CN102526600A

CN102526600A - Drug for curing persistent high fever caused by leukemia

Info

Publication number: CN102526600A
Application number: CN2012100514947A
Authority: CN
Inventors: 郭完祥
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-03-01
Filing date: 2012-03-01
Publication date: 2012-07-04

Abstract

The invention relates to a drug which is prepared by taking traditional Chinese medicine as raw material and is used for curing a persistent high fever caused by leukemia. Powder of yellow weasel, powder of embryonated egg, Chinese date, tsaoko, magnolia bark, areca seed, scutellaria root, anemarrhena rhizome, wrinkled giant hyssop, herb of forune eupatorium, carapax amydae, stellaria root, wofberry bark, honeysuckle flower, herb of sweet wormwood, root of kudzuvine, dark plum, the root of largeleaf gentian, plantain seed and rhinoceros horn are selected and cleaned through clear water, and uniformly mixed and crushed into 100 to 120 powder drug; and bacteria disinfection is performed, and then a powdered drug product is obtained according to the conventional method. The drug has the effects of nourishing yin to reduce pathogenic fire, facilitaing production of body fluids to extinguishthirst, removing toxic heat, removing heat from the blood and bringing down a fever, has obvious curative effect on fever caused by leukemia, and has little toxic and side effects.

Description

A kind of medicine of treating the leukemia high fever

Technical field

The present invention relates to a kind of medicine of treating the leukemia high fever, relating in particular to a kind of is the medicine of the treatment leukemia high fever of crude drug preparation with Chinese medicine.

Background technology

Leukemia is also referred to as leukemia, is the malignant clone property disease of hematopoietic stem cell.Hematopoietic stem cell among the human bone marrow can be made thousands of erythrocyte and leukocyte every day; But the jejune leukocyte of leukemia patient meeting excessive production harms other work of bone marrow; The function that makes bone marrow produce other hemocyte reduces, and has suppressed normal hematopoiesis.Leukemia occupies first in the sickness rate of department of pediatrics malignant tumor.Leukemic main clinical manifestation is that anemia, hemorrhage, infectious fever and each organ soak into symptom.Wherein infectious fever is one of common clinical manifestation of leukemia, and untimely treatment can increase the weight of the leukemia state of an illness, and causes other diseases.

The main Therapeutic Method of leukemia high fever is on the leukemic basis of treatment, use the antiinflammatory drug for abating fever, but actual effect is general more, and takes for a long time easily medicine is produced drug resistance, influences leukemic treatment.

Summary of the invention

The purpose of this invention is to provide that a kind of toxic and side effects is little, the medicine of therapeutic effect obvious treatment leukemia high fever.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Carnis Mustela powder 500～1000 Embryo Gallus domesticus powdered egg 500～1000 Fructus Jujubaes 1000～2000

Fructus Tsaoko 30～40 Cortex Magnoliae Officinalis 20～30 Semen Arecaes 30～40

Radix Scutellariae 30～60 Rhizoma Anemarrhenaes 20～30 Herba Pogostemoniss 30～40

Herba Eupatorii 30～40 Carapax Trionycis 30～60 Radix Stellariaes 30～40

Cortex Lycii 40～60 Flos Loniceraes 20～40 Herba Artemisiae Annuaes 30～40

Radix Puerariae 40～60 Fructus Mumes 40～50 Radix Gentianae Macrophyllae 20～30

Semen Plantaginis 20～30 Cornu rhinocerotis 2～3.

Wherein, described Carnis Mustela powder be with the Carnis Mustela of peeling hair in wine, soaks removing stench flavor after, dry, porphyrize obtains; Described Embryo Gallus domesticus powdered egg is when egg hatching extremely chicken feather do not occurred, with the yellow soil parcel, burns ripe back porphyrize and obtains.

The medicine of above-mentioned each component can be processed said peroral dosage form on any pharmaceuticss such as tablet, pill, powder, capsule, and the preferred dosage form of the present invention is a powder.

The concrete method for preparing of drug powder of the present invention is: said medicine by said parts by weight mix homogeneously, is ground into 100～120 purpose medicated powder, and sterilization makes the powder product.

Motherland's medical science thinks that leukemic pathogenic factor is a congenital defect, the vital essence loss, or multiple temperature-sensitive heresy causes; Since deficiency of vital QI, the susceptible exopathogen, the temperature poison is flourishing, and bone marrow caves in; Heat is disturbed nutrient blood makes myelocyteization give birth to against random functional disorder, imbalance of YIN and YANG; Deficiency of vital energy blood loses the basic reason that takes place for disease, and osteopyrexia and fever is to cause leukemic principal element, so the fever hyperpyrexia is one of leukemic common clinical symptoms.

In the prescription of the present invention, the Carnis Mustela powder is anticancer, change the effect of tumor, enhancing immunity, can improve hemoglobin, platelet increasing quantity, and for hepatopathy and thrombocytopenia, leukopenia, the hematopathy aspect truly has curative effect; Embryo Gallus domesticus powdered egg is nutritious; Contain protein, fat, vitamin and inorganic salt, ferment etc., these nutrition have very big effect to growth promoter, the good health and a long life of human body; Simultaneously because chicken embryo is fired with the yellow soil parcel, " go into spleen channel " and more strengthened the absorption of nutrition because of parching with earth; The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind; Fructus Tsaoko dampness warming middle-JIAO, the expectorant preventing the attack (or recurrence) of malaria; The expectorant of Cortex Magnoliae Officinalis dampness, the therapeutic method to keep the adverse QI flowing downwards is removed full; The Semen Arecae killing insect and eliminating accumulation, the capable water of sending down the abnormal ascending QI; The Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication; Rhizoma Anemarrhenae clearing away heat-fire promotes the production of body fluid and moisturizes; Herba Pogostemonis appetizing preventing or arresting vomiting is delivered expelling summer-heat; The Herba Eupatorii removing dampness by means of aromatics, expelling summer-heat is delivered in the appetizing of being amusing; The Carapax Trionycis nourishing YIN for suppressing the hyperactive YANG is brought down a fever to remove and is steamed hard masses softening and resolving; The Radix Stellariae clearind deficient heat, dispelling fever with infantile malnutrition; The Cortex Lycii removing heat from blood removes and steams the lung heat clearing pathogenic fire reducing; The Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens; The Herba Artemisiae Annuae clearing away summer-heat removes and steams; The Radix Puerariae expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst; Fructus Mume is astringed the lung, and astringing intestine to stop diarrhea promotes the production of body fluid; The Radix Gentianae Macrophyllae wind-damp dispelling, clearing away damp-heat; The Semen Plantaginis clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria; The Cornu rhinocerotis clearing away heat and cooling blood, detoxifcation.All medicines share, and can play nourishing YIN to lower pathogenic fire, promoting the production of body fluid to quench thirst, and the effect that heat-clearing and toxic substances removing, removing heat from blood are brought down a fever, evident in efficacy to the high fever that the treatment leukemia causes, toxic and side effects is little.

For further investigating the clinical efficacy of Drug therapy leukemia high fever of the present invention, select 20 routine acute myeloid leukemia patients to carry out clinical observation on the therapeutic effect.

1, clinical data

20 routine acute myeloid leukemia patients all are clinic case, wherein male 12 examples, women 8 examples; At minimum 9 years old of age, maximum 47 years old, all cases all possessed the clinical symptoms of acute myeloid leukemia; And make a definite diagnosis through auxiliary examinations such as hemogram, bone marrow smears, and all case body temperature every day have dizziness, spontaneous perspiration, inappetence between 39.5 ℃-40 ℃; Vomiting and nausea, the blood nosebleed is more than, the symptom of recurrent oral ulceration.

2, Therapeutic Method

Adopt powder agent medicine of the present invention, every day 4 times, each 30 grams.

3, criterion of therapeutical effect

The national leukemia chemotherapy symposium who holds with reference to Suzhou in 1987 goes up the standard of formulating, and the criterion of therapeutical effect that combines the clinical manifestation of leukemia high fever to formulate.

Clinical cure: stop chemotherapy 5 years or DFS and reach 10 years persons and be called clinical cure.

Clinical remission (being clinical produce effects again): the patient has 1011～1012/L leukaemia in the body at the initial stage of a disease; Can reduce to 109～1010/L through the treatment leukaemia; This moment is clinical symptom disappearance generally, and hemogram, bone marrow smear recover normal, are called clinical remission.

Part is alleviated (commentaries on classics of applauding again): hemogram does not recover normally, but hyperpyrexia fever phenomenon is alleviated or recovered normal.

Do not alleviate: bone marrow smear, hemogram and three of clinical manifestations all do not reach above-mentioned standard person.

4, therapeutic effect

The observation of curative effect result sees table 1

Table 1 acute myeloid leukemia high fever patient's clinical observation on the therapeutic effect

The example number	Clinical cure %	Clinical remission %	Part is alleviated %	Do not alleviate %	Total effective rate %
						20	9（45）	4（20）	7（35）	0（0）	20（100）

The clinical observation on the therapeutic effect result shows that Drug therapy leukemia high fever convenient drug administration of the present invention, evident in efficacy has no side effect, and cure rate is high.

The specific embodiment

Embodiment 1

Get the Carnis Mustela of fresh execution, remove fur, clean large intestine, all place wine to soak 7 days in meat, bone and internal organs, except that after the smelling removal, taking-up is dried, porphyrize obtains the Carnis Mustela powder.Do not take out when egg hatching extremely chicken feather occurred, ripe with yellow soil parcel burning, porphyrize obtains Embryo Gallus domesticus powdered egg.

Get Carnis Mustela powder 500g, Embryo Gallus domesticus powdered egg 500 g, Fructus Jujubae 1000 g, Fructus Tsaoko 30 g, Cortex Magnoliae Officinalis 20 g, Semen Arecae 30 g, Radix Scutellariae 30 g, the Rhizoma Anemarrhenae 20 g, Herba Pogostemonis 30 g, Herba Eupatorii 30 g, Carapax Trionycis 30 g, Radix Stellariae 30 g, Cortex Lycii 40 g, Flos Lonicerae 20 g, Herba Artemisiae Annuae 30 g, Radix Puerariae 40 g, Fructus Mume 40 g, Radix Gentianae Macrophyllae 20 g, Semen Plantaginis 20 g, Cornu rhinocerotis 2 g mix homogeneously selected, that clear water is cleaned; Be ground into 100～120 medicated powder, sterilization makes the powder product by conventional method.

Embodiment 2

Get Carnis Mustela powder 250g, Embryo Gallus domesticus powdered egg 250 g, Fructus Jujubae 500 g, Fructus Tsaoko 15g, Cortex Magnoliae Officinalis 10 g, Semen Arecae 15 g, Radix Scutellariae 15 g, Rhizoma Anemarrhenae 10g, Herba Pogostemonis 15 g, Herba Eupatorii 15 g, Carapax Trionycis 15g, Radix Stellariae 15 g, Cortex Lycii 20 g, Flos Lonicerae 10 g, Herba Artemisiae Annuae 15g, Radix Puerariae 20g, Fructus Mume 20g, Radix Gentianae Macrophyllae 10 g, Semen Plantaginis 10 g, Cornu rhinocerotis 1 g mix homogeneously selected, that clear water is cleaned; Be ground into 100～120 medicated powder, sterilization makes the powder product by conventional method.

Claims

1. medicine of treating the leukemia high fever is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Herba Eupatorii 30～40 Carapax Trionycis 30～60 Radix Stellariaes 30～40

Cortex Lycii 40～60 Flos Loniceraes 20～40 Herba Artemisiae Annuaes 30～40

Semen Plantaginis 20～30 Cornu rhinocerotis 2～3;

Described Carnis Mustela powder be with the Carnis Mustela of peeling hair in wine, soaks removing stench flavor after, dry, porphyrize obtains; Described Embryo Gallus domesticus powdered egg is when egg hatching extremely chicken feather do not occurred, with the yellow soil parcel, burns ripe back porphyrize and obtains.

2. the method for preparing of the medicine of the said treatment leukemia of claim 1 high fever is characterized in that: said medicine by said parts by weight mix homogeneously, is ground into 100～120 purpose medicated powder, and sterilization makes powder product .