RU2539595C2 - Изоксазолины в качестве ингибиторов амидгидролазы жирных кислот - Google Patents

Изоксазолины в качестве ингибиторов амидгидролазы жирных кислот Download PDF

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RU2539595C2
RU2539595C2 RU2011151635/04A RU2011151635A RU2539595C2 RU 2539595 C2 RU2539595 C2 RU 2539595C2 RU 2011151635/04 A RU2011151635/04 A RU 2011151635/04A RU 2011151635 A RU2011151635 A RU 2011151635A RU 2539595 C2 RU2539595 C2 RU 2539595C2
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RU2011151635A (ru
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Марк Л. БЕНКЕ
Альфредо С. КАСТРО
Лоуренс К. ЧАН
Кэтрин А. ЭВАНС
Луи ГРЕНЬЕ
Майкл Дж. ГРОГАН
Ив Леблан
Тао ЛЮ
Стефан ПЕЛЮЗО
Дэниел А. СНАЙДЕР
Томас Т. ТИББИТТС
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Инфинити Фармасьютикалз, Инк.
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    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
RU2011151635/04A 2009-05-18 2010-05-18 Изоксазолины в качестве ингибиторов амидгидролазы жирных кислот RU2539595C2 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17928509P 2009-05-18 2009-05-18
US17928009P 2009-05-18 2009-05-18
US17928309P 2009-05-18 2009-05-18
US61/179,283 2009-05-18
US61/179,280 2009-05-18
US61/179,285 2009-05-18
PCT/US2010/035309 WO2010135360A1 (en) 2009-05-18 2010-05-18 Isoxazolines as inhibitors of fatty acid amide hydrolase

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RU2011151635A RU2011151635A (ru) 2013-06-27
RU2539595C2 true RU2539595C2 (ru) 2015-01-20

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EP (1) EP2432771A4 (enExample)
JP (1) JP2012527467A (enExample)
KR (1) KR20120042766A (enExample)
CN (1) CN102459202B (enExample)
AR (1) AR076687A1 (enExample)
AU (1) AU2010249674A1 (enExample)
BR (1) BRPI1011049A2 (enExample)
CA (1) CA2762527A1 (enExample)
IL (1) IL216420A0 (enExample)
MX (1) MX2011012263A (enExample)
NZ (2) NZ596585A (enExample)
RU (1) RU2539595C2 (enExample)
SG (2) SG10201402443PA (enExample)
TW (1) TW201043620A (enExample)
WO (1) WO2010135360A1 (enExample)
ZA (1) ZA201108657B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12178804B2 (en) 2018-09-13 2024-12-31 Syneurx International (Taiwan) Corp. Salts of cycloserine compounds and applications thereof

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
DK2074123T3 (da) 2006-10-16 2013-01-14 Bionomics Ltd Nye anxiolytiske forbindelser
US8927551B2 (en) 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
WO2011085216A2 (en) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
EP2681198A4 (en) 2011-03-02 2014-09-03 Bionomics Ltd NEW LITTLE MOLECULES AS THERAPIES
NZ615466A (en) 2011-05-12 2016-02-26 Bionomics Ltd Methods for preparing naphthyridines
WO2018112843A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. Heteroaryl piperidine ether allosteric modulators of the m4 muscarinic acetylcholine receptor
WO2019031618A1 (ja) * 2017-08-10 2019-02-14 大正製薬株式会社 アゾールで置換されたピリジン化合物
WO2020081572A1 (en) * 2018-10-15 2020-04-23 Dana-Farber Cancer Institute, Inc. Transcriptional enhanced associate domain (tead) transcription factor inhibitors and uses thereof
CN110016142B (zh) * 2019-04-30 2021-08-03 合肥工业大学 一种含嘧啶硼酸结构的硅油及其制备方法
MX2021014443A (es) 2019-05-31 2022-01-06 Ikena Oncology Inc Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
AU2020282759A1 (en) 2019-05-31 2021-12-23 Ikena Oncology, Inc. TEAD inhibitors and uses thereof
CN116888101A (zh) * 2021-02-11 2023-10-13 巴斯夫欧洲公司 取代的异噁唑啉衍生物
EP4043444A1 (en) 2021-02-11 2022-08-17 Basf Se Substituted isoxazoline derivatives
US20240140917A1 (en) 2021-02-11 2024-05-02 Basf Se Substituted isoxazoline derivatives
AU2022378463A1 (en) 2021-10-25 2024-05-09 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
US20250163037A1 (en) 2022-03-02 2025-05-22 Basf Se Substituted isoxazoline derivatives
EP4238971A1 (en) 2022-03-02 2023-09-06 Basf Se Substituted isoxazoline derivatives
EP4342885A1 (en) 2022-09-20 2024-03-27 Basf Se N-(3-(aminomethyl)-phenyl)-5-(4-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-amine derivatives and similar compounds as pesticides
CN120152959A (zh) 2022-09-20 2025-06-13 巴斯夫欧洲公司 作为杀有害生物剂的n-(3-(氨基甲基)-苯基)-5-(4-苯基)-5-(三氟甲基)-4,5-二氢异噁唑-3-胺衍生物及类似化合物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070155747A1 (en) * 2005-12-29 2007-07-05 Kadmus Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
EP1813606A1 (en) * 2004-11-18 2007-08-01 Takeda Pharmaceutical Company Limited Amide compound
RU2331637C2 (ru) * 2004-02-26 2008-08-20 Санофи-Авентис Производные алкилпиперазин- и алкилгомопиперазинкарбоксилатов, их получение и применение в качестве ингибиторов фермента faah
WO2009011904A1 (en) * 2007-07-19 2009-01-22 Renovis, Inc. Compounds useful as faah modulators and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9505651D0 (en) * 1995-03-21 1995-05-10 Agrevo Uk Ltd AgrEvo UK Limited
EA008767B1 (ru) * 2002-10-08 2007-08-31 Зе Скрипс Ресеч Инститьют Ингибиторы гидролазы амидов жирных кислот
WO2004044169A2 (en) * 2002-11-14 2004-05-27 The Scripps Research Institute Crystalline form of fatty acid amine hydrolase (faah)
WO2005034952A2 (en) * 2003-10-07 2005-04-21 The Feinstein Institute For Medical Research Isoxazole and isothiazole compounds useful in the treatment of inflammation
ITMI20061279A1 (it) * 2006-06-30 2008-01-01 Consiglio Nazionale Ricerche Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
CA2710743A1 (en) * 2007-12-27 2009-07-09 Bial-Portela & Ca., S.A. 5-o-substituted 3-n-phenyl-1,3,4-oxadiazolones for medical use
JP5529044B2 (ja) * 2008-01-25 2014-06-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 殺菌性複素環化合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2331637C2 (ru) * 2004-02-26 2008-08-20 Санофи-Авентис Производные алкилпиперазин- и алкилгомопиперазинкарбоксилатов, их получение и применение в качестве ингибиторов фермента faah
EP1813606A1 (en) * 2004-11-18 2007-08-01 Takeda Pharmaceutical Company Limited Amide compound
US20070155747A1 (en) * 2005-12-29 2007-07-05 Kadmus Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
WO2009011904A1 (en) * 2007-07-19 2009-01-22 Renovis, Inc. Compounds useful as faah modulators and uses thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12178804B2 (en) 2018-09-13 2024-12-31 Syneurx International (Taiwan) Corp. Salts of cycloserine compounds and applications thereof

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AU2010249674A1 (en) 2011-12-15
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CA2762527A1 (en) 2010-11-25
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