CN102459202B - 作为脂肪酸酰胺水解酶的抑制剂的异噁唑啉 - Google Patents

作为脂肪酸酰胺水解酶的抑制剂的异噁唑啉 Download PDF

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CN102459202B
CN102459202B CN201080032435.4A CN201080032435A CN102459202B CN 102459202 B CN102459202 B CN 102459202B CN 201080032435 A CN201080032435 A CN 201080032435A CN 102459202 B CN102459202 B CN 102459202B
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substituted
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compound
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CN102459202A (zh
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马克·L·本克
阿尔弗雷多·C·卡斯特罗
劳伦斯·K·陈
凯瑟琳·A·埃文斯
路易斯·格勒涅尔
迈克尔·J·格罗根
伊夫·勒布朗
刘涛
斯特凡·佩卢索
丹尼尔·A·斯奈德
托马斯·T·帝比茨
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Infinity Pharmaceuticals Inc
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CN201080032435.4A 2009-05-18 2010-05-18 作为脂肪酸酰胺水解酶的抑制剂的异噁唑啉 Expired - Fee Related CN102459202B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17928009P 2009-05-18 2009-05-18
US17928509P 2009-05-18 2009-05-18
US17928309P 2009-05-18 2009-05-18
US61/179,285 2009-05-18
US61/179,280 2009-05-18
US61/179,283 2009-05-18
PCT/US2010/035309 WO2010135360A1 (en) 2009-05-18 2010-05-18 Isoxazolines as inhibitors of fatty acid amide hydrolase

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CN102459202A CN102459202A (zh) 2012-05-16
CN102459202B true CN102459202B (zh) 2015-11-25

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EP (1) EP2432771A4 (enExample)
JP (1) JP2012527467A (enExample)
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AR (1) AR076687A1 (enExample)
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CA (1) CA2762527A1 (enExample)
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PL2074123T3 (pl) 2006-10-16 2013-04-30 Bionomics Ltd Nowe związki o działaniu przeciwlękowym
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
AU2012222874B2 (en) 2011-03-02 2015-04-16 Bionomics Limited Novel small-molecules as therapeutics
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WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
CA3072420A1 (en) * 2017-08-10 2019-02-14 Taisho Pharmaceutical Co., Ltd. Pyridine compound substituted with azole
US10485790B1 (en) 2018-09-13 2019-11-26 Syneurx International (Taiwan) Corp. Salts of cycloserine compounds and applications thereof
EP3866798A4 (en) * 2018-10-15 2022-07-13 Dana-Farber Cancer Institute, Inc. ENHANCED TRANSCRIPTIONAL ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES
CN110016142B (zh) * 2019-04-30 2021-08-03 合肥工业大学 一种含嘧啶硼酸结构的硅油及其制备方法
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MX2023009402A (es) 2021-02-11 2023-08-23 Basf Se Derivados de isoxazolina sustituida.
EP4043444A1 (en) 2021-02-11 2022-08-17 Basf Se Substituted isoxazoline derivatives
CN116888101A (zh) * 2021-02-11 2023-10-13 巴斯夫欧洲公司 取代的异噁唑啉衍生物
US20250051338A1 (en) 2021-10-25 2025-02-13 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
EP4238971A1 (en) 2022-03-02 2023-09-06 Basf Se Substituted isoxazoline derivatives
EP4486740A1 (en) 2022-03-02 2025-01-08 Basf Se Substituted isoxazoline derivatives
EP4342885A1 (en) 2022-09-20 2024-03-27 Basf Se N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides
CN120152959A (zh) 2022-09-20 2025-06-13 巴斯夫欧洲公司 作为杀有害生物剂的n-(3-(氨基甲基)-苯基)-5-(4-苯基)-5-(三氟甲基)-4,5-二氢异噁唑-3-胺衍生物及类似化合物

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