CN102471763B - 果糖基氨基酸氧化酶 - Google Patents

果糖基氨基酸氧化酶 Download PDF

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Publication number
CN102471763B
CN102471763B CN201080034342.5A CN201080034342A CN102471763B CN 102471763 B CN102471763 B CN 102471763B CN 201080034342 A CN201080034342 A CN 201080034342A CN 102471763 B CN102471763 B CN 102471763B
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China
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ala
leu
amino acid
gly
lys
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Expired - Fee Related
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CN201080034342.5A
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English (en)
Chinese (zh)
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CN102471763A (zh
Inventor
K.索德
K.伊克布库罗
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F Hoffmann La Roche AG
Ultizyme International Ltd
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F Hoffmann La Roche AG
Ultizyme International Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080034342.5A 2009-08-03 2010-08-02 果糖基氨基酸氧化酶 Expired - Fee Related CN102471763B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09009969.8 2009-08-03
EP09009969A EP2287295A1 (en) 2009-08-03 2009-08-03 Mutant Fructosyl amino acid oxidase
PCT/EP2010/004708 WO2011015326A2 (en) 2009-08-03 2010-08-02 Fructosyl amino acid oxidase

Publications (2)

Publication Number Publication Date
CN102471763A CN102471763A (zh) 2012-05-23
CN102471763B true CN102471763B (zh) 2014-07-09

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CN201080034342.5A Expired - Fee Related CN102471763B (zh) 2009-08-03 2010-08-02 果糖基氨基酸氧化酶

Country Status (7)

Country Link
US (1) US8497083B2 (https=)
EP (2) EP2287295A1 (https=)
JP (1) JP5897463B2 (https=)
CN (1) CN102471763B (https=)
ES (1) ES2720287T3 (https=)
PL (1) PL2462223T3 (https=)
WO (1) WO2011015326A2 (https=)

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KR20110069138A (ko) 2008-10-09 2011-06-22 교와 메덱스 가부시키가이샤 신규 프럭토실펩티드옥시다아제
CN102171338B (zh) * 2008-10-10 2014-08-13 东洋纺织株式会社 具有果糖基缬氨酰基组氨酸氧化酶活性的蛋白质及其修饰产物以及其应用
WO2012018094A1 (ja) * 2010-08-06 2012-02-09 キッコーマン株式会社 基質特異性が改変されたアマドリアーゼ
US9708586B2 (en) 2010-08-06 2017-07-18 Kikkoman Corporation Amadoriase having altered substrate specificity
WO2012043601A1 (ja) * 2010-09-29 2012-04-05 キッコーマン株式会社 アマドリアーゼ改変体
JP6282115B2 (ja) 2011-12-28 2018-02-21 キッコーマン株式会社 熱安定性が向上したアマドリアーゼ、その遺伝子および組換えｄｎａならびに熱安定性が向上したアマドリアーゼの製造法
WO2013162035A1 (ja) * 2012-04-27 2013-10-31 キッコーマン株式会社 フルクトシルヘキサペプチドに作用する改変型アマドリアーゼ
JP6363327B2 (ja) * 2013-03-25 2018-07-25 キッコーマン株式会社 改変アマドリアーゼ
ES2848705T3 (es) 2013-08-09 2021-08-11 Kikkoman Corp Amadoriasa modificada y método para producirla, agente para mejorar la resistencia a tensioactivos de la amadoriasa y composición para medir la HbA1c usando la misma
JP6542671B2 (ja) 2013-10-25 2019-07-10 キッコーマン株式会社 ヘモグロビンＡ１ｃの測定方法および測定キット
CN105683390B (zh) * 2013-10-25 2021-02-26 龟甲万株式会社 使用作用于糖基化肽的阿马多里酶的HbA1c测定方法
CN103695380B (zh) * 2013-12-27 2016-05-25 宁波美康生物科技股份有限公司 果糖氨基酸氧化酶、制备方法及含该酶的糖化白蛋白检测试剂盒
EP3786291B1 (en) 2014-10-24 2023-10-18 Kikkoman Corporation Amadoriase having enhanced dehydrogenase activity
WO2016072520A1 (ja) * 2014-11-07 2016-05-12 キッコーマン株式会社 アニオン性界面活性剤耐性が向上したアマドリアーゼ
JP6576170B2 (ja) * 2015-09-02 2019-09-18 旭化成ファーマ株式会社 くし型電極を用いた糖化タンパク質の測定方法
KR102596402B1 (ko) * 2016-04-22 2023-10-31 기꼬만 가부시키가이샤 HbA1c 디히드로게나아제
TWI668229B (zh) * 2016-12-13 2019-08-11 財團法人工業技術研究院 重組蛋白質及其製造方法與應用
EP3589948A4 (en) 2017-03-03 2020-12-30 Polymer Technology Systems, Inc. SYSTEMS AND METHODS FOR ENZYMATIC A1C DETECTION AND QUANTIFICATION
US11703513B2 (en) 2017-08-07 2023-07-18 Polymer Technology Systems, Inc. Systems and methods for enzymatic A1C detection and quantification
CN109232745B (zh) * 2018-09-18 2020-02-28 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽
EP3989822A4 (en) * 2019-06-26 2023-07-05 Polymer Technology Systems, Inc. SYSTEMS AND METHODS FOR REDUCING OXYGEN TENSION IN ELECTROCHEMICAL BIOSENSORS
CN111676236A (zh) * 2020-03-12 2020-09-18 北京达成生物科技有限公司 一种重组flod蛋白的大肠杆菌表达方法
JPWO2023145689A1 (https=) * 2022-01-27 2023-08-03
CN120936716A (zh) * 2023-07-19 2025-11-11 株式会社普欧威盖特 果糖基氨基酸氧化酶、基因、表达载体、糖化蛋白传感器、糖化蛋白的测定方法以及果糖基氨基酸氧化酶的制造方法

Citations (1)

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Also Published As

Publication number Publication date
PL2462223T3 (pl) 2019-07-31
CN102471763A (zh) 2012-05-23
JP5897463B2 (ja) 2016-03-30
EP2287295A1 (en) 2011-02-23
EP2462223B1 (en) 2019-02-13
WO2011015326A2 (en) 2011-02-10
US8497083B2 (en) 2013-07-30
ES2720287T3 (es) 2019-07-19
WO2011015326A8 (en) 2012-02-23
WO2011015326A3 (en) 2011-07-07
JP2013500729A (ja) 2013-01-10
US20120208226A1 (en) 2012-08-16
EP2462223A2 (en) 2012-06-13

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