EA029954B1 - Анти-muc1 антитела - Google Patents

Анти-muc1 антитела Download PDF

Info

Publication number
EA029954B1
EA029954B1 EA201270207A EA201270207A EA029954B1 EA 029954 B1 EA029954 B1 EA 029954B1 EA 201270207 A EA201270207 A EA 201270207A EA 201270207 A EA201270207 A EA 201270207A EA 029954 B1 EA029954 B1 EA 029954B1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody
fragment
amino acid
derivative
epitope
Prior art date
Application number
EA201270207A
Other languages
English (en)
Russian (ru)
Other versions
EA201270207A1 (ru
Inventor
Штеффен Голетц
Антье Даниельчик
Ренате Штан
Уве Карстен
Original Assignee
Гликотоп Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гликотоп Гмбх filed Critical Гликотоп Гмбх
Publication of EA201270207A1 publication Critical patent/EA201270207A1/ru
Publication of EA029954B1 publication Critical patent/EA029954B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EA201270207A 2009-07-31 2010-07-30 Анти-muc1 антитела EA029954B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23021109P 2009-07-31 2009-07-31
EP09009942A EP2281844A1 (en) 2009-07-31 2009-07-31 MUC 1 antibodies
PCT/EP2010/004663 WO2011012309A1 (en) 2009-07-31 2010-07-30 Muc1 antibodies

Publications (2)

Publication Number Publication Date
EA201270207A1 EA201270207A1 (ru) 2012-07-30
EA029954B1 true EA029954B1 (ru) 2018-06-29

Family

ID=41460131

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270207A EA029954B1 (ru) 2009-07-31 2010-07-30 Анти-muc1 антитела

Country Status (17)

Country Link
US (1) US9217038B2 (enExample)
EP (3) EP2281844A1 (enExample)
JP (2) JP5922018B2 (enExample)
KR (1) KR101773506B1 (enExample)
CN (1) CN102574926B (enExample)
AR (1) AR077334A1 (enExample)
AU (1) AU2010278302B2 (enExample)
BR (1) BR112012002226A2 (enExample)
CA (1) CA2768888C (enExample)
CU (1) CU23972B1 (enExample)
EA (1) EA029954B1 (enExample)
IL (1) IL217827A (enExample)
MX (1) MX2012000874A (enExample)
NZ (1) NZ597563A (enExample)
SG (2) SG177527A1 (enExample)
WO (1) WO2011012309A1 (enExample)
ZA (1) ZA201200166B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2073842E (pt) 2006-09-10 2015-04-07 Glycotope Gmbh Utilização de células humanas provenientes de uma leucemia mielóide para expressão de anticorpos
EP1920782A1 (en) * 2006-11-10 2008-05-14 Glycotope Gmbh Carboyhdrate specific cellular immunity inducing microorganisms and fractions thereof
EP2281844A1 (en) 2009-07-31 2011-02-09 Glycotope GmbH MUC 1 antibodies
US8518405B2 (en) 2009-10-08 2013-08-27 The University Of North Carolina At Charlotte Tumor specific antibodies and uses therefor
JP6334166B2 (ja) 2010-08-10 2018-05-30 グリコトープ ゲーエムベーハー Ｆａｂグリコシル化抗体
US9845362B2 (en) 2010-10-08 2017-12-19 The University Of North Carolina At Charlotte Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same
WO2013026887A1 (en) 2011-08-22 2013-02-28 Glycotope Gmbh Microorganisms carrying a tumor antigen
CN103848890B (zh) * 2012-11-30 2015-09-09 北京市结核病胸部肿瘤研究所 Muc1自身抗体识别的抗原多肽
EP2963126B1 (en) * 2013-03-01 2019-04-03 Saitama Medical University Method for evaluating side-effect onset risk in anticancer drug treatment, including detecting muc4 gene polymorphism
US10208125B2 (en) * 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
EP3127919A4 (en) * 2014-02-06 2017-08-16 Medicinal Chemistry Pharmaceuticals Co., Ltd. Antibody against mucin 4 (muc 4) glycopeptide and use therefor
CA2947404C (en) * 2014-04-28 2023-05-16 Medicinal Chemistry Pharmaceuticals, Co., Ltd. Anti-muc1 antibody or antigen-binding fragment thereof and uses thereof
WO2016026143A1 (en) * 2014-08-22 2016-02-25 Huiru Wang Saccharide-based biomarkers and therapeutics
US11554181B2 (en) 2014-09-05 2023-01-17 The University Of North Carolina At Charlotte Tumor specific antibody conjugates and uses therefor
WO2016130726A1 (en) * 2015-02-10 2016-08-18 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
WO2017139975A1 (en) 2016-02-19 2017-08-24 Huiru Wang Antibodies against n-acetylglucosamine and n-acetyl-galactosamine
EP3543337B1 (en) 2016-11-18 2022-04-20 Astellas Pharma Inc. Novel anti-human muc1 antibody fab fragment
EP3570881A4 (en) * 2017-01-18 2020-08-19 Nanocruise Pharmaceutical Ltd. MONOCLONAL AND HUMANIZED ANTIBODIES DIRECTED AGAINST CANCER GLYCOPEPTIDE
EP3574015A1 (en) * 2017-01-27 2019-12-04 Glycotope GmbH Anti-cancer treatments with an anti-muc1 antibody and an erbb inhibitor
JP2020511959A (ja) 2017-03-29 2020-04-23 グリコトープ ゲーエムベーハー ヒト化抗ｃｄ４０抗体
CA3057758A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Pd-l1 and ta-muc1 antibodies
CA3055438A1 (en) * 2017-03-29 2018-10-04 Glycotope Gmbh Multispecific antibody constructs binding to muc1 and cd3
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
CN117003875A (zh) 2017-09-29 2023-11-07 第一三共株式会社 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用
US11161911B2 (en) 2017-10-23 2021-11-02 Go Therapeutics, Inc. Anti-glyco-MUC1 antibodies and their uses
EP3700936A4 (en) * 2017-10-24 2021-05-26 Go Therapeutics, Inc. ANTI-GLYCO-MUC1 ANTIBODIES AND THEIR USES
CN111819203A (zh) * 2018-03-01 2020-10-23 葛莱高托普有限公司 包含抗muc1抗体和il-15的融合蛋白构建体
WO2019221269A1 (ja) * 2018-05-17 2019-11-21 アステラス製薬株式会社 抗ヒトＭＵＣ１抗体Ｆａｂフラグメント、ペプチドリンカー及び／又は配位子を含む複合体
SG11202010496WA (en) 2018-05-18 2020-12-30 Daiichi Sankyo Co Ltd Anti-muc1 antibody-drug conjugate
CN108982854B (zh) * 2018-06-19 2021-07-27 哈尔滨医科大学 蛋白质muc13在制备诊断肝内胆管癌的试剂中的应用
EP3814384A4 (en) * 2018-06-29 2022-03-23 Go Therapeutics, Inc. ANTI-GLYC0-MUC1 ANTIBODIES AND THEIR USES
CN112839683B (zh) 2018-10-10 2023-11-14 安斯泰来制药株式会社 含有标记部-抗人抗体Fab片段复合物的药物组合物
TWI856078B (zh) 2019-03-25 2024-09-21 日商第一三共股份有限公司 抗體–吡咯并苯二氮呯衍生物結合物、其製造方法及其用途
CA3139180A1 (en) 2019-03-27 2020-10-01 Daiichi Sankyo Company, Limited Combination of antibody-pyrrolobenzodiazepine derivative conjugate and parp inhibitor
CN118475617A (zh) * 2021-12-21 2024-08-09 美勒斯公司 针对与癌症相关的muc1的结合域
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
TW202506190A (zh) 2023-04-05 2025-02-16 日商第一三共股份有限公司 利用抗ｍｕｃ１抗體－藥物結合物投予的藥劑低敏感性癌之治療方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060292643A1 (en) * 2003-01-23 2006-12-28 Steffen Goletz Recognition molecules for the treatment and detection of tumours

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5683674A (en) 1987-01-07 1997-11-04 Imperial Cancer Research Technology Ltd. Antibody against human mucin core protein and method of preparing and using same
DE69329643T2 (de) 1992-04-13 2001-03-01 Dana-Farber Cancer Institute, Inc. Gegen karzinom-assoziierte antigene gerichtete antikörper
US5804187A (en) 1992-11-16 1998-09-08 Cancer Research Fund Of Contra Costa Modified antibodies with human milk fat globule specificity
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US6465220B1 (en) 1998-12-21 2002-10-15 Glycozym Aps Glycosylation using GalNac-T4 transferase
US7147850B2 (en) 1999-08-18 2006-12-12 Altarex Medical Corp. Therapeutic binding agents against MUC-1 antigen and methods for their use
ATE290879T1 (de) 1999-08-18 2005-04-15 Altarex Medical Corp Therapeutische antikörper gegen das muc-1 antigen und verfahren zu deren verwendung
GB0029360D0 (en) 2000-12-01 2001-01-17 Univ Nottingham Humanised antibodies and uses thereof
PT1529060E (pt) 2002-07-22 2014-11-28 Glycotope Gmbh Processo para a produção de uma mucina imuno-estimuladora (muc1)
SI1530628T1 (sl) 2002-08-16 2011-02-28 Glycotope Gmbh Postopek za proizvodnjo s temperaturo induciranih lizatov tumorskih celic za uporabo kot imunogenske spojine
PT1654353E (pt) 2003-08-18 2013-08-23 Glycotope Gmbh Linhas de células tumorais nm f9 (dsm acc2606) e nm d4 (dsm acc2605), suas utilizações
JP4913604B2 (ja) 2004-02-13 2012-04-11 グリコトープ ゲーエムベーハー 高活性糖タンパク質−製造条件、及びその効率的製造方法
PT2073842E (pt) 2006-09-10 2015-04-07 Glycotope Gmbh Utilização de células humanas provenientes de uma leucemia mielóide para expressão de anticorpos
EP2281844A1 (en) 2009-07-31 2011-02-09 Glycotope GmbH MUC 1 antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060292643A1 (en) * 2003-01-23 2006-12-28 Steffen Goletz Recognition molecules for the treatment and detection of tumours

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALMAGRO JUAN C; FRANSSON JOHAN: "Humanization of antibodies", FRONTIERS IN BIOSCIENCE, FRONTIERS IN BIOSCIENCE, ALBERTSON, NY, US, vol. 13, 1 January 2008 (2008-01-01), US, pages 1619 - 1633, XP009126790, ISSN: 1093-9946 *
ANTJE DANIELCZYK ; RENATE STAHN ; DORIAN FAULSTICH ; ANJA L�FFLER ; ANGELA M�RTEN ; UWE KARSTEN ; STEFFEN GOLETZ: "PankoMab: a potent new generation anti-tumour MUC1 antibody", CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN, DE, vol. 55, no. 11, 17 February 2006 (2006-02-17), Berlin, DE, pages 1337 - 1347, XP019422497, ISSN: 1432-0851, DOI: 10.1007/s00262-006-0135-9 *
PRICE M. R., ET AL.: "SUMMARY REPORT ON THE ISOBM TD-4 WORKSHOP: ANALYSIS OF 56 MONOCLONAL ANTIBODIES AGAINST THE MUC1 MUCIN.", TUMOR BIOLOGY, KARGER, BASEL, CH, vol. 19., no. SUPPL. 01., 1 January 1998 (1998-01-01), CH, pages 01 - 20., XP002071245, ISSN: 1010-4283, DOI: 10.1159/000056500 *

Also Published As

Publication number Publication date
AR077334A1 (es) 2011-08-17
US9217038B2 (en) 2015-12-22
WO2011012309A8 (en) 2011-04-07
ZA201200166B (en) 2013-03-27
AU2010278302A1 (en) 2012-02-09
JP2013500703A (ja) 2013-01-10
JP2016041771A (ja) 2016-03-31
JP6272916B2 (ja) 2018-01-31
IL217827A (en) 2017-05-29
CN102574926A (zh) 2012-07-11
EA201270207A1 (ru) 2012-07-30
EP3421497A1 (en) 2019-01-02
SG177527A1 (en) 2012-02-28
IL217827A0 (en) 2012-03-29
WO2011012309A1 (en) 2011-02-03
EP2459595A1 (en) 2012-06-06
US20120128676A1 (en) 2012-05-24
BR112012002226A2 (pt) 2016-11-08
EP2281844A1 (en) 2011-02-09
AU2010278302B2 (en) 2014-12-18
JP5922018B2 (ja) 2016-05-24
CU23972B1 (es) 2013-12-27
CN102574926B (zh) 2014-10-15
CA2768888A1 (en) 2011-02-03
KR101773506B1 (ko) 2017-08-31
MX2012000874A (es) 2012-02-01
SG10201404019XA (en) 2014-09-26
NZ597563A (en) 2013-08-30
CA2768888C (en) 2019-02-26
CU20120019A7 (es) 2012-06-21
KR20120051724A (ko) 2012-05-22

Similar Documents

Publication Publication Date Title
EA029954B1 (ru) Анти-muc1 антитела
CN104662044B (zh) 用于治疗ror1癌症并抑制转移的抗体和疫苗
KR102316091B1 (ko) Bcma를 표적으로 하는 키메라 항원 수용체 및 이의 용도
Masuko et al. Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells
CN120365432A (zh) 双特异性抗体
WO2011054359A2 (en) Method for early detection of cancer
EP3556771B1 (en) Anti-claudin 5 antibody, and medicine containing said antibody
JP2022513008A (ja) 融合タンパク質およびその使用
WO2015076425A1 (ja) 新規モノクローナル抗体
CN104098698A (zh) 一种抗cd3抗体及其制法和应用
dos Santos et al. Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer
Gellini et al. Generation of human single-chain antibody to the CD99 cell surface determinant specifically recognizing Ewing’s sarcoma tumor cells
EP3760722A1 (en) Anti-integrin alpha11 monoclonal antibody and use thereof
CN104470950B (zh) 抗cxadr抗体
JP7082112B2 (ja) 抗ｇｐｒ２０抗体
JP2021508468A (ja) メディトープ対応ｔ細胞
CN111479827B (zh) 结合hERG1和hERG1/整联蛋白β1的单特异性和双特异性抗体
EP4567045A1 (en) Anti-ddr2 nano-antibody and use thereof
KR102757518B1 (ko) Cd47에 특이적인 항체 및 이의 용도
JP2013013327A (ja) Ｍａｎｓｃ１蛋白質に結合し、抗癌活性を有する抗体
RU2794450C2 (ru) Гуманизированные антитела против psma
TW202535920A (zh) 程序性死亡配體1（pd-l1）嵌合抗原受體及其應用
JP4473730B2 (ja) 過剰増殖性細胞を認識する抗体ならびにその作製および使用方法
WO2024093147A1 (zh) 一种特异性结合CD44的v5外显子的抗体及其用途
WO2025012620A1 (en) Binding constructs