CN102612514B - 抗流感剂 - Google Patents

抗流感剂 Download PDF

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Publication number
CN102612514B
CN102612514B CN201080040870.1A CN201080040870A CN102612514B CN 102612514 B CN102612514 B CN 102612514B CN 201080040870 A CN201080040870 A CN 201080040870A CN 102612514 B CN102612514 B CN 102612514B
Authority
CN
China
Prior art keywords
dideoxy
anhydro
glycerol
acetamido
galactose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080040870.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN102612514A (zh
Inventor
马克·冯伊兹思坦
杰弗里·克利福德·戴亚森
罗宾·汤姆森
桑托什·鲁德拉沃
莫罗·帕斯克鲁提
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Griffith University
Original Assignee
Griffith University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2009903329A external-priority patent/AU2009903329A0/en
Application filed by Griffith University filed Critical Griffith University
Publication of CN102612514A publication Critical patent/CN102612514A/zh
Application granted granted Critical
Publication of CN102612514B publication Critical patent/CN102612514B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201080040870.1A 2009-07-16 2010-07-16 抗流感剂 Expired - Fee Related CN102612514B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2009903329A AU2009903329A0 (en) 2009-07-16 Anti-influenza agents
AU2009903329 2009-07-16
PCT/AU2010/000905 WO2011006208A1 (en) 2009-07-16 2010-07-16 Anti -influenza agents

Publications (2)

Publication Number Publication Date
CN102612514A CN102612514A (zh) 2012-07-25
CN102612514B true CN102612514B (zh) 2016-01-13

Family

ID=43448806

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080040870.1A Expired - Fee Related CN102612514B (zh) 2009-07-16 2010-07-16 抗流感剂

Country Status (11)

Country Link
US (1) US20120202877A1 (enExample)
EP (1) EP2454248A4 (enExample)
JP (1) JP2012532894A (enExample)
CN (1) CN102612514B (enExample)
AU (1) AU2010273184B2 (enExample)
CA (1) CA2768081A1 (enExample)
IL (1) IL217523A0 (enExample)
MX (1) MX2012000576A (enExample)
RU (1) RU2012105073A (enExample)
SG (1) SG177633A1 (enExample)
WO (1) WO2011006208A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9788539B2 (en) 2011-05-17 2017-10-17 Velico Medical, Inc. Platelet protection solution having beta-galactosidase and sialidase inhibitors
EP2903430A1 (en) 2012-10-05 2015-08-12 Velico Medical, Inc. Platelet additive solution having a beta-galactosidase inhibitor
JP6453050B2 (ja) * 2013-11-15 2019-01-16 国立大学法人富山大学 ２−デオキシ−２，３−ジデヒドロシアル酸誘導体およびその製造法
JP6786095B2 (ja) * 2016-07-27 2020-11-18 国立研究開発法人理化学研究所 シアル酸類縁体
US11773129B2 (en) 2017-05-25 2023-10-03 The Governors Of The University Of Alberta Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase
CA3148756A1 (en) * 2019-07-30 2021-02-04 Griffith University Antiviral agents and uses thereof
WO2024118503A1 (en) 2022-11-28 2024-06-06 Hongene Biotech Corporation Functionalized n-acetylgalactosamine analogs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016320A1 (en) * 1990-04-24 1991-10-31 Biota Scientific Management Pty Ltd Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11279168A (ja) * 1996-07-22 1999-10-12 Sankyo Co Ltd ノイラミン酸誘導体
AU711845B2 (en) * 1996-09-10 1999-10-21 Daikin Industries, Ltd. 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
AUPR001000A0 (en) * 2000-09-08 2000-10-05 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
WO2002076971A1 (en) * 2001-03-08 2002-10-03 Biocryst Pharmaceuticals, Inc. Compounds useful for inhibiting paramyxovirus neuraminidase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016320A1 (en) * 1990-04-24 1991-10-31 Biota Scientific Management Pty Ltd Derivatives and analogues of 2-deoxy-2,3-didehydro-n-acetyl neuraminic acid and their use as antiviral agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Alfonso T. García-Sosa ET AL.Design of Multi-Binding-Site Inhibitors, Ligand Efficiency, and Consensus Screening of Avian Influenza H5N1 Wild-Type Neuraminidase and of the Oseltamivir-Resistant H274Y Variant.《J. Chem. Inf. Model.》.2008,第48卷(第10期),2074–2080. *
Design of Multi-Binding-Site Inhibitors, Ligand Efficiency, and Consensus Screening of Avian Influenza H5N1 Wild-Type Neuraminidase and of the Oseltamivir-Resistant H274Y Variant;Alfonso T. García-Sosa ET AL;《J. Chem. Inf. Model.》;20081011;第48卷(第10期);2074–2080 *
Novel UDP-glycal derivatives as transition state analogue inhibitors of UDP-GlcNAc 2-epimerase;Florian Stolz ET AL;《JOURNAL OF ORGANIC CHEMISTRY》;20041001;第69卷(第3期);665-679 *
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design;Rupert J. Russell ET AL;《NATURE》;20060816;第443卷(第7107期);45-49 *

Also Published As

Publication number Publication date
IL217523A0 (en) 2012-02-29
CN102612514A (zh) 2012-07-25
MX2012000576A (es) 2012-07-20
AU2010273184B2 (en) 2015-07-09
US20120202877A1 (en) 2012-08-09
JP2012532894A (ja) 2012-12-20
EP2454248A4 (en) 2013-04-03
CA2768081A1 (en) 2011-01-20
EP2454248A1 (en) 2012-05-23
WO2011006208A1 (en) 2011-01-20
AU2010273184A1 (en) 2012-03-01
SG177633A1 (en) 2012-02-28
RU2012105073A (ru) 2013-08-27

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160113

Termination date: 20200716