CA2768888C - Muc1 antibodies - Google Patents
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- CA2768888C CA2768888C CA2768888A CA2768888A CA2768888C CA 2768888 C CA2768888 C CA 2768888C CA 2768888 A CA2768888 A CA 2768888A CA 2768888 A CA2768888 A CA 2768888A CA 2768888 C CA2768888 C CA 2768888C
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23021109P | 2009-07-31 | 2009-07-31 | |
| EP09009942A EP2281844A1 (en) | 2009-07-31 | 2009-07-31 | MUC 1 antibodies |
| US61/230,211 | 2009-07-31 | ||
| EP09009942.5 | 2009-07-31 | ||
| PCT/EP2010/004663 WO2011012309A1 (en) | 2009-07-31 | 2010-07-30 | Muc1 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2768888A1 CA2768888A1 (en) | 2011-02-03 |
| CA2768888C true CA2768888C (en) | 2019-02-26 |
Family
ID=41460131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2768888A Active CA2768888C (en) | 2009-07-31 | 2010-07-30 | Muc1 antibodies |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9217038B2 (enExample) |
| EP (3) | EP2281844A1 (enExample) |
| JP (2) | JP5922018B2 (enExample) |
| KR (1) | KR101773506B1 (enExample) |
| CN (1) | CN102574926B (enExample) |
| AR (1) | AR077334A1 (enExample) |
| AU (1) | AU2010278302B2 (enExample) |
| BR (1) | BR112012002226A2 (enExample) |
| CA (1) | CA2768888C (enExample) |
| CU (1) | CU23972B1 (enExample) |
| EA (1) | EA029954B1 (enExample) |
| IL (1) | IL217827A (enExample) |
| MX (1) | MX2012000874A (enExample) |
| NZ (1) | NZ597563A (enExample) |
| SG (2) | SG177527A1 (enExample) |
| WO (1) | WO2011012309A1 (enExample) |
| ZA (1) | ZA201200166B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2073842E (pt) | 2006-09-10 | 2015-04-07 | Glycotope Gmbh | Utilização de células humanas provenientes de uma leucemia mielóide para expressão de anticorpos |
| EP1920782A1 (en) * | 2006-11-10 | 2008-05-14 | Glycotope Gmbh | Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof |
| EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
| US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
| JP6334166B2 (ja) | 2010-08-10 | 2018-05-30 | グリコトープ ゲーエムベーハー | Ｆａｂグリコシル化抗体 |
| US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
| WO2013026887A1 (en) | 2011-08-22 | 2013-02-28 | Glycotope Gmbh | Microorganisms carrying a tumor antigen |
| CN103848890B (zh) * | 2012-11-30 | 2015-09-09 | 北京市结核病胸部肿瘤研究所 | Muc1自身抗体识别的抗原多肽 |
| EP2963126B1 (en) * | 2013-03-01 | 2019-04-03 | Saitama Medical University | Method for evaluating side-effect onset risk in anticancer drug treatment, including detecting muc4 gene polymorphism |
| US10208125B2 (en) * | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| EP3127919A4 (en) * | 2014-02-06 | 2017-08-16 | Medicinal Chemistry Pharmaceuticals Co., Ltd. | Antibody against mucin 4 (muc 4) glycopeptide and use therefor |
| CA2947404C (en) * | 2014-04-28 | 2023-05-16 | Medicinal Chemistry Pharmaceuticals, Co., Ltd. | Anti-muc1 antibody or antigen-binding fragment thereof and uses thereof |
| WO2016026143A1 (en) * | 2014-08-22 | 2016-02-25 | Huiru Wang | Saccharide-based biomarkers and therapeutics |
| US11554181B2 (en) | 2014-09-05 | 2023-01-17 | The University Of North Carolina At Charlotte | Tumor specific antibody conjugates and uses therefor |
| WO2016130726A1 (en) * | 2015-02-10 | 2016-08-18 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies |
| WO2017139975A1 (en) | 2016-02-19 | 2017-08-24 | Huiru Wang | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
| EP3543337B1 (en) | 2016-11-18 | 2022-04-20 | Astellas Pharma Inc. | Novel anti-human muc1 antibody fab fragment |
| EP3570881A4 (en) * | 2017-01-18 | 2020-08-19 | Nanocruise Pharmaceutical Ltd. | MONOCLONAL AND HUMANIZED ANTIBODIES DIRECTED AGAINST CANCER GLYCOPEPTIDE |
| EP3574015A1 (en) * | 2017-01-27 | 2019-12-04 | Glycotope GmbH | Anti-cancer treatments with an anti-muc1 antibody and an erbb inhibitor |
| JP2020511959A (ja) | 2017-03-29 | 2020-04-23 | グリコトープ ゲーエムベーハー | ヒト化抗ｃｄ４０抗体 |
| CA3057758A1 (en) * | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Pd-l1 and ta-muc1 antibodies |
| CA3055438A1 (en) * | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Multispecific antibody constructs binding to muc1 and cd3 |
| TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| CN117003875A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用 |
| US11161911B2 (en) | 2017-10-23 | 2021-11-02 | Go Therapeutics, Inc. | Anti-glyco-MUC1 antibodies and their uses |
| EP3700936A4 (en) * | 2017-10-24 | 2021-05-26 | Go Therapeutics, Inc. | ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES |
| CN111819203A (zh) * | 2018-03-01 | 2020-10-23 | 葛莱高托普有限公司 | 包含抗muc1抗体和il-15的融合蛋白构建体 |
| WO2019221269A1 (ja) * | 2018-05-17 | 2019-11-21 | アステラス製薬株式会社 | 抗ヒトＭＵＣ１抗体Ｆａｂフラグメント、ペプチドリンカー及び／又は配位子を含む複合体 |
| SG11202010496WA (en) | 2018-05-18 | 2020-12-30 | Daiichi Sankyo Co Ltd | Anti-muc1 antibody-drug conjugate |
| CN108982854B (zh) * | 2018-06-19 | 2021-07-27 | 哈尔滨医科大学 | 蛋白质muc13在制备诊断肝内胆管癌的试剂中的应用 |
| EP3814384A4 (en) * | 2018-06-29 | 2022-03-23 | Go Therapeutics, Inc. | ANTI-GLYC0-MUC1 ANTIBODIES AND THEIR USES |
| CN112839683B (zh) | 2018-10-10 | 2023-11-14 | 安斯泰来制药株式会社 | 含有标记部-抗人抗体Fab片段复合物的药物组合物 |
| TWI856078B (zh) | 2019-03-25 | 2024-09-21 | 日商第一三共股份有限公司 | 抗體–吡咯并苯二氮呯衍生物結合物、其製造方法及其用途 |
| CA3139180A1 (en) | 2019-03-27 | 2020-10-01 | Daiichi Sankyo Company, Limited | Combination of antibody-pyrrolobenzodiazepine derivative conjugate and parp inhibitor |
| CN118475617A (zh) * | 2021-12-21 | 2024-08-09 | 美勒斯公司 | 针对与癌症相关的muc1的结合域 |
| WO2023240135A2 (en) | 2022-06-07 | 2023-12-14 | Actinium Pharmaceuticals, Inc. | Bifunctional chelators and conjugates |
| TW202506190A (zh) | 2023-04-05 | 2025-02-16 | 日商第一三共股份有限公司 | 利用抗ｍｕｃ１抗體－藥物結合物投予的藥劑低敏感性癌之治療方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5683674A (en) | 1987-01-07 | 1997-11-04 | Imperial Cancer Research Technology Ltd. | Antibody against human mucin core protein and method of preparing and using same |
| DE69329643T2 (de) | 1992-04-13 | 2001-03-01 | Dana-Farber Cancer Institute, Inc. | Gegen karzinom-assoziierte antigene gerichtete antikörper |
| US5804187A (en) | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US6465220B1 (en) | 1998-12-21 | 2002-10-15 | Glycozym Aps | Glycosylation using GalNac-T4 transferase |
| US7147850B2 (en) | 1999-08-18 | 2006-12-12 | Altarex Medical Corp. | Therapeutic binding agents against MUC-1 antigen and methods for their use |
| ATE290879T1 (de) | 1999-08-18 | 2005-04-15 | Altarex Medical Corp | Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung |
| GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
| PT1529060E (pt) | 2002-07-22 | 2014-11-28 | Glycotope Gmbh | Processo para a produção de uma mucina imuno-estimuladora (muc1) |
| SI1530628T1 (sl) | 2002-08-16 | 2011-02-28 | Glycotope Gmbh | Postopek za proizvodnjo s temperaturo induciranih lizatov tumorskih celic za uporabo kot imunogenske spojine |
| DE10303664A1 (de) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
| PT1654353E (pt) | 2003-08-18 | 2013-08-23 | Glycotope Gmbh | Linhas de células tumorais nm f9 (dsm acc2606) e nm d4 (dsm acc2605), suas utilizações |
| JP4913604B2 (ja) | 2004-02-13 | 2012-04-11 | グリコトープ ゲーエムベーハー | 高活性糖タンパク質−製造条件、及びその効率的製造方法 |
| PT2073842E (pt) | 2006-09-10 | 2015-04-07 | Glycotope Gmbh | Utilização de células humanas provenientes de uma leucemia mielóide para expressão de anticorpos |
| EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
-
2009
- 2009-07-31 EP EP09009942A patent/EP2281844A1/en not_active Withdrawn
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2010
- 2010-07-28 AR ARP100102737A patent/AR077334A1/es not_active Application Discontinuation
- 2010-07-30 MX MX2012000874A patent/MX2012000874A/es active IP Right Grant
- 2010-07-30 EP EP10746999A patent/EP2459595A1/en not_active Withdrawn
- 2010-07-30 SG SG2012000865A patent/SG177527A1/en unknown
- 2010-07-30 JP JP2012522029A patent/JP5922018B2/ja active Active
- 2010-07-30 WO PCT/EP2010/004663 patent/WO2011012309A1/en not_active Ceased
- 2010-07-30 KR KR1020127005121A patent/KR101773506B1/ko active Active
- 2010-07-30 CA CA2768888A patent/CA2768888C/en active Active
- 2010-07-30 BR BR112012002226A patent/BR112012002226A2/pt not_active Application Discontinuation
- 2010-07-30 CN CN201080033969.9A patent/CN102574926B/zh active Active
- 2010-07-30 EA EA201270207A patent/EA029954B1/ru unknown
- 2010-07-30 AU AU2010278302A patent/AU2010278302B2/en active Active
- 2010-07-30 US US13/387,587 patent/US9217038B2/en active Active
- 2010-07-30 NZ NZ597563A patent/NZ597563A/xx unknown
- 2010-07-30 EP EP18181262.9A patent/EP3421497A1/en active Pending
- 2010-07-30 SG SG10201404019XA patent/SG10201404019XA/en unknown
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2012
- 2012-01-09 ZA ZA2012/00166A patent/ZA201200166B/en unknown
- 2012-01-30 IL IL217827A patent/IL217827A/en active IP Right Grant
- 2012-01-30 CU CU2012000019A patent/CU23972B1/es active IP Right Grant
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2016
- 2016-01-04 JP JP2016000133A patent/JP6272916B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AR077334A1 (es) | 2011-08-17 |
| US9217038B2 (en) | 2015-12-22 |
| WO2011012309A8 (en) | 2011-04-07 |
| ZA201200166B (en) | 2013-03-27 |
| AU2010278302A1 (en) | 2012-02-09 |
| JP2013500703A (ja) | 2013-01-10 |
| JP2016041771A (ja) | 2016-03-31 |
| JP6272916B2 (ja) | 2018-01-31 |
| IL217827A (en) | 2017-05-29 |
| CN102574926A (zh) | 2012-07-11 |
| EA201270207A1 (ru) | 2012-07-30 |
| EP3421497A1 (en) | 2019-01-02 |
| SG177527A1 (en) | 2012-02-28 |
| IL217827A0 (en) | 2012-03-29 |
| WO2011012309A1 (en) | 2011-02-03 |
| EP2459595A1 (en) | 2012-06-06 |
| US20120128676A1 (en) | 2012-05-24 |
| BR112012002226A2 (pt) | 2016-11-08 |
| EP2281844A1 (en) | 2011-02-09 |
| AU2010278302B2 (en) | 2014-12-18 |
| JP5922018B2 (ja) | 2016-05-24 |
| EA029954B1 (ru) | 2018-06-29 |
| CU23972B1 (es) | 2013-12-27 |
| CN102574926B (zh) | 2014-10-15 |
| CA2768888A1 (en) | 2011-02-03 |
| KR101773506B1 (ko) | 2017-08-31 |
| MX2012000874A (es) | 2012-02-01 |
| SG10201404019XA (en) | 2014-09-26 |
| NZ597563A (en) | 2013-08-30 |
| CU20120019A7 (es) | 2012-06-21 |
| KR20120051724A (ko) | 2012-05-22 |
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Effective date: 20150729 |