CN102342977A - Keteling capsule and preparation method thereof - Google Patents
Keteling capsule and preparation method thereof Download PDFInfo
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- CN102342977A CN102342977A CN2011101987515A CN201110198751A CN102342977A CN 102342977 A CN102342977 A CN 102342977A CN 2011101987515 A CN2011101987515 A CN 2011101987515A CN 201110198751 A CN201110198751 A CN 201110198751A CN 102342977 A CN102342977 A CN 102342977A
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- capsule
- cough
- chlorphenamine maleate
- keteling
- ketelin
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Abstract
The invention discloses a Keteling capsule and a preparation method thereof. The Keteling capsule consists of ficus microcarpa and chlorphenamine maleate. The Keteling capsule disclosed by the invention is mainly used for treating chronic bronchitis and is a new medicament for relieving a cough. The Keteling capsule is used for relieving various cough symptoms such as acute and chronic bronchitis, bronchial asthma, cough caused by cold, whooping cough and the like, eliminating phlegm, relieving asthma and diminishing inflammation and is also used for relieving cough with dyspnea and cough caused by chronic bronchitis.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine and western medicine compound preparation ketelin capsule and preparation method thereof.
Background technology
At present; The ketelin preparation adopts tablet more; Tablet is as a kind of traditional dosage form; Because of its steady quality, dosage accurately, take, easy to carry, mechanization degree is high, production cost is low and become one of at present the most frequently used dosage form, but because of the tablet extrusion forming; Disintegrate is slower; Bioavailability is lower, and the part patient difficulty of swallowing comparatively, thereby promoting the use of to a certain extent of tablet is restricted.Capsule then exists: can cover adverse drug and smell flavor or improve medicine stability; Bioavailability of medicament is higher; Can remedy the deficiency of other solid dosage formss; Can delay the release of medicine and the advantage of positioning release medicine.Be isolated from the outside because of medicine is contained in the capsule shells, avoided the influence of moisture, air, light, bad flavor or the unsettled medicine smelt of tool had covering to a certain extent, protection and Stabilization.Medicine in the capsule is directly to load in softgel shell with powder or graininess, the influence of factor such as be not stressed, so dispersion rapidly, stripping and absorption in gastrointestinal tract, its bioavailability will be higher than pill, tablets and other formulations.Medicine that oil content is high or liquid drug are difficult to process pill, tablet etc., but can be made into soft capsule.Medicine can be processed on demand during slow-releasing granules incapsulates, reached the effect of slow release prolongation of effect, the contac capsule promptly belongs to this type; Process enteric coated capsule and the medicine location can be released to small intestinal for absorption, also can be made into the capsule of rectally or vagina administration, make to be positioned at these tract releases; To absorb protide, polypeptide drug preferably at colonic segment, can be made into segmented intestine targeted capsule.
Summary of the invention
The invention provides a kind of Chinese medicine and western medicine compound preparation ketelin capsule and preparation method thereof.
A kind of ketelin capsule that the present invention proposes and preparation method thereof is made up of Foliole banyan, chlorphenamine maleate; Its prescription is Foliole banyan 75-95%, chlorphenamine maleate 0.05-0.5% by weight percentage.
Among the present invention, described a kind of ketelin capsule and preparation method thereof, its prescription preferred version by weight percentage is: Foliole banyan 90%, chlorphenamine maleate 0.35%.
Among the present invention, described a kind of ketelin capsule and preparation method thereof, dosage form is a capsule.
Foliole banyan is used as medicine to lead and uses its leaf, there are some researches show mainly to contain flavone, triterpenes, oleanolic acid, aliphatic compound and steroidal compounds etc. in the Folium fici microcarpae.Wherein medicinal ingredient all has significant effect to treatment cardiovascular disease, antiinflammatory, aspect such as antibacterial, use is arranged morning among the people, and record in ministry standard with the asthma and the chronic bronchitis curative ketelin capsule of its extractum as main constituent.
Among the present invention, described a kind of ketelin capsule and preparation method thereof comprises the steps,
1. Folium fici microcarpae dries or is air-dry, is that 1:12 soaks 6-8h with Folium fici microcarpae according to the weight ratio of Folium fici microcarpae and water, boiling water boil carry the water extract;
2. the water extract is filtered with 100 mesh sieves, filtrating through concentrating under reduced pressure (60-70 ℃ ,-0.075MPa) be the thick paste of 1. 00-1. 20 (50 ℃) to relative density;
3. the chlorphenamine maleate fine powder is added in the above-mentioned thick paste, fully mixed powder is broken into fine powder, crosses the 100-300 mesh sieve, and is subsequent use;
4. the medicament mixed with above-mentioned mix homogeneously is even, incapsulate, both.
Among the present invention, described a kind of ketelin capsule is mainly used in the treatment chronic bronchitis.Control and cough new drug.Be used for acute/chronic bronchitis, bronchial asthma, cold cough, pertussis and various cough disease antitussive, eliminate the phlegm, relieving asthma antiinflammatory.Be used for the cough of cough with asthma and chronic bronchitis.
Usage: oral, one time 3,2 times on the one.
The specific embodiment
Below in conjunction with embodiment a kind of ketelin capsule of the present invention and preparation method thereof is described.
Embodiment 1.
Among the present invention, described a kind of ketelin capsule and preparation method thereof comprises the steps,
1. Folium fici microcarpae dries or is air-dry, is that 1:12 soaks 6-8h with Folium fici microcarpae according to the weight ratio of Folium fici microcarpae and water, boiling water boil carry the water extract;
2. the water extract is filtered with 100 mesh sieves, filtrating through concentrating under reduced pressure (60-70 ℃ ,-0.075MPa) be the thick paste of 1. 00-1. 20 (50 ℃) to relative density;
3. the chlorphenamine maleate fine powder is added in the above-mentioned thick paste, fully mixed powder is broken into fine powder, crosses the 100-300 mesh sieve, and is subsequent use;
4. the medicament mixed with above-mentioned mix homogeneously is even, incapsulate, both.
Case.
Zhang, the woman, 42 years old, suffered from chronic bronchial asthma 4 years, in June, 2010, after 2 months, symptom did not repeatedly appear in recovery from illness rehabilitation so far through the treatment of this medicine.
Lee, the man, 27 years old, suffered from chronic bronchitis 6 years, in January, 2010, after 5 months, symptom did not repeatedly appear in recovery from illness rehabilitation so far through the treatment of this medicine.
Song, the man, 65 years old, cold cough, treat through this medicine in March, 2011, after 5 days, the recovery from illness rehabilitation.
The above; Only be the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is in the technical scope that the present invention discloses; Be equal to replacement or change according to technical scheme of the present invention and inventive concept thereof, all should be encompassed within protection scope of the present invention.
Claims (4)
1. a ketelin capsule is characterized in that: be made up of Foliole banyan, chlorphenamine maleate; Its prescription is Foliole banyan 75-95%, chlorphenamine maleate 0.05-0.5% by weight percentage.
2. a kind of ketelin capsule according to claim 1 is characterized in that: its prescription is by weight percentage: Foliole banyan 90%, chlorphenamine maleate 0.35%.
3. a kind of ketelin capsule according to claim 1 is characterized in that: dosage form is a capsule.
4. according to the method for preparing of the described a kind of ketelin capsule of arbitrary claim in the claim 1, it is characterized in that: comprise the steps,
1. Folium fici microcarpae dries or is air-dry, is that 1:12 soaks 6-8h with Folium fici microcarpae according to the weight ratio of Folium fici microcarpae and water, boiling water boil carry the water extract;
2. the water extract is filtered with 100 mesh sieves, filtrating through concentrating under reduced pressure (60-70 ℃ ,-0.075MPa) be the thick paste of 1. 00-1. 20 (50 ℃) to relative density;
3. the chlorphenamine maleate fine powder is added in the above-mentioned thick paste, fully mixed powder is broken into fine powder, crosses the 100-300 mesh sieve, and is subsequent use;
4. the medicament mixed with above-mentioned mix homogeneously is even, incapsulate, both.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101987515A CN102342977A (en) | 2011-07-15 | 2011-07-15 | Keteling capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101987515A CN102342977A (en) | 2011-07-15 | 2011-07-15 | Keteling capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102342977A true CN102342977A (en) | 2012-02-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011101987515A Pending CN102342977A (en) | 2011-07-15 | 2011-07-15 | Keteling capsule and preparation method thereof |
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| CN (1) | CN102342977A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106606541A (en) * | 2017-01-10 | 2017-05-03 | 吉林省现代中药工程研究中心有限公司 | Novel feeding method of Keteling capsule |
| CN107456483A (en) * | 2017-08-31 | 2017-12-12 | 吉林修正药业新药开发有限公司 | A kind of pharmaceutical composition for being used for cough and asthma and chronic bronchitis and preparation method thereof |
| CN107823263A (en) * | 2017-12-08 | 2018-03-23 | 湖南康寿制药有限公司 | A kind of preventing phlegm from forming and stopping coughing Chinese medicine composition and preparation method thereof |
| CN111084810A (en) * | 2019-12-29 | 2020-05-01 | 广东罗浮山国药股份有限公司 | Application of keteling preparation in treating senile dementia |
| CN111084808A (en) * | 2019-12-29 | 2020-05-01 | 广东罗浮山国药股份有限公司 | Application of keteling preparation in treating hepatitis B |
| CN111450143A (en) * | 2020-04-24 | 2020-07-28 | 广州白云山医药集团股份有限公司白云山制药总厂 | Application of ficus microcarpa extract in preparation of medicine for preventing and/or treating liver pathological changes |
| CN111450144A (en) * | 2020-04-24 | 2020-07-28 | 广州白云山医药集团股份有限公司白云山制药总厂 | Application of ficus microcarpa extract in preparation of medicines for preventing and/or treating diabetes and complications thereof |
-
2011
- 2011-07-15 CN CN2011101987515A patent/CN102342977A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106606541A (en) * | 2017-01-10 | 2017-05-03 | 吉林省现代中药工程研究中心有限公司 | Novel feeding method of Keteling capsule |
| CN106606541B (en) * | 2017-01-10 | 2020-02-14 | 吉林省现代中药工程研究中心有限公司 | Novel feeding method of Keteling capsules |
| CN107456483A (en) * | 2017-08-31 | 2017-12-12 | 吉林修正药业新药开发有限公司 | A kind of pharmaceutical composition for being used for cough and asthma and chronic bronchitis and preparation method thereof |
| CN107456483B (en) * | 2017-08-31 | 2020-05-19 | 吉林修正药业新药开发有限公司 | A pharmaceutical composition for treating cough and asthma and chronic bronchitis, and its preparation method |
| CN107823263A (en) * | 2017-12-08 | 2018-03-23 | 湖南康寿制药有限公司 | A kind of preventing phlegm from forming and stopping coughing Chinese medicine composition and preparation method thereof |
| CN111084810A (en) * | 2019-12-29 | 2020-05-01 | 广东罗浮山国药股份有限公司 | Application of keteling preparation in treating senile dementia |
| CN111084808A (en) * | 2019-12-29 | 2020-05-01 | 广东罗浮山国药股份有限公司 | Application of keteling preparation in treating hepatitis B |
| CN111450143A (en) * | 2020-04-24 | 2020-07-28 | 广州白云山医药集团股份有限公司白云山制药总厂 | Application of ficus microcarpa extract in preparation of medicine for preventing and/or treating liver pathological changes |
| CN111450144A (en) * | 2020-04-24 | 2020-07-28 | 广州白云山医药集团股份有限公司白云山制药总厂 | Application of ficus microcarpa extract in preparation of medicines for preventing and/or treating diabetes and complications thereof |
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Application publication date: 20120208 |