CU20120019A7 - Anticuerpos muc1 - Google Patents
Anticuerpos muc1Info
- Publication number
- CU20120019A7 CU20120019A7 CU20120019A CU20120019A CU20120019A7 CU 20120019 A7 CU20120019 A7 CU 20120019A7 CU 20120019 A CU20120019 A CU 20120019A CU 20120019 A CU20120019 A CU 20120019A CU 20120019 A7 CU20120019 A7 CU 20120019A7
- Authority
- CU
- Cuba
- Prior art keywords
- muc1 antibodies
- antibodies
- present
- recognition
- muc1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a anticuerpos antimucina con mejores propiedades de unión y/o reconocimiento de antígeno así como un procedimiento para mejorar la unión y/o reconocimiento de antígeno de un anticuerpo antimucina. En particular, la presente invención está dirigida a anticuerpos anti-MUC1 útiles en el tratamiento del cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23021109P | 2009-07-31 | 2009-07-31 | |
EP09009942A EP2281844A1 (en) | 2009-07-31 | 2009-07-31 | MUC 1 antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20120019A7 true CU20120019A7 (es) | 2012-06-21 |
CU23972B1 CU23972B1 (es) | 2013-12-27 |
Family
ID=41460131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2012000019A CU23972B1 (es) | 2009-07-31 | 2012-01-30 | Anticuerpos muc1 |
Country Status (17)
Country | Link |
---|---|
US (1) | US9217038B2 (es) |
EP (3) | EP2281844A1 (es) |
JP (2) | JP5922018B2 (es) |
KR (1) | KR101773506B1 (es) |
CN (1) | CN102574926B (es) |
AR (1) | AR077334A1 (es) |
AU (1) | AU2010278302B2 (es) |
BR (1) | BR112012002226A2 (es) |
CA (1) | CA2768888C (es) |
CU (1) | CU23972B1 (es) |
EA (1) | EA029954B1 (es) |
IL (1) | IL217827A (es) |
MX (1) | MX2012000874A (es) |
NZ (1) | NZ597563A (es) |
SG (2) | SG10201404019XA (es) |
WO (1) | WO2011012309A1 (es) |
ZA (1) | ZA201200166B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2073842T4 (da) | 2006-09-10 | 2024-01-15 | Glycotope Gmbh | Anvendelse af humane celler af myloid leukæmioprindelse til udtrykkelse af anti-stoffer |
EP1920781B1 (en) * | 2006-11-10 | 2015-03-04 | Glycotope GmbH | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
US8518405B2 (en) * | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
DK2603528T3 (en) | 2010-08-10 | 2016-11-28 | Glycotope Gmbh | FAB-glycosylated ANTIBODIES |
US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
WO2013026887A1 (en) | 2011-08-22 | 2013-02-28 | Glycotope Gmbh | Microorganisms carrying a tumor antigen |
CN103848890B (zh) * | 2012-11-30 | 2015-09-09 | 北京市结核病胸部肿瘤研究所 | Muc1自身抗体识别的抗原多肽 |
US9873920B2 (en) | 2013-03-01 | 2018-01-23 | Saitama Medical University | Method for evaluating side-effect onset risk in anticancer drug treatment, including detecting MUC4 gene polymorphism |
US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
EP3127919A4 (en) | 2014-02-06 | 2017-08-16 | Medicinal Chemistry Pharmaceuticals Co., Ltd. | Antibody against mucin 4 (muc 4) glycopeptide and use therefor |
EP3150634B1 (en) * | 2014-04-28 | 2020-04-22 | Medicinal Chemistry Pharmaceuticals Co., Ltd. | Anti-muc1 antibody or antigen-binding fragment thereof, and uses thereof |
WO2016026143A1 (en) * | 2014-08-22 | 2016-02-25 | Huiru Wang | Saccharide-based biomarkers and therapeutics |
US11554181B2 (en) | 2014-09-05 | 2023-01-17 | The University Of North Carolina At Charlotte | Tumor specific antibody conjugates and uses therefor |
JP6895890B2 (ja) | 2015-02-10 | 2021-06-30 | ミネルバ バイオテクノロジーズ コーポレーション | ヒト化抗muc1* 抗体 |
WO2017139975A1 (en) | 2016-02-19 | 2017-08-24 | Huiru Wang | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
MY195529A (en) | 2016-11-18 | 2023-01-30 | Astellas Pharma Inc | Novel Anti-Human MUC1 Antibody Fab Fragment |
EP3570881A4 (en) * | 2017-01-18 | 2020-08-19 | Nanocruise Pharmaceutical Ltd. | MONOCLONAL AND HUMANIZED ANTIBODIES DIRECTED AGAINST CANCER GLYCOPEPTIDE |
CN110177807B (zh) * | 2017-01-27 | 2024-02-23 | 葛莱高托普有限公司 | 使用抗MUC1抗体和ErbB抑制剂的抗癌治疗 |
CN110382541A (zh) | 2017-03-29 | 2019-10-25 | 葛莱高托普有限公司 | 人源化抗cd40抗体 |
CA3055438A1 (en) | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Multispecific antibody constructs binding to muc1 and cd3 |
CA3057758A1 (en) * | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Pd-l1 and ta-muc1 antibodies |
TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類CEACAM5抗體Fab片段 |
CN117003875A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用 |
US11161911B2 (en) | 2017-10-23 | 2021-11-02 | Go Therapeutics, Inc. | Anti-glyco-MUC1 antibodies and their uses |
BR112020008001A2 (pt) * | 2017-10-24 | 2020-10-20 | Go Therapeutics, Inc. | anticorpo anti-glico-muc1 ou fragmento de ligação de antígeno, proteína de fusão, receptor de antígeno quimérico, conjugado de anticorpo-fármaco, ácido nucleico, vetor, célula hospedeira, composição farmacêutica, e, métodos de tratar câncer e de detectar câncer em uma amostra biológica. |
JP2021514625A (ja) * | 2018-03-01 | 2021-06-17 | グリコトープ ゲーエムベーハー | 抗muc1抗体およびil−15を含む融合タンパク質構築物 |
JP7360766B2 (ja) * | 2018-05-17 | 2023-10-13 | アステラス製薬株式会社 | 抗ヒトMUC1抗体Fabフラグメント、ペプチドリンカー及び/又は配位子を含む複合体 |
RS64379B1 (sr) * | 2018-05-18 | 2023-08-31 | Glycotope Gmbh | Anti-muc1 antitelo |
CN108982854B (zh) * | 2018-06-19 | 2021-07-27 | 哈尔滨医科大学 | 蛋白质muc13在制备诊断肝内胆管癌的试剂中的应用 |
US20210269552A1 (en) * | 2018-06-29 | 2021-09-02 | Go Therapeutics, Inc. | Anti-glyco-muc1 antibodies and their uses |
TW202102228A (zh) | 2019-03-25 | 2021-01-16 | 日商第一三共股份有限公司 | 抗體-吡咯并苯二氮呯衍生物結合物 |
WO2020196712A1 (ja) | 2019-03-27 | 2020-10-01 | 第一三共株式会社 | 抗体-ピロロベンゾジアゼピン誘導体コンジュゲートとparp阻害剤の組み合わせ |
WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5683674A (en) | 1987-01-07 | 1997-11-04 | Imperial Cancer Research Technology Ltd. | Antibody against human mucin core protein and method of preparing and using same |
CA2118010C (en) | 1992-04-13 | 2003-10-28 | Donald Kufe | Antibodies specific for carcinoma-associated antigens |
US5804187A (en) | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
US6465220B1 (en) | 1998-12-21 | 2002-10-15 | Glycozym Aps | Glycosylation using GalNac-T4 transferase |
US7147850B2 (en) | 1999-08-18 | 2006-12-12 | Altarex Medical Corp. | Therapeutic binding agents against MUC-1 antigen and methods for their use |
ATE290879T1 (de) | 1999-08-18 | 2005-04-15 | Altarex Medical Corp | Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung |
GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
WO2004009632A2 (de) | 2002-07-22 | 2004-01-29 | Nemod Immuntherapie Ag | Verfahren zur herstellung eines immunstimulatorischen muzins (muc1) |
SI1530628T1 (sl) | 2002-08-16 | 2011-02-28 | Glycotope Gmbh | Postopek za proizvodnjo s temperaturo induciranih lizatov tumorskih celic za uporabo kot imunogenske spojine |
DE10303664A1 (de) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
SI1654353T1 (sl) | 2003-08-18 | 2013-09-30 | Glycotope Gmbh | Tumorski celični liniji NM-F9 (DSM ACC2606) in NM-D4 (DSM ACC2605), njihove uporabe |
US8609370B2 (en) | 2004-02-13 | 2013-12-17 | Glycotope Gmbh | Highly active glycoproteins-process conditions and an efficient method for their production |
DK2073842T4 (da) | 2006-09-10 | 2024-01-15 | Glycotope Gmbh | Anvendelse af humane celler af myloid leukæmioprindelse til udtrykkelse af anti-stoffer |
EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
-
2009
- 2009-07-31 EP EP09009942A patent/EP2281844A1/en not_active Withdrawn
-
2010
- 2010-07-28 AR ARP100102737A patent/AR077334A1/es not_active Application Discontinuation
- 2010-07-30 WO PCT/EP2010/004663 patent/WO2011012309A1/en active Application Filing
- 2010-07-30 NZ NZ597563A patent/NZ597563A/xx unknown
- 2010-07-30 JP JP2012522029A patent/JP5922018B2/ja active Active
- 2010-07-30 KR KR1020127005121A patent/KR101773506B1/ko active IP Right Grant
- 2010-07-30 AU AU2010278302A patent/AU2010278302B2/en active Active
- 2010-07-30 SG SG10201404019XA patent/SG10201404019XA/en unknown
- 2010-07-30 MX MX2012000874A patent/MX2012000874A/es active IP Right Grant
- 2010-07-30 EA EA201270207A patent/EA029954B1/ru unknown
- 2010-07-30 CA CA2768888A patent/CA2768888C/en active Active
- 2010-07-30 CN CN201080033969.9A patent/CN102574926B/zh active Active
- 2010-07-30 SG SG2012000865A patent/SG177527A1/en unknown
- 2010-07-30 BR BR112012002226A patent/BR112012002226A2/pt not_active Application Discontinuation
- 2010-07-30 US US13/387,587 patent/US9217038B2/en active Active
- 2010-07-30 EP EP10746999A patent/EP2459595A1/en not_active Withdrawn
- 2010-07-30 EP EP18181262.9A patent/EP3421497A1/en active Pending
-
2012
- 2012-01-09 ZA ZA2012/00166A patent/ZA201200166B/en unknown
- 2012-01-30 IL IL217827A patent/IL217827A/en active IP Right Grant
- 2012-01-30 CU CU2012000019A patent/CU23972B1/es active IP Right Grant
-
2016
- 2016-01-04 JP JP2016000133A patent/JP6272916B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US9217038B2 (en) | 2015-12-22 |
IL217827A0 (en) | 2012-03-29 |
MX2012000874A (es) | 2012-02-01 |
CN102574926A (zh) | 2012-07-11 |
EA201270207A1 (ru) | 2012-07-30 |
CN102574926B (zh) | 2014-10-15 |
BR112012002226A2 (pt) | 2016-11-08 |
KR20120051724A (ko) | 2012-05-22 |
IL217827A (en) | 2017-05-29 |
WO2011012309A1 (en) | 2011-02-03 |
EA029954B1 (ru) | 2018-06-29 |
JP6272916B2 (ja) | 2018-01-31 |
AU2010278302B2 (en) | 2014-12-18 |
EP2459595A1 (en) | 2012-06-06 |
NZ597563A (en) | 2013-08-30 |
CA2768888C (en) | 2019-02-26 |
CA2768888A1 (en) | 2011-02-03 |
JP2013500703A (ja) | 2013-01-10 |
EP3421497A1 (en) | 2019-01-02 |
KR101773506B1 (ko) | 2017-08-31 |
US20120128676A1 (en) | 2012-05-24 |
SG10201404019XA (en) | 2014-09-26 |
EP2281844A1 (en) | 2011-02-09 |
CU23972B1 (es) | 2013-12-27 |
AR077334A1 (es) | 2011-08-17 |
AU2010278302A1 (en) | 2012-02-09 |
JP5922018B2 (ja) | 2016-05-24 |
ZA201200166B (en) | 2013-03-27 |
JP2016041771A (ja) | 2016-03-31 |
SG177527A1 (en) | 2012-02-28 |
WO2011012309A8 (en) | 2011-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU20120019A7 (es) | Anticuerpos muc1 | |
TN2015000396A1 (en) | Antibody drug conjugates | |
CY1122978T1 (el) | Αντισωματα εναντι-vla-4 | |
BR112012016742A2 (pt) | metodos para tratamento de cancer pancreatico | |
MX2012004415A (es) | Inmunoglobulinas de dominio variable doble y usos de las mismas. | |
SG178602A1 (en) | Dual variable domain immunoglobulins and uses thereof | |
MX2012001262A (es) | Inmunoglobulinas de dominio variable doble y usos de las misma. | |
MX2011011669A (es) | Inmunoglobulinas de dominio variable dual y usos de las misma. | |
MX2015012122A (es) | Conjugados de anticuerpo-farmaco y los anticuerpos correspondientes. | |
CR20120036A (es) | Terapia de combinación de un anticuerpo cd20 afucosilado y bendamustina | |
MX2014009289A (es) | Anticuerpos c1orf32 y usos de los mismos para el tratamiento del cancer. | |
AR090973A1 (es) | Anticuerpos utiles para el diagnostico del cancer | |
WO2012092336A3 (en) | Molecular profiling for cancer | |
MX2013006392A (es) | Tratamiento de cancer positivo para her2 con paclitaxel y trastuzumab-mcc-dm1. | |
MX341076B (es) | Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados. | |
UY33591A (es) | Nuevas proteínas de unión a antígenos | |
TN2016000577A1 (en) | Anti-cdh6 antibody drug conjugates | |
BR112015023797A2 (pt) | proteínas de ligação de especificidade dupla dirigidas contra il-1b e/ou il-17 | |
NZ704718A (en) | Epcam aptamer for detection of cancer stem cells | |
EA201201474A1 (ru) | Способы лечения рака молочной железы | |
NZ704719A (en) | Cd133 aptamers for detection of cancer stem cells | |
PH12016500580B1 (en) | Conjugated antibodies against ly75 for the treatment of cancer | |
AU2012371260A8 (en) | Predicitive biomarker for cancer treatment with ADCC enhanced antibodies | |
MX2016004420A (es) | Proteinas de union especificas duales dirigidas contra los receptores de células inmunes y autoantígenos de señalización de tlr. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant of patent |