CN102574926B - Muc1抗体 - Google Patents

Muc1抗体 Download PDF

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Publication number
CN102574926B
CN102574926B CN201080033969.9A CN201080033969A CN102574926B CN 102574926 B CN102574926 B CN 102574926B CN 201080033969 A CN201080033969 A CN 201080033969A CN 102574926 B CN102574926 B CN 102574926B
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CN
China
Prior art keywords
antibody
fragment
derivative
chain variable
amino acid
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CN201080033969.9A
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English (en)
Chinese (zh)
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CN102574926A (zh
Inventor
S·高尔兹
A·丹尼尔奇克
R·施塔恩
U·卡斯滕
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Daiichi Sankyo Co Ltd
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Glycotope GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201080033969.9A 2009-07-31 2010-07-30 Muc1抗体 Active CN102574926B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23021109P 2009-07-31 2009-07-31
EP09009942A EP2281844A1 (en) 2009-07-31 2009-07-31 MUC 1 antibodies
US61/230,211 2009-07-31
EP09009942.5 2009-07-31
PCT/EP2010/004663 WO2011012309A1 (en) 2009-07-31 2010-07-30 Muc1 antibodies

Publications (2)

Publication Number Publication Date
CN102574926A CN102574926A (zh) 2012-07-11
CN102574926B true CN102574926B (zh) 2014-10-15

Family

ID=41460131

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080033969.9A Active CN102574926B (zh) 2009-07-31 2010-07-30 Muc1抗体

Country Status (17)

Country Link
US (1) US9217038B2 (enExample)
EP (3) EP2281844A1 (enExample)
JP (2) JP5922018B2 (enExample)
KR (1) KR101773506B1 (enExample)
CN (1) CN102574926B (enExample)
AR (1) AR077334A1 (enExample)
AU (1) AU2010278302B2 (enExample)
BR (1) BR112012002226A2 (enExample)
CA (1) CA2768888C (enExample)
CU (1) CU23972B1 (enExample)
EA (1) EA029954B1 (enExample)
IL (1) IL217827A (enExample)
MX (1) MX2012000874A (enExample)
NZ (1) NZ597563A (enExample)
SG (2) SG177527A1 (enExample)
WO (1) WO2011012309A1 (enExample)
ZA (1) ZA201200166B (enExample)

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PT2073842E (pt) 2006-09-10 2015-04-07 Glycotope Gmbh Utilização de células humanas provenientes de uma leucemia mielóide para expressão de anticorpos
EP1920782A1 (en) * 2006-11-10 2008-05-14 Glycotope Gmbh Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof
EP2281844A1 (en) 2009-07-31 2011-02-09 Glycotope GmbH MUC 1 antibodies
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
JP6334166B2 (ja) 2010-08-10 2018-05-30 グリコトープ ゲーエムベーハー Ｆａｂグリコシル化抗体
US9845362B2 (en) 2010-10-08 2017-12-19 The University Of North Carolina At Charlotte Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same
WO2013026887A1 (en) 2011-08-22 2013-02-28 Glycotope Gmbh Microorganisms carrying a tumor antigen
CN103848890B (zh) * 2012-11-30 2015-09-09 北京市结核病胸部肿瘤研究所 Muc1自身抗体识别的抗原多肽
EP2963126B1 (en) * 2013-03-01 2019-04-03 Saitama Medical University Method for evaluating side-effect onset risk in anticancer drug treatment, including detecting muc4 gene polymorphism
US10208125B2 (en) * 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
EP3127919A4 (en) * 2014-02-06 2017-08-16 Medicinal Chemistry Pharmaceuticals Co., Ltd. Antibody against mucin 4 (muc 4) glycopeptide and use therefor
CA2947404C (en) * 2014-04-28 2023-05-16 Medicinal Chemistry Pharmaceuticals, Co., Ltd. Anti-muc1 antibody or antigen-binding fragment thereof and uses thereof
WO2016026143A1 (en) * 2014-08-22 2016-02-25 Huiru Wang Saccharide-based biomarkers and therapeutics
US11554181B2 (en) 2014-09-05 2023-01-17 The University Of North Carolina At Charlotte Tumor specific antibody conjugates and uses therefor
WO2016130726A1 (en) * 2015-02-10 2016-08-18 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
WO2017139975A1 (en) 2016-02-19 2017-08-24 Huiru Wang Antibodies against n-acetylglucosamine and n-acetyl-galactosamine
EP3543337B1 (en) 2016-11-18 2022-04-20 Astellas Pharma Inc. Novel anti-human muc1 antibody fab fragment
EP3570881A4 (en) * 2017-01-18 2020-08-19 Nanocruise Pharmaceutical Ltd. MONOCLONAL AND HUMANIZED ANTIBODIES DIRECTED AGAINST CANCER GLYCOPEPTIDE
EP3574015A1 (en) * 2017-01-27 2019-12-04 Glycotope GmbH Anti-cancer treatments with an anti-muc1 antibody and an erbb inhibitor
JP2020511959A (ja) 2017-03-29 2020-04-23 グリコトープ ゲーエムベーハー ヒト化抗ｃｄ４０抗体
CA3057758A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Pd-l1 and ta-muc1 antibodies
CA3055438A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Multispecific antibody constructs binding to muc1 and cd3
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
CN117003875A (zh) 2017-09-29 2023-11-07 第一三共株式会社 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用
US11161911B2 (en) 2017-10-23 2021-11-02 Go Therapeutics, Inc. Anti-glyco-MUC1 antibodies and their uses
EP3700936A4 (en) * 2017-10-24 2021-05-26 Go Therapeutics, Inc. ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES
CN111819203A (zh) * 2018-03-01 2020-10-23 葛莱高托普有限公司 包含抗muc1抗体和il-15的融合蛋白构建体
WO2019221269A1 (ja) * 2018-05-17 2019-11-21 アステラス製薬株式会社 抗ヒトＭＵＣ１抗体Ｆａｂフラグメント、ペプチドリンカー及び／又は配位子を含む複合体
SG11202010496WA (en) 2018-05-18 2020-12-30 Daiichi Sankyo Co Ltd Anti-muc1 antibody-drug conjugate
CN108982854B (zh) * 2018-06-19 2021-07-27 哈尔滨医科大学 蛋白质muc13在制备诊断肝内胆管癌的试剂中的应用
EP3814384A4 (en) * 2018-06-29 2022-03-23 Go Therapeutics, Inc. ANTI-GLYC0-MUC1 ANTIBODIES AND THEIR USES
CN112839683B (zh) 2018-10-10 2023-11-14 安斯泰来制药株式会社 含有标记部-抗人抗体Fab片段复合物的药物组合物
TWI856078B (zh) 2019-03-25 2024-09-21 日商第一三共股份有限公司 抗體–吡咯并苯二氮呯衍生物結合物、其製造方法及其用途
CA3139180A1 (en) 2019-03-27 2020-10-01 Daiichi Sankyo Company, Limited Combination of antibody-pyrrolobenzodiazepine derivative conjugate and parp inhibitor
CN118475617A (zh) * 2021-12-21 2024-08-09 美勒斯公司 针对与癌症相关的muc1的结合域
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
TW202506190A (zh) 2023-04-05 2025-02-16 日商第一三共股份有限公司 利用抗ｍｕｃ１抗體－藥物結合物投予的藥劑低敏感性癌之治療方法

Citations (1)

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US20060292643A1 (en) * 2003-01-23 2006-12-28 Steffen Goletz Recognition molecules for the treatment and detection of tumours

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DE69329643T2 (de) 1992-04-13 2001-03-01 Dana-Farber Cancer Institute, Inc. Gegen karzinom-assoziierte antigene gerichtete antikörper
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Publication number Priority date Publication date Assignee Title
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Non-Patent Citations (1)

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Also Published As

Publication number Publication date
AR077334A1 (es) 2011-08-17
US9217038B2 (en) 2015-12-22
WO2011012309A8 (en) 2011-04-07
ZA201200166B (en) 2013-03-27
AU2010278302A1 (en) 2012-02-09
JP2013500703A (ja) 2013-01-10
JP2016041771A (ja) 2016-03-31
JP6272916B2 (ja) 2018-01-31
IL217827A (en) 2017-05-29
CN102574926A (zh) 2012-07-11
EA201270207A1 (ru) 2012-07-30
EP3421497A1 (en) 2019-01-02
SG177527A1 (en) 2012-02-28
IL217827A0 (en) 2012-03-29
WO2011012309A1 (en) 2011-02-03
EP2459595A1 (en) 2012-06-06
US20120128676A1 (en) 2012-05-24
BR112012002226A2 (pt) 2016-11-08
EP2281844A1 (en) 2011-02-09
AU2010278302B2 (en) 2014-12-18
JP5922018B2 (ja) 2016-05-24
EA029954B1 (ru) 2018-06-29
CU23972B1 (es) 2013-12-27
CA2768888A1 (en) 2011-02-03
KR101773506B1 (ko) 2017-08-31
MX2012000874A (es) 2012-02-01
SG10201404019XA (en) 2014-09-26
NZ597563A (en) 2013-08-30
CA2768888C (en) 2019-02-26
CU20120019A7 (es) 2012-06-21
KR20120051724A (ko) 2012-05-22

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C06 Publication
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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
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Effective date of registration: 20250520

Address after: Ri Ben

Patentee after: DAIICHI SANKYO Co.,Ltd.

Country or region after: Japan

Address before: Berlin

Patentee before: GLYCOTOPE GmbH

Country or region before: Germany