CN102448984A - 使用包含抗体-受体组合的多特异性结合蛋白的组合物和方法 - Google Patents

使用包含抗体-受体组合的多特异性结合蛋白的组合物和方法 Download PDF

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CN102448984A
CN102448984A CN2010800230893A CN201080023089A CN102448984A CN 102448984 A CN102448984 A CN 102448984A CN 2010800230893 A CN2010800230893 A CN 2010800230893A CN 201080023089 A CN201080023089 A CN 201080023089A CN 102448984 A CN102448984 A CN 102448984A
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seq
vegf
antibody
binding protein
bispecific binding
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CN2010800230893A
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English (en)
Chinese (zh)
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Q.潘
C.W.伯克斯
P.V.西瓦库马
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Zymogenetics Inc
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Zymogenetics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2010800230893A 2009-03-27 2010-03-26 使用包含抗体-受体组合的多特异性结合蛋白的组合物和方法 Pending CN102448984A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16402309P 2009-03-27 2009-03-27
US61/164,023 2009-03-27
PCT/US2010/028877 WO2010111625A1 (en) 2009-03-27 2010-03-26 Compositions and methods for using multispecific-binding proteins comprising an antibody-receptor combination

Publications (1)

Publication Number Publication Date
CN102448984A true CN102448984A (zh) 2012-05-09

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CN2010800230893A Pending CN102448984A (zh) 2009-03-27 2010-03-26 使用包含抗体-受体组合的多特异性结合蛋白的组合物和方法

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Country Link
US (1) US20120134993A1 (enExample)
EP (1) EP2411407A1 (enExample)
JP (1) JP2012521768A (enExample)
KR (1) KR20110134494A (enExample)
CN (1) CN102448984A (enExample)
AU (1) AU2010229705A1 (enExample)
MX (1) MX2011009810A (enExample)
WO (1) WO2010111625A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105122068A (zh) * 2013-03-15 2015-12-02 因特穆内公司 蛋白质组学ipf标志物
WO2016011935A1 (zh) * 2014-07-21 2016-01-28 暨南大学 人fgfr2c胞外段蛋白质及其编码基因与应用
CN118420715A (zh) * 2023-03-23 2024-08-02 湖南中晟全肽生物科技股份有限公司 一种结合fgfr2受体的多肽及其用途

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EP3013851A4 (en) * 2013-06-25 2016-12-28 Sépia Pesquisa E Desenvolvimento MODULATORS OF BRADYKININ RECEPTORS AND THEIR USE
US9879081B2 (en) 2013-06-25 2018-01-30 Samsung Electronics Co., Ltd. Protein complex, bispecific antibody including the protein complex, and method of preparation thereof
KR102060187B1 (ko) 2013-07-19 2019-12-27 삼성전자주식회사 Vegf-c, vegf-d 및/또는 안지오포이에틴-2를 동시에 저해하는 융합 폴리펩타이드 및 이의 용도
PL3041513T3 (pl) 2013-09-08 2021-01-25 Kodiak Sciences Inc. Obojnaczojonowe polimerowe koniugaty czynnika viii
WO2015200905A2 (en) * 2014-06-28 2015-12-30 Oligasis, Llc Dual pdgf/vegf antagonists
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CN113957146A (zh) 2014-09-26 2022-01-21 詹森药业有限公司 使用fgfr突变基因组鉴定将对用fgfr抑制剂进行治疗有反应的癌症患者
KR102210104B1 (ko) 2014-10-17 2021-02-01 코디악 사이언시스 인코포레이티드 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트
US12428483B2 (en) 2014-12-22 2025-09-30 Systimmune, Inc. Bispecific tetravalent antibodies and methods of making and using thereof
WO2016106158A1 (en) 2014-12-22 2016-06-30 Systimmune, Inc. Bispecific tetravalent antibodies and methods of making and using thereof
UA128057C2 (uk) 2015-07-15 2024-03-27 Ґенмаб А/С Гуманізоване або химерне антитіло, яке зв'язує cd3 людини
WO2017091850A1 (en) * 2015-11-30 2017-06-08 Pieris Australia Pty Ltd. Novel anti-angiogenic fusion polypeptides
CA3010056A1 (en) 2015-12-30 2017-07-06 Kodiak Sciences Inc. Antibodies and conjugates thereof
WO2018011421A1 (en) 2016-07-14 2018-01-18 Genmab A/S Multispecific antibodies against cd40 and cd137
PT3592769T (pt) 2017-03-09 2024-07-31 Genmab As Anticorpos contra pd-l1
UA127586C2 (uk) 2017-03-31 2023-10-25 Ґенмаб Холдінґ Б.В. Біспецифічні анти-cd37-антитіла, моноклональні анти-cd37-антитіла та способи їх застосування
CN111406067B (zh) 2017-08-04 2022-11-08 健玛保 与pd-l1和cd137结合的结合剂及其用途
CN112203679A (zh) 2018-03-02 2021-01-08 科达制药股份有限公司 Il-6抗体及其融合构建体和缀合物
US12077586B2 (en) 2018-09-19 2024-09-03 LAVA Therapeutics N.V. Bispecific antibodies for use in the treatment of hematological malignancies
MA53812A (fr) 2018-10-04 2021-08-11 Genmab Holding B V Compositions pharmaceutiques comprenant des anticorps anti-cd37 bispécifiques
KR20210124959A (ko) 2018-11-06 2021-10-15 젠맵 에이/에스 항체 제제
NL2022494B1 (en) 2019-02-01 2020-08-19 Lava Therapeutics B V Novel CD40-binding antibodies
EP3917960A1 (en) 2019-02-01 2021-12-08 LAVA Therapeutics N.V. Novel cd40-binding antibodies
JPWO2021010326A1 (enExample) * 2019-07-12 2021-01-21
EP3792283A1 (en) 2019-09-16 2021-03-17 Lava Therapeutics B.V. Treatment of cancer comprising administration of vgamma9vdelta2 t cell receptor binding antibodies
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法
WO2021155916A1 (en) 2020-02-04 2021-08-12 BioNTech SE Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137
MY210125A (en) 2020-03-18 2025-08-28 Genmab As Antibodies binding to b7h4
JP2023524149A (ja) 2020-05-08 2023-06-08 ジェンマブ エー／エス Ｃｄ３およびｃｄ２０に対する二重特異性抗体
US20230272110A1 (en) 2020-07-08 2023-08-31 LAVA Therapeutics N.V. Antibodies that bind psma and gamma-delta t cell receptors
JP2023536340A (ja) 2020-08-06 2023-08-24 ビオンテック・ソシエタス・エウロパエア コロナウイルスｓタンパク質のための結合剤
BR112023004327A2 (pt) 2020-09-10 2023-04-04 Genmab As Método para tratar leucemia linfocítica crônica em um sujeito humano
MX2023002545A (es) 2020-09-10 2023-03-14 Genmab As Anticuerpo biespecifico contra cumulo de diferenciacion 3 (cd3) y cumulo de diferenciacion 20 (cd20) en terapia de combinacion para el tratamiento de linfoma difuso de celulas b grandes.
JP2024501403A (ja) 2020-12-10 2024-01-12 ラヴァ・セラピューティクス・エヌ・ヴイ ガンマ－デルタｔ細胞受容体に結合する抗体
US20240141071A1 (en) 2021-02-26 2024-05-02 LAVA Therapeutics N.V. Antibodies that bind cd123 and gamma-delta t cell receptors
US20240383982A1 (en) 2021-05-07 2024-11-21 Genmab A/S Pharmaceutical compositions comprising bispecific antibodies binding to b7h4 and cd3
IL309319A (en) 2021-06-21 2024-02-01 Genmab As Combined dosage regimen CD137 and PD-L1 binding agents
TW202328193A (zh) 2021-09-13 2023-07-16 美商健生生物科技公司 用於治療癌症的CD33 x Vδ2多特異性抗體
AU2022361691A1 (en) 2021-10-08 2024-03-28 Genmab A/S Antibodies binding to cd30 and cd3
EP4419109A1 (en) 2021-10-21 2024-08-28 LAVA Therapeutics N.V. Uses of gamma delta t cell activating antibodies
WO2023174521A1 (en) 2022-03-15 2023-09-21 Genmab A/S Binding agents binding to epcam and cd137
EP4285926A1 (en) 2022-05-30 2023-12-06 LAVA Therapeutics N.V. Combination treatment for chronic lymphocytic leukemia
EP4292609A1 (en) 2022-06-15 2023-12-20 LAVA Therapeutics N.V. Compositions comprising antibodies that bind gamma-delta t cell receptors
EP4292610A1 (en) 2022-06-15 2023-12-20 LAVA Therapeutics N.V. Variant antibodies that bind gamma-delta t cell receptors
NL2032398B1 (en) 2022-07-06 2024-01-23 Academisch Ziekenhuis Leiden Bispecific antibody and uses thereof
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WO2024200573A1 (en) 2023-03-27 2024-10-03 LAVA Therapeutics N.V. Nectin-4 binding agents and methods of use
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105122068A (zh) * 2013-03-15 2015-12-02 因特穆内公司 蛋白质组学ipf标志物
WO2016011935A1 (zh) * 2014-07-21 2016-01-28 暨南大学 人fgfr2c胞外段蛋白质及其编码基因与应用
CN118420715A (zh) * 2023-03-23 2024-08-02 湖南中晟全肽生物科技股份有限公司 一种结合fgfr2受体的多肽及其用途
CN118420715B (zh) * 2023-03-23 2025-01-24 湖南中晟全肽生物科技股份有限公司 一种结合fgfr2受体的多肽及其用途

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WO2010111625A1 (en) 2010-09-30
EP2411407A1 (en) 2012-02-01
JP2012521768A (ja) 2012-09-20
US20120134993A1 (en) 2012-05-31
KR20110134494A (ko) 2011-12-14
MX2011009810A (es) 2011-09-30
AU2010229705A1 (en) 2011-10-20

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Application publication date: 20120509