JPS56169635A - Halohydrin derivative and its preparation - Google Patents

Halohydrin derivative and its preparation

Info

Publication number
JPS56169635A
JPS56169635A JP7368380A JP7368380A JPS56169635A JP S56169635 A JPS56169635 A JP S56169635A JP 7368380 A JP7368380 A JP 7368380A JP 7368380 A JP7368380 A JP 7368380A JP S56169635 A JPS56169635 A JP S56169635A
Authority
JP
Japan
Prior art keywords
formula
expressed
butyl
compound
butylphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7368380A
Other languages
Japanese (ja)
Other versions
JPS6351132B2 (en
Inventor
Mitsuo Mazaki
Toru Yamanaka
Hiromitsu Takeda
Isoo Kadosaka
Atsushi Tendou
Tomio Yamakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Chemiphar Co Ltd
Original Assignee
Nippon Chemiphar Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co Ltd filed Critical Nippon Chemiphar Co Ltd
Priority to JP7368380A priority Critical patent/JPS56169635A/en
Publication of JPS56169635A publication Critical patent/JPS56169635A/en
Publication of JPS6351132B2 publication Critical patent/JPS6351132B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A halohydrin derivative expressed by formula I (X is halogen; R is H or t-butyl).
EXAMPLE: 3-(2-Bromo-4-t-butylphenyl)-1-chloro-2-propanol.
USE: A synthetic intermediate for pharmaceuticals, e.g. 5-(o-bromobenzyl)-2-oxazolidone having anti-inflammatory, analgesic and mussle relaxing actions.
PROCESS: Br2 is reacted with a 3-(4-t-butylphenyl)-1-halo-2-propanol expressed by formula II in an aqueous solution thereof at room temperature for 1W4hr to give a compound expressed by formula I in which R is t-butyl. If necessary, the compound is reacted with AlCl3 in an organic solvent at room temperature for 1W10hr to eliminate the t-butyl group and afford a compound expressed by formula I in which R is H.
COPYRIGHT: (C)1981,JPO&Japio
JP7368380A 1980-06-03 1980-06-03 Halohydrin derivative and its preparation Granted JPS56169635A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7368380A JPS56169635A (en) 1980-06-03 1980-06-03 Halohydrin derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7368380A JPS56169635A (en) 1980-06-03 1980-06-03 Halohydrin derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS56169635A true JPS56169635A (en) 1981-12-26
JPS6351132B2 JPS6351132B2 (en) 1988-10-13

Family

ID=13525253

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7368380A Granted JPS56169635A (en) 1980-06-03 1980-06-03 Halohydrin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56169635A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016040296A (en) * 2009-07-07 2016-03-24 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Method for preparing (2,4-dimethylbiphenyl-3-yl)acetic acids, esters thereof and intermediate compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016040296A (en) * 2009-07-07 2016-03-24 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Method for preparing (2,4-dimethylbiphenyl-3-yl)acetic acids, esters thereof and intermediate compounds

Also Published As

Publication number Publication date
JPS6351132B2 (en) 1988-10-13

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