CN102532229B - 一类含有原酸酯基团的孕甾烷糖苷类化合物及其用途 - Google Patents

一类含有原酸酯基团的孕甾烷糖苷类化合物及其用途 Download PDF

Info

Publication number
CN102532229B
CN102532229B CN201010589234.6A CN201010589234A CN102532229B CN 102532229 B CN102532229 B CN 102532229B CN 201010589234 A CN201010589234 A CN 201010589234A CN 102532229 B CN102532229 B CN 102532229B
Authority
CN
China
Prior art keywords
extract
obtains
volume ratio
mouse
medicinal extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201010589234.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN102532229A (zh
Inventor
赵维民
左建平
杨以阜
王罗医
杨扬
陈振华
唐炜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Materia Medica of CAS
Original Assignee
Shanghai Institute of Materia Medica of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Institute of Materia Medica of CAS filed Critical Shanghai Institute of Materia Medica of CAS
Priority to CN201010589234.6A priority Critical patent/CN102532229B/zh
Priority to PCT/CN2011/002023 priority patent/WO2012079279A1/fr
Publication of CN102532229A publication Critical patent/CN102532229A/zh
Application granted granted Critical
Publication of CN102532229B publication Critical patent/CN102532229B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201010589234.6A 2010-12-15 2010-12-15 一类含有原酸酯基团的孕甾烷糖苷类化合物及其用途 Active CN102532229B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201010589234.6A CN102532229B (zh) 2010-12-15 2010-12-15 一类含有原酸酯基团的孕甾烷糖苷类化合物及其用途
PCT/CN2011/002023 WO2012079279A1 (fr) 2010-12-15 2011-12-02 Composés prégnane glycosides contenant des groupes ortho-esters et leur utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201010589234.6A CN102532229B (zh) 2010-12-15 2010-12-15 一类含有原酸酯基团的孕甾烷糖苷类化合物及其用途

Publications (2)

Publication Number Publication Date
CN102532229A CN102532229A (zh) 2012-07-04
CN102532229B true CN102532229B (zh) 2015-01-07

Family

ID=46244013

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201010589234.6A Active CN102532229B (zh) 2010-12-15 2010-12-15 一类含有原酸酯基团的孕甾烷糖苷类化合物及其用途

Country Status (2)

Country Link
CN (1) CN102532229B (fr)
WO (1) WO2012079279A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107759653B (zh) * 2016-08-16 2020-05-12 中国科学院上海药物研究所 一类三萜化合物、其制备方法及用途
CN107056855A (zh) * 2017-03-24 2017-08-18 昆明理工大学 一种16,17开环孕甾烷糖苷化合物及其应用
CN108785321B (zh) * 2017-04-28 2021-02-05 南京葆赫生物技术有限公司 黑骨藤c21甾类化合物在制备ido抑制剂中的用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593503A (zh) * 2004-07-13 2005-03-16 天津中医学院 香加皮强心作用有效提取物、制备方法及用途
CN1939324A (zh) * 2005-09-29 2007-04-04 中国科学院上海药物研究所 杠柳苷a和e的医学用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1593503A (zh) * 2004-07-13 2005-03-16 天津中医学院 香加皮强心作用有效提取物、制备方法及用途
CN1939324A (zh) * 2005-09-29 2007-04-04 中国科学院上海药物研究所 杠柳苷a和e的医学用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii;Feng, Jiaquan等;《Phytochemistry》;20081001;第69卷(第15期);2716-2723 *

Also Published As

Publication number Publication date
WO2012079279A1 (fr) 2012-06-21
CN102532229A (zh) 2012-07-04

Similar Documents

Publication Publication Date Title
TW201505645A (zh) 降脂護肝中藥組合物及其製備方法和應用
KR102271821B1 (ko) 오를리스타트 및 아커만시아 뮤시니필라 eb-amdk19 균주를 포함하는 조성물
CN102532229B (zh) 一类含有原酸酯基团的孕甾烷糖苷类化合物及其用途
CN101250207B (zh) 鸡骨草总黄酮碳苷有效部位、其制备方法和用途
KR19990015612A (ko) 황백피와 마타리 식물의 혼합추출물을 함유하는 c형 간염 치료제조성물
CN108159204B (zh) 一种具有解毒保肝作用的藏药组合物
KR100414187B1 (ko) 흰점박이꽃무지 추출물 및 이의 용도
CN109568419B (zh) 一种巴戟天总环烯醚萜苷及其制备方法和用途
CN101152234B (zh) 杜仲木脂素及其提取物在抗心血管重塑上的应用
CN100493522C (zh) 一种苦参素和多糖的药物组合物
CN102462772A (zh) 胡黄连总苷提取物在制备用于预防和治疗脂肪肝药物中的用途
CN109876088A (zh) 一种通过调节肠道菌群平衡发挥降糖作用的天然降糖制剂
CN103845354A (zh) 一种含有龙胆苦苷的药物组合物及其制剂和用途
CN1977888B (zh) 一种由黄芩苷、灵芝和丹参制成的药物组合物
CN103223144B (zh) 一种防治肝癌的中药组合物
CN110885385B (zh) 翼首草毒素a及其应用和低肝损伤毒性翼首草提取物的制备方法
CN102138965B (zh) 花锚提取物及其制备方法、药物组合物和用途
CN101880217A (zh) 一种治疗免疫疾病的药物组合物、其制备及用途
CN101108190B (zh) 隐丹参酮在制备防治自身免疫性疾病药中的应用
CN101537086A (zh) 一种抗乙型肝炎病毒、降脂和减轻脂肪肝病变的药物组合物及其制备方法
CN1970001A (zh) 一种苦参素、五味子和人参配伍的治疗肝炎的药物组合物
CN101322735A (zh) 雷公藤减毒炮制的优化方法及相关制剂
CN101049336B (zh) 一种抗癌药物组合物
WO2012167457A1 (fr) Utilisation de la flavone globale d'hypericum japonicum thunb. dans la préparation d'un médicament destiné au traitement de la fibrose hépatique
CN103479601A (zh) 油松节中茋类化合物作为免疫抑制活性成分在制备药物或保健品中的用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant