AU2010328410B2 - Inhibitors of diacylglycerol acyltransferase - Google Patents

Inhibitors of diacylglycerol acyltransferase Download PDF

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Publication number
AU2010328410B2
AU2010328410B2 AU2010328410A AU2010328410A AU2010328410B2 AU 2010328410 B2 AU2010328410 B2 AU 2010328410B2 AU 2010328410 A AU2010328410 A AU 2010328410A AU 2010328410 A AU2010328410 A AU 2010328410A AU 2010328410 B2 AU2010328410 B2 AU 2010328410B2
Authority
AU
Australia
Prior art keywords
benzazepin
dihydro
imidazo
compound
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010328410A
Other languages
English (en)
Other versions
AU2010328410A1 (en
Inventor
Macklin Brian Arnold
Thomas James Beauchamp
Emily Jane Canada
Erik James Hembre
Jianliang Lu
John Robert Rizzo
John Mehnert Schaus
Qing Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU2010328410A1 publication Critical patent/AU2010328410A1/en
Application granted granted Critical
Publication of AU2010328410B2 publication Critical patent/AU2010328410B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2010328410A 2009-12-10 2010-12-07 Inhibitors of diacylglycerol acyltransferase Ceased AU2010328410B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28531709P 2009-12-10 2009-12-10
US61/285,317 2009-12-10
PCT/US2010/059158 WO2011071840A1 (en) 2009-12-10 2010-12-07 Inhibitors of diacylglycerol acyltransferase

Publications (2)

Publication Number Publication Date
AU2010328410A1 AU2010328410A1 (en) 2012-07-26
AU2010328410B2 true AU2010328410B2 (en) 2014-02-06

Family

ID=43569741

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010328410A Ceased AU2010328410B2 (en) 2009-12-10 2010-12-07 Inhibitors of diacylglycerol acyltransferase

Country Status (14)

Country Link
US (1) US8299061B2 (enExample)
EP (1) EP2509981B1 (enExample)
JP (1) JP5631411B2 (enExample)
KR (1) KR101395428B1 (enExample)
CN (1) CN102666543B (enExample)
AR (1) AR079170A1 (enExample)
AU (1) AU2010328410B2 (enExample)
BR (1) BR112012013918A2 (enExample)
CA (1) CA2783684C (enExample)
EA (1) EA020128B1 (enExample)
ES (1) ES2509922T3 (enExample)
MX (1) MX2012006646A (enExample)
TW (1) TWI392680B (enExample)
WO (1) WO2011071840A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
US8841487B2 (en) 2010-07-16 2014-09-23 Abbvie Inc. Phosphine ligands for catalytic reactions
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
NZ705225A (en) 2010-07-16 2016-11-25 Abbvie Bahamas Ltd Process for preparing antiviral compounds
WO2015120610A1 (en) * 2014-02-14 2015-08-20 Eli Lilly And Company Gpr142 agonist compound
CN105153195B (zh) * 2015-09-01 2017-09-26 汤文建 一种三环吡唑[1,5‑d][1,4]苯并氧氮杂卓酮衍生物及其制备方法与用途
CA3142360C (en) * 2019-05-31 2023-11-14 Medshine Discovery Inc. Bicyclic compound as rip-1 kinase inhibitor and application thereof
TWI824259B (zh) * 2020-07-01 2023-12-01 美商雷傑製藥公司 Rip1k抑制劑

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014671A1 (en) * 1993-11-22 1995-06-01 Merck & Co., Inc. 3-acylaminobenzazepines

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847248A (en) * 1986-12-23 1989-07-11 Merck & Co., Inc. 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists
US4735941A (en) * 1986-12-23 1988-04-05 Merck & Co., Inc. 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents
EP0272866A1 (en) 1986-12-23 1988-06-29 Merck & Co. Inc. 1,4-Benzodiazepines with 5-membered heterocyclic rings
IL101850A (en) * 1991-06-13 1996-01-31 Janssen Pharmaceutica Nv 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them
EP0523846A3 (en) 1991-06-14 1993-03-17 Merck & Co. Inc. 1,4-benzodiazepines with 5-membered heterocyclic rings
US5679672A (en) * 1993-11-22 1997-10-21 Merck & Co., Inc. Benzodiazepines
US5439906A (en) * 1993-11-22 1995-08-08 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5834464A (en) * 1994-11-18 1998-11-10 Merck & Co., Inc. Imidazolinobenzodiazepines
ZA9711537B (en) 1996-12-23 1998-06-25 Athena Neurosciences Inc Eli L Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting ß-amyloid peptide release and/or its synthesis by use of such compounds.
GB0012671D0 (en) * 2000-05-24 2000-07-19 Merck Sharp & Dohme Therapeutic agents
EP1784390A2 (en) * 2004-08-13 2007-05-16 Amgen Inc. Substituted benzofused heterocycles
JP2008540485A (ja) * 2005-05-10 2008-11-20 エフ．ホフマン−ラ ロシュ アーゲー ジアシルグリセロールアシルトランスフェラーゼ阻害剤
CA2615463A1 (en) 2005-07-29 2007-02-08 Merck & Co., Inc. Heterocyclic benzodiazepine cgrp receptor antagonists
US7569590B2 (en) * 2006-09-19 2009-08-04 Bristol-Myers Squibb Company Use of thianecarboxamides as dgat inhibitors
US8324241B2 (en) 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
WO2009126861A2 (en) 2008-04-11 2009-10-15 Bristol-Myers Squibb Company Triazolopyridine compounds useful as dgat1 inhibitors
JP2010116364A (ja) * 2008-11-14 2010-05-27 Banyu Pharmaceut Co Ltd アゼピノン誘導体
US20110319396A1 (en) 2009-01-23 2011-12-29 Msd K.K. Benzodiazepin-2-on derivatives
AU2010216632A1 (en) 2009-02-17 2011-08-04 Msd K.K. 1,4-benzodiazepin-2-on derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995014671A1 (en) * 1993-11-22 1995-06-01 Merck & Co., Inc. 3-acylaminobenzazepines

Also Published As

Publication number Publication date
AU2010328410A1 (en) 2012-07-26
JP2013513607A (ja) 2013-04-22
EA020128B1 (ru) 2014-08-29
AR079170A1 (es) 2011-12-28
CN102666543A (zh) 2012-09-12
CN102666543B (zh) 2014-12-24
MX2012006646A (es) 2012-06-25
US20110144091A1 (en) 2011-06-16
KR101395428B1 (ko) 2014-05-14
CA2783684A1 (en) 2011-06-16
BR112012013918A2 (pt) 2016-04-26
TWI392680B (zh) 2013-04-11
TW201130844A (en) 2011-09-16
EP2509981A1 (en) 2012-10-17
EA201200868A1 (ru) 2012-12-28
WO2011071840A1 (en) 2011-06-16
ES2509922T3 (es) 2014-10-20
KR20120099457A (ko) 2012-09-10
US8299061B2 (en) 2012-10-30
EP2509981B1 (en) 2014-08-06
CA2783684C (en) 2014-02-25
JP5631411B2 (ja) 2014-11-26

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired