant (P＞0.05), has comparability.
Diagnostic criteria
Treat uremic clinical research guideline according to new Chinese medicine, work out following standard: 1. endogenous creatinine clearance rate Ccr drops to below the 25mL/min; 2. serum creatinine surpasses 221 μ mol/L; 3. the patient has tangible uremia symptom and clinical CKD medical history.
Therapeutic Method
All case all gives: the treatment of underlying diseases; Controlling blood pressure; High-quality is hanged down albumen, low-phosphorous, high caloric diet; Correct anemia.Matched group hemodialysis 2 times weekly on the basis of above-mentioned treatment, treatment is organized weekly hemodialysis 1 time, takes the Chinese medicine composition syrup 1 that the present invention makes simultaneously every day, treat 2 times, each 1 time sooner or later, 150ml at every turn.
Observation item
Dialyse weekly before and after look patient serum creatinine, carbamide, potassium, sodium, chlorine, calcium 1 time are looked into its routine blood test, UCr clearance rate, blood fat before the treatment.Treat after 3 months whole cases are carried out routine blood test, UCr clearance rate, blood fat check.
Criterion of therapeutical effect
The criterion of therapeutical effect standard that academic conference was drafted with reference to national renal failure conservative treatment special topic in 1987.Produce effects: 1. sx or disappearance; 2. endogenous creatinine clearance rate increases >=30%; 3. serum creatinine reduces >=30%, more than 1. indispensable, 2. 3. possessing 1 is decidable.Effectively: 1. sx or disappearance; 2. endogenous creatinine clearance rate increases >=20%; 3. serum creatinine reduces >=20%, more than 1. indispensable, 2. 3. possessing 1 is decidable.Invalid: as 1. not meet produce effects, effective decision condition person; 2. nausea and vomiting before the dialysis can not be taken food, the limbs edema, and serum creatinine, carbamide, blood potassium raise significantly.
Statistical method
Carry out statistical analysis with SPSS 13.0 softwares, relatively use χ between the rate
2Check is checked with t between the mean.
The result
Two groups of curative effects are relatively seen table 1, can find out from table 1, and the Chinese medicine composition syrup of taking the embodiment of the invention 1 preparation has significant advantage at treatment uremic prescription mask.
Table 1 liang group curative effect relatively
| Group | The example number | Produce effects | Effectively | Invalid | Total effective rate (%) |
| The treatment group | 105 | 63 | 41 | 1 | 99.0％ |
| Matched group | 82 | 42 | 25 | 15 | 81.7％ |
Table 2 is relatively seen in 2 groups of blood creatinines, blood urea nitrogen, potassium content treatment front and back.
Each item index relatively before and after 2 groups of treatments of table 2
| Group | Cr/(μmol/L) | BUN/(mmol/L) | K +/(μmol/L) | |
| Matched group | After the dialysis | 327.97±117.65 | 16.20±6.50 | 3.70±1.60 |
| Before the dialysis | 834.56±128.96 | 38.10±11.80 | 5.00±1.80 | |
| Difference | 496.59±11.31 | 21.90±5.30 | 1.30±0.20 | |
| The treatment group | After the dialysis | 318.05±120.63 | 16.10±7.50 | 4.00±1.50 |
| Before the dialysis | 824.10±123.30 | 38.90±12.10 | 4.90±1.60 | |
| Difference | 506.06±2.97 | 22.80±4.60 | 0.90±0.10 |
Table 3 is relatively seen in 2 groups of sodium, chlorine, calcium content treatment front and back.
Each item index relatively before and after 2 groups of treatments of table 3
| Group | Na +/(μmol/L) | Cl/(mmol/L) | Ca +/(μmol/L) | |
| Matched group | After the dialysis | 138.40±8.90 | 95.20±12.30 | 3.10±1.30 |
| Before the dialysis | 140.50±12.80 | 95.60±12.10 | 3.00±1.20 | |
| Difference | 2.10±3.90 | 0.40±0.20 | 0.10±0.10 | |
| The treatment group | After the dialysis | 138.40±9.20 | 94.60±10.80 | 3.20±1.20 |
| Before the dialysis | 140.30±10.80 | 95.30±10.90 | 3.00±1.10 | |
| Difference | 1.90±1.60 | 0.70±0.10 | 0.20±0.10 |
Review result is relatively seen table 4, from table 4, can find out that index treatment front and back comparing differences such as treatment group creatinine clearance rate, hemoglobin, blood fat have statistical significance (P＜0.05), and treatment back treatment group and matched group relatively have statistical significance (P＜0.05).
Each item index relatively before and after 2 groups of checks of table 4
Model case 1
Lin, the woman, 51 years old, uremic patient, first visit on October 4 in 2010, hemodialysis is 1 year, 3 times weekly.Long-term inappetence, weak is accompanied serious anemia, Hb42g/l, though there is not improvement through dialysis and with EPO, patient's emaciated physique, the low voice timidness due to deficiency of QI, the fat tender tongue of light red tongue is few, thready and weak pulse.Card genus deficiency of spleen-QI and stomach-QI is taken the syrup of the embodiment of the invention 2 preparations, every day 2 times, and each 150ml, the warp treatment is received to eat and is promoted, and through controlling 2 wheat harvesting periods, symptom takes a favorable turn, Hb79g/L.
This intellectual property of primary enforcement that all are above-mentioned is not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above only is preferred embodiment of the present invention, is not to be the restriction of the present invention being made other form, and any professional and technical personnel of being familiar with possibly utilize the technology contents of above-mentioned announcement to change or be modified as the equivalent embodiment of equivalent variations.But everyly do not break away from technical scheme content of the present invention, to any simple modification, equivalent variations and remodeling that above embodiment did, still belong to the protection domain of technical scheme of the present invention according to technical spirit of the present invention.
Claims (10)
1. one kind cooperates the uremic Chinese medicine composition of hemodialysis; It is characterized in that, comprising: Herba Cissampelotis pareiae, Radix Glehniae, Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Paeoniae Alba, Concha Ostreae, Herba Ecliptae, Cortex Dictamni, Radix Rehmanniae Preparata, Flos Chrysanthemi, Rhizoma Chuanxiong, Herba Plantaginis, Folium Pyrrosiae, Radix Ophiopogonis, Fructus Lycii, Herba Epimedii, Radix Et Rhizoma Rhei, Herba Schizonepetae, Natrii Sulfas, Caulis Spatholobi and Rhizoma Polygonati.
2. Chinese medicine composition as claimed in claim 1 is characterized in that:
The weight fraction of each component ratio does in the said Chinese medicine composition,
Herba Cissampelotis pareiae 10～20 weight portions; Radix Glehniae 20～30 weight portions; Pseudobulbus Bletillae (Rhizoma Bletillae) 10～20 weight portions; The Radix Paeoniae Alba 25～35 weight portions; Concha Ostreae 10～20 weight portions; Herba Ecliptae 30～40 weight portions; Cortex Dictamni 10～20 weight portions; Radix Rehmanniae Preparata 20～30 weight portions; Flos Chrysanthemi 15～25 weight portions; Rhizoma Chuanxiong 20～30 weight portions; Herba Plantaginis 10～20 weight portions; Folium Pyrrosiae 10～20 weight portions; Radix Ophiopogonis 30～40 weight portion; Fructus Lycii 25～35 weight portions; Herba Epimedii 10～20 weight portions; Radix Et Rhizoma Rhei 60～70 weight portions; Herba Schizonepetae 10～20 weight portions; Natrii Sulfas 15～25 weight portions; Caulis Spatholobi 25～35 weight portions and Rhizoma Polygonati 30～40 weight portions.
3. according to claim 1 or claim 2 Chinese medicine composition is characterized in that:
The ratio of weight and number of each component does in the said Chinese medicine composition,
Herba Cissampelotis pareiae 15～20 weight portions; Radix Glehniae 25～30 weight portions; Pseudobulbus Bletillae (Rhizoma Bletillae) 15～20 weight portions; The Radix Paeoniae Alba 30～35 weight portions; Concha Ostreae 15～20 weight portions; Herba Ecliptae 35～40 weight portions; Cortex Dictamni 15～20 weight portions; Radix Rehmanniae Preparata 25～30 weight portions; Flos Chrysanthemi 20～25 weight portions; Rhizoma Chuanxiong 25～30 weight portions; Herba Plantaginis 15～20 weight portions; Folium Pyrrosiae 15～20 weight portions; Radix Ophiopogonis 35～40 weight portion; Fructus Lycii 30～35 weight portions; Herba Epimedii 15～20 weight portions; Radix Et Rhizoma Rhei 65～70 weight portions; Herba Schizonepetae 15～20 weight portions; Natrii Sulfas 20～25 weight portions; Caulis Spatholobi 30～35 weight portions and Rhizoma Polygonati 35～40 weight portions.
4. like the described Chinese medicine composition of claim 1 to 3, it is characterized in that:
Can also further add Herba Agrimoniae and Rhizoma Imperatae in the said Chinese medicine composition, said Herba Agrimoniae and the Rhizoma Imperatae parts by weight in said Chinese medicine composition are Herba Agrimoniae 15～25 weight portions and Rhizoma Imperatae 10～20 weight portions.
5. like the described Chinese medicine composition of claim 1 to 4, it is characterized in that:
Can also further add Rhizoma Coptidis and Caulis Bambusae In Taenia in the said Chinese medicine composition, said Rhizoma Coptidis and the Caulis Bambusae In Taenia weight fraction in said Chinese medicine composition is Rhizoma Coptidis 10～20 weight portions and Caulis Bambusae In Taenia 5～15 weight portions.
6. like the described Chinese medicine composition of claim 1 to 5, it is characterized in that: the dosage form of said Chinese medicine composition is decoct, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule, colloid or syrup.
7. the method for preparing of the said Chinese medicine composition of claim 1 to 6 is characterized in that, comprising:
The first step with each component proportional mixing in the said Chinese medicine composition, is ground into 100 orders～200 purpose powder;
In second step, the determining alcohol that adds 2～4 times of the powder qualities that obtain with respect to the first step is 80～90% ethanol, and reflux 1～3 hour is extracted; Obtain extracting solution, filter and obtain first alcohol extract, filtering the medicinal residues that obtain, to add determining alcohol with respect to 1～2 times of filtering residue quality again be 70～80% ethanol, reflux 1～3 hour; Extract, obtain extracting solution, filter and obtain second alcohol extract, first filtrate and second filtrate are mixed; Concentrating under reduced pressure removes and to desolvate, and drying obtains and gets dry extract;
The 3rd step was broken into 200 orders～400 purpose powder with said dried cream powder, added various auxiliary additives and prepared needed various dosage form.
8. the method for preparing of the said Chinese medicine composition of claim 7 is characterized in that:
When the dosage form of said Chinese medicine composition is syrup; Said the 3rd step is for adding the water dissolution with respect to 2～3 times of powder qualities in the powder after pulverizing; Regulate pH value to 7.0 with 40% sodium hydroxide solution; Add correctives sucrose, antiseptic mix homogeneously subsequently; Promptly get syrup, the correctives of adding, antiseptic and the content in medicine thereof: sucrose 25～70%, Pyrusussuriensis acids antiseptic such as potassium sorbate 0.1～0.3%, paraben preservative such as ethyl hydroxybenzoate 0.01～0.05%.
9. the method for preparing of the said Chinese medicine composition of claim 7 is characterized in that:
When the dosage form of said Chinese medicine composition is capsule; Said the 3rd step is to add 5～7 weight portion carboxymethyl starch sodium, 5～50 weight portion starch mix homogeneously in the powder after pulverizing, 3～5 weight portion magnesium stearate, and 150～200 weight portion determining alcohols are 80%～90% alcohol granulation; Dry; Granulate is packed in the gelatine capsule then, processes capsule.
10. the described Chinese medicine composition of claim 1 to 6 is in the application that is used for cooperating the uremic medicine of hemodialysis of the various dosage forms of preparation.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935214A (en) * | 2012-11-27 | 2013-02-20 | 杨文琳 | Traditional Chinese medicinal composition for treating uremia |
| CN103330846A (en) * | 2013-05-27 | 2013-10-02 | 吴艾潼 | Traditional Chinese medicine for treating nephrotic syndrome |
| CN104324253A (en) * | 2014-09-29 | 2015-02-04 | 赵霞 | Traditional Chinese medicine preparation for treating uremia and preparation method thereof |
| CN104667179A (en) * | 2015-02-10 | 2015-06-03 | 青岛市市立医院 | Traditional Chinese medicine for treating uremia matched with dialysis |
| CN105878419A (en) * | 2014-11-06 | 2016-08-24 | 李汝芬 | Compound preparation cooperating with hemodialysis for treatment of chronic renal failure and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256931A (en) * | 1998-12-15 | 2000-06-21 | 魏国栋 | Traditional Chinese medicine for treating uremia and fortifying kidney and productive method thereof |
| WO2004050026A2 (en) * | 2002-12-02 | 2004-06-17 | Jiafang Chen | Compositions and methods for treating prostate cancer |
| KR100589672B1 (en) * | 2001-09-08 | 2006-06-15 | 주식회사 프렌닥터 | Composition for inhibiting obesity and increasing stamina comprising mountain todok extract |
| CN101085259A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine decoction for treating chronic nephritis |
| WO2010035262A2 (en) * | 2008-09-25 | 2010-04-01 | Life Biotech Medical Research Ltd | Herbal formulations |
-
2012
- 2012-06-14 CN CN2012102240551A patent/CN102716339B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1256931A (en) * | 1998-12-15 | 2000-06-21 | 魏国栋 | Traditional Chinese medicine for treating uremia and fortifying kidney and productive method thereof |
| KR100589672B1 (en) * | 2001-09-08 | 2006-06-15 | 주식회사 프렌닥터 | Composition for inhibiting obesity and increasing stamina comprising mountain todok extract |
| WO2004050026A2 (en) * | 2002-12-02 | 2004-06-17 | Jiafang Chen | Compositions and methods for treating prostate cancer |
| CN101085259A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine decoction for treating chronic nephritis |
| WO2010035262A2 (en) * | 2008-09-25 | 2010-04-01 | Life Biotech Medical Research Ltd | Herbal formulations |
Non-Patent Citations (1)
| Title |
|---|
| 张忠其: "中西医结合治疗慢性肾功能衰竭51例观察", 《实用中医药杂志》, vol. 20, no. 4, 30 April 2004 (2004-04-30), pages 186 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102935214A (en) * | 2012-11-27 | 2013-02-20 | 杨文琳 | Traditional Chinese medicinal composition for treating uremia |
| CN103330846A (en) * | 2013-05-27 | 2013-10-02 | 吴艾潼 | Traditional Chinese medicine for treating nephrotic syndrome |
| CN104324253A (en) * | 2014-09-29 | 2015-02-04 | 赵霞 | Traditional Chinese medicine preparation for treating uremia and preparation method thereof |
| CN105878419A (en) * | 2014-11-06 | 2016-08-24 | 李汝芬 | Compound preparation cooperating with hemodialysis for treatment of chronic renal failure and preparation method thereof |
| CN104667179A (en) * | 2015-02-10 | 2015-06-03 | 青岛市市立医院 | Traditional Chinese medicine for treating uremia matched with dialysis |
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