CN102666570B - 新的肽基α-羟基甘氨酸α-酰胺化裂合酶 - Google Patents

新的肽基α-羟基甘氨酸α-酰胺化裂合酶 Download PDF

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Publication number
CN102666570B
CN102666570B CN201080054717.4A CN201080054717A CN102666570B CN 102666570 B CN102666570 B CN 102666570B CN 201080054717 A CN201080054717 A CN 201080054717A CN 102666570 B CN102666570 B CN 102666570B
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gly
enzyme
xaa
polypeptide
val
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Expired - Fee Related
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CN102666570A (zh
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A.C.肖
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/02—Amidine-lyases (4.3.2)
    • C12Y403/02005—Peptidylamidoglycolate lyase (4.3.2.5)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080054717.4A 2009-12-01 2010-12-01 新的肽基α-羟基甘氨酸α-酰胺化裂合酶 Expired - Fee Related CN102666570B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09177593.2 2009-12-01
EP09177593 2009-12-01
US26671109P 2009-12-04 2009-12-04
US61/266711 2009-12-04
PCT/EP2010/068630 WO2011067283A1 (en) 2009-12-01 2010-12-01 Novel peptidyl alpha-hydroxyglycine alpha-amidating lyases

Publications (2)

Publication Number Publication Date
CN102666570A CN102666570A (zh) 2012-09-12
CN102666570B true CN102666570B (zh) 2015-12-02

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CN201080054717.4A Expired - Fee Related CN102666570B (zh) 2009-12-01 2010-12-01 新的肽基α-羟基甘氨酸α-酰胺化裂合酶

Country Status (6)

Country Link
US (2) US9096843B2 (cg-RX-API-DMAC7.html)
EP (1) EP2507258B1 (cg-RX-API-DMAC7.html)
JP (1) JP5931738B2 (cg-RX-API-DMAC7.html)
CN (1) CN102666570B (cg-RX-API-DMAC7.html)
ES (1) ES2583259T3 (cg-RX-API-DMAC7.html)
WO (1) WO2011067283A1 (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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KR20160098278A (ko) * 2013-12-20 2016-08-18 에프. 호프만-라 로슈 아게 Ｃ-말단 아미드화를 위한 펩티딜글라이신 알파-아미드화 모노옥시게나제 (ｐａｍ) 의 용도
CN105985995A (zh) * 2015-01-29 2016-10-05 暨南大学 一种利用家蚕生物反应器生产普兰林肽(pa)的方法
CN113302310B (zh) * 2018-12-18 2024-05-03 帕西昂奥地利有限两合公司 单步生物催化酰胺化
CN110034855B (zh) * 2019-04-10 2021-12-14 国网辽宁省电力有限公司 一种信息传输校验方法及系统
MX2022010556A (es) * 2020-02-26 2022-11-30 Pam Theragnostics Gmbh Uso de peptidilglicina alfa-amidante monooxigenasa (pam) para proposito terapeutico.
EP4111201A1 (en) * 2020-02-26 2023-01-04 PAM Theragnostics GmbH Methods for determining peptidylglycine alpha-amidating monooxygenase (pam) and its use for diagnostic purpose
EP4142792A4 (en) 2020-05-01 2024-11-27 Kashiv Biosciences, LLC An improved process of purification of protein
WO2023180977A1 (en) * 2022-03-23 2023-09-28 Kashiv Biosciences, Llc An improved process for the separation and analysis of pancreatic enzymes
WO2025133225A1 (en) * 2023-12-22 2025-06-26 Pam Theragnostics Gmbh Pharmaceutical combination of peptide-gly and peptidylglycine alpha-amidating monooxygenase (pam)

Citations (2)

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EP0465404A3 (en) * 1990-06-01 1992-04-08 Ciba-Geigy Ag Peptdidylhydroxylglycine n-c lyase and dna coding therefor
CN101287840A (zh) * 2005-06-24 2008-10-15 尤尼基因实验室公司 表达在酰胺化产物的制备中有用的酶的细胞系

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JPS60501140A (ja) 1983-04-22 1985-07-25 アムジエン 酵母による外因性ポリペプチドの分泌
NZ207926A (en) 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
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CN101287840A (zh) * 2005-06-24 2008-10-15 尤尼基因实验室公司 表达在酰胺化产物的制备中有用的酶的细胞系

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Also Published As

Publication number Publication date
US20160083713A1 (en) 2016-03-24
US20120322733A1 (en) 2012-12-20
CN102666570A (zh) 2012-09-12
US9096843B2 (en) 2015-08-04
EP2507258B1 (en) 2016-04-20
WO2011067283A1 (en) 2011-06-09
JP5931738B2 (ja) 2016-06-08
JP2013511997A (ja) 2013-04-11
ES2583259T3 (es) 2016-09-20
EP2507258A1 (en) 2012-10-10

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Granted publication date: 20151202

Termination date: 20171201