CN101837089A - Chinese medicinal herb extract for clearing away heat and toxic material and method for preparing preparation thereof - Google Patents
Chinese medicinal herb extract for clearing away heat and toxic material and method for preparing preparation thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal herb extract for clearing away heat and toxic material and a method for preparing preparation thereof. The extract and the method are secondary development for the original formulation process and preparation, and aiming at the active ingredients and effective parts in the prescription, more reasonable extraction process route and preparation process route are designed, the active ingredients and effective parts are retained to the greatest extent and a large amount of components and impurities irrelative to the therapeutic effect are removed from the original process. The prescription consists of twelve Chinese medicinal plants of gypsum, honeysuckle, figwort, radix rehmanniae, fructus forsythiae, gardenia, herba violae, baikal skullcap root, gentian, indigowoad root, anemarrhena asphodeloides bunge and tuber of dwarf lilyturf. The extract and the method can be used for preparing the formulations such as soft capsules, drops, capsules, tablets, granules, pills and the like; and compared with the original formulation, all the formulations have the advantages of small dosage and high curative effect after process improvement.
Description
Technical field
What the present invention relates to is a kind of Chinese medicine compound preparation method of extract and formulation preparation method thereof that is used for heat-clearing and toxic substances removing.
Background technology
This prescription is for having the compound Chinese medicinal preparation of heat-clearing toxin-expelling functions.Be used for the heating flushed complexion due to the hyperactivity of toxic heat, irritated thirsty, laryngopharynx swelling and pain; Influenza, upper respiratory tract infection etc. are seen above-mentioned disease person.The related dosage form of this prescription is the secondary development to former dosage form QINGRE JIEDU KOUFUYE, at effective ingredient and the effective site in this prescription, more rational extraction process route and preparation process route have been designed, farthest keep effective ingredient and effective site, remove composition and impurity that a large amount of and curative effect that contains in the former technology has nothing to do.For tcm product, drop pill, soft capsule, tablet, capsule, granule, pill etc. all belong to modern formulation.New preparation is through after the process modification, compares with former dosage form and accomplished that really dose is few, the advantage that curative effect is high.
Summary of the invention
The present invention is Chinese medicine compound preparation method of extract and the formulation preparation method thereof that a kind of heat-clearing and toxic substances removing is provided on the basis of QINGRE JIEDU KOUFUYE.
Technical scheme
Method for preparing extractive of the present invention comprises the steps:
(1) with Radix Scutellariae in the above-mentioned 12 flavor medicines, adds 15-20 times of water gaging and divide three extractions, each 1-2 hour.Collecting decoction, filter, filtrate concentrates and add hydrochloric acid solution in the time of 60-90 ℃ regulates pH value to 1.0～3.0 in right amount, be incubated 1-2 hour, left standstill 8-24 hour, filter, precipitation adds 4-10 times of water gaging, regulate pH value to 5.0-8.0 with sodium hydroxide solution, add equivalent ethanol again, stir and make dissolving, filter, filtrate is regulated pH value to 1.0～3.0 with hydrochloric acid solution, and 50-80 ℃ is incubated 20-40 minute, left standstill 8-24 hour, filter, precipitation is washed till pH value 5.0-8.0 with ethanol, wave most ethanol after, Radix Scutellariae extract.
(2) Gypsum Fibrosum adds 15-20 times of water gaging and divides and singly fry in shallow oil for three times, each 1-2 hour, filter, decocting liquid is deposited standby in addition, Gypsum Fibrosum extract.
(3) ten flavors such as all the other Flos Loniceraes add 15-20 times of water gaging and divide three decoction, 1-2 hour at every turn.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 60-80%, fully stir, left standstill the leaching supernatant 8-24 hour, reclaim ethanol to there not being the alcohol flavor, add 3-5 times of water gaging, left standstill 8-24 hour, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make the alcohol amount of containing reach 70-90%, fully stir, left standstill 8-24 hour, the leaching supernatant, decompression recycling ethanol is to there not being the alcohol flavor.
(4) add to add Radix Scutellariae extract, Gypsum Fibrosum extract in (1) (2) in above-mentioned (3), and it is an amount of to add water, stirs evenly, adds active carbon an amount of (0.5%), heat 30 minutes, filtration, it is 1.45 or spray drying that filtrate is concentrated into relative density, gets total extract.
Formulation preparation method of the present invention comprises following dosage form:
(1) this total extract and total extract and adjuvant are with 1: the ratio of 0.5-3 is mixed mutually, drips through equipment and makes drop pill.Wherein adjuvant is meant Macrogol 4000, polyethylene glycol 6000, sodium stearate, tristerin, glycerol-gelatin.
(2) this total extract mixes mutually with adjuvant, is pressed into soft capsule through equipment.Wherein adjuvant is meant glycerol, gelatin, PEG400, soybean oil, soybean phospholipid, Cera Flava.Its adjunct ingredient can be that above-mentioned one or more add simultaneously.
(3) this total extract mixes mutually with adjuvant, makes tablet or capsule through equipment.Wherein adjuvant is meant diluent: starch, microcrystalline cellulose, lactose, magnesium oxide; Lubricant: Pulvis Talci, stearic acid and salt thereof, silicon dioxide; Correctives can be sucrose, protein sugar, stevioside, and the composition of its diluent, lubricant, correctives can be that above-mentioned one or more add simultaneously.
(4) this total extract mixes mutually with adjuvant, makes granule through equipment.
(5) this total extract mixes mutually with adjuvant, makes pill through equipment.
The specific embodiment
Embodiment 1
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Method for preparing drop pills: the part by weight of total extract and polyethylene glycol 6000 1: 2, heated and stirred is even, makes drop pill.
Embodiment 2
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Method for preparing drop pills: the part by weight of total extract and Macrogol 4000 1: 2, heated and stirred is even, makes drop pill.
Embodiment 3
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Soft capsule preparation method: the part by weight of total extract and refined soybean oil 1: 2.5; Softgel shell is to be made by by weight gelatin 1, arabic gum 0.25, glycerol 0.75.
Embodiment 4
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Soft capsule preparation method: total extract, refined soybean oil, mellisic part by weight 1: 1: 0.02; Softgel shell is to be made by by weight gelatin 1, glycerol 0.43, water 1.02.
Embodiment 5
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Soft capsule preparation method: the part by weight of total extract, PEG400 1: 3; Softgel shell is to be made by by weight gelatin 1, glycerol 0.35, water 0.9.
Embodiment 6
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Tablet or capsule preparation method thereof: the part by weight of total extract, starch, microcrystalline cellulose, lactose, stearic acid and salt thereof 76: 10: 8: 4: 2; Mixing and stirring is made granule, and refabrication becomes capsule or tablet.
Embodiment 7
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Process for producing granula: total extract and an amount of Icing Sugar, dextrin; Mixing and stirring is made granule.
Embodiment 8
According to prescription 12 flavors, baikal skullcap root decoction pieces adds 18 times of water gagings and divides three extractions, each 1.5 hours.Collecting decoction filters, and filtrate concentrates and add the 2mol/L hydrochloric acid solution in the time of 80 ℃ regulates pH value to 1.0～2.0 in right amount, be incubated 1 hour, left standstill 12 hours, filter, precipitation adds 6～8 times of water gagings, regulates pH value to 7.0 with 40% sodium hydroxide solution, adds equivalent ethanol again, stirring makes dissolving, filters, and filtrate is regulated pH value to 2.0 with the 2mol/L hydrochloric acid solution, 60 ℃ are incubated 30 minutes, leave standstill 12 hours, filter, precipitation is washed till pH value 7.0 with ethanol, and it is standby to wave most ethanol.Gypsum Fibrosum adds 20 times of water gagings and divides and singly fry in shallow oil for three times, and each 1.5 hours, filter, decocting liquid is deposited standby in addition.Ten flavors such as all the other Flos Loniceraes add 18 times of water gagings and divide three decoctions, each 1.5 hours.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 70%, fully stir, left standstill the leaching supernatant 12 hours, reclaim ethanol to there not being the alcohol flavor, add 3～4 times of water gagings, left standstill 12 hours, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make to contain alcohol amount and reach 80%, fully stir, left standstill 12 hours, the leaching supernatant reclaims ethanol to there not being the alcohol flavor.Add above-mentioned Radix Scutellariae, Gypsum Fibrosum extract, and it is an amount of to add water, stirs evenly, add active carbon an amount of (0.5%), heated 30 minutes, filter, it is 1.45 that filtrate is concentrated into relative density, gets total extract.
Pill preparation method: total extract and suitable amount of adhesive; Make pill.
Claims (7)
1. one kind is used for the Chinese medicine compound method for preparing extractive of heat-clearing and toxic substances removing and the preparation that utilizes this extract to make, and it is characterized in that:
(1) this compound recipe is mainly by 670 parts in Gypsum Fibrosum, 134 parts of Flos Loniceraes, 107 parts of Radix Scrophulariaes, 80 parts of Radix Rehmanniae, 67 parts of Fructus Forsythiaes, 67 parts of Fructus Gardeniaes, 67 parts of Herba Gueldenstaedtiaes, 67 parts of Radix Scutellariaes, 67 parts of Radix Gentianae, 67 parts of Radix Isatidis, 54 parts of the Rhizoma Anemarrhenaes, Radix Ophiopogonis 54 parts of compositions the extract of medicine.
(2), be meant that medicinal liquid is concentrated into extractum that relative density is 1.45 (wideer scope can be provided) or the dry powder after the spray drying according to the extract described in (1) point in claims 1.
(3) preparation of making according to the extract described in claims 1 is meant drop pill, soft capsule, tablet, granule, capsule, pill.
2. according to the method for preparing extractive described in claims 1, it is characterized in that:
(1) with Radix Scutellariae in the above-mentioned 12 flavor medicines, adds 15-20 times of water gaging and divide three times (1～3 time) to extract, each 1-2 hour.Collecting decoction, filter, filtrate concentrates and add hydrochloric acid solution in the time of 60-90 ℃ regulates pH value to 1.0～3.0 in right amount, be incubated 1-2 hour, left standstill 8-24 hour, filter, precipitation adds 4-10 times of water gaging, regulate pH value to 5.0-8.0 with sodium hydroxide solution, add equivalent ethanol again, stir and make dissolving, filter, filtrate is regulated pH value to 1.0～3.0 with hydrochloric acid solution, and 50-80 ℃ is incubated 20-40 minute, left standstill 8-24 hour, filter, precipitation is washed till pH value 5.0-8.0 with ethanol, wave most ethanol after, Radix Scutellariae extract.
(2) Gypsum Fibrosum adds 15-20 times of water gaging and divides and singly fry in shallow oil for three times, each 1-2 hour, filter, decocting liquid is deposited standby in addition, Gypsum Fibrosum extract.
(3) ten flavors such as all the other Flos Loniceraes add 15-20 times of water gaging and divide three times (1～3 time) to decoct, each 1-2 hour.Above-mentioned water extract filters, and it is 1.10～1.15 that filtrate is concentrated into relative density, adds ethanol, makes to contain the alcohol amount and reach 50-80%, fully stir, left standstill the leaching supernatant 8-24 hour, reclaim ethanol to there not being the alcohol flavor, add 3-5 times of water gaging, left standstill 8-24 hour, the leaching supernatant, being concentrated into relative density is 1.10～1.15, puts cold, add ethanol, make the alcohol amount of containing reach 70-90%, fully stir, left standstill 8-24 hour, the leaching supernatant, decompression recycling ethanol is to there not being the alcohol flavor.
(4) add to add Radix Scutellariae extract, Gypsum Fibrosum extract in (1) (2) in above-mentioned (3), and it is an amount of to add water, stirs evenly, adds active carbon an amount of (0.5%), heat 30 minutes, filtration, it is 1.45 or spray drying that filtrate is concentrated into relative density, gets total extract.
According to the drop pill described in (3) in the right 1 at total extract and adjuvant with 1: the ratio of 0.5-3 is mixed mutually, drips through equipment and makes drop pill.Wherein adjuvant is meant Macrogol 4000, polyethylene glycol 6000, sodium stearate, tristerin, glycerol-gelatin.
4. mix mutually with adjuvant at total extract according to the soft capsule described in (3) in the right 1, be pressed into soft capsule through equipment.Wherein adjuvant is meant glycerol, gelatin, PEG400, soybean oil, soybean phospholipid, Cera Flava.Its adjunct ingredient can be that above-mentioned one or more add simultaneously.
5. mix mutually with adjuvant at total extract according to tablet described in (3) or capsule in the right 1, make tablet or capsule through equipment.Wherein adjuvant is meant diluent: starch, microcrystalline cellulose, lactose, magnesium oxide; Lubricant: Pulvis Talci, stearic acid and salt thereof, silicon dioxide; Correctives can be sucrose, protein sugar, stevioside, and the composition of its diluent, lubricant, correctives can be that above-mentioned one or more add simultaneously.
6. mix mutually with adjuvant at total extract according to the granule described in (3) in the right 1, make granule through equipment.
7. mix mutually with adjuvant at total extract according to the pill described in (3) in the right 1, make pill through equipment.
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| CN200910119477A CN101837089A (en) | 2009-03-17 | 2009-03-17 | Chinese medicinal herb extract for clearing away heat and toxic material and method for preparing preparation thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102178836A (en) * | 2011-05-16 | 2011-09-14 | 成都市农林科学院 | Injection for clearing away heat and toxic material and preparation method thereof |
| CN105560813A (en) * | 2016-01-05 | 2016-05-11 | 成都富豪斯生物科技有限公司 | Oral drug for treating swollen and sore throat caused by excess toxic heat and preparation method thereof |
| CN106421189A (en) * | 2016-08-26 | 2017-02-22 | 吉林大学珠海学院 | Traditional Chinese medicine compound patch pellicle agent for treating dental ulcer and preparation process thereof |
| CN108355622A (en) * | 2018-03-22 | 2018-08-03 | 西安新润药业有限公司 | A kind of purification process for isolating and purifying the adsorbent composition and Chinese medical extract of Chinese medical extract |
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2009
- 2009-03-17 CN CN200910119477A patent/CN101837089A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178836A (en) * | 2011-05-16 | 2011-09-14 | 成都市农林科学院 | Injection for clearing away heat and toxic material and preparation method thereof |
| CN102178836B (en) * | 2011-05-16 | 2012-09-12 | 成都市农林科学院 | Injection for clearing away heat and toxic material and preparation method thereof |
| CN105560813A (en) * | 2016-01-05 | 2016-05-11 | 成都富豪斯生物科技有限公司 | Oral drug for treating swollen and sore throat caused by excess toxic heat and preparation method thereof |
| CN106421189A (en) * | 2016-08-26 | 2017-02-22 | 吉林大学珠海学院 | Traditional Chinese medicine compound patch pellicle agent for treating dental ulcer and preparation process thereof |
| CN108355622A (en) * | 2018-03-22 | 2018-08-03 | 西安新润药业有限公司 | A kind of purification process for isolating and purifying the adsorbent composition and Chinese medical extract of Chinese medical extract |
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Open date: 20100922 |