CN102548981B - N1-酰基-5-氟嘧啶酮衍生物 - Google Patents
N1-酰基-5-氟嘧啶酮衍生物 Download PDFInfo
- Publication number
- CN102548981B CN102548981B CN201080045370.7A CN201080045370A CN102548981B CN 102548981 B CN102548981 B CN 102548981B CN 201080045370 A CN201080045370 A CN 201080045370A CN 102548981 B CN102548981 B CN 102548981B
- Authority
- CN
- China
- Prior art keywords
- phenyl
- herbicides
- insecticides
- compounds
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- JBLJSEJOJGOMSW-UHFFFAOYSA-N CN(Cc1ccccc1)C(C(F)=CN1)=NC1=O Chemical compound CN(Cc1ccccc1)C(C(F)=CN1)=NC1=O JBLJSEJOJGOMSW-UHFFFAOYSA-N 0.000 description 1
- JPQWLWFWPXNLPS-UHFFFAOYSA-N CN(Cc1ccccc1)C(C(F)=CN1C(c2ccc[s]2)=O)=NC1=O Chemical compound CN(Cc1ccccc1)C(C(F)=CN1C(c2ccc[s]2)=O)=NC1=O JPQWLWFWPXNLPS-UHFFFAOYSA-N 0.000 description 1
- YXISIJYSMOEQKS-UHFFFAOYSA-N CN(Cc1ccccc1)c(nc(nc1)Cl)c1F Chemical compound CN(Cc1ccccc1)c(nc(nc1)Cl)c1F YXISIJYSMOEQKS-UHFFFAOYSA-N 0.000 description 1
- WHPFEQUEHBULBW-UHFFFAOYSA-N Fc(cnc(Cl)n1)c1Cl Chemical compound Fc(cnc(Cl)n1)c1Cl WHPFEQUEHBULBW-UHFFFAOYSA-N 0.000 description 1
- QIQITDHWZYEEPA-UHFFFAOYSA-N O=C(c1ccc[s]1)Cl Chemical compound O=C(c1ccc[s]1)Cl QIQITDHWZYEEPA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23222309P | 2009-08-07 | 2009-08-07 | |
| US61/232,223 | 2009-08-07 | ||
| PCT/US2010/044576 WO2011017538A1 (en) | 2009-08-07 | 2010-08-05 | N1-acyl-5-fluoropyrimidinone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102548981A CN102548981A (zh) | 2012-07-04 |
| CN102548981B true CN102548981B (zh) | 2015-05-13 |
Family
ID=43535292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080045370.7A Active CN102548981B (zh) | 2009-08-07 | 2010-08-05 | N1-酰基-5-氟嘧啶酮衍生物 |
Country Status (33)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA106764C2 (uk) * | 2009-08-07 | 2014-10-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-сульфоніл-5-фторпіримідинону |
| KR102012992B1 (ko) * | 2011-08-17 | 2019-08-21 | 아다마 마켓심 리미티드 | 5-플루오로-4-이미노-3-(치환된)-3,4-디히드로피리미딘-2-(1ｈ)-온 유도체 |
| HK1214518A1 (zh) * | 2012-12-28 | 2016-07-29 | Adama Makhteshim Ltd. | 1-(经取代之苯甲醯基)-5-氟-4-亚胺基-3-甲基-3，4-二氢嘧啶-2(1h)-酮衍生物 |
| US9622474B2 (en) | 2012-12-28 | 2017-04-18 | Adama Makhteshim Ltd. | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxylate derivatives |
| US9321734B2 (en) | 2012-12-28 | 2016-04-26 | Dow Agrosciences Llc | N-(substituted)-5-fluoro-4-imino-3-methyl-2-oxo-3,4-dihydropyrimidine-1(2H)-carboxamide derivatives |
| AU2013370494B2 (en) | 2012-12-31 | 2017-08-17 | Adama Makhteshim Ltd. | 3-alkyl-5-fluoro-4-substituted-imino-3,4-dihydropyrimidin-2(1H)-one derivatives as fungicides |
| CN106068268A (zh) | 2013-12-31 | 2016-11-02 | 阿达玛马克西姆股份有限公司 | 5‑氟‑4‑亚氨基‑3‑（烷基/取代烷基）‑1‑（芳基磺酰基）‑3,4‑二氢嘧啶‑2（1h）‑酮及其制备方法 |
| EA030056B1 (ru) | 2013-12-31 | 2018-06-29 | Адама Мактешим Лтд. | Синергетические фунгицидные смеси и синергетические фунгицидные композиции для борьбы с грибами |
| EP3197903B1 (en) | 2014-09-26 | 2019-11-27 | The Chemours Company FC, LLC | Isocyanate derived organosilanes |
| MA49639A (fr) | 2017-07-17 | 2020-05-27 | Adama Makhteshim Ltd | Polymorphes de 5-fluoro-4-imino-3-méthyl-1-tosyl-3,4-dihydropyrimidin-2-one |
| CR20210270A (es) | 2018-11-05 | 2021-07-20 | Adama Makhteshim Ltd | Mezclas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2-ona, y métodos de uso de los mismos |
| US12466796B2 (en) | 2019-09-23 | 2025-11-11 | Adama Makhteshim Ltd. | Process for preparing 5-(fluoro-4-imino-3-methyl)-1-tosyl-3,4 dihydropyrimidine-(1H)-one and derivatives of the compound |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH421973A (de) * | 1962-05-01 | 1966-10-15 | Hoffmann La Roche | Verfahren zur Herstellung eines Cytosin-Derivates |
| US3309359A (en) | 1965-10-22 | 1967-03-14 | Hoffmann La Roche | N-mono-acyl-5-fluorocytosine derivatives and process |
| US3368938A (en) * | 1966-01-13 | 1968-02-13 | Hoffmann La Roche | Controlling fungi with 5-fluorocytosine |
| US3868373A (en) | 1970-01-27 | 1975-02-25 | Hoffmann La Roche | 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines |
| CH579057A5 (enExample) | 1973-09-07 | 1976-08-31 | Hoffmann La Roche | |
| FR2530636A1 (fr) | 1982-07-23 | 1984-01-27 | Rhone Poulenc Agrochimie | Nouveaux derives de la tetrahydro-2,3,6,7 5h-thiazolo (3,2-a) pyrimidine, leur preparation et leur utilisation comme herbicides |
| GR80171B (en) | 1983-08-29 | 1985-01-02 | Ciba Geigy Ag | N-(2-nitrophenyl)-4-aminopyrimidine derivatives process for the preparation thereof and use |
| US4845081A (en) | 1984-10-18 | 1989-07-04 | University Of Florida | Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes |
| ES2057172T3 (es) | 1988-03-09 | 1994-10-16 | Ciba Geigy Ag | Agente para la proteccion de plantas contra enfermedades. |
| DE3821711A1 (de) | 1988-06-28 | 1990-02-08 | Bayer Ag | Thiazolopyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel |
| JP3217191B2 (ja) | 1992-07-16 | 2001-10-09 | ビーエーエスエフ アクチェンゲゼルシャフト | ヘテロ芳香族化合物およびこれを含有する植物保護剤 |
| ES2167586T3 (es) | 1995-07-05 | 2002-05-16 | Du Pont | Pirimidinonas fungicidas. |
| AU716248B2 (en) * | 1996-03-11 | 2000-02-24 | Novartis Ag | Pyrimidin-4-one derivatives as pesticide |
| HRP970239B1 (en) | 1997-05-09 | 2004-04-30 | Inst Ru Er Bouekovic | Process for the preparation of sulfonyl-pyrimidine derivatives with antitumor activity |
| GT199900185A (es) | 1998-11-06 | 2001-04-18 | Novedosa pirimidin-4-enamina como fungicida. | |
| US7914799B2 (en) | 2001-08-27 | 2011-03-29 | Immunitor USA, Inc. | Anti-fungal composition |
| WO2005095419A1 (ja) | 2004-04-01 | 2005-10-13 | Takeda Pharmaceutial Company Limited | チアゾロピリミジン誘導体 |
| WO2008005303A2 (en) | 2006-06-30 | 2008-01-10 | Janssen Pharmaceutica N.V. | Thiazolopyrimidine modulators of trpv1 |
| PT2252594E (pt) | 2008-01-22 | 2015-11-30 | Dow Agrosciences Llc | Derivados de 5-fluoro-pirimidina como fungicidas |
| UA107651C2 (en) | 2008-08-01 | 2015-02-10 | Dow Agrosciences Llc | Use of 5-fluorocytosine as a fungicide |
| ME02254B (me) | 2009-01-23 | 2015-12-31 | Euro Celtique Sa | Derivati hidroksamske kiseline |
| UA106764C2 (uk) | 2009-08-07 | 2014-10-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Похідні n1-сульфоніл-5-фторпіримідинону |
-
2010
- 2010-05-08 UA UAA201202731A patent/UA106889C2/uk unknown
- 2010-08-05 AU AU2010279402A patent/AU2010279402B2/en not_active Ceased
- 2010-08-05 EA EA201270253A patent/EA023411B1/ru not_active IP Right Cessation
- 2010-08-05 CN CN201080045370.7A patent/CN102548981B/zh active Active
- 2010-08-05 PE PE2012000169A patent/PE20120688A1/es not_active Application Discontinuation
- 2010-08-05 WO PCT/US2010/044576 patent/WO2011017538A1/en not_active Ceased
- 2010-08-05 PL PL10807171T patent/PL2519512T3/pl unknown
- 2010-08-05 MX MX2012001620A patent/MX2012001620A/es active IP Right Grant
- 2010-08-05 US US12/851,236 patent/US8470839B2/en active Active - Reinstated
- 2010-08-05 HR HRP20190919TT patent/HRP20190919T1/hr unknown
- 2010-08-05 IN IN539DEN2012 patent/IN2012DN00539A/en unknown
- 2010-08-05 ES ES10807171T patent/ES2728966T3/es active Active
- 2010-08-05 LT LTEP10807171.3T patent/LT2519512T/lt unknown
- 2010-08-05 PT PT10807171T patent/PT2519512T/pt unknown
- 2010-08-05 DK DK10807171.3T patent/DK2519512T3/da active
- 2010-08-05 SI SI201031893T patent/SI2519512T1/sl unknown
- 2010-08-05 HU HUE10807171A patent/HUE045290T2/hu unknown
- 2010-08-05 EP EP10807171.3A patent/EP2519512B1/en active Active
- 2010-08-05 CA CA2768510A patent/CA2768510C/en not_active Expired - Fee Related
- 2010-08-05 KR KR1020127005927A patent/KR101792285B1/ko not_active Expired - Fee Related
- 2010-08-05 NZ NZ597570A patent/NZ597570A/en unknown
- 2010-08-05 BR BR112012002810-3A patent/BR112012002810B1/pt active IP Right Grant
- 2010-08-05 TR TR2019/08180T patent/TR201908180T4/tr unknown
- 2010-08-05 JP JP2012523950A patent/JP5748754B2/ja active Active
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2012
- 2012-01-18 CR CR20120030A patent/CR20120030A/es unknown
- 2012-02-02 ZA ZA2012/00819A patent/ZA201200819B/en unknown
- 2012-02-02 HN HN2012000269A patent/HN2012000269A/es unknown
- 2012-02-03 NI NI201200022A patent/NI201200022A/es unknown
- 2012-02-05 IL IL217952A patent/IL217952A/en active IP Right Grant
- 2012-02-06 CO CO12019954A patent/CO6491117A2/es active IP Right Grant
- 2012-02-06 CL CL2012000316A patent/CL2012000316A1/es unknown
- 2012-02-07 EC ECSP12011653 patent/ECSP12011653A/es unknown
-
2019
- 2019-06-06 CY CY20191100603T patent/CY1122115T1/el unknown
Non-Patent Citations (2)
| Title |
|---|
| Nucleosides with furanyl scaffolds;Sanjib Bera,et al.;《Tetrahedron》;20021231;第58卷;4865-4871 * |
| Nucleosides. XXXIII. N4-Acylated 5-Fluorocytosines and a Direct Synthesis of 5-Fluoro-2"-deoxycytidine;R. DUSCHINSKY,et al.;《Journal of medicinal chemistry》;19660731;第9卷;566-572 * |
Also Published As
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1172894 Country of ref document: HK |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Boebel Timothy Inventor after: Bryan Kristy Inventor after: Lorsbach Beth Inventor after: Martin Teresita Inventor after: Owen W. John Inventor after: Pobanz Mark Inventor after: Thornburgh Scott Inventor after: Webster Jeffery Inventor after: Yao Chenglin Inventor before: Boebel Timothy Inventor before: Bryan Kristy Inventor before: Lorsbach Beth Inventor before: Martin Teresita Inventor before: Owen W. Inventor before: Pobanz Mark Inventor before: Thornburgh Scott Inventor before: Webster Jeffery Inventor before: Yao Chenglin |
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| COR | Change of bibliographic data | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1172894 Country of ref document: HK |
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| TR01 | Transfer of patent right |
Effective date of registration: 20161222 Address after: Beersheba, Israel Patentee after: ADAMA MAKHTESHIM LTD. Address before: indiana Patentee before: Dow Agrosciences LLC |
|
| TR01 | Transfer of patent right |