CN114129642A - Liver and gallbladder benefiting powder, use method and preparation method thereof - Google Patents

Liver and gallbladder benefiting powder, use method and preparation method thereof Download PDF

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Publication number
CN114129642A
CN114129642A CN202111303383.6A CN202111303383A CN114129642A CN 114129642 A CN114129642 A CN 114129642A CN 202111303383 A CN202111303383 A CN 202111303383A CN 114129642 A CN114129642 A CN 114129642A
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liver
gallbladder
powder
weight
root
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拓章松
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Henan Huikang Animal Pharmaceutical Co ltd
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Henan Huikang Animal Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
    • A—HUMAN NECESSITIES
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
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    • A61K36/78—Saururaceae (Lizard's-tail family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
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    • A61K36/906—Zingiberaceae (Ginger family)
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract

The invention relates to the technical field of aquaculture, in particular to liver and gallbladder benefiting powder, a using method and a preparation method thereof, wherein the liver and gallbladder benefiting powder is prepared from the following raw materials in parts by weight: 45-70 g of bupleurum, 60-90 g of oriental wormwood, 45-70 g of gentian, 60-90 g of plantain, 70-100 g of houttuynia cordata, 70-90 g of dandelion, 40-70 g of honeysuckle, 45-75 g of poria cocos, 15-45 g of akebia stem, 40-90 g of rhizoma alismatis, 80-120 g of isatis root, 100 g of astragalus root, 230 g of 180 g of jujube and 400 g of liquorice 275 g of fructus gleditsiae. The invention has the functions of soothing liver, benefiting gallbladder, clearing away heat and toxic materials, protecting liver, benefiting gallbladder, purging and promoting urination, reduces the overload of livers of fishes, shrimps and crabs caused by high protein, high fat and high energy, further protects the liver and spleen of aquatic animals by adding the rhubarb, the forsythia and the radix curcumae, classifies the efficacies of the gentian into heat-clearing medicines, has strong effect of purging excessive fire of liver and gallbladder, grinds and crushes the raw materials, grinds the raw materials to more than 100 meshes, improves the absorption and utilization rate of the aquatic animals, and avoids unnecessary waste.

Description

Liver and gallbladder benefiting powder, use method and preparation method thereof
Technical Field
The invention relates to the technical field of aquaculture, and in particular relates to liver and gallbladder benefiting powder, a using method and a preparation method thereof.
Background
It is known that the liver in animals has the greatest function of detoxification, one is to remove some substances harmful to the body in food and the other is to secrete bile to promote the digestion of protein in food, so that liver problems often occur in fish, shrimp and crab in aquaculture, mainly because the liver of fish, shrimp and crab is overloaded due to high density of modern culture and high protein, high fat and high energy of aquatic feed, so that liver diseases such as gill rot, enteritis, rotten skin (red skin), bleeding, ulcer and the like caused by fish and special aquatic animals (shrimp, crab, turtle and frog) are caused, and liver and gall syndromes such as fish, special aquatic animals (shrimp, crab, turtle and frog) are caused. In aquaculture, shrimps are relatively fragile and weaker in liver, so that the problem of livers of fishes, shrimps and crabs is solved fundamentally, and Chinese patent medicines for aquatic product liver protection are mainly used for prevention, so that the aquaculture risk is reduced.
Disclosure of Invention
In view of the above, the present invention provides a liver and gallbladder benefiting powder, a using method thereof and a preparation method thereof, so as to solve the problems in the background art.
In order to achieve the purpose, the invention is realized by the following technical scheme: the invention provides a liver and gallbladder benefiting powder which is characterized by comprising the following raw materials in parts by weight: 45-70 g of bupleurum, 60-90 g of oriental wormwood, 45-70 g of gentian, 60-90 g of plantain, 70-100 g of houttuynia cordata, 70-90 g of dandelion, 40-70 g of honeysuckle, 45-75 g of poria cocos, 15-45 g of akebia stem, 40-90 g of rhizoma alismatis, 80-120 g of isatis root, 100 g of astragalus root, 230 g of 180 g of jujube and 400 g of liquorice 275 g of fructus gleditsiae.
In the liver and gallbladder benefiting powder, as a preferable scheme, 45-65 g of bupleurum, 60-70 g of oriental wormwood, 45-65 g of gentian, 60-75 g of plantain, 70-85 g of houttuynia cordata, 70-80 g of dandelion, 40-65 g of honeysuckle, 45-65 g of poria cocos, 15-35 g of akebia stem, 40-70 g of rhizoma alismatis, 80-110 g of isatis root, 100 g of astragalus root, 180 g of jujube, 210 g of fructus zizaniae albiflora and 350 g of liquorice 275.
In the liver and gallbladder benefiting powder, 60-70 g of bupleurum, 70-90 g of oriental wormwood, 55-70 g of gentian, 75-90 g of plantain, 80-100 g of cordate houttuynia, 70-90 g of dandelion, 55-70 g of honeysuckle, 55-75 g of poria cocos, 25-45 g of akebia stem, 55-90 g of alisma orientale, 100 g of isatis root, 140 g of astragalus root, 230 g of jujube 220 and 400 g of liquorice 300 and the like are taken as preferable schemes.
In the above-mentioned liver and gallbladder benefiting powder, as a preferred scheme, the raw material composition further includes: 50-80 g of rhubarb, 45-65 g of forsythia and 30-50 g of radix curcumae.
The invention also provides a preparation method of the liver and gallbladder benefiting powder, which comprises the following steps:
step 1: cleaning the Chinese thorowax root, the oriental wormwood, the gentian, the plantain herb, the houttuynia cordata, the tuckahoe, the akebia stem, the alisma orientale, the isatis root, the astragalus mongholicus, the Chinese date and the liquorice in parts by weight;
step 2: drying or airing the material cleaned in the step 1;
and step 3: adding the dandelion and the honeysuckle in parts by weight into the material in the step 2, mixing and crushing the mixture to obtain a crushed material with the granularity of 100 meshes and 150 meshes to obtain the composition A.
Further, the preparation method also comprises the following steps: step 1: cleaning the Chinese thorowax root, the oriental wormwood, the gentian, the plantain herb, the houttuynia cordata, the tuckahoe, the akebia stem, the alisma orientale, the isatis root, the astragalus mongholicus, the Chinese date and the liquorice in parts by weight;
step 2: soaking and decocting the materials cleaned in the step 1, adding the dandelion and the honeysuckle in parts by weight during decoction to obtain a mixed solution A, and filtering and collecting filtrate;
and step 3: standing the filtrate obtained in the step 2, taking supernate, carrying out ultrasonic treatment, and drying to obtain a paste mixture;
and 4, step 4: and (3) adding the rhubarb, the forsythia and the radix curcumae in parts by weight into the paste mixture obtained in the step (3), mixing and crushing, wherein the crushing mesh number is 100-150 meshes, and thus obtaining the composition B.
In the above preparation method of Gandanlikang powder, as a preferable scheme, the mixing time is 20-40 minutes, the standing time is 12-15 hours, the ultrasonic time is 10-15 minutes, the drying time is 115-130 minutes, and the drying temperature is 70-80 ℃.
The invention also provides a using method of the liver and gallbladder benefiting powder, the composition A and the composition B are decocted to form a concentrated solution, and the concentrated solution is added into feed for use, wherein the weight ratio of the composition A to the feed is 1: (100-200), wherein the weight ratio of the composition B to the feed is 1: (200-350).
The invention provides liver and gallbladder benefiting powder, a using method and a preparation method thereof, and the liver and gallbladder benefiting powder has the following beneficial effects: radix bupleuri, herba artemisiae scopariae, felwort, plantain herb, houttuynia cordata, poria cocos, akebia stem, rhizoma alismatis, radix isatidis, astragalus mongholicus, Chinese date and liquorice are used as raw materials, liver soothing, gallbladder benefiting, heat clearing and detoxifying effects are achieved, the effects of protecting the liver, benefiting the gallbladder, purging and inducing diuresis are achieved, the excessive liver burden of fishes, shrimps and crabs caused by high protein, high fat and high energy is reduced, the liver and spleen of aquatic animals are further protected by adding the rheum officinale, the fructus forsythiae and the radix curcumae, the felwort is classified into heat clearing medicines with efficacy, the effect of purging the excessive fire of the liver and the gallbladder is strong, the raw materials are ground and crushed, the raw materials are ground to be more than 100 meshes, the absorption utilization rate of the aquatic animals is improved, and unnecessary waste is avoided.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The following description is made in conjunction with specific cases.
Example 1
The liver and gallbladder benefiting powder is prepared from the following raw materials in parts by weight: 45 g of bupleurum, 60 g of oriental wormwood, 45 g of gentian, 60 g of plantain, 70 g of heartleaf houttuynia herb, 70 g of dandelion, 40 g of honeysuckle, 45 g of tuckahoe, 15 g of akebia stem, 40 g of rhizoma alismatis, 80 g of radix isatidis, 100 g of astragalus, 180 g of Chinese date and 275 g of liquorice.
The invention also provides a preparation method of the liver and gallbladder benefiting powder, which comprises the following steps:
step 1: cleaning the Chinese thorowax root, the oriental wormwood, the gentian, the plantain herb, the houttuynia cordata, the tuckahoe, the akebia stem, the alisma orientale, the isatis root, the astragalus mongholicus, the Chinese date and the liquorice in parts by weight;
step 2: drying or airing the material cleaned in the step 1;
and step 3: adding the dandelion and the honeysuckle in parts by weight into the material in the step 2, mixing and crushing the mixture to obtain a crushed material with the granularity of 100 meshes and 150 meshes to obtain the composition A.
Example 2
The liver and gallbladder benefiting powder consists of the following raw materials in parts by weight: 60 g of bupleurum, 70 g of oriental wormwood, 60 g of gentian, 70 g of plantain, 80 g of heartleaf houttuynia herb, 80 g of dandelion, 60 g of honeysuckle, 60 g of tuckahoe, 60 g of akebia stem, 60 g of rhizoma alismatis, 100 g of radix isatidis, 120 g of astragalus, 200 g of Chinese date and 350 g of liquorice.
Example 3
The liver and gallbladder benefiting powder is prepared from the following raw materials in parts by weight: 60 g of bupleurum, 70 g of oriental wormwood, 60 g of gentian, 70 g of plantain, 80 g of heartleaf houttuynia herb, 80 g of dandelion, 60 g of honeysuckle, 60 g of tuckahoe, 60 g of akebia stem, 60 g of rhizoma alismatis, 100 g of radix isatidis, 120 g of astragalus root, 200 g of Chinese date, 350 g of liquorice, 50 g of rhubarb, 45 g of forsythia and 30 g of radix curcumae.
Example 4
The liver and gallbladder benefiting powder is prepared from the following raw materials in parts by weight: 70 g of bupleurum, 90 g of oriental wormwood, 70 g of gentian, 90 g of plantain, 100 g of heartleaf houttuynia herb, 90 g of dandelion, 70 g of honeysuckle, 75 g of tuckahoe, 45 g of akebia stem, 90 g of rhizoma alismatis, 120 g of radix isatidis, 140 g of astragalus root, 230 g of Chinese date, 400 g of liquorice, 80 g of rhubarb, 65 g of forsythia and 50 g of radix curcumae.
The invention also provides a preparation method of the liver and gallbladder benefiting powder, which comprises the following steps:
step 1: cleaning radix bupleuri, herba artemisiae scopariae, radix gentianae, plantain, houttuynia cordata, poria cocos, akebia stem, rhizoma alismatis, radix isatidis, astragalus membranaceus, Chinese date and liquorice in parts by weight, and cleaning with running water;
step 2: soaking and decocting the cleaned material in the step 1, and adding dandelion and honeysuckle during decoction to obtain a mixed solution A;
and step 3: cooling and precipitating the mixed solution A, taking out the liquid after precipitation, filtering again, then carrying out ultrasonic treatment, and drying to obtain a paste mixture;
and 4, step 4: mixing and crushing the paste mixture, adding rhubarb, forsythia and radix curcumae during mixing and crushing, and obtaining a composition B with the crushing mesh number of 130 meshes;
in the above liver and gallbladder linkang powder, as a preferable scheme, the mixing time is 30 minutes, the standing time is 12 hours, the ultrasonic time is 10 minutes, the drying time is 120 minutes, and the drying temperature is 75 ℃.
Results of the experiment
Animal experiments were carried out using the hepatobiliary powder obtained in the above examples.
Fish with the weight of about 1-2kg are randomly selected from an aquaculture farm in Kanghai city, Henan province, and are averagely divided into 5 groups, each group comprises 200 fish, and the fish are respectively fed with basic feed for 10 days, wherein the composition A in the example 1 is added into the basic feed, and the weight ratio is 125: 1, feeding for 10 days, adding the composition A in the example 2 into the basic feed in a weight ratio of 175:1, feeding for 10 days, adding the composition B in the example 3 into the basic feed in a weight ratio of 225: 1, feeding for 10 days, adding the composition B in the example 4 into a basal feed, wherein the weight ratio is 310: 1, feeding for 10 days, decocting the composition A and the composition B to obtain concentrated solution.
The results of the experiment are shown in table 1 below:
TABLE 1
Test group 1 Test group 2 Test group 3 Test group 4 Comparative group 1
Specific gravity/g 125:1 175:1 225:1 310:1 200:1
Incidence rate/%) 18 14 12 8 56
Mortality rate/%) 62 51 34 21 68
And (4) conclusion: the liver and gallbladder benefiting powder has the following effects:
1. reducing negative pressure, removing toxic substances, protecting liver, and promoting function of gallbladder;
2. protecting the liver of the aquatic animal;
3. the resistance of the aquatic animals is increased, and the death rate or the illness rate is reduced;
finally, the Chinese thorowax root, virgate wormwood herb, gentian, plantain herb, heartleaf houttuynia herb, dandelion, honeysuckle flower, tuckahoe, akebia stem, rhizoma alismatis, indigowoad root, astragalus root, Chinese date, liquorice, rhubarb, weeping forsythia capsule and turmeric root-tuber are used for protecting the liver and benefiting the gallbladder and clearing away heat and toxic materials, so that the liver protection, gallbladder benefiting, purgative and diuresis effects are achieved, the heavy burden of the liver of the fish, shrimp and crab caused by high protein, high fat and high energy is reduced, the liver and spleen of aquatic animals are further protected by adding the rhubarb, the weeping forsythia capsule and the turmeric root-tuber, when the Chinese medicinal composition is used, the materials are ground into 100 meshes and 200 meshes, the absorption is benefited, the utilization rate is improved, all the raw materials are decocted to form thick liquid, the thick liquid is mixed with the feed, when the feed is 40 kilograms, the composition is 260 grams, the composition can be continuously used for 5 to 10 days, the cure, when the composition is used once every 15 days, the dosage is reduced by half, the composition is 130 grams, can be continuously used for 2-4 days, and can effectively prevent liver and gallbladder syndromes such as gill rot, enteritis, putrid skin, fin and tail rot, hemorrhage, ulcer, etc.
Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The foregoing detailed description of the embodiments of the present invention has been presented for purposes of illustration and description, and is intended to be exemplary only and is not intended to be exhaustive or to limit the invention to the precise forms disclosed; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.

Claims (8)

1. The liver and gallbladder benefiting powder is characterized by comprising the following raw materials in parts by weight: 45-70 g of bupleurum, 60-90 g of oriental wormwood, 45-70 g of gentian, 60-90 g of plantain, 70-100 g of houttuynia cordata, 70-90 g of dandelion, 40-70 g of honeysuckle, 45-75 g of poria cocos, 15-45 g of akebia stem, 40-90 g of rhizoma alismatis, 80-120 g of isatis root, 100 g of astragalus root, 230 g of 180 g of jujube and 400 g of liquorice 275 g of fructus gleditsiae.
2. The Gandanlikang powder for liver and gallbladder according to claim 1, which is prepared from the following raw materials (by weight portion): 45-65 g of bupleurum, 60-70 g of oriental wormwood, 45-65 g of gentian, 60-75 g of plantain, 70-85 g of houttuynia cordata, 70-80 g of dandelion, 40-65 g of honeysuckle, 45-65 g of poria cocos, 15-35 g of akebia stem, 40-70 g of rhizoma alismatis, 80-110 g of isatis root, 100 g of astragalus root, 210 g of Chinese date 180-.
3. The Gandanlikang powder for liver and gallbladder according to claim 1, which is prepared from the following raw materials (by weight portion): 60-70 g of bupleurum, 70-90 g of oriental wormwood, 55-70 g of gentian, 75-90 g of plantain, 80-100 g of houttuynia cordata, 70-90 g of dandelion, 55-70 g of honeysuckle, 55-75 g of poria cocos, 25-45 g of akebia stem, 55-90 g of rhizoma alismatis, 100 g of isatis root, 140 g of astragalus root, 230 g of jujube 220-.
4. The Gandanlikang powder for liver and gallbladder according to claims 1-3, wherein said raw material composition further comprises: 50-80 g of rhubarb, 45-65 g of forsythia and 30-50 g of radix curcumae.
5. A process for preparing a Gandanlikang powder for treating liver and gallbladder diseases according to claims 1-4, which comprises the steps of:
step 1: cleaning the Chinese thorowax root, the oriental wormwood, the gentian, the plantain herb, the houttuynia cordata, the tuckahoe, the akebia stem, the alisma orientale, the isatis root, the astragalus mongholicus, the Chinese date and the liquorice in parts by weight;
step 2: drying or airing the material cleaned in the step 1;
and step 3: adding the dandelion and the honeysuckle in parts by weight into the material in the step 2, mixing and crushing the mixture to obtain a crushed material with the granularity of 100 meshes and 150 meshes to obtain the composition A.
6. The method of claim 5, further comprising the steps of:
step 1: cleaning the Chinese thorowax root, the oriental wormwood, the gentian, the plantain herb, the houttuynia cordata, the tuckahoe, the akebia stem, the alisma orientale, the isatis root, the astragalus mongholicus, the Chinese date and the liquorice in parts by weight;
step 2: soaking and decocting the materials cleaned in the step 1, adding the dandelion and the honeysuckle in parts by weight during decoction to obtain a mixed solution A, and filtering and collecting filtrate;
and step 3: standing the filtrate obtained in the step 2, taking supernate, carrying out ultrasonic treatment, and drying to obtain a paste mixture;
and 4, step 4: and (3) adding the rhubarb, the forsythia and the radix curcumae in parts by weight into the paste mixture obtained in the step (3), mixing and crushing, wherein the crushing mesh number is 100-150 meshes, and thus obtaining the composition B.
7. The method for preparing Gandanlikang powder for treating liver and gallbladder diseases as claimed in claim 6, wherein said mixing time is 20-40 min, standing time is 12-15 h, ultrasonic time is 10-15 min, drying time is 115-130 min, and drying temperature is 70-80 ℃.
8. The use method of the Gandanlikang powder as claimed in claims 1-4, wherein the composition A and the composition B are decocted to form a concentrated solution, and the concentrated solution is added into feed for use, wherein the weight ratio of the composition A to the feed is 1: (100-200), wherein the weight ratio of the composition B to the feed is 1: (200-350).
CN202111303383.6A 2021-11-05 2021-11-05 Liver and gallbladder benefiting powder, use method and preparation method thereof Pending CN114129642A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103041318A (en) * 2013-01-27 2013-04-17 吉林农业大学 Traditional Chinese medicine composition for treating gosling viral hepatitis
CN106852396A (en) * 2015-12-08 2017-06-16 上海泓宝绿色水产股份有限公司 A kind of aquatic livestock liver-care preparations and its preparation and application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103041318A (en) * 2013-01-27 2013-04-17 吉林农业大学 Traditional Chinese medicine composition for treating gosling viral hepatitis
CN106852396A (en) * 2015-12-08 2017-06-16 上海泓宝绿色水产股份有限公司 A kind of aquatic livestock liver-care preparations and its preparation and application

Non-Patent Citations (1)

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Title
王利: "茵陈蒿汤加味治疗犬传染性肝炎", 《中兽医医药杂志》 *

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Application publication date: 20220304