CN102460174B - 使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断 - Google Patents
使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断 Download PDFInfo
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- CN102460174B CN102460174B CN201080031411.7A CN201080031411A CN102460174B CN 102460174 B CN102460174 B CN 102460174B CN 201080031411 A CN201080031411 A CN 201080031411A CN 102460174 B CN102460174 B CN 102460174B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4728—Details alpha-Glycoproteins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/775—Apolipopeptides
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/54—Determining the risk of relapse
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7057—(Intracellular) signaling and trafficking pathways
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610085002.4A CN105866423A (zh) | 2009-05-14 | 2010-05-13 | 使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17833409P | 2009-05-14 | 2009-05-14 | |
US61/178,334 | 2009-05-14 | ||
PCT/IB2010/001343 WO2010133967A1 (en) | 2009-05-14 | 2010-05-13 | Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610085002.4A Division CN105866423A (zh) | 2009-05-14 | 2010-05-13 | 使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102460174A CN102460174A (zh) | 2012-05-16 |
CN102460174B true CN102460174B (zh) | 2016-03-16 |
Family
ID=42663624
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080031411.7A Active CN102460174B (zh) | 2009-05-14 | 2010-05-13 | 使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断 |
CN201610085002.4A Pending CN105866423A (zh) | 2009-05-14 | 2010-05-13 | 使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610085002.4A Pending CN105866423A (zh) | 2009-05-14 | 2010-05-13 | 使用一组新型低丰度人类血浆蛋白生物标记对肝纤维化进行临床诊断 |
Country Status (9)
Country | Link |
---|---|
US (3) | US8889364B2 (zh) |
EP (2) | EP2430451B1 (zh) |
JP (3) | JP5813630B2 (zh) |
KR (1) | KR20120041175A (zh) |
CN (2) | CN102460174B (zh) |
CA (1) | CA2761692A1 (zh) |
ES (2) | ES2897692T3 (zh) |
HK (1) | HK1166368A1 (zh) |
WO (1) | WO2010133967A1 (zh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100706385B1 (ko) * | 2005-09-16 | 2007-04-10 | 주식회사 팬택앤큐리텔 | 이동통신 시스템에서 바이러스치료기능을 갖는이동통신단말기 |
EP2430451B1 (en) * | 2009-05-14 | 2014-08-13 | The Chancellors, Masters and Scholars of the University of Oxford | Clinical diagnosis of hepatic fibrosis / cirrhosis using low abundant human plasma protein biomarkers |
WO2011092219A1 (en) * | 2010-01-26 | 2011-08-04 | University College Dublin, National University Of Ireland | Biomarkers of cardiovascular disease including lrg |
CN102183661B (zh) * | 2011-03-16 | 2014-05-28 | 天津宝瑞生物技术有限公司 | 蛋白质及蛋白质组在制备肝硬化诊断试剂中的应用 |
US20140155411A1 (en) * | 2012-04-13 | 2014-06-05 | Somalogic, Inc. | Tuberculosis Biomarkers and Uses Thereof |
JP6651446B2 (ja) * | 2013-08-02 | 2020-02-19 | エコセンスEchosens | ヒトまたは動物の信頼できる、規格化されかつ完全なスコアを算出するための非侵襲的システム |
GB201315747D0 (en) * | 2013-09-04 | 2013-10-16 | Cambridge University Hospitals Nhs Foundation Trust | Biomarkers associated with diabetes and firosis |
CN104330570B (zh) * | 2014-10-11 | 2016-03-16 | 中国科学院微生物研究所 | 人热休克蛋白gp96在制备筛查肝病的产品中的应用 |
CN105301259A (zh) * | 2015-10-10 | 2016-02-03 | 广西医科大学 | 血清rbp4蛋白作为肝癌病人血清标志物及其应用 |
GB201614455D0 (en) * | 2016-08-24 | 2016-10-05 | Univ Oxford Innovation Ltd | Biomarkers |
CN106198985B (zh) * | 2016-08-31 | 2018-03-27 | 天津市泌尿外科研究所 | 用于检测去势抵抗性前列腺癌的elisa试剂盒及使用方法 |
WO2019076830A1 (en) * | 2017-10-16 | 2019-04-25 | Biopredictive | METHOD OF PROGNOSIS AND MONITORING OF CANCER OF THE PRIMITIVE LIVER |
EP3470843A1 (en) * | 2017-10-16 | 2019-04-17 | Biopredictive | Method of prognosis of primary liver cancer |
EP3511716A1 (en) * | 2018-01-16 | 2019-07-17 | Koninklijke Philips N.V. | Periodontitis diagnostic methods, uses and kits |
EP3553520A1 (en) * | 2018-04-12 | 2019-10-16 | Koninklijke Philips N.V. | Methods, uses and kits for monitoring or predicting response to periodontal disease treatment |
CN110221337B (zh) * | 2019-06-28 | 2022-07-01 | 南华大学 | 一种利用α-1抗蛋白酶评价铀矿粉尘内照射生物损伤的方法 |
CN114729935A (zh) * | 2019-11-29 | 2022-07-08 | 积水医疗株式会社 | 使用免疫反应的分析物的测量方法和测量试剂 |
CN111239408B (zh) * | 2020-01-19 | 2023-02-10 | 深圳格道糖生物技术有限公司 | 特定凝集素组合在构建基于唾液糖蛋白糖链鉴别肝纤维化的测试工具方面的应用 |
CN111751551B (zh) * | 2020-06-08 | 2023-03-17 | 郑州大学第一附属医院 | 蛋白分子作为诊断肝硬化的生物标志物及其预后方法 |
CN114113624A (zh) * | 2020-08-28 | 2022-03-01 | 香港城市大学深圳研究院 | 利用免疫球蛋白关联蛋白质组开发疾病标志物的方法及装置 |
CN115436622B (zh) * | 2022-09-26 | 2024-03-08 | 重庆医科大学国际体外诊断研究院 | 一种单分子蛋白的检测方法及其试剂盒和应用 |
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2010
- 2010-05-13 EP EP10725863.4A patent/EP2430451B1/en not_active Not-in-force
- 2010-05-13 CN CN201080031411.7A patent/CN102460174B/zh active Active
- 2010-05-13 WO PCT/IB2010/001343 patent/WO2010133967A1/en active Application Filing
- 2010-05-13 CN CN201610085002.4A patent/CN105866423A/zh active Pending
- 2010-05-13 US US12/779,349 patent/US8889364B2/en not_active Expired - Fee Related
- 2010-05-13 JP JP2012510385A patent/JP5813630B2/ja active Active
- 2010-05-13 KR KR20117029487A patent/KR20120041175A/ko not_active Application Discontinuation
- 2010-05-13 ES ES14175203T patent/ES2897692T3/es active Active
- 2010-05-13 CA CA2761692A patent/CA2761692A1/en not_active Abandoned
- 2010-05-13 EP EP14175203.0A patent/EP2799876B1/en active Active
- 2010-05-13 ES ES10725863.4T patent/ES2527455T3/es active Active
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2012
- 2012-07-13 HK HK12106932.4A patent/HK1166368A1/zh unknown
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2014
- 2014-05-16 JP JP2014102475A patent/JP5897638B2/ja active Active
- 2014-10-23 US US14/521,813 patent/US20150105293A1/en not_active Abandoned
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2016
- 2016-03-02 JP JP2016039857A patent/JP2016138891A/ja active Pending
- 2016-03-22 US US15/076,894 patent/US20160202274A1/en not_active Abandoned
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CN1759320A (zh) * | 2003-01-14 | 2006-04-12 | Vib研究所 | 检测肝纤维化的血清标记 |
TW200521139A (en) * | 2003-12-19 | 2005-07-01 | Ind Tech Res Inst | Biomakers for liver diseases and method for using same |
WO2008031051A2 (en) * | 2006-09-08 | 2008-03-13 | United Therapeutics Corporation | Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers |
CN101003831A (zh) * | 2007-01-17 | 2007-07-25 | 王贤理 | 肝胆系统疾病诊断试剂盒 |
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EP2799876B1 (en) | 2021-11-03 |
EP2799876A2 (en) | 2014-11-05 |
JP5897638B2 (ja) | 2016-03-30 |
US20100291602A1 (en) | 2010-11-18 |
HK1166368A1 (zh) | 2012-10-26 |
JP5813630B2 (ja) | 2015-11-17 |
WO2010133967A1 (en) | 2010-11-25 |
EP2799876A3 (en) | 2015-07-29 |
ES2527455T3 (es) | 2015-01-23 |
EP2430451A1 (en) | 2012-03-21 |
ES2897692T3 (es) | 2022-03-02 |
CN102460174A (zh) | 2012-05-16 |
CA2761692A1 (en) | 2010-11-25 |
JP2016138891A (ja) | 2016-08-04 |
KR20120041175A (ko) | 2012-04-30 |
US8889364B2 (en) | 2014-11-18 |
JP2014197006A (ja) | 2014-10-16 |
US20160202274A1 (en) | 2016-07-14 |
US20150105293A1 (en) | 2015-04-16 |
EP2430451B1 (en) | 2014-08-13 |
CN105866423A (zh) | 2016-08-17 |
JP2012526980A (ja) | 2012-11-01 |
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