CN102552106A - 延长缓释超过2个月的类固醇眼内植入物 - Google Patents

延长缓释超过2个月的类固醇眼内植入物 Download PDF

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Publication number
CN102552106A
CN102552106A CN2012100012851A CN201210001285A CN102552106A CN 102552106 A CN102552106 A CN 102552106A CN 2012100012851 A CN2012100012851 A CN 2012100012851A CN 201210001285 A CN201210001285 A CN 201210001285A CN 102552106 A CN102552106 A CN 102552106A
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China
Prior art keywords
implant
steroid
release
polymer
hole
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Pending
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CN2012100012851A
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English (en)
Chinese (zh)
Inventor
G·T·黄
T·尼维吉利
L·T·斯帕达
杉本博
W·M·布兰达
张念原
O·奥勒尼克
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Allergan Inc
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Allergan Inc
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Publication of CN102552106A publication Critical patent/CN102552106A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
CN2012100012851A 2004-04-30 2005-04-28 延长缓释超过2个月的类固醇眼内植入物 Pending CN102552106A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/837,356 2004-04-30
US10/837,356 US8119154B2 (en) 2004-04-30 2004-04-30 Sustained release intraocular implants and related methods

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2005800137427A Division CN1972678B (zh) 2004-04-30 2005-04-28 延长缓释超过2个月的类固醇眼内植入物

Publications (1)

Publication Number Publication Date
CN102552106A true CN102552106A (zh) 2012-07-11

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN2012100012851A Pending CN102552106A (zh) 2004-04-30 2005-04-28 延长缓释超过2个月的类固醇眼内植入物
CN2005800137427A Expired - Lifetime CN1972678B (zh) 2004-04-30 2005-04-28 延长缓释超过2个月的类固醇眼内植入物

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CN2005800137427A Expired - Lifetime CN1972678B (zh) 2004-04-30 2005-04-28 延长缓释超过2个月的类固醇眼内植入物

Country Status (18)

Country Link
US (6) US8119154B2 (enExample)
EP (1) EP1750688B1 (enExample)
JP (2) JP5009786B2 (enExample)
KR (1) KR101117919B1 (enExample)
CN (2) CN102552106A (enExample)
AR (1) AR048725A1 (enExample)
AT (1) ATE381928T1 (enExample)
AU (3) AU2005240092B2 (enExample)
BR (1) BRPI0509333A (enExample)
CA (2) CA2774146A1 (enExample)
DE (1) DE602005004022T2 (enExample)
DK (1) DK1750688T3 (enExample)
ES (1) ES2297716T3 (enExample)
MX (1) MXPA06012289A (enExample)
NZ (1) NZ549825A (enExample)
PL (1) PL1750688T3 (enExample)
TW (1) TWI354558B (enExample)
WO (1) WO2005107727A1 (enExample)

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陈祖基: "眼植入剂—一种新的眼用药物长效定量缓释制剂", 《国外医学眼科学分册》 *

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