CN102666543B - 二酰基甘油酰基转移酶抑制剂 - Google Patents

二酰基甘油酰基转移酶抑制剂 Download PDF

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Publication number
CN102666543B
CN102666543B CN201080055334.9A CN201080055334A CN102666543B CN 102666543 B CN102666543 B CN 102666543B CN 201080055334 A CN201080055334 A CN 201080055334A CN 102666543 B CN102666543 B CN 102666543B
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CN
China
Prior art keywords
benzazepine
dihydro
imidazo
hours
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201080055334.9A
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English (en)
Chinese (zh)
Other versions
CN102666543A (zh
Inventor
M·B·阿诺尔德
T·J·博尚
E·J·加纳达
E·J·亨布雷
J·陆
J·R·里佐
J·M·绍斯
Q·史
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Eli Lilly and Co
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Eli Lilly and Co
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Publication of CN102666543A publication Critical patent/CN102666543A/zh
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Publication of CN102666543B publication Critical patent/CN102666543B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201080055334.9A 2009-12-10 2010-12-07 二酰基甘油酰基转移酶抑制剂 Expired - Fee Related CN102666543B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28531709P 2009-12-10 2009-12-10
US61/285,317 2009-12-10
PCT/US2010/059158 WO2011071840A1 (en) 2009-12-10 2010-12-07 Inhibitors of diacylglycerol acyltransferase

Publications (2)

Publication Number Publication Date
CN102666543A CN102666543A (zh) 2012-09-12
CN102666543B true CN102666543B (zh) 2014-12-24

Family

ID=43569741

Family Applications (1)

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CN201080055334.9A Expired - Fee Related CN102666543B (zh) 2009-12-10 2010-12-07 二酰基甘油酰基转移酶抑制剂

Country Status (14)

Country Link
US (1) US8299061B2 (enExample)
EP (1) EP2509981B1 (enExample)
JP (1) JP5631411B2 (enExample)
KR (1) KR101395428B1 (enExample)
CN (1) CN102666543B (enExample)
AR (1) AR079170A1 (enExample)
AU (1) AU2010328410B2 (enExample)
BR (1) BR112012013918A2 (enExample)
CA (1) CA2783684C (enExample)
EA (1) EA020128B1 (enExample)
ES (1) ES2509922T3 (enExample)
MX (1) MX2012006646A (enExample)
TW (1) TWI392680B (enExample)
WO (1) WO2011071840A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20180412A (es) 2010-07-16 2018-11-01 Abbvie Ireland Unlimited Co Proceso para preparar compuestos antivirales
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8841487B2 (en) 2010-07-16 2014-09-23 Abbvie Inc. Phosphine ligands for catalytic reactions
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
WO2015120610A1 (en) * 2014-02-14 2015-08-20 Eli Lilly And Company Gpr142 agonist compound
CN105153195B (zh) * 2015-09-01 2017-09-26 汤文建 一种三环吡唑[1,5‑d][1,4]苯并氧氮杂卓酮衍生物及其制备方法与用途
AU2020285269B2 (en) * 2019-05-31 2022-11-17 Medshine Discovery Inc. Bicyclic compound as RIP-1 kinase inhibitor and application thereof
TWI824259B (zh) * 2020-07-01 2023-12-01 美商雷傑製藥公司 Rip1k抑制劑

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014671A1 (en) * 1993-11-22 1995-06-01 Merck & Co., Inc. 3-acylaminobenzazepines
WO2006020959A2 (en) * 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
CN101171231A (zh) * 2005-05-10 2008-04-30 霍夫曼-拉罗奇有限公司 二酰基甘油酰基转移酶抑制剂
WO2010056496A1 (en) * 2008-11-14 2010-05-20 Merck Sharp & Dohme Corp. Azepinone derivatives

Family Cites Families (16)

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EP0272866A1 (en) 1986-12-23 1988-06-29 Merck & Co. Inc. 1,4-Benzodiazepines with 5-membered heterocyclic rings
US4735941A (en) 1986-12-23 1988-04-05 Merck & Co., Inc. 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents
US4847248A (en) 1986-12-23 1989-07-11 Merck & Co., Inc. 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
EP0523846A3 (en) 1991-06-14 1993-03-17 Merck & Co. Inc. 1,4-benzodiazepines with 5-membered heterocyclic rings
US5439906A (en) 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
EP0730596A4 (en) 1993-11-22 1997-07-30 Merck & Co Inc BENZODIAZEPINE
US5834464A (en) 1994-11-18 1998-11-10 Merck & Co., Inc. Imidazolinobenzodiazepines
IL158355A0 (en) 1996-12-23 2004-05-12 Elan Pharm Inc CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS beta-AMYLOID PEPTIDE RELEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB0012671D0 (en) 2000-05-24 2000-07-19 Merck Sharp & Dohme Therapeutic agents
JP2009502929A (ja) 2005-07-29 2009-01-29 メルク エンド カムパニー インコーポレーテッド ヘテロ環式ベンゾジアゼピンｃｇｒｐ受容体アンタゴニスト
US7569590B2 (en) 2006-09-19 2009-08-04 Bristol-Myers Squibb Company Use of thianecarboxamides as dgat inhibitors
WO2009126861A2 (en) 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolopyridine compounds useful as dgat1 inhibitors
WO2009126624A1 (en) 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolo compounds useful as dgat1 inhibitors
AU2010207190A1 (en) 2009-01-23 2011-08-04 Msd K.K. Benzodiazepin-2-on derivatives
JP2012517997A (ja) 2009-02-17 2012-08-09 Ｍｓｄ株式会社 １，４−ベンゾジアゼピン−２−オン誘導体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014671A1 (en) * 1993-11-22 1995-06-01 Merck & Co., Inc. 3-acylaminobenzazepines
WO2006020959A2 (en) * 2004-08-13 2006-02-23 Amgen Inc. Substituted benzofused heterocycles
CN101171231A (zh) * 2005-05-10 2008-04-30 霍夫曼-拉罗奇有限公司 二酰基甘油酰基转移酶抑制剂
WO2010056496A1 (en) * 2008-11-14 2010-05-20 Merck Sharp & Dohme Corp. Azepinone derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor;Gang Zhao，等;《J. Med. Chem.》;20080110;第51卷(第3期);第380-383页，参见全文 *

Also Published As

Publication number Publication date
JP5631411B2 (ja) 2014-11-26
CA2783684A1 (en) 2011-06-16
EA201200868A1 (ru) 2012-12-28
AR079170A1 (es) 2011-12-28
BR112012013918A2 (pt) 2016-04-26
EA020128B1 (ru) 2014-08-29
WO2011071840A1 (en) 2011-06-16
US20110144091A1 (en) 2011-06-16
KR20120099457A (ko) 2012-09-10
US8299061B2 (en) 2012-10-30
AU2010328410A1 (en) 2012-07-26
MX2012006646A (es) 2012-06-25
EP2509981A1 (en) 2012-10-17
AU2010328410B2 (en) 2014-02-06
ES2509922T3 (es) 2014-10-20
CA2783684C (en) 2014-02-25
CN102666543A (zh) 2012-09-12
EP2509981B1 (en) 2014-08-06
TWI392680B (zh) 2013-04-11
TW201130844A (en) 2011-09-16
KR101395428B1 (ko) 2014-05-14
JP2013513607A (ja) 2013-04-22

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