KR101404893B1 - 트랜스-4-［［(5ｓ)-5-［［［3,5-비스(트리플루오로메틸)페닐］메틸］ (2-메틸-2ｈ-테트라졸-5-일)아미노］-2,3,4,5-테트라히드로-7,9-디메틸-1ｈ-1-벤즈아제핀-1-일］메틸］-시클로헥산카르복실산 - Google Patents

트랜스-4-［［(5ｓ)-5-［［［3,5-비스(트리플루오로메틸)페닐］메틸］ (2-메틸-2ｈ-테트라졸-5-일)아미노］-2,3,4,5-테트라히드로-7,9-디메틸-1ｈ-1-벤즈아제핀-1-일］메틸］-시클로헥산카르복실산 Download PDF

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Publication number
KR101404893B1
KR101404893B1 KR1020117031449A KR20117031449A KR101404893B1 KR 101404893 B1 KR101404893 B1 KR 101404893B1 KR 1020117031449 A KR1020117031449 A KR 1020117031449A KR 20117031449 A KR20117031449 A KR 20117031449A KR 101404893 B1 KR101404893 B1 KR 101404893B1
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South Korea
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methyl
dimethyl
tetrahydro
amino
tetrazol
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Korean (ko)
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KR20120027426A (ko
Inventor
신차오 첸
스코트 알란 프랭크
데이비드 마이클 레믹
스티븐 웨인 페더슨
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일라이 릴리 앤드 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020117031449A 2009-06-30 2010-06-28 트랜스-4-［［(5ｓ)-5-［［［3,5-비스(트리플루오로메틸)페닐］메틸］ (2-메틸-2ｈ-테트라졸-5-일)아미노］-2,3,4,5-테트라히드로-7,9-디메틸-1ｈ-1-벤즈아제핀-1-일］메틸］-시클로헥산카르복실산 Expired - Fee Related KR101404893B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22170809P 2009-06-30 2009-06-30
US61/221,708 2009-06-30
PCT/US2010/040125 WO2011002696A1 (en) 2009-06-30 2010-06-28 Trans-4-[[(5s)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl] (2-methyl-2h-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1h-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid

Publications (2)

Publication Number Publication Date
KR20120027426A KR20120027426A (ko) 2012-03-21
KR101404893B1 true KR101404893B1 (ko) 2014-06-20

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EP (1) EP2448933B1 (enExample)
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* Cited by examiner, † Cited by third party
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US20080269284A1 (en) * 2004-06-24 2008-10-30 Eli Lilly And Company Compounds and Methods for Treating Dyslipidemia
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
CN103648495A (zh) 2011-07-08 2014-03-19 诺华股份有限公司 在高甘油三酯对象中治疗动脉粥样硬化的方法
CN103958501B (zh) * 2012-07-16 2016-08-17 上海恒瑞医药有限公司 苯并七元杂环类衍生物、其制备方法及其在医药上的应用
AU2014213125B2 (en) 2013-01-31 2016-06-02 Chong Kun Dang Pharmaceutical Corp. Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors
CN105017085B (zh) * 2014-04-28 2018-06-29 中国科学院上海药物研究所 一类kcnq钾通道激动剂、其制备方法和用途
WO2016016157A1 (en) 2014-07-30 2016-02-04 F. Hoffmann-La Roche Ag Genetic markers for predicting responsiveness to therapy with hdl-raising or hdl mimicking agent
TWI691331B (zh) 2014-09-26 2020-04-21 日商興和股份有限公司 脂質異常症治療劑
CN108456213B (zh) * 2017-02-22 2021-01-15 浙江九洲药业股份有限公司 一种3-氟-4-羟基环己烷羧酸酯的制备方法
WO2025093129A1 (en) 2023-11-01 2025-05-08 Newamsterdam Pharma B.V. Treatment and prevention of age-related macular degeneration using a cetp inhibitor

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WO2006002342A1 (en) 2004-06-24 2006-01-05 Eli Lilly And Company Compounds and methods for treating dyslipidemia

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US6147089A (en) * 1998-09-17 2000-11-14 Pfizer Inc. Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
US6197786B1 (en) * 1998-09-17 2001-03-06 Pfizer Inc 4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
GT199900147A (es) 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
HN2000000203A (es) * 1999-11-30 2001-06-13 Pfizer Prod Inc Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
CO5271716A1 (es) 1999-11-30 2003-04-30 Pfizer Prod Inc Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida
CA2445623A1 (en) * 2001-04-30 2002-11-07 Pfizer Products Inc. Methods for preparing cetp inhibitors
US7332514B2 (en) * 2002-08-30 2008-02-19 Japan Tobacco Inc. Dibenzylamine compound and medicinal use thereof
PL376156A1 (en) * 2002-10-04 2005-12-27 Millennium Pharmaceuticals, Inc. Pgd2 receptor antagonists for the treatment of inflammatory diseases
JP2006523218A (ja) * 2003-03-04 2006-10-12 高砂香料工業株式会社 光学活性アミン類の製造方法
US20040204450A1 (en) * 2003-03-28 2004-10-14 Pfizer Inc Quinoline and quinoxaline compounds
WO2005037796A1 (en) * 2003-10-08 2005-04-28 Eli Lilly And Company Compounds and methods for treating dyslipidemia
BRPI0508966A (pt) 2004-03-26 2007-08-21 Lilly Co Eli composto, composição farmacêutica, e, uso de um composto
CN1972927A (zh) * 2004-06-24 2007-05-30 伊莱利利公司 用于治疗血脂障碍的化合物和方法
US7700774B2 (en) * 2004-12-20 2010-04-20 Dr. Reddy's Laboratories Ltd. Heterocyclic compounds and their pharmaceutical compositions
TWI450896B (zh) * 2009-06-30 2014-09-01 Lilly Co Eli 反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸

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Publication number Publication date
CR20110669A (es) 2012-03-16
CA2764425C (en) 2015-01-06
IL216655A (en) 2015-02-26
SI2448933T1 (sl) 2013-11-29
CO6480934A2 (es) 2012-07-16
HRP20130950T1 (hr) 2013-11-22
ME01606B (me) 2014-09-20
RS52988B (sr) 2014-02-28
TN2011000638A1 (en) 2013-05-24
DK2448933T3 (da) 2013-10-07
AU2010266537B2 (en) 2013-04-18
UA109409C2 (ru) 2015-08-25
ES2435293T3 (es) 2013-12-18
TW201113275A (en) 2011-04-16
KR20120027426A (ko) 2012-03-21
BRPI1011931A2 (pt) 2016-04-19
PT2448933E (pt) 2013-10-29
MA33385B1 (fr) 2012-06-01
PL2448933T3 (pl) 2014-01-31
GT201100321A (es) 2012-11-15
IL216655A0 (en) 2012-02-29
DOP2011000405A (es) 2012-01-15
AR077208A1 (es) 2011-08-10
JP5689875B2 (ja) 2015-03-25
CN102639528A (zh) 2012-08-15
EP2448933B1 (en) 2013-08-28
MY157121A (en) 2016-05-13
NZ596820A (en) 2013-07-26
JO2867B1 (en) 2015-03-15
CN102639528B (zh) 2014-07-16
US20100331309A1 (en) 2010-12-30
WO2011002696A1 (en) 2011-01-06
ZA201108707B (en) 2013-05-29
US8299060B2 (en) 2012-10-30
US8329688B2 (en) 2012-12-11
JP2012532106A (ja) 2012-12-13
ECSP11011551A (es) 2012-01-31
EA020600B1 (ru) 2014-12-30
US20120058990A1 (en) 2012-03-08
CA2764425A1 (en) 2011-01-06
CL2011003263A1 (es) 2012-07-27
EP2448933A1 (en) 2012-05-09
SG177413A1 (en) 2012-02-28
TWI450896B (zh) 2014-09-01
PE20120538A1 (es) 2012-05-09
EA201270099A1 (ru) 2012-05-30
AU2010266537A1 (en) 2012-02-02
MX2011014024A (es) 2012-04-20

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