CN103041318A - Traditional Chinese medicine composition for treating gosling viral hepatitis - Google Patents
Traditional Chinese medicine composition for treating gosling viral hepatitis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gosling viral hepatitis, comprising the following components in parts by weight: hypericum japonicum, sedum sarmentosum, gentian, isatis root, curcuma aromatica, polygonum cuspidatum, rheum officinale, fructus gardeniae, oriental wormwood, fructus forsythiae, poria cocos, rhizoma alismatis, radix bupleuri and liquorice. The traditional Chinese medicine composition for treating gosling viral hepatitis, disclosed by the invention, has the effects of clearing heat, promoting diuresis, purging fire while removing toxin, soothing liver-qi stagnation, removing heat from the liver and improving vision. The medicines are organically combined, dialectically matched and mutually assisted, and then the effects of the traditional Chinese medicine composition of clearing heat, promoting diuresis, purging fire and removing toxin are enhanced, so that the aim of healing oral lesions of gosling viral hepatitis is achieved. A traditional Chinese medicine decoction prepared by adopting the invention is more obvious in effect, and clinical applications show that the traditional Chinese medicine composition has a special effect on treating the gosling viral hepatitis. Clinical treatment statistics prove that the cure rate can be more than 94.83% and the effective rate is 98.86%.
Description
Technical field:
The invention belongs to the animal field of medicaments, particularly a kind of pure Chinese medicine decoction composition and method of making the same that is specifically designed to the young goose viral hepatitis for the treatment of.
Background technology
Young goose viral hepatitis is a kind of acute viral disease of young goose, and sick goose or be with malicious goose toxin expelling from feces pollutes feedstuff, drinking-water etc., by digestive tract and respiratory tract infection.Feeding and management is improper, is deficient in vitamin and mineral, and brood house humidity, low temperature and stocking density are excessive etc., all can accelerate the generation of primary disease.Be characterized in liver enlargement and hemorrhage speckle is arranged, morbidity is anxious, the course of disease is short, mortality rate is high, and the provisions goose is already caused very large loss.
1, epidemiology
Primary disease all can occur throughout the year, only betides duckling when naturally breaking out, and is mainly for 3 ages in week with interior duckling, and with 3-9 age in days susceptible, particularly the 7 age in days left and right sides are multiple, and adult duck is inapparent infection, without clinical symptoms, and does not affect laying rate, but can toxin expelling.The sickness rate in one age in week can be up to 100%, and it is about 50% that mortality rate can reach 95%, 2-3 mortality rate in age in week, and along with the growth of duckling age in days and the raising of immunity of organism level, mortality rate reduces gradually, and the M ﹠ M of duckling is all very low after 4 ages in week.Primary disease can be by digestive tract and respiratory tract infection, and main route of transmission is the immediate contagion with sick duck, the indirect infections such as feces that also can be by sick duck, tableware, drinking-water.In addition, feeding and management is not good at, and is deficient in vitamin in the feedstuff and mineral, and the goose house is moist, and is crowded, all can bring out primary disease.
2 clinical symptoms and pathological change
The normal non-evident sympton of morbus acutissimus example, or rarely seen opisthotonus, tic arranged, death falls down to the ground suddenly.It is extremely depressed that most sick young birds begin to show spirit, the necking down hogback, and the eye semi-closure is the lethargy shape, is slow in action.Poor appetite or absolutely useless, falling ill about 12-24 hour the whole body tic occurs, swings to a side, and head and neck is upwards to layback, and two lower limbs are kicked at random backward and are angle anti-sheet shape, or are clonospasm, and the initial stage, sick young amount of drinking water increased, and the later stage does not eat or drink.Dyspnea, beak and two pawl cyanosis, last how dying because dehydration dies of exhaustion.Cut open the inspection major lesions at liver, show as liver enlargement, matter is crisp, the surface is scattered with petechia or the ecchymosis shape that differs in size, and liver is the colour of loess or reddish yellow more.Abdominal viscera is congested, the gallbladder enlargement, and bile is thin., spleen renomegaly pancreas has hemorrhage speckle.
3, at present prophylactico-therapeutic measures
This disease is widely distributed, and more or less a hundred country all is found in the world wide, has caused great economic loss to aviculture.From treatment, modern veterinary mainly adopts various antiviral Western medicine, but effect is unsatisfactory, and some medicine, bans use of such as medicines such as amantadine, ribavirins.Although yolk antibody, hyper-immune serum and monoclonal antibody have good curative effect, because price is more expensive, the source of goods is in short supply, causes practical application less.Also have some Chinese medicine preparation, because its prescription is unreasonable or just simple pulverizing, particle diameter is excessive, and drug release is slower, causes its bioavailability lower, and clinical effectiveness is not fine.Therefore researching and developing a kind of specific medicament for the treatment of young goose viral hepatitis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention:
The object of the invention is to overcome at present in the weak point of the young goose viral hepatitis for the treatment of, provide a kind of draw materials easy, easy to prepare, reduce drug residue and toxic and side effects, and the decoction medicine of the higher young goose viral hepatitis for the treatment of of cheap curative effect.
A kind of Chinese medicine composition for the treatment of young goose viral hepatitis, its composition by weight is: Herba Hyperici Japonici 50-70 part, Herba Sedi 50-70 part, Radix Gentianae 40-60 part, Radix Isatidis 40-60 part, Radix Curcumae 30-50 part, Rhizoma Polygoni Cuspidati 30-50 part, Radix Et Rhizoma Rhei 30-50 part, Fructus Gardeniae 30-50 part, Herba Artemisiae Scopariae 30-50 part, Fructus Forsythiae 20-40 part, Poria 20-40 part, Rhizoma Alismatis 20-40 part, Radix Bupleuri 20-40 part, Radix Glycyrrhizae 20-40 part.
Preferred composition by weight is:
70 parts of Herba Hyperici Japonici, 70 parts of Herba Sedis, 60 parts of Radix Gentianaes, 60 parts of Radix Isatidis, 50 parts of Radix Curcumaes, 50 parts of Rhizoma Polygoni Cuspidati, 50 parts of Radix Et Rhizoma Rhei, 50 parts of Fructus Gardeniaes, 50 parts of Herba Artemisiae Scopariaes, 40 parts of Fructus Forsythiaes, 40 parts in Poria, 40 parts of Rhizoma Alismatis, 40 parts of Radix Bupleuri, 40 parts in Radix Glycyrrhizae.
Or be:
50 parts of Herba Hyperici Japonici, 50 parts of Herba Sedis, 40 parts of Radix Gentianaes, 40 parts of Radix Isatidis, 30 parts of Radix Curcumaes, 30 parts of Rhizoma Polygoni Cuspidati, 30 parts of Radix Et Rhizoma Rhei, 30 parts of Fructus Gardeniaes, 30 parts of Herba Artemisiae Scopariaes, 20 parts of Fructus Forsythiaes, 20 parts in Poria, 20 parts of Rhizoma Alismatis, 20 parts of Radix Bupleuri, 20 parts in Radix Glycyrrhizae.
Or be:
60 parts of Herba Hyperici Japonici, 60 parts of Herba Sedis, 50 parts of Radix Gentianaes, 50 parts of Radix Isatidis, 40 parts of Radix Curcumaes, 40 parts of Rhizoma Polygoni Cuspidati, 40 parts of Radix Et Rhizoma Rhei, 40 parts of Fructus Gardeniaes, 40 parts of Herba Artemisiae Scopariaes, 30 parts of Fructus Forsythiaes, 30 parts in Poria, 30 parts of Rhizoma Alismatis, 30 parts of Radix Bupleuri, 30 parts in Radix Glycyrrhizae.
Another purpose of the present invention provides a kind of Chinese medicine decoction for the treatment of young goose viral hepatitis, is by following method preparation:
1) takes by weighing each component by a kind of proportioning raw materials for the treatment of the Chinese medicine composition of young goose viral hepatitis, after the pulverizing, soaked 30-40 minute;
2) soaked raw material is refrigerated to freeze all;
3) be the 20-30KHZ ultrasonoscope with frequency, ultrasonicly melt to raw material;
4) put into decoction pot, decocted 30 minutes, filter medicinal residues, get filtrate;
Described soaking, amount of water are 7 times of each component gross weight;
Described filtrate contains crude drug 0.62-0.66g/ml.
Composition principle of the present invention:
Tradition veterinary of motherland thinks that young goose viral hepatitis is owing to experienced the epidemic disease caused by damp-heat pathogen poison, controls suitable clearing away heat-damp and promoting diuresis, eliminating fire and detoxication.Herba Hyperici Japonici, Herba Sedi, the bitter diarrhea of Herba Artemisiae Scopariae fall in the side, and the clearing away heat-damp and promoting diuresis detoxifcation has significant hepatoprotective effect, is the common drug for the treatment of acute, chronic hepatitis, is monarch drug; Radix Gentianae heat clearing and damp drying, eliminating pathogen in the liver are through excess-fire, and liver heat removing is through damp and hot.Radix Isatidis, Fructus Gardeniae, Rhizoma Polygoni Cuspidati, the detoxifcation of Fructus Forsythiae clearing away heat-fire have good antibiotic, antivirus action.Fructus Gardeniae can also be drawn damp and hot descending by principal drug assistance.Be ministerial drug altogether; Radix Curcumae blood circulation promoting and blood stasis dispelling, catharsis irritability.The Radix Et Rhizoma Rhei removing blood stasis that purges heat is led stagnant heat and is gone out from feces.Poria, Rhizoma Alismatis eliminating dampness and diuresis.Radix Bupleuri is apt to catharsis, has the effect of good dispersing the stagnated live-QI to relieve the stagnation of QI.Be adjuvant drug altogether; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription is for making medicine.All medicines share, can removing fire from the livers, again can clearing away damp-heat, and have the merit of clearing away heat-damp and promoting diuresis, eliminating fire and detoxication, young goose viral hepatitis is had preferably therapeutical effect; All medicines share the agent that becomes altogether clearing away heat-damp and promoting diuresis, eliminating fire and detoxication.
The side's of system characteristics: we hold concurrently with dispersing the stagnated live-QI to relieve the stagnation of QI the effect of liver heat removing and eyesight improving with clearing away heat-damp and promoting diuresis, eliminating fire and detoxication and usefulness.Said medicine is through organic assembling, and dialectical compatibility and mutually assisting a ruler in governing a country has strengthened the effect of the party's clearing away heat-damp and promoting diuresis, eliminating fire and detoxication, thereby reached the purpose of curing young goose viral hepatitis.The Chinese medicine decoction effect that adopts the present invention to make is more obvious, shows to treating young goose viral hepatitis specially good effect is arranged through clinical practice.Through the clinical treatment statistical confirmation, cure rate can reach 94.83%, effective percentage 98.86%.And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.Reasonable recipe of the present invention, preparation technology is simple; Chinese crude drug is pulverized immersion, after freezing, ultrasonic thawing, decoct again again, solved the deficiency that Chinese medicine powder crude fiber content is high, effective ingredient is difficult to stripping.Decoction after the decoction uses conveniently, absorbs rapidly.Medicinal herb components wide material sources, the cost that adopts is low, cure rate is high; The medicine noresidue has no side effect, and is easy to young goose and absorbs.Have significant disinfecting detoxifying and the effect that improves body's immunity, effectively treat young goose viral hepatitis, shorten the period of convalescence the curative effect highly significant.
The specific embodiment
Embodiment 1
Composition by weight: 70 parts of Herba Hyperici Japonici, 70 parts of Herba Sedis, 60 parts of Radix Gentianaes, 60 parts of Radix Isatidis, 50 parts of Radix Curcumaes, 50 parts of Rhizoma Polygoni Cuspidati, 50 parts of Radix Et Rhizoma Rhei, 50 parts of Fructus Gardeniaes, 50 parts of Herba Artemisiae Scopariaes, 40 parts of Fructus Forsythiaes, 40 parts in Poria, 40 parts of Rhizoma Alismatis, 40 parts of Radix Bupleuri, 40 parts in Radix Glycyrrhizae.By 7 extraordinarily entry of total dose, both 4970 parts of water became 1128 parts of medicinal liquids after decocting, and both every milliliter of medicinal liquid contained about 0.63 gram of crude drug.
Embodiment 2
Composition by weight: 50 parts of Herba Hyperici Japonici, 50 parts of Herba Sedis, 40 parts of Radix Gentianaes, 40 parts of Radix Isatidis, 30 parts of Radix Curcumaes, 30 parts of Rhizoma Polygoni Cuspidati, 30 parts of Radix Et Rhizoma Rhei, 30 parts of Fructus Gardeniaes, 30 parts of Herba Artemisiae Scopariaes, 20 parts of Fructus Forsythiaes, 20 parts in Poria, 20 parts of Rhizoma Alismatis, 20 parts of Radix Bupleuri, 20 parts in Radix Glycyrrhizae.By 7 extraordinarily entry of total dose, both 3010 parts of water became 652 parts of medicinal liquids after decocting, and both every milliliter of medicinal liquid contained about 0.66 gram of crude drug.
Embodiment 3
Composition by weight: 60 parts of Herba Hyperici Japonici, 60 parts of Herba Sedis, 50 parts of Radix Gentianaes, 50 parts of Radix Isatidis, 40 parts of Radix Curcumaes, 40 parts of Rhizoma Polygoni Cuspidati, 40 parts of Radix Et Rhizoma Rhei, 40 parts of Fructus Gardeniaes, 40 parts of Herba Artemisiae Scopariaes, 30 parts of Fructus Forsythiaes, 30 parts in Poria, 30 parts of Rhizoma Alismatis, 30 parts of Radix Bupleuri, 30 parts in Radix Glycyrrhizae.By 7 extraordinarily entry of total dose, both 3990 parts of water became 891 parts of medicinal liquids after decocting, and both every milliliter of medicinal liquid contained about 0.64 gram of crude drug.
Embodiment 4
Weigh by embodiment 1,2 or 3 proportionings, put into pot for boiling chinese traditional medicine, add water by proportional quantity, soaked first before the decoction 35 minutes; After making raw material fully moistening, pull raw material out; Putting into-10 ℃ of refrigerator-freezers is refrigerated to all and freezes; Be the 20-30KHZ ultrasonoscope with frequency again, ultrasonicly melt to raw material; Put back in the decoction pot, heated and boiled keeps temperature, decocts 30 minutes again, and filtrate is got in slagging-off, and filtrate both had been decoction.
Wherein embodiment 1 adds 4970 parts in water, concentrated filtrate to 1128 part;
Embodiment 2 adds 3010 parts in water, concentrated filtrate to 652 part;
Embodiment 3 adds 3990 parts in water, concentrated filtrate to 851 part.
Experimental example
1. method: publish the plant of sick young goose viral hepatitis and four at the goose family of recuperating, 3566 of total ill young geese, the age is the 6-9 age in days.The young goose that will fall ill is divided into three groups, is respectively the loose group of of the present invention group, Herba Artemisiae Scopariae and matched group.
Of the present invention group: the concentrated medicament with embodiment 3 and embodiment 4 make gavages at twice by every young goose 4ml.For the ill young goose that can drink water, for the ease of drinking, can in medicinal liquid, add an amount of white sugar, can drip clothes with dropper for the young goose that is in a bad way, 15 of every young geese, twice of every day.Medicine temperature control: 40-50 ℃ decoction being taken warmly.
The loose group of Herba Artemisiae Scopariae: 100 parts of Herba Artemisiae Scopariaes, 100 parts of Radix Isatidis, 50 parts of Radix Gentianaes, 50 parts of Fructus Forsythiaes, 50 parts of Radix Curcumaes, 40 parts in Radix Et Rhizoma Rhei, 50 parts of Fructus Gardeniaees, 50 parts of Radix Bupleuri, 50 parts of the Radix Paeoniae Albas, 40 parts of Cortex Moutans, 50 parts of Herba Pogostemoniss, 50 parts in Radix Glycyrrhizae, 7 extraordinarily entry by total dose, both 4760 parts of water, become 1032 parts of medicinal liquids after decocting, both every milliliter of medicinal liquid contained about 0.66 gram of crude drug.With the concentrated medicament that makes, gavage at twice by every young goose 4ml.For the ill young goose that can drink water, for the ease of drinking, can in medicinal liquid, add an amount of white sugar, can drip clothes with dropper for the young goose that is in a bad way, 15 of every young geese, twice of every day.Medicine temperature control: 40-50 ℃ decoction being taken warmly.
Matched group: just in drinking-water, add an amount of white sugar.Water temperature control: 40-50 ℃ of decoction being taken warmly.
Treatment time is five days, and every day at the upper and lower noon respectively drinks once.
The young goose grouping of table 1 and primary treatment method
| Group | Suffer from goose quantity (only) | Therapeutic Method |
| Of the present invention group | 1642 | With the concentrated medicament that makes, every young goose 4ml gavages at twice by every day |
| The loose group of Herba Artemisiae Scopariae | 1548 | The same |
| Matched group | 376 | Add an amount of white sugar in the drinking-water |
2. efficacy determination:
Cure: the complete obiteration of young goose viral hepatitis symptom, appetite and drinking-water recover normal, and pathology cuts open the inspection no abnormality seen;
Take a turn for the better: young goose viral hepatitis symptom takes a turn for the better to some extent, and appetite and drinking-water recover to some extent, and pathology takes a turn for the better before cuing open inspection;
Invalid: young goose viral hepatitis symptom does not change, and it is front identical with treatment that appetite, drinking-water and pathology cut open inspection.
3. result: 3566 young geese are by different dosage regimens, and after five days treatment, therapeutic effect of each group sees Table 2.
The various therapeutic schemes of table 2 are treated young goose effect
| Group | Treatment quantity | Cure | Take a turn for the better | Invalid | Cure rate (%) | Total effective rate (%) |
| Of the present invention group | 1662 | 1576 | 67 | 19 | 94.83 | 98.86 |
| The loose group of Herba Artemisiae Scopariae | 1548 | 1045 | 297 | 206 | 67.51 | 86.69 |
| Matched group | 376 | 32 | 46 | 298 | 8.51 | 20.74 |
By table 2 as seen, treatment and matched group have different therapeutic effect to young goose viral hepatitis, and wherein best with of the present invention group of therapeutic effect, cure rate reaches 94.83%, and total effective rate 98.86%, the utmost point are significantly higher than other two groups (P＜0. 01); The loose group of Herba Artemisiae Scopariae is taken second place, and matched group does not have therapeutical effect, and statistical result shows that each group difference is (P＜0. 01) significantly.Of the present invention group of 19 invalid routine young geese are the case in treatment initial stage 1-3 days death, because the state of an illness is heavier, internal organs of the body is depleted, do not wait until that drug effect plays a role fully and dead.
Facts have proved that medicine of the present invention can removing fire from the liver, again can clearing away damp-heat, have the merit of clearing away heat-damp and promoting diuresis, eliminating fire and detoxication, can effectively treat young goose viral hepatitis, significant disinfecting detoxifying is arranged and improve the effect of body's immunity, evident in efficacy.Young goose viral hepatitis had preferably therapeutical effect.And medicament sources of the present invention is extensive, cost is low, cure rate is high; The medicine noresidue has no side effect, and is easy to young goose and absorbs, for this disease of clinical treatment provides a kind of practicable new drug.
Above-mentioned detailed description of this Chinese medicine composition for the treatment of young goose viral hepatitis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (7)
1. Chinese medicine composition for the treatment of young goose viral hepatitis, its composition by weight is: Herba Hyperici Japonici 50-70 part, Herba Sedi 50-70 part, Radix Gentianae 40-60 part, Radix Isatidis 40-60 part, Radix Curcumae 30-50 part, Rhizoma Polygoni Cuspidati 30-50 part, Radix Et Rhizoma Rhei 30-50 part, Fructus Gardeniae 30-50 part, Herba Artemisiae Scopariae 30-50 part, Fructus Forsythiae 20-40 part, Poria 20-40 part, Rhizoma Alismatis 20-40 part, Radix Bupleuri 20-40 part, Radix Glycyrrhizae 20-40 part.
2. a kind of Chinese medicine composition for the treatment of young goose viral hepatitis according to claim 1, it is characterized in that its composition by weight is: 70 parts of Herba Hyperici Japonici, 70 parts of Herba Sedis, 60 parts of Radix Gentianaes, 60 parts of Radix Isatidis, 50 parts of Radix Curcumaes, 50 parts of Rhizoma Polygoni Cuspidati, 50 parts of Radix Et Rhizoma Rhei, 50 parts of Fructus Gardeniaes, 50 parts of Herba Artemisiae Scopariaes, 40 parts of Fructus Forsythiaes, 40 parts in Poria, 40 parts of Rhizoma Alismatis, 40 parts of Radix Bupleuri, 40 parts in Radix Glycyrrhizae.
3. a kind of Chinese medicine composition for the treatment of young goose viral hepatitis according to claim 1, it is characterized in that its composition by weight is: 50 parts of Herba Hyperici Japonici, 50 parts of Herba Sedis, 40 parts of Radix Gentianaes, 40 parts of Radix Isatidis, 30 parts of Radix Curcumaes, 30 parts of Rhizoma Polygoni Cuspidati, 30 parts of Radix Et Rhizoma Rhei, 30 parts of Fructus Gardeniaes, 30 parts of Herba Artemisiae Scopariaes, 20 parts of Fructus Forsythiaes, 20 parts in Poria, 20 parts of Rhizoma Alismatis, 20 parts of Radix Bupleuri, 20 parts in Radix Glycyrrhizae.
4. a kind of Chinese medicine composition for the treatment of young goose viral hepatitis according to claim 1, it is characterized in that its composition by weight is: 60 parts of Herba Hyperici Japonici, 60 parts of Herba Sedis, 50 parts of Radix Gentianaes, 50 parts of Radix Isatidis, 40 parts of Radix Curcumaes, 40 parts of Rhizoma Polygoni Cuspidati, 40 parts of Radix Et Rhizoma Rhei, 40 parts of Fructus Gardeniaes, 40 parts of Herba Artemisiae Scopariaes, 30 parts of Fructus Forsythiaes, 30 parts in Poria, 30 parts of Rhizoma Alismatis, 30 parts of Radix Bupleuri, 30 parts in Radix Glycyrrhizae.
5. Chinese medicine decoction for the treatment of young goose viral hepatitis is by following method preparation:
1) a kind of proportioning raw materials for the treatment of the Chinese medicine composition of young goose viral hepatitis is taken by weighing each component, after the pulverizing, soaked 30-40 minute;
2) soaked raw material is refrigerated to freeze all;
3) be the 20-30KHZ ultrasonoscope with frequency, ultrasonicly melt to raw material;
4) put into decoction pot, decocted 30 minutes, filter medicinal residues, get filtrate.
6. a kind of Chinese medicine decoction for the treatment of young goose viral hepatitis according to claim 5, it is characterized in that: described soaking, amount of water are 7 times of each component gross weight.
7. a kind of Chinese medicine decoction for the treatment of the horse diarrhea due to damp-heat according to claim 6, it is characterized in that: described filtrate contains crude drug 0.62-0.66g/ml.
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| CN114129642A (en) * | 2021-11-05 | 2022-03-04 | 河南惠康动物药业有限公司 | Liver and gallbladder benefiting powder, use method and preparation method thereof |
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| CN103041318B (en) | 2014-04-09 |
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