RU2012105073A - Противогриппозные агенты - Google Patents
Противогриппозные агенты Download PDFInfo
- Publication number
- RU2012105073A RU2012105073A RU2012105073/04A RU2012105073A RU2012105073A RU 2012105073 A RU2012105073 A RU 2012105073A RU 2012105073/04 A RU2012105073/04 A RU 2012105073/04A RU 2012105073 A RU2012105073 A RU 2012105073A RU 2012105073 A RU2012105073 A RU 2012105073A
- Authority
- RU
- Russia
- Prior art keywords
- optionally substituted
- anhydro
- glycero
- galacto
- dideoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims abstract 28
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 19
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract 18
- 239000001257 hydrogen Substances 0.000 claims abstract 17
- 125000005017 substituted alkenyl group Chemical group 0.000 claims abstract 17
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 16
- 125000002252 acyl group Chemical group 0.000 claims abstract 12
- 150000002431 hydrogen Chemical group 0.000 claims abstract 12
- 125000000217 alkyl group Chemical group 0.000 claims abstract 11
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 10
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims abstract 10
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 8
- 150000003852 triazoles Chemical class 0.000 claims abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 5
- 102000005348 Neuraminidase Human genes 0.000 claims abstract 4
- 108010006232 Neuraminidase Proteins 0.000 claims abstract 4
- 229940124639 Selective inhibitor Drugs 0.000 claims abstract 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 4
- 125000003107 substituted aryl group Chemical group 0.000 claims abstract 4
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 4
- 150000002148 esters Chemical class 0.000 claims abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 3
- 125000004426 substituted alkynyl group Chemical group 0.000 claims abstract 3
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000004404 heteroalkyl group Chemical group 0.000 claims abstract 2
- 239000000651 prodrug Substances 0.000 claims abstract 2
- 229940002612 prodrug Drugs 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 150000003536 tetrazoles Chemical class 0.000 claims abstract 2
- 125000003441 thioacyl group Chemical group 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 19
- 230000008030 elimination Effects 0.000 claims 6
- 238000003379 elimination reaction Methods 0.000 claims 6
- 125000006239 protecting group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 241000712431 Influenza A virus Species 0.000 claims 3
- -1 R 3 Chemical class 0.000 claims 3
- 206010022000 influenza Diseases 0.000 claims 3
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000007306 functionalization reaction Methods 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 238000005852 acetolysis reaction Methods 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 238000007068 beta-elimination reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 150000004292 cyclic ethers Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012039 electrophile Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910001385 heavy metal Inorganic materials 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000006138 lithiation reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000010802 sludge Substances 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2009903329A AU2009903329A0 (en) | 2009-07-16 | Anti-influenza agents | |
| AU2009903329 | 2009-07-16 | ||
| PCT/AU2010/000905 WO2011006208A1 (en) | 2009-07-16 | 2010-07-16 | Anti -influenza agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012105073A true RU2012105073A (ru) | 2013-08-27 |
Family
ID=43448806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012105073/04A RU2012105073A (ru) | 2009-07-16 | 2010-07-16 | Противогриппозные агенты |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120202877A1 (enExample) |
| EP (1) | EP2454248A4 (enExample) |
| JP (1) | JP2012532894A (enExample) |
| CN (1) | CN102612514B (enExample) |
| AU (1) | AU2010273184B2 (enExample) |
| CA (1) | CA2768081A1 (enExample) |
| IL (1) | IL217523A0 (enExample) |
| MX (1) | MX2012000576A (enExample) |
| RU (1) | RU2012105073A (enExample) |
| SG (1) | SG177633A1 (enExample) |
| WO (1) | WO2011006208A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9788539B2 (en) | 2011-05-17 | 2017-10-17 | Velico Medical, Inc. | Platelet protection solution having beta-galactosidase and sialidase inhibitors |
| WO2014055988A1 (en) | 2012-10-05 | 2014-04-10 | Velico Medical, Inc. | Platelet additive solution having a beta-galactosidase inhibitor |
| JP6453050B2 (ja) * | 2013-11-15 | 2019-01-16 | 国立大学法人富山大学 | ２−デオキシ−２，３−ジデヒドロシアル酸誘導体およびその製造法 |
| JP6786095B2 (ja) * | 2016-07-27 | 2020-11-18 | 国立研究開発法人理化学研究所 | シアル酸類縁体 |
| WO2018213933A1 (en) | 2017-05-25 | 2018-11-29 | The Governors Of The University Of Alberta | Methods of preventing or treating atherosclerosis with inhibitors of specific isoenzymes of human neuraminidase |
| CN114423754A (zh) * | 2019-07-30 | 2022-04-29 | 格里菲斯大学 | 抗病毒剂和其用途 |
| US12116382B2 (en) | 2022-11-28 | 2024-10-15 | Hongene Biotech Corporation | Functionalized N-acetylgalactosamine analogs |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP249A (en) * | 1990-04-24 | 1993-03-17 | Biota Scient Management Pty Ltd | Anti-viral compounds. |
| JPH11279168A (ja) * | 1996-07-22 | 1999-10-12 | Sankyo Co Ltd | ノイラミン酸誘導体 |
| US5948816A (en) * | 1996-09-10 | 1999-09-07 | Daikin Industries, Ltd. | 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds |
| AUPR001000A0 (en) * | 2000-09-08 | 2000-10-05 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
| US7045535B2 (en) * | 2001-03-08 | 2006-05-16 | Biocryst Pharmaceuticals, Inc. | Compounds useful for inhibiting paramyxovirus neuraminidase |
-
2010
- 2010-07-16 US US13/384,198 patent/US20120202877A1/en not_active Abandoned
- 2010-07-16 RU RU2012105073/04A patent/RU2012105073A/ru not_active Application Discontinuation
- 2010-07-16 CN CN201080040870.1A patent/CN102612514B/zh not_active Expired - Fee Related
- 2010-07-16 AU AU2010273184A patent/AU2010273184B2/en not_active Ceased
- 2010-07-16 SG SG2012002341A patent/SG177633A1/en unknown
- 2010-07-16 MX MX2012000576A patent/MX2012000576A/es not_active Application Discontinuation
- 2010-07-16 WO PCT/AU2010/000905 patent/WO2011006208A1/en not_active Ceased
- 2010-07-16 EP EP20100799291 patent/EP2454248A4/en not_active Withdrawn
- 2010-07-16 JP JP2012519850A patent/JP2012532894A/ja active Pending
- 2010-07-16 CA CA2768081A patent/CA2768081A1/en not_active Abandoned
-
2012
- 2012-01-12 IL IL217523A patent/IL217523A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010273184A1 (en) | 2012-03-01 |
| IL217523A0 (en) | 2012-02-29 |
| AU2010273184B2 (en) | 2015-07-09 |
| SG177633A1 (en) | 2012-02-28 |
| CA2768081A1 (en) | 2011-01-20 |
| US20120202877A1 (en) | 2012-08-09 |
| WO2011006208A1 (en) | 2011-01-20 |
| CN102612514A (zh) | 2012-07-25 |
| CN102612514B (zh) | 2016-01-13 |
| MX2012000576A (es) | 2012-07-20 |
| EP2454248A1 (en) | 2012-05-23 |
| JP2012532894A (ja) | 2012-12-20 |
| EP2454248A4 (en) | 2013-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20160309 |