CN102481001A - 用于食品制品的含盐微胶囊 - Google Patents
用于食品制品的含盐微胶囊 Download PDFInfo
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- CN102481001A CN102481001A CN2010800375568A CN201080037556A CN102481001A CN 102481001 A CN102481001 A CN 102481001A CN 2010800375568 A CN2010800375568 A CN 2010800375568A CN 201080037556 A CN201080037556 A CN 201080037556A CN 102481001 A CN102481001 A CN 102481001A
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- Prior art keywords
- oil
- calcium
- microcapsules
- magnesium
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000005017 polysaccharide Substances 0.000 claims abstract description 12
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- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 38
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 37
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- 238000002360 preparation method Methods 0.000 claims description 21
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 16
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- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims description 5
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- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 3
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- OKRXSXDSNLJCRS-NLOQLBMISA-L calcium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;(2r,3r,4r,5r)-2,3,5,6-tetrahydroxy-4-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanoate;hydrate Chemical compound O.[Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.[O-]C(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O OKRXSXDSNLJCRS-NLOQLBMISA-L 0.000 claims description 3
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- 238000002955 isolation Methods 0.000 claims description 3
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- 239000011777 magnesium Substances 0.000 claims description 3
- 229910052749 magnesium Inorganic materials 0.000 claims description 3
- 235000002538 magnesium citrate Nutrition 0.000 claims description 3
- 229960003543 magnesium pidolate Drugs 0.000 claims description 3
- 229940091250 magnesium supplement Drugs 0.000 claims description 3
- JQAACYUZYRBHGG-QHTZZOMLSA-L magnesium;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Mg+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 JQAACYUZYRBHGG-QHTZZOMLSA-L 0.000 claims description 3
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Abstract
本发明涉及通过含有蛋白质多糖壳基质和含食用盐的活性材料的微胶囊将食用盐递送到食品制品中的组合物。
Description
发明背景
对于食品配方设计师和开发者来说用钙来强化食品制品是持续的挑战。大多数钙盐在水性介质中特别是在热加工期间反应性非常强，其通常导致不希望的功能和感觉结果诸如沉淀、絮凝、沉降和砂样口感。微溶的或不溶的钙盐已成功地加入选择的食品制剂中；然而，其宽泛的使用受需要将粉末磨碎成亚微米粒度所限制。尽管其对口感有积极影响，但是微粉化扩大了粒子的表面积，使其对相互作用更加敏感。此外，通常发现粒度减小工艺是极其劳动密集的且成本过高的。
一种扩展活性组分在食品中以及其它生物系统中的利用的方法是通过微囊化，由此将矿物质、调味剂、香料或其它生物活性物或无机活性物的粒子或分子放入可保护粒子或分子免受其微环境影响的保护性基质中，因此限制其移动性和相互作用，但最重要的是控制其释放。
在过去的二十年中已报道了微胶囊设计及方法技术中上重要进展。技术诸如流化床粒子包覆、喷雾干燥、冷冻干燥、挤压、共挤压、乳化、凝聚及其组合已有效地用于微封装多种活性成分。尽管存在这些进步，但由于很多技术原因，封装矿物质特别是钙仍然是一个挑战，特别是食品强化应用需要的高浓度元素钙。例如，对于成人，当前美国对钙的推荐每日供给量(RDA)与11mg锌或27mg铁相比是1200mg每单位食品。
US 6468568B1描述了用于封装钙和其它矿物质的挤压系统，该系统利用热熔挤压而埋入玻璃状糖基质中，随后磨碎成希望的粒度。尽管其存在高流通量和经济优势，但利用该方法制备的微胶囊的使用完全局限于表面喷洒及其它低湿度应用。WO 03/095085A1专利声明了用于食品强化应用的已通过乙二胺四乙酸(EDTA)和食品级蛋白质来稳定的钙纳米胶囊。由于管制关注以及这种螯合剂对其它矿物质的生物利用度的潜在干扰，EDTA的存在可严格地限制这种纳米胶囊在很多食品系统中的使用。WO2007/062723A1描述了具有增强的稳定性和生物利用度的稳定的纳米尺寸钙胶囊的制备。尽管存在生产这种粒子的技术优势，但是该发明具有两个主要限制。首先，强化食品制品中获得的钙水平低，其次，食品工业近期关注利用纳米粒子和/或公开其掺入到食品制剂中的管制政策。
含有钙和明胶的组合物已相当广泛地使用，由此掺入极小量的钙来帮助加强壳材料，但是对于营养强化应用来说是不够的。US 2004/0091544A1公开了药物口服制剂诸如胰岛素，其包覆在纤维素或磷酸钙的粒子上并进一步封装在明胶胶囊中或可压制成片剂。
JP 61-115019A声明了明胶膜中含有磷酸钙的药物制剂。声明当口服施用时，胶囊在消化道中迅速溶解以立即释放药物。通过混合明胶、甘油、钙磷灰石(calcium apatite)和水来制备胶囊膜。
而且，由于壳材料分解且随后从微胶囊中释放矿物盐，现有技术发展水平的微胶囊在水性介质中缺乏稳定性。这种稳定性缺乏表明强化具有高度或中等含水量的食品的重要缺陷。
因此，对于用高浓度钙强化食品制剂以满足消费者每日需求，而在成品的功能方面或感觉方面不存在不良影响的稳定的递送系统仍然存在需求。
发明详述
本发明提供了含有至少一种矿物盐的稳定的微胶囊，其中所述矿物盐完全隔离在微胶囊内。在本发明的上下文中，稳定的微胶囊指在疏水介质和/或亲水介质中微胶囊均能够维持其形状和尺寸。
本发明的稳定的微胶囊包括蛋白质多糖壳基质(protein-polysaccharideshell matrix)和芯(core)，所述芯包括至少一种矿物盐的水分散体或溶液在食用油中的乳状液，所述矿物盐被放入微胶囊的芯中，且所述矿物盐与蛋白质多糖基质隔离。这种组装提供了微胶囊在水性介质中或具有高度或中等含水量的食品制剂中的稳定性。微胶囊的结构允许掺入高浓度的那些矿物质并减小对食品制品的功能方面和感觉方面的任何负面影响。
在本发明的实施方案中，稳定的微胶囊的蛋白质选自但不限于包括以下的组：明胶、酪蛋白和酪蛋白酸盐、乳清蛋白、大豆蛋白、豌豆蛋白、小麦蛋白、玉米蛋白、大麦蛋白、卵蛋白、肌肉蛋白、来自其它豆类和根茎类的蛋白、糖蛋白诸如软骨素、葡糖胺聚糖或凝集素及其组合。在本发明优选的实施方案中，蛋白质是明胶。
在本发明的实施方案中，稳定的微胶囊的多糖选自但不限于包括以下的组：琼脂；低聚果糖(fructo-oligosaccharide)，诸如菊粉；淀粉，改性淀粉和天然淀粉及包括直链淀粉和支链淀粉的淀粉部分(starch fraction)；果胶，诸如低甲氧基果胶或高甲氧基果胶；藻酸盐，诸如藻酸钠或藻酸钾；天然树胶及合成树胶，诸如阿拉伯树胶、结冷胶(gellan gum)、韦兰胶(welangum)、黄蓍胶、黄原胶、瓜耳胶或刺槐豆胶；纤维素，诸如羧甲基纤维素、羟丙基纤维素、羟甲基纤维素、羟丁基羧甲基纤维素、羟丙基乙基纤维素或甲基乙基纤维素；短醒霉多糖；角叉菜胶，诸如α-角叉菜胶、γ-角叉菜胶、ι-角叉菜胶、κ-角叉菜胶或λ-角叉菜胶；及其组合。在本发明优选的实施方案中，多糖是琼脂。
在本发明的实施方案中，矿物盐可以是可溶性矿物盐或不溶性矿物盐。优选地，可溶性矿物盐或不溶性矿物盐是二价矿物盐。不溶性矿物盐指在25℃下在水中溶度积优选为10-5或更少的盐。可以掺入本发明的微胶囊中的二价矿物盐选自但不限于包括以下的组：磷酸三钙、磷酸氢钙、磷酸二氢钙、焦磷酸钙、碳酸钙、氢氧化钙、氧化钙、珊瑚钙(coral calcium)、羟磷灰石钙(calcium hydroxyapatite)、硫酸钙、柠檬酸钙、氯化钙、苹果酸钙、乳酸钙、抗坏血酸钙、醋酸钙、琥珀酸钙、丙酮酸钙、柠檬酸-苹果酸钙(calcium citrate-malate)、葡萄糖酸钙、乳酸-葡萄糖酸钙(calciumlactate-gluconate)、葡乳醛酸钙(calcium glubionate)、甘油磷酸钙、葡庚糖酸钙(calcium glucoheptonate)、潘氨酸钙(calcium pangamate)、硫酸镁、磷酸镁、焦磷酸镁、碳酸镁、氢氧化镁、氧化镁、氯化镁、柠檬酸镁、柠檬酸三镁(trimagnesium citrate)、葡萄糖酸镁、乳酸镁、天冬氨酸镁(magnesium aspartate)、乙酰丙酸镁、吡咯烷酮酸镁(magnesium pidolate)、乳清酸镁(magnesium ororate)及其组合。在本发明优选的实施方案中，二价矿物盐是磷酸三钙(TCP)。
本发明的微胶囊中矿物盐的量在微胶囊总重量的0.01-60％，优选在0.1-40％，且最优选在1-20％的范围内变化。
本发明的稳定的微胶囊中含有的乳状液的食用油是食品级油，并选自包括以下的组：植物油诸如大豆油、棕榈仁油、棕榈油、菜子油、红花油、亚麻子油、月见草油、芝麻油、葵花子油、低芥酸菜子油、棉子油、巴巴苏油、橄榄油或藻油(algae oil)，动物源脂肪诸如猪油，牛脂，海生动物油(marine oil)，鱼油诸如沙丁鱼油、鱼肝油、步鱼油(menhaden oil)、鲑鱼油(salmon oil)、鲱鱼油(herring oil)、鲭鱼油(mackerel oil)或鲚鱼油(anchovies oil)，它们可被分级、部分氢化和/或酯交换，及其混合物。也可以使用食用的减少的脂肪(edible reduced-fat)或低卡路里脂肪或非消化性脂肪、脂肪替代物或合成脂肪，诸如蔗糖聚酯、来自植物来源的天然存在的甘油三酯、合成甘油三酯及脂肪酸的天然甘油三酯，多不饱和脂肪酸(PUFA)的烷基酯或甘油三酯的商用混合物诸如Incromega、
或
中链甘油三酯油(MCT油)，及其混合物。在本发明优选的实施方案中，食用油是中链甘油三酯油(MCT油)。MCT油可以优选具有6-12个碳原子，最优选8-12个碳原子的脂肪酸链长。可用于本发明中的中链甘油三酯可包括例如商用混合物，诸如辛酸甘油三酯/癸酸甘油三酯(
GTC/C)、三辛酸/癸酸甘油酯(
810和812)、
M5、Bergabest MCT油、玉米油、花生油、单油酸甘油酯
或及其混合物。
本发明的稳定的微胶囊可以任选地包括至少一种增塑剂。增塑剂选自但不限于包括以下的组：甘油；山梨糖醇；麦芽糖醇；丙二醇；聚乙二醇；葡萄糖；蔗糖；羊毛脂；棕榈酸；油酸；硬脂酸；脂肪酸诸如硬脂酸或棕榈酸的金属盐，硬脂酸钠、硬脂酸钾；甘油卵磷脂(glyceryl lecithin)；单硬脂酸甘油酯；单硬脂酸丙二醇酯；乙酰化甘油酯诸如乙酰化单甘油酯或三醋酸甘油酯；柠檬酸的烷基酯诸如柠檬酸三乙酸酯、柠檬酸三丁酯、乙酰柠檬酸三丁酯或乙酰柠檬酸三乙酯；邻苯二甲酸酯诸如邻苯二甲酸二乙酯；蜡，例如天然蜡和合成蜡，动物蜡诸如蜂蜡，植物蜡诸如巴西棕榈蜡(carnauba wax)、小烛树蜡或小冠巴西棕蜡，氢化植物油诸如大豆油或棉子油，石油蜡诸如聚氨酯蜡、聚乙烯蜡、石蜡或微晶蜡，矿物蜡诸如地蜡(ozokerite)，脂肪蜡(fatty wax)，失水山梨糖醇单硬脂酸酯，牛脂；及其混合物。在本发明优选的实施方案中，增塑剂是甘油。增塑剂含量的范围可以是微胶囊总重量的0.01-10％，优选在0.05-8％，且最优选在0.1-5％。
为了对微胶囊提供另外的浮力并减小其沉降在给定的液体制剂的底部的趋势，本发明的微胶囊可以任选地包括至少一种蜡。蜡可以是微胶囊基质的组分和/或可用作微胶囊表面上的外部包衣。蜡选自包括以下的组：天然蜡和合成蜡，动物蜡诸如蜂蜡，植物蜡诸如巴西棕榈蜡、小烛树蜡或小冠巴西棕蜡，氢化植物油诸如大豆油或棉子油，石油蜡诸如聚氨酯蜡、聚乙烯蜡、石蜡或微晶蜡，矿物蜡诸如地蜡(ozokerite)，脂肪蜡，失水山梨糖醇单硬脂酸酯，牛脂，及其混合物。
在本发明的实施方案中，本发明的稳定的微胶囊的直径在0.1微米至15毫米之间，优选在1微米至10毫米之间，且最优选在10微米至5毫米之间。
本发明的稳定的微胶囊可通过食品及医药工业中任何已知的不同的技术来制备：喷雾干燥、冷冻干燥、挤出、共挤出、乳化、凝聚及其组合。在优选的实施方案中，微胶囊通过凝聚方法制备。
本发明还提供了用于形成本发明稳定的微胶囊的凝聚方法，然而微胶囊在油浴中形成并回收。允许通过重力控制滴落机制到冷油浴中来形成多糖、蛋白质和矿物盐的油乳液的凝聚体(coacervate)的小滴。由于微胶囊在疏水性介质和/或亲水性介质中的广泛使用，冷油浴对微胶囊提供了另外的稳定性。小滴经过的距离可根据溶液的粘度和/或期望的小滴尺寸来调节。
本发明的凝聚方法中使用的油浴中的油选自食品级油的组，优选MCT。油浴的温度小于30℃，优选小于15℃，其最优选在1-10℃之间。
在优选的实施方案中，本发明方法中的凝聚的微胶囊通过混合含有明胶和琼脂的水相与MCT油中含有磷酸三钙水分散体的乳相而形成。
本发明还提供了含有本发明稳定的微胶囊的强化食品制品。本发明的强化食品制品是富含矿物质的，但没有表现出不利的感官作用，诸如苦味、垩白、含沙或砂样口感。
本发明的强化食品制品含有按重量计0.5％-50％，优选1-40％，且最优选5-30％的所述微胶囊。
在本发明的实施方案中，本发明的强化食品制品的微胶囊中所含的矿物盐是钙矿物盐。
在本发明的实施方案中，稳定的微胶囊可以含有来自天然来源或合成来源的一种或多种食品级防腐剂。防腐剂例如选自但不限于包括以下的组：山梨酸的盐、二氧化硫、亚硫酸氢钠、亚硫酸氢钾、丙酸钙、硝酸钠、亚硝酸钠、丁羟茴醚、丁羟甲苯、乳酸和乳酸盐、葡糖酸盐，及其混合物。
在本发明的实施方案中，也可包括抗氧化剂，诸如，例如，但不限于丁羟甲苯(BHT)、丁羟茴醚(BHA)、叔丁基对苯二酚(TBHQ)，没食子酸酯诸如没食子酸丙酯、生育酚诸如维生素E醋酸酯、抗坏血酸、抗坏血酸盐及酯诸如抗坏血酸棕榈酸盐(酯)或抗坏血酸醋酸盐(酯)，及其混合物。
在本发明的实施方案中，本发明的稳定的微胶囊还可包括但不限于在食品工业中通常使用的其它添加剂，诸如着色剂、调味剂、增香剂，味道改良剂诸如糖、增甜剂、酸味剂、苦味剂、涩味剂(astringent agent)、成味剂，及其混合物。
本发明的强化食品制品适合于人类或动物消耗，并还可以是专用食品诸如婴儿食品、医药食品、运动食品、功能食品或营养棒。在本发明的实施方案中，强化食品制品包括但不限于果冻型甜食、水果蜜饯和蔬菜蜜饯，乳制品诸如牛奶、婴儿配方奶粉、酸奶、奶酪、奶油、人造奶油、奶昔或冰淇淋，大豆制品诸如豆乳、大豆酸奶或豆乳酪(soy cheese)，植物合成乳诸如杏仁乳或米乳(rice milk)，饮料，糖浆，甜点诸如布丁、乳蛋糕或其它糊状食品或奶油食品，及糖果制品(confectionary formulation)，诸如口香糖、巧克力、耐嚼糖果、硬糖(hard candy)、硬糖(boiled candy)、焦糖、软糖(fudge)、果冻、橡皮糖(gummy)、明胶糖或硬芯糖和软芯糖。微胶囊可以被直接地加入强化食品制品中，或可被放置在单独的囊(sachet)中。本发明的微胶囊可被直接加入即食甜点或儿童制品中的果冻型制品。
在本发明的实施方案中，强化食品制品的每单位部分的所述强化食品制品中包含成人的矿物质需求的100％推荐每日供给量(RDA)。掺入本发明微胶囊中的高浓度矿物盐允许制备出含有足够量的矿物质以达到成人的RDA摄入的强化食品制品。在本发明的优选的实施方案中，矿物质是钙。
本发明还提供了用于递送成人的矿物质需求的100％推荐每日供给量的方法，其包括施用含有本发明的微胶囊的强化食品制品。优选地，矿物质是钙。
本发明还提供了用于治疗和/或预防骨质脱矿(demineralization)、骨质疏松症或额外钙需求的方法，其包括施用足够量的含有本发明的钙微胶囊的强化食品制品。对于例如怀孕女性、泌乳女性或绝经后女性推荐RDA以上的额外钙需求量。儿童也需要补充钙的摄入。
因此，本发明还提供了微胶囊在制备用于治疗或预防骨质脱矿、骨质疏松症或额外钙需求量的强化食品制品中的用途。
还通过以下非限制性实施例对本发明进行了说明，除非另外指明，其中份、百分比、比例和比率全部按重量计，且温度全部以℃计。
附图简述
图1显示了用Leica MZFLIII共聚焦显微镜以25x放大拍摄的含TCP的微胶囊的截面的共聚焦显微照片，其中钙芯被琼脂-明胶凝聚壳包围。钙专一性染色(Von Kossa法)显示随着钙含量增加而增加的强度(0-15％TCP)。染色表明，钙被完全放入微胶囊的芯中，且完全与多糖蛋白质基质隔离。
实施例
bloom值240的B型鱼明胶(pH 5.71)获自Lapi Gelatin，意大利，且琼脂由Quimivita(西班牙)提供。细粒度(平均3微米)磷酸三钙TCP由Budenheim(德国)提供，且具有60∶40的C-8∶C-12比的MCT油(Bergabest商标)由Sternchemie Lipid technology，德国提供。由CRODA(英国)提供鱼油，Incromega TG3322(甘油三酯，最少60％ω-3 PUFA)和Incromega E3322(乙酯，最少60％ω-3PUFA)。蜂蜡来自SonnebornRefined Products B.V.(荷兰)。干果冻粉由Hacendado(阿利坎特，西班牙)提供。这些实验中使用的水全部是蒸馏的并去离子的。
实施例1.制备钙微胶囊
i.制备TCP乳状液：将磷酸三钙(10g)与水(26g)混和，并利用超六角转头混合器(ultra-turrax mixer)与MCT油(16g)和甘油(2g)充分地混合以形成乳状液。
ii.制备明胶/琼脂混合物：使明胶(22g)在水(60g)中水合30分钟并加热至50℃。将琼脂(2g)分散于水(62g)中并加热至55℃，且立即加入到热明胶溶液并充分混合。
将TCP乳状液迅速加入明胶/琼脂制剂中，随后连续搅拌以形成稠厚的均质体。使后者通过0.5mm孔滴加到冷(4℃)MCT油浴中。得到的微胶囊通过过滤或倾析回收。
实施例2.以甘油作为增塑剂制备钙微胶囊
除了在明胶/琼脂制剂中加入甘油增塑剂以外，以与实施例1相似的方式制备微胶囊。
实施例3.制备鱼油微胶囊
除了在TCP乳状液中用鱼油代替MCT油以外，以与实施例1相似的方式制备微胶囊。
实施例4.制备含蜡微胶囊
除了在TCP乳状液中用蜂蜡部分代替一些MCT油以外，以与实施例1相似的方式制备微胶囊。在滴入油浴之前将凝聚混合物维持于65℃。
实施例5.制备蜡包覆的微胶囊
利用实施例1制备的微胶囊还用蜂蜡薄膜包覆。将100g钙胶囊放置于旋转盘包衣器中，并将熔化的蜂蜡的精细喷雾施加到胶囊上直到达到充分的包覆。
实施例6.将钙微胶囊掺入果冻型甜点中
使水(250ml)沸腾并缓慢地加入柠檬味干果冻粉的商用制剂(15g)。进一步搅拌混合物(根据制造商的指示)直到粉末完全溶解。加入冷水(250ml)并继续混合直到明胶溶液的温度下降至约30℃。加入实施例1的含钙微胶囊(15g)并轻轻地混合该制剂，然后将该制剂在冰箱中在4℃下冷却至少3小时。发现本发明的微胶囊在果冻制剂中在制品的保存期(3个月)内是稳定的。
实施例7.将钙微胶囊掺入底部有水果的酸奶中
将3g实施例1的钙微胶囊轻轻地与100g水果制剂混合，并在90℃下消毒3分钟。将酸奶盖在消毒的制剂上并立即放入4℃冰箱中。检查制剂的稳定性，并发现在4℃下在21天的期间内钙微胶囊是完好无损的。
Claims (15)
1.一种稳定的微胶囊，包括蛋白质多糖壳基质和芯，所述芯包括至少一种矿物盐的水分散体或溶液在食用油中的乳状液，所述矿物盐被放入所述微胶囊的所述芯中，且所述矿物盐与所述蛋白质多糖基质隔离。
2.根据权利要求1所述的微胶囊，特征在于：所述壳基质的所述蛋白质选自包括以下的组：明胶、酪蛋白和酪蛋白酸盐、乳清蛋白，来自豆类和根茎类的蛋白、大豆蛋白、豌豆蛋白、小麦蛋白、玉米蛋白、大麦蛋白，卵蛋白、肌肉蛋白、糖蛋白、软骨素、葡糖胺聚糖、凝集素及其组合。
3.根据权利要求1所述的微胶囊，特征在于：所述壳基质的所述多糖选自包括以下的组：琼脂、低聚果糖、菊粉、改性淀粉、天然淀粉、淀粉部分、直链淀粉、支链淀粉、果胶、低甲氧基果胶、高甲氧基果胶、藻酸盐、藻酸钠、藻酸钾、天然树胶、合成树胶、阿拉伯树胶、结冷胶、韦兰胶、黄蓍胶、黄原胶、瓜耳胶、刺槐豆胶、纤维素、羧甲基纤维素、羟丙基纤维素、羟甲基纤维素、羟丁基羧甲基纤维素、羟丙基乙基纤维素和甲基乙基纤维素、短醒霉多糖、角叉菜胶及其组合。
4.根据权利要求1所述的微胶囊，特征在于：所述矿物盐是二价矿物盐。
5.根据权利要求4所述的微胶囊，特征在于：所述二价矿物盐选自包括以下的组：磷酸三钙、磷酸氢钙、焦磷酸钙、碳酸钙、珊瑚钙、羟磷灰石钙、硫酸钙、柠檬酸钙、氯化钙、苹果酸钙、乳酸钙、抗坏血酸钙、醋酸钙、琥珀酸钙、丙酮酸钙、柠檬酸-苹果酸钙、葡萄糖酸钙、乳酸-葡萄糖酸钙、葡乳醛酸钙、甘油磷酸钙、葡庚糖酸钙、潘氨酸钙、硫酸镁、磷酸镁、焦磷酸镁、碳酸镁、氯化镁、柠檬酸镁、三柠檬酸镁、葡萄糖酸镁、乳酸镁、天冬氨酸镁、乙酰丙酸镁、吡咯烷酮酸镁、乳清酸镁及其组合。
6.根据权利要求1所述的微胶囊，特征在于：所述矿物盐的量的范围是所述微胶囊总重量的0.01-60％。
7.根据权利要求1所述的微胶囊，特征在于：所述乳状液的所述食用油选自包括以下的组：植物油、大豆油、棕榈仁油、棕榈油、菜子油、红花油、亚麻子油、月见草油、芝麻油、葵花子油、低芥酸菜子油、棉子油、巴巴苏油、橄榄油、藻油、动物源脂肪、猪油、牛脂、海生动物油、鱼油，沙丁鱼油、鱼肝油、步鱼油、鲑鱼油、鲱鱼油、鲭鱼油、鲚鱼油、食用的减少的脂肪、低卡路里脂肪、非消化性脂肪、脂肪替代物、合成脂肪、蔗糖聚酯、来自植物来源的天然存在的甘油三酯、脂肪酸的合成甘油三酯、脂肪酸的天然甘油三酯、多不饱和脂肪酸(PUFA)的烷基酯或甘油三酯的商用混合物、中链甘油三酯油(MCT油)、辛酸甘油三酯/癸酸甘油三酯、三辛酸/癸酸甘油酯、玉米油、花生油、单油酸甘油酯、其部分氢化衍生物及其混合物。
8.根据权利要求1所述的微胶囊，特征在于：所述微胶囊包含至少一种增塑剂。
9.根据权利要求1所述的微胶囊，特征在于：所述微胶囊包含基质中和/或作为外部包衣的至少一种蜡。
10.一种形成根据权利要求1中所述的稳定的微胶囊的凝聚方法，所述方法包括在油浴中形成并回收所述微胶囊。
11.一种强化食品制品，所述强化食品制品含有权利要求1中所述的微胶囊。
12.根据权利要求11所述的强化食品制品，其含有按重量计0.5％-50％的所述微胶囊。
13.根据权利要求11所述的强化食品制品，特征在于：所述强化食品制品选自包括以下的组：果冻型甜食、水果蜜饯和蔬菜蜜饯、乳制品、牛奶、婴儿配方奶粉、酸奶、奶酪、奶油、人造奶油、奶昔和冰淇淋、大豆制品、豆乳、大豆酸奶、豆乳酪、植物合成乳、杏仁乳、米乳、饮料、糖浆、甜点、布丁、乳蛋糕、糊状食品、奶油食品及糖果制品。
14.根据权利要求11所述的强化食品制品，特征在于：所述强化食品制品的每单位部分的所述强化食品制品中包含成人的矿物质需求的100％推荐每日供给量。
15.根据权利要求1所述的稳定的微胶囊在制备用于治疗和/或预防骨质脱矿、骨质疏松症或额外钙需求的强化食品制品中的用途。
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| CN104812380A (zh) * | 2012-09-28 | 2015-07-29 | 株式会社爱茉莉太平洋 | 含有源自植物的糖蛋白的微胶囊 |
| CN104812380B (zh) * | 2012-09-28 | 2018-05-22 | 株式会社爱茉莉太平洋 | 含有源自植物的糖蛋白的微胶囊 |
| CN103340398A (zh) * | 2013-06-16 | 2013-10-09 | 杭州元海生物科技有限公司 | 一种以食用菌超微细粉为主要壁材的鱼油微胶囊产品的生产方法 |
| CN103340398B (zh) * | 2013-06-16 | 2014-08-06 | 杭州元海生物科技有限公司 | 一种以食用菌超微细粉为主要壁材的鱼油微胶囊产品的生产方法 |
| CN104783028A (zh) * | 2014-01-21 | 2015-07-22 | 四川亿生元科技有限公司 | 一种益生元及其加工方法 |
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| CN106666731A (zh) * | 2016-12-29 | 2017-05-17 | 浙江新维普添加剂有限公司 | 一种稳定的脂溶性营养素微胶囊及其制备方法和应用 |
| CN107495126A (zh) * | 2017-09-14 | 2017-12-22 | 武汉华康臣生物科技有限公司 | 一种豆基钙质营养强化食品氧化酸败防控技术 |
| CN107712543A (zh) * | 2017-09-20 | 2018-02-23 | 徐宝军 | 一种抗絮凝姜黄素微胶囊、制备方法及其应用 |
| CN107712543B (zh) * | 2017-09-20 | 2021-04-16 | 徐宝军 | 一种抗絮凝姜黄素微胶囊、制备方法及其应用 |
| CN111557441A (zh) * | 2020-04-16 | 2020-08-21 | 江西省蚕桑茶叶研究所(江西省经济作物研究所) | 一种桑叶年糕及其制备方法 |
| CN111467380A (zh) * | 2020-05-13 | 2020-07-31 | 四川大学 | 一种赶黄草提取物微胶囊及其制备方法 |
| CN114271369A (zh) * | 2022-01-10 | 2022-04-05 | 好维康有限责任公司 | 一种软糖基底及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2771131A1 (en) | 2011-03-10 |
| IN2012DN02548A (zh) | 2015-08-28 |
| EP2292102A1 (en) | 2011-03-09 |
| US20120156288A1 (en) | 2012-06-21 |
| JP2013503611A (ja) | 2013-02-04 |
| WO2011026612A1 (en) | 2011-03-10 |
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