CN102639528B - 反式-4-[[(5s)-5-[[[3，5-双(三氟甲基)苯基]甲基](2-甲基-2h-四唑-5-基)氨基]-2，3，4，5-四氢-7，9-二甲基-1h-1-苯并氮杂*-1-基]甲基]-环己烷羧酸 - Google Patents

反式-4-[[(5s)-5-[[[3，5-双(三氟甲基)苯基]甲基](2-甲基-2h-四唑-5-基)氨基]-2，3，4，5-四氢-7，9-二甲基-1h-1-苯并氮杂*-1-基]甲基]-环己烷羧酸 Download PDF

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Publication number
CN102639528B
CN102639528B CN201080029957.9A CN201080029957A CN102639528B CN 102639528 B CN102639528 B CN 102639528B CN 201080029957 A CN201080029957 A CN 201080029957A CN 102639528 B CN102639528 B CN 102639528B
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China
Prior art keywords
methyl
dimethyl
phenyl
amino
trans
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Expired - Fee Related
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CN201080029957.9A
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English (en)
Chinese (zh)
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CN102639528A (zh
Inventor
X·陈
S·A·弗兰克
D·M·雷米克
S·W·彼得森
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Eli Lilly and Co
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Eli Lilly and Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080029957.9A 2009-06-30 2010-06-28 反式-4-[[(5s)-5-[[[3，5-双(三氟甲基)苯基]甲基](2-甲基-2h-四唑-5-基)氨基]-2，3，4，5-四氢-7，9-二甲基-1h-1-苯并氮杂*-1-基]甲基]-环己烷羧酸 Expired - Fee Related CN102639528B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22170809P 2009-06-30 2009-06-30
US61/221,708 2009-06-30
US61/221708 2009-06-30
PCT/US2010/040125 WO2011002696A1 (en) 2009-06-30 2010-06-28 Trans-4-[[(5s)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl] (2-methyl-2h-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1h-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid

Publications (2)

Publication Number Publication Date
CN102639528A CN102639528A (zh) 2012-08-15
CN102639528B true CN102639528B (zh) 2014-07-16

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CN201080029957.9A Expired - Fee Related CN102639528B (zh) 2009-06-30 2010-06-28 反式-4-[[(5s)-5-[[[3，5-双(三氟甲基)苯基]甲基](2-甲基-2h-四唑-5-基)氨基]-2，3，4，5-四氢-7，9-二甲基-1h-1-苯并氮杂*-1-基]甲基]-环己烷羧酸

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US (2) US8299060B2 (enExample)
EP (1) EP2448933B1 (enExample)
JP (1) JP5689875B2 (enExample)
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AR (1) AR077208A1 (enExample)
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CA (1) CA2764425C (enExample)
CL (1) CL2011003263A1 (enExample)
CO (1) CO6480934A2 (enExample)
CR (1) CR20110669A (enExample)
DK (1) DK2448933T3 (enExample)
DO (1) DOP2011000405A (enExample)
EA (1) EA020600B1 (enExample)
EC (1) ECSP11011551A (enExample)
ES (1) ES2435293T3 (enExample)
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MA (1) MA33385B1 (enExample)
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PL (1) PL2448933T3 (enExample)
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RS (1) RS52988B (enExample)
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TN (1) TN2011000638A1 (enExample)
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UA (1) UA109409C2 (enExample)
WO (1) WO2011002696A1 (enExample)
ZA (1) ZA201108707B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200700119A1 (ru) * 2004-06-24 2007-10-26 Эли Лилли Энд Компани Соединения и способы лечения дислипидемии
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
TWI627167B (zh) * 2011-07-08 2018-06-21 諾華公司 用於高三酸甘油酯個體治療動脈粥狀硬化之方法
CN103958501B (zh) * 2012-07-16 2016-08-17 上海恒瑞医药有限公司 苯并七元杂环类衍生物、其制备方法及其在医药上的应用
RU2627361C2 (ru) 2013-01-31 2017-08-07 Чонг Кун Данг Фармасьютикал Корп. Биарил- или гетероциклические биарилзамещенные производные циклогексена в качестве ингибиторов сетр
CN105017085B (zh) * 2014-04-28 2018-06-29 中国科学院上海药物研究所 一类kcnq钾通道激动剂、其制备方法和用途
EP3795695A1 (en) 2014-07-30 2021-03-24 F. Hoffmann-La Roche AG Genetic markers for predicting responsiveness to therapy
TWI691331B (zh) 2014-09-26 2020-04-21 日商興和股份有限公司 脂質異常症治療劑
CN108456213B (zh) * 2017-02-22 2021-01-15 浙江九洲药业股份有限公司 一种3-氟-4-羟基环己烷羧酸酯的制备方法
WO2025093129A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor

Citations (2)

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CN1972932A (zh) * 2004-06-24 2007-05-30 伊莱利利公司 治疗血脂障碍的化合物和方法
CN1972927A (zh) * 2004-06-24 2007-05-30 伊莱利利公司 用于治疗血脂障碍的化合物和方法

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US6147089A (en) 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
CO5271716A1 (es) 1999-11-30 2003-04-30 Pfizer Prod Inc Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida
HN2000000203A (es) 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
CZ20032898A3 (cs) 2001-04-30 2004-07-14 Pfizer Products Inc. Způsob výroby inhibitorů CETP
SK2332004A3 (en) 2002-08-30 2004-12-01 Japan Tobacco Inc Dibenzylamine compound and medicinal use thereof
EP1556047A4 (en) 2002-10-04 2009-09-30 Millennium Pharm Inc ANTAGONISTS AGAINST THE PGD2 RECEPTOR FOR THE TREATMENT OF INFLAMMATORY DISEASES
WO2004078730A2 (en) 2003-03-04 2004-09-16 Takasago International Corporation Method for producing optically active amines
US20040204450A1 (en) 2003-03-28 2004-10-14 Pfizer Inc Quinoline and quinoxaline compounds
MXPA06003927A (es) 2003-10-08 2008-02-07 Lilly Co Eli Compuestos y metodos para tratar dislipidemia.
ATE433984T1 (de) 2004-03-26 2009-07-15 Lilly Co Eli Verbindungen und verfahren zur behandlung von dyslipidämie
WO2006069162A1 (en) 2004-12-20 2006-06-29 Reddy Us Therapeutics, Inc. Novel heterocyclic compounds and their pharmaceutical compositions
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸

Patent Citations (2)

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CN1972932A (zh) * 2004-06-24 2007-05-30 伊莱利利公司 治疗血脂障碍的化合物和方法
CN1972927A (zh) * 2004-06-24 2007-05-30 伊莱利利公司 用于治疗血脂障碍的化合物和方法

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MX2011014024A (es) 2012-04-20
TW201113275A (en) 2011-04-16
US8329688B2 (en) 2012-12-11
PE20120538A1 (es) 2012-05-09
US8299060B2 (en) 2012-10-30
US20120058990A1 (en) 2012-03-08
HRP20130950T1 (hr) 2013-11-22
IL216655A0 (en) 2012-02-29
BRPI1011931A2 (pt) 2016-04-19
DK2448933T3 (da) 2013-10-07
CA2764425A1 (en) 2011-01-06
EA201270099A1 (ru) 2012-05-30
TN2011000638A1 (en) 2013-05-24
JP5689875B2 (ja) 2015-03-25
EA020600B1 (ru) 2014-12-30
ES2435293T3 (es) 2013-12-18
JO2867B1 (en) 2015-03-15
MY157121A (en) 2016-05-13
EP2448933A1 (en) 2012-05-09
CL2011003263A1 (es) 2012-07-27
WO2011002696A1 (en) 2011-01-06
NZ596820A (en) 2013-07-26
CO6480934A2 (es) 2012-07-16
IL216655A (en) 2015-02-26
PL2448933T3 (pl) 2014-01-31
US20100331309A1 (en) 2010-12-30
ME01606B (me) 2014-09-20
RS52988B (sr) 2014-02-28
AU2010266537B2 (en) 2013-04-18
CA2764425C (en) 2015-01-06
ECSP11011551A (es) 2012-01-31
PT2448933E (pt) 2013-10-29
AU2010266537A1 (en) 2012-02-02
UA109409C2 (ru) 2015-08-25
KR101404893B1 (ko) 2014-06-20
AR077208A1 (es) 2011-08-10
MA33385B1 (fr) 2012-06-01
DOP2011000405A (es) 2012-01-15
KR20120027426A (ko) 2012-03-21
JP2012532106A (ja) 2012-12-13
SG177413A1 (en) 2012-02-28
EP2448933B1 (en) 2013-08-28
TWI450896B (zh) 2014-09-01
ZA201108707B (en) 2013-05-29
CN102639528A (zh) 2012-08-15
CR20110669A (es) 2012-03-16
GT201100321A (es) 2012-11-15
SI2448933T1 (sl) 2013-11-29

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