CN102471215B - 制备（2,4-二甲基联苯-3-基）乙酸、其酯及中间体化合物的方法 - Google Patents

制备（2,4-二甲基联苯-3-基）乙酸、其酯及中间体化合物的方法 Download PDF

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Publication number
CN102471215B
CN102471215B CN201080030850.6A CN201080030850A CN102471215B CN 102471215 B CN102471215 B CN 102471215B CN 201080030850 A CN201080030850 A CN 201080030850A CN 102471215 B CN102471215 B CN 102471215B
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China
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formula
stands
acid
compound
tert
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Expired - Fee Related
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CN201080030850.6A
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English (en)
Chinese (zh)
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CN102471215A (zh
Inventor
R·菲舍尔
T·希姆勒
W·乔尔格斯
W·林纳
W·A·莫拉迪
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Bayer Pharma AG
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Bayer CropScience AG
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Priority to CN201410213343.6A priority Critical patent/CN103980109B/zh
Priority to CN201710343202.XA priority patent/CN107266306A/zh
Publication of CN102471215A publication Critical patent/CN102471215A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/007—Esters of unsaturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CN201080030850.6A 2009-07-07 2010-06-25 制备（2,4-二甲基联苯-3-基）乙酸、其酯及中间体化合物的方法 Expired - Fee Related CN102471215B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201410213343.6A CN103980109B (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法
CN201710343202.XA CN107266306A (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09164792 2009-07-07
EP09164792.5 2009-07-07
PCT/EP2010/003911 WO2011003530A2 (de) 2009-07-07 2010-06-25 Verfahren zur herstellung von (2,4-dimethylbiphenyl-3-yl)essigsäuren, deren ester sowie zwischenverbindungen

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201410213343.6A Division CN103980109B (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法
CN201710343202.XA Division CN107266306A (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法

Publications (2)

Publication Number Publication Date
CN102471215A CN102471215A (zh) 2012-05-23
CN102471215B true CN102471215B (zh) 2014-06-11

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201080030850.6A Expired - Fee Related CN102471215B (zh) 2009-07-07 2010-06-25 制备（2,4-二甲基联苯-3-基）乙酸、其酯及中间体化合物的方法
CN201410213343.6A Expired - Fee Related CN103980109B (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法
CN201710343202.XA Pending CN107266306A (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法

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CN201410213343.6A Expired - Fee Related CN103980109B (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法
CN201710343202.XA Pending CN107266306A (zh) 2009-07-07 2010-06-25 制备（2,4‑二甲基联苯‑3‑基）乙酸、其酯及中间体化合物的方法

Country Status (11)

Country Link
US (1) US8664428B2 (https=)
EP (1) EP2451767B1 (https=)
JP (2) JP6081797B2 (https=)
KR (1) KR101715047B1 (https=)
CN (3) CN102471215B (https=)
BR (1) BR112012000244B1 (https=)
DK (1) DK2451767T3 (https=)
ES (1) ES2751974T3 (https=)
IL (1) IL217134A (https=)
MX (1) MX2012000278A (https=)
WO (1) WO2011003530A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2473476B1 (de) * 2009-08-31 2015-01-14 Bayer Intellectual Property GmbH Tetraarylborat verfahren zur herstellung von substituierten biphenylen
FR3013351B1 (fr) * 2013-11-15 2016-01-01 Rhodia Operations Procede de preparation de compose aromatique mandelique et de compose aldehyde aromatique
ES2733477T3 (es) * 2017-07-04 2019-11-29 Fis Fabbrica Italiana Sintetici Spa Procedimiento eficaz para la preparación de sitagliptina a través de una preparación muy eficaz del intermedio ácido 2,4,5-trifluorofenilacético
JP7353295B2 (ja) 2018-04-10 2023-09-29 バイエル・アクチエンゲゼルシヤフト ２，６－ジアルキルフェニル酢酸の製造方法
CN119330876A (zh) * 2024-09-10 2025-01-21 山东京博农化科技股份有限公司 一种Flupyroxystrobin的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1215390A (zh) * 1996-04-02 1999-04-28 拜尔公司 取代的苯基酮烯醇杀虫剂及除草剂
CN1863806A (zh) * 2003-08-14 2006-11-15 拜尔农作物科学股份公司 4－联苯基取代的吡唑烷－3,5－二酮衍生物
WO2008067911A1 (de) * 2006-12-04 2008-06-12 Bayer Cropscience Ag Biphenylsubstituierte spirocyclische ketoenole

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860169A (en) 1953-03-25 1958-11-11 California Research Corp Process for producing 1, 2, 3-trialkylbenzenes by alkyl transfer reactions
JPS56169635A (en) * 1980-06-03 1981-12-26 Nippon Chemiphar Co Ltd Halohydrin derivative and its preparation
FR2686876B1 (fr) 1992-02-04 1994-05-13 Hoechst Ste Francaise Procede de preparation d'acides arylacetiques et de leurs sels de metaux alcalins.
CN1152860C (zh) 1995-06-30 2004-06-09 拜尔公司 二烷基-卤代苯基取代的酮-烯醇
US5945567A (en) * 1997-08-20 1999-08-31 American Cyanamid Company Fungicidal 2-methoxybenzophenones
DE19813354A1 (de) * 1998-03-26 1999-09-30 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
EP1186583A1 (de) 2000-09-07 2002-03-13 Degussa AG Verfahren zur Durchführung von CC-Kupplungsreaktionen
AU2003212278A1 (en) * 2002-03-08 2003-09-22 Vicuron Pharmaceuticals Inc. A process for the production of ramoplanin-like amide derivatives
DE10301804A1 (de) 2003-01-20 2004-07-29 Bayer Cropscience Ag 2,4-Dihalogen-6-(C2-C3-alkyl)-phenyl substituierte Tetramsäure-Derivate
AR052930A1 (es) * 2005-03-02 2007-04-11 Basf Ag Procedimiento para la preparacion de bifenilos sustituidos
EP1764365A1 (en) * 2005-09-20 2007-03-21 KRKA, D.D., Novo Mesto A process for the preparation of sartan derivates and intermediates useful in such process
WO2009078999A1 (en) * 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1215390A (zh) * 1996-04-02 1999-04-28 拜尔公司 取代的苯基酮烯醇杀虫剂及除草剂
CN1863806A (zh) * 2003-08-14 2006-11-15 拜尔农作物科学股份公司 4－联苯基取代的吡唑烷－3,5－二酮衍生物
WO2008067911A1 (de) * 2006-12-04 2008-06-12 Bayer Cropscience Ag Biphenylsubstituierte spirocyclische ketoenole

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Cleavage and migration of tert-butyl radicals during chemical reactions. II. 1,3-Dimethyl-5-tert-butylbenzene and its derivatives;BUU-HOI ET AL;《BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE》;19421231;第9卷;889-892 *
SYNTHESIS OF ALKYL-SUBSTITUTED 3-PHENYL-PHYDROXYCOUMARIN;B.VAN ZANTEN et al.;《Recueil des Travaux Chimiques des Pays-Bas》;19601231;第79卷;1211-1222 *
Synthesis of three Xylocaine analogs. Steric effects in the reaction between 2,6-dimethylphenyllithium and epichlorohydrin;LOFGREN, NIL et al.;《ACTA CHEMICA SCANDINAVICA》;19631231;第17卷(第5期);1252-1261 *

Also Published As

Publication number Publication date
CN103980109B (zh) 2017-05-03
WO2011003530A8 (de) 2012-01-12
DK2451767T3 (da) 2019-11-11
KR20120037004A (ko) 2012-04-18
IL217134A (en) 2014-11-30
JP6081797B2 (ja) 2017-02-15
EP2451767B1 (de) 2019-08-21
WO2011003530A3 (de) 2011-03-17
ES2751974T3 (es) 2020-04-02
EP2451767A2 (de) 2012-05-16
CN102471215A (zh) 2012-05-23
US8664428B2 (en) 2014-03-04
US20120116118A1 (en) 2012-05-10
JP2012532158A (ja) 2012-12-13
IL217134A0 (en) 2012-02-29
BR112012000244B1 (pt) 2019-01-08
CN103980109A (zh) 2014-08-13
CN107266306A (zh) 2017-10-20
KR101715047B1 (ko) 2017-03-10
WO2011003530A2 (de) 2011-01-13
JP2016040296A (ja) 2016-03-24
MX2012000278A (es) 2012-01-27
BR112012000244A2 (pt) 2016-02-16

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Owner name: BAYER INTELLECTUAL PROPERTY GMBH

Free format text: FORMER OWNER: BAYER LANDWIRTSCHAFTLICHE KULTURPFLANZEN SCIENCE AG

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Patentee after: Bayer Pharma Aktiengesellschaft

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Granted publication date: 20140611

Termination date: 20210625