CN102058832B - Medicine composition preparation and preparation method thereof - Google Patents
Medicine composition preparation and preparation method thereof Download PDFInfo
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- CN102058832B CN102058832B CN200910237567XA CN200910237567A CN102058832B CN 102058832 B CN102058832 B CN 102058832B CN 200910237567X A CN200910237567X A CN 200910237567XA CN 200910237567 A CN200910237567 A CN 200910237567A CN 102058832 B CN102058832 B CN 102058832B
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Abstract
The invention discloses a medicine composition preparation and a preparation method thereof. The medicine composition preparation comprises the following 15 material medicines: calculus bovis artifactus, pulvis fellis suis, baikal skullcap root, tuber of aromatic turmeric, cape jasmine fruit, borneol, goldthread, pearl, ocher, realgar, cinnabar, menthol crystal, gypsum, buffalo horn concentrated powder and mother-of-pearl. The preparation method of the medicine composition comprises the following steps of: firstly grouping the material medicines and respectively preparing into intermediates and medicine powder; mixing and processing with a conventional process; and finally adding conventional auxiliary materials and preparing into a preparation form which is acceptable pharmaceutically. Pharmacodynamic experiments prove that the medicine composition prepared with the method disclosed in the invention has the effects of clearing heat, resisting inflammation and thrombopoiesis and reducing blood pressure.
Description
Technical field
The present invention relates to a kind of drug combination preparation and preparation method thereof.
Background technology
Annaowan bolus is the prescriptions of Chinese medicine that is recorded in the 13 77 pages in the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation; Standard is numbered WS3-B-2517-97, and the prescription of having put down in writing Annaowan bolus in the standard comprises: artificial Calculus Bovis, Pulvis Fellis Suis, Cinnabaris, Borneolum Syntheticum, Pulvis Cornus Bubali Concentratus, Margarita, Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Realgar, Radix Curcumae, Gypsum Fibrosum, Haematitum, Concha Margaritifera and Mentholum; The patent No. is the prescription consumption proportion relation that 93100258.3 patent applications disclose Annaowan bolus, and conventional preparation technology; The open Annaowan bolus of available data has heat-clearing and toxic substances removing, refreshment and tranquilization, eliminates phlegm for resuscitation, the relieving convulsion effect that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and nowadays is hyperpyrexia, the delirious clinical application that a kind of treatment acute inflammation commonly used causes.
Yet; Annaowan bolus has existed for many years as the honeyed pill dosage form; By the simple and regular preparation technology that pulverizing, water fly, step such as refined honey is formed can't solve this prescription products all the time and have that potential toxic and side effects, wastage of material are more, dosage form is original causes fully being absorbed, taking by human body problems such as inconvenience; The problems referred to above exert an influence to the market prospect of this prescription products in the environment that nowadays tradition is write out a prescription and high-tech is combined closely, and simplifying prescription, improveing dosage form, improve preparation technology all is problem demanding prompt solutions that Annaowan bolus faces.
Summary of the invention
The objective of the invention is to disclose a kind of drug combination preparation, the present invention also aims to open method of making preparation.
The present invention seeks to realize through following scheme.
The crude drug of drug combination preparation of the present invention consists of:
Artificial Calculus Bovis 0.5-2 weight portion Pulvis Fellis Suis 7-20 weight portion Rhizoma Coptidis 5-15 weight portion
Radix Scutellariae 5-15 weight portion Margarita 1-5 weight portion Fructus Gardeniae 5-15 weight portion
Radix Curcumae 5-15 weight portion Haematitum 2-6 weight portion Realgar 3-9 weight portion
Cinnabaris 2-6 weight portion Mentholum 0.5-2 weight portion Gypsum Fibrosum 5-12 weight portion
Borneolum Syntheticum 0.5-4 weight portion Pulvis Cornus Bubali Concentratus 7-20 weight portion
Concha Margaritifera 2-8 weight portion.
The crude drug composition of drug combination preparation of the present invention is preferably:
Artificial Calculus Bovis's 1 weight portion Pulvis Fellis Suis 13 weight portion Rhizoma Coptidis 10 weight portions
Radix Scutellariae 10 weight portion Margaritas 3 weight portion Fructus Gardeniaes 10 weight portions
Radix Curcumae 10 weight portion Haematitums 4 weight portion Realgars 6 weight portions
Cinnabaris 4 weight portion Mentholums 1 weight portion Gypsum Fibrosum 8 weight portions
Borneolum Syntheticum 2 weight portion Pulvis Cornus Bubali Concentratuss 13 weight portion Concha Margaritiferas 5 weight portions.
The crude drug composition of drug combination preparation of the present invention is preferably:
Artificial Calculus Bovis's 0.7 weight portion Pulvis Fellis Suis 18 weight portion Rhizoma Coptidis 6 weight portions
Radix Scutellariae 14 weight portion Margaritas 2 weight portion Fructus Gardeniaes 14 weight portions
Radix Curcumae 6 weight portion Haematitums 5 weight portion Realgars 4 weight portions
Cinnabaris 5 weight portion Mentholums 0.7 weight portion Gypsum Fibrosum 11 weight portions
Borneolum Syntheticum 1 weight portion Pulvis Cornus Bubali Concentratus 18 weight portion Concha Margaritiferas 3 weight portions.
The crude drug composition of drug combination preparation of the present invention is preferably:
Artificial Calculus Bovis's 1.8 weight portion Pulvis Fellis Suiss 9 weight portion Rhizoma Coptidis 14 weight portions
Radix Scutellariae 6 weight portion Margaritas 4 weight portion Fructus Gardeniaes 6 weight portions
Radix Curcumae 14 weight portion Haematitums 3 weight portion Realgars 8 weight portions
Cinnabaris 3 weight portion Mentholums 1.8 weight portion Gypsum Fibrosum 6 weight portions
Borneolum Syntheticum 3.5 weight portion Pulvis Cornus Bubali Concentratuss 9 weight portion Concha Margaritiferas 7 weight portions.
The method for preparing of drug combination preparation of the present invention is following method:
Technology 1: form by following steps A, B, C, D and E
Steps A: preparation intermediate compound I
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid; Be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid; Be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution reclaims ethanol, concentrates; Spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Step B: preparation intermediate II
B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrating transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrating transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant; Reclaim ethanol, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add the 3-10% dilute hydrochloric acid respectively, consumption is the 5-15 times of weight; Make into suspension; Left standstill 12-48 hour, and filtered, filtrating transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filtration, filtrating is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and gets the extract of Pulvis Cornus Bubali Concentratus powder, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;
Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder,, add the 3-10% dilute hydrochloric acid respectively; Consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour; Filter, filtrating transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill; Get supernatant, reclaim ethanol, be concentrated into relative density 1-1.0～1.4, centrifugal; Supernatant is crossed macroporous resin column, and the 30-80% ethanol elution reclaims ethanol; Concentrate, get the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;
Step C: preparation intermediate III
C1: get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 3-5% sodium hydroxide 4-8 times of weight, left standstill 12-48 hour, filter, filtrating transfers pH value to 3-5, concentrates, and adds 30-80% ethanol 8-15 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get intermediate III; Or after the drying the powder of intermediate III;
Or C2: get Pulvis Fellis Suis and be broken into fine powder, add 3-5% sodium hydroxide 4-8 times of weight, left standstill 12-48 hour, filter, filtrating transfers pH value to 3-5, concentrates, and adds 30-80% ethanol 8-15 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 4-8 times of weight 5-10% hydrochloric acid, left standstill 8-24 hour, filter, filtrating accent pH value concentrates to 3-5, adds washing to colourless, promptly gets Realgar extract, or gets the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, intermediate III or the powder of intermediate III;
Step D: preparation medicated powder
D1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or D2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder;
Step e: preparation
The powder of intermediate compound I, II, III or intermediate compound I, II, III is mixed with medicated powder; Press common process; Add conventional adjuvant and process pharmaceutically acceptable dosage form, like powder, granule, tablet, capsule, dispersible tablet, drop pill, watered pill, honey pill agent, pellet, concentrated pill, soft capsule, slow releasing agent, oral liquid or injection.
The preferred following method of steps A wherein:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol; Concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
The preferred following method of step B wherein:
B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, is concentrated into relative density 1-1.2, and centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filtration, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and gets the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;
Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill; Get supernatant, reclaim ethanol, be concentrated into relative density 1-1.2, centrifugal; Supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol; Concentrate, get the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.
The preferred following method of step C wherein:
C1: get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrating is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get intermediate III; Or after the drying the powder of intermediate III;
Or C2: get Pulvis Fellis Suis and be broken into fine powder, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrating is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 6 times of weight, 8% hydrochloric acid, left standstill 24 hours, filter, filtrating accent pH value to 4 concentrates, and adds washing to colourless, promptly gets Realgar extract, or gets the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, intermediate III or the powder of intermediate III.
The preferred following method of step D wherein:
D1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or D2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Wherein, above-mentioned any step all can be substituted by conventional method.
Wherein, above-mentioned macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.
The method for preparing of drug combination preparation of the present invention can also be following method:
Technology 2: form by following steps A, B, C and D
Steps A: preparation intermediate compound I
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid; Be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid; Be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution reclaims ethanol, concentrates; Spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Step B: preparation intermediate II
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add the 30-80% ethanol of 4-10 times of weight; 40-60 ℃ warm macerating 12-48 hour, filter, get filtrating; Reclaim ethanol, concentrate, promptly get intermediate II; Or after the drying the powder of intermediate II;
Step C: preparation medicated powder
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder;
Step D: preparation
The powder of intermediate compound I, II or intermediate compound I, II is mixed with medicated powder; Press common process; Add conventional adjuvant and process pharmaceutically acceptable dosage form, like powder, granule, tablet, capsule, dispersible tablet, drop pill, watered pill, honey pill agent, pellet, concentrated pill, soft capsule, slow releasing agent, oral liquid or injection.
The preferred following method of steps A wherein:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol; Concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
The preferred following method of step B wherein:
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrating, reclaim ethanol, concentrate, and promptly get intermediate II; Or after the drying the powder of intermediate II.
The preferred following method of step C wherein:
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Wherein, above-mentioned any step all can be substituted by conventional method.
Wherein, above-mentioned macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.
Through pharmacodynamic experiment, that the pharmaceutical composition that shows the method for the invention preparation has is analgesic, antiinflammatory, antithrombotic forms and the effect of blood pressure lowering.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The medicinal composition powders of the present invention that the said method for distilling of experimental example 1 embodiment of the invention 1-48 is processed is to the hypertensive influence of rat experiment property
Laboratory animal: healthy male Waster rat, body weight 190g～210g;
Experiment equipment: RBP-1 type rat blood pressure meter;
Experimental drug and reagent: modeling agent: androlin; Get the medicinal composition powders of the present invention that the said method for distilling of embodiment of the invention 1-48 is processed, be mixed with 100mg/ml, 4-5 ℃ of preservation with normal saline.
Experimental technique: get healthy rat, be divided into 28 groups at random, 8 every group, survey normotensive value and continuous measurement 3 days.After the METHOD FOR CONTINUOUS DETERMINATION 3 days, subcutaneous injection androlin 25mg/kg/ day, each group is irritated the powder that the different method for preparinies of clothes equivalent (1g/kg) the present invention are processed, continuous 10 days respectively.Measure animal blood pressure on time, observe its blood pressure, the result sees table 1.
The pharmaceutical composition of table 1 the inventive method preparation is to the hypertensive influence of rat test property (n=8, mmHg, X ± S)
Table 1 shows that optimum extracting method is embodiment 23,24,35,36 among the embodiment 1-48, the said scheme of 41-48.
The medicinal composition powders of the present invention that the said method for distilling of experimental example 2 embodiment of the invention 1-48 is processed is to the analgesic and antiinflammatory action of inflammatory rat
Laboratory animal: healthy male Waster rat, body weight 190g～210g;
Experiment equipment: pointer electron temperature indicator.
Pyrogen: 1% carrageenin.
Experimental technique: take by weighing carrageenin 100mg, add sterile saline 10ml, mixing, in 4 ℃ of refrigerators, take out morning next day, is inverted to make suspension even for several times, subsequent use; Get the medicinal composition powders of the present invention that the said method for distilling of embodiment of the invention 1-48 is processed, be mixed with 100mg/ml with normal saline respectively, 4 ℃ of preservations are subsequent use; Healthy rat every day is surveyed axil temperature 2 times (upper and lower noon each 1 time) with the electronics temperature indicator, continuous 3 days, chooses the body temperature rat that is no more than 0.3 ℃ of fluctuating and is divided into 28 groups at random, 10 every group.Irritate the powder 1g/kg that the different method for preparinies of clothes the present invention are processed for every group, after this administration measures its axil temperature simultaneously in rat rear foot ripple plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ pawl on time, and the result sees table 2.
The influence of rat fever due to the pharmaceutical composition on Carrageenan of table 2 distinct methods preparation of the present invention (℃, X ± S)
Table 2 shows that the best approach is embodiment 23,24,35,36, the said scheme of 41-48 among the embodiment 1-48.
Following embodiment all can realize the said effect of above-mentioned experimental example.
The specific embodiment
Crude drug described in the following embodiment forms 1:
Artificial Calculus Bovis 1kg Pulvis Fellis Suis 13kg Rhizoma Coptidis 10kg
Radix Scutellariae 10kg Margarita 3kg Fructus Gardeniae 10kg
Radix Curcumae 10kg Haematitum 4kg Realgar 6kg
Cinnabaris 4kg Mentholum 1kg Gypsum Fibrosum 8kg
Borneolum Syntheticum 2kg Pulvis Cornus Bubali Concentratus 13kg Concha Margaritifera 5kg.
Said crude drug forms 2:
Artificial Calculus Bovis 0.7kg Pulvis Fellis Suis 18kg Rhizoma Coptidis 6kg
Radix Scutellariae 14kg Margarita 2kg Fructus Gardeniae 14kg
Radix Curcumae 6kg Haematitum 5kg Realgar 4kg
Cinnabaris 5kg Mentholum 0.7kg Gypsum Fibrosum 11kg
Borneolum Syntheticum 1kg Pulvis Cornus Bubali Concentratus 18kg Concha Margaritifera 3kg.
Said crude drug forms 3:
Artificial Calculus Bovis 1.8kg Pulvis Fellis Suis 9kg Rhizoma Coptidis 14kg
Radix Scutellariae 6kg Margarita 4kg Fructus Gardeniae 6kg
Radix Curcumae 14kg Haematitum 3kg Realgar 8kg
Cinnabaris 3kg Mentholum 1.8kg Gypsum Fibrosum 6kg
Borneolum Syntheticum 3.5kg Pulvis Cornus Bubali Concentratus 9kg Concha Margaritifera 7kg.
Said technology 1 steps A 1 is:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, get the powder of intermediate compound I after the drying.
Said technology 1 steps A 2 is:
Crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Said technology 1 steps A 3 is:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Said technology 1 steps A 4 is:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol; Concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Said technology 1 step B1 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II.
Said technology 1 step B2 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, is concentrated into relative density 1-1.2, and centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II.
Said technology 1 step B3 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filtration, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and gets the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.
Said technology 1 step B4 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrating is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrating is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill; Get supernatant, reclaim ethanol, be concentrated into relative density 1-1.2, centrifugal; Supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol; Concentrate, get the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.
Said technology 1 step C1 is:
Get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrating is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get intermediate III; Or after the drying the powder of intermediate III.
Said technology 1 step C2 is:
Get Pulvis Fellis Suis and be broken into fine powder, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrating is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 6 times of weight, 8% hydrochloric acid, left standstill 24 hours, filter, filtrating accent pH value to 4 concentrates, and adds washing to colourless, promptly gets Realgar extract, or gets the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, intermediate III or the powder of intermediate III.
Said technology 1 step D1 is:
Respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder.
Said technology 1 step D2 is:
Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Said technology 2 steps A 1 are:
Crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Said technology 2 steps A 2 are:
Crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Said technology 2 steps A 3 are:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Said technology 2 steps A 4 are:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol; Concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Said technology 2 step B1 are:
Crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrating, reclaim ethanol, concentrate, and promptly get intermediate II; Or after the drying the powder of intermediate II.
Said technology 2 step C1 are:
Respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or mix medicated powder.
Said technology 2 step C2 are:
Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Embodiment 1: powder
Crude drug forms 1
Processing step is steps A 1, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 2: powder
Crude drug forms 2
Processing step is steps A 2, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 3: powder
Crude drug forms 3
Processing step is steps A 3, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 4: granule
Crude drug forms 1
Processing step is steps A 4, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes granule.
Embodiment 5: granule
Crude drug forms 2
Processing step is steps A 1, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes granule.
Embodiment 6: granule
Crude drug forms 3
Processing step is steps A 2, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes granule.
Embodiment 7: tablet
Crude drug forms 1
Processing step is steps A 3, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes tablet.
Embodiment 8: tablet
Crude drug forms 2
Processing step is steps A 4, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes tablet.
Embodiment 9: tablet
Crude drug forms 3
Processing step is steps A 1, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes tablet.
Embodiment 10: capsule
Crude drug forms 1
Processing step is steps A 2, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes capsule.
Embodiment 11: capsule
Crude drug forms 2
Processing step is steps A 3, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes capsule.
Embodiment 12: capsule
Crude drug forms 3
Processing step is steps A 4, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes capsule.
Embodiment 13: dispersible tablet
Crude drug forms 1
Processing step is steps A 1, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes dispersible tablet.
Embodiment 14: dispersible tablet
Crude drug forms 2
Processing step is steps A 2, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes dispersible tablet.
Embodiment 15: dispersible tablet
Crude drug forms 3
Processing step is steps A 3, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes dispersible tablet.
Embodiment 16: drop pill
Crude drug forms 1
Processing step is steps A 4, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes drop pill.
Embodiment 17: drop pill
Crude drug forms 2
Processing step is steps A 1, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes drop pill.
Embodiment 18: drop pill
Crude drug forms 3
Processing step is steps A 2, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes drop pill.
Embodiment 19: the watered pill
Crude drug forms 1
Processing step is steps A 3, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes the watered pill.
Embodiment 20: the watered pill
Crude drug forms 2
Processing step is steps A 4, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes the watered pill.
Embodiment 21: the watered pill
Crude drug forms 3
Processing step is steps A 1, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes the watered pill.
Embodiment 22: honeyed pill
Crude drug forms 1
Processing step is steps A 2, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes honeyed pill.
Embodiment 23: powder
Crude drug forms 1
Processing step is steps A 3, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 24: powder
Crude drug forms 1
Processing step is steps A 4, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 25: honeyed pill
Crude drug forms 1
Processing step is steps A 1, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes honeyed pill.
Embodiment 26: honeyed pill
Crude drug forms 2
Processing step is steps A 2, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes honeyed pill.
Embodiment 27: micropill
Crude drug forms 3
Processing step is steps A 3, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes micropill.
Embodiment 28: micropill
Crude drug forms 1
Processing step is steps A 4, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes micropill.
Embodiment 29: concentrated pill
Crude drug forms 2
Processing step is steps A 1, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes concentrated pill.
Embodiment 30: concentrated pill
Crude drug forms 3
Processing step is steps A 2, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes concentrated pill.
Embodiment 31: soft capsule
Crude drug forms 1
Processing step is steps A 3, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes soft capsule.
Embodiment 32: soft capsule
Crude drug forms 2
Processing step is steps A 4, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes soft capsule.
Embodiment 33: slow releasing agent
Crude drug forms 3
Processing step is steps A 1, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes slow releasing agent.
Embodiment 34: slow releasing agent
Crude drug forms 1
Processing step is steps A 2, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes slow releasing agent.
Embodiment 35: powder
Crude drug forms 1
Processing step is steps A 3, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 36: powder
Crude drug forms 1
Processing step is steps A 4, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 37: oral liquid
Crude drug forms 1
Processing step is steps A 1, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes oral liquid.
Embodiment 38: oral liquid
Crude drug forms 2
Processing step is steps A 2, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes oral liquid.
Embodiment 39: powder
Crude drug forms 3
Processing step is steps A 3, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 40: powder
Crude drug forms 1
Processing step is steps A 4, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 41: powder
Crude drug forms 1
Processing step is steps A 1, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 42: powder
Crude drug forms 1
Processing step is steps A 2, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 43: powder
Crude drug forms 1
Processing step is steps A 3, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 44: powder
Crude drug forms 1
Processing step is steps A 4, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 45: powder
Crude drug forms 1
Processing step is steps A 1, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 46: powder
Crude drug forms 1
Processing step is steps A 2, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 47: powder
Crude drug forms 1
Processing step is steps A 3, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Embodiment 48: powder
Crude drug forms 1
Processing step is steps A 4, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, presses common process, adds conventional adjuvant and processes powder.
Claims (12)
1. drug combination preparation, the crude drug of said preparation consists of:
Artificial Calculus Bovis 0.5-2 weight portion Pulvis Fellis Suis 7-20 weight portion Rhizoma Coptidis 5-15 weight portion
Radix Scutellariae 5-15 weight portion Margarita 1-5 weight portion Fructus Gardeniae 5-15 weight portion
Radix Curcumae 5-15 weight portion Haematitum 2-6 weight portion Realgar 3-9 weight portion
Cinnabaris 2-6 weight portion Mentholum 0.5-2 weight portion Gypsum Fibrosum 5-12 weight portion
Borneolum Syntheticum 0.5-4 weight portion Pulvis Cornus Bubali Concentratus 7-20 weight portion
Concha Margaritifera 2-8 weight portion;
It is characterized in that said preparation is prepared by following method:
Steps A: preparation intermediate compound I
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid; Be concentrated into relative density 1: 1.0～1.4, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid; Be concentrated into relative density 1: 1.0～1.4, centrifugal, supernatant is crossed macroporous resin column; The 30-80% ethanol elution reclaims ethanol, concentrates; Spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Step B: preparation intermediate II
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add the 30-80% ethanol of 4-10 times of weight; 40-60 ℃ warm macerating 12-48 hour, filter, get filtrating; Reclaim ethanol, concentrate, promptly get intermediate II; Or after the drying the powder of intermediate II;
Step C: preparation medicated powder
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder;
Step D: preparation
The powder of intermediate compound I, II or intermediate compound I, II is mixed with medicated powder; Press common process, add conventional adjuvant and process pharmaceutically acceptable powder, granule, tablet, capsule, drop pill, watered pill, honey pill agent, pellet, concentrated pill, slow releasing agent, oral liquid or injection; Wherein said macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.
2. drug combination preparation as claimed in claim 1 is characterized in that the A step in the method for making preparation is following method:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution; Reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was subsequent use; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2; Centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol; Concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
3. according to claim 1 or claim 2 drug combination preparation is characterized in that the B step in the method for making preparation is following method:
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrating, reclaim ethanol, concentrate, and promptly get intermediate II; Or after the drying the powder of intermediate II.
4. like the arbitrary described drug combination preparation of claim 1-2, it is characterized in that the C step in the method for making preparation is following method:
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
5. drug combination preparation as claimed in claim 3 is characterized in that the C step in the method for making preparation is following method:
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
6. like claim 1,2,5 arbitrary described drug combination preparations, it is characterized in that the crude drug of said preparation consists of:
Artificial Calculus Bovis's 1 weight portion Pulvis Fellis Suis 13 weight portion Rhizoma Coptidis 10 weight portions
Radix Scutellariae 10 weight portion Margaritas 3 weight portion Fructus Gardeniaes 10 weight portions
Radix Curcumae 10 weight portion Haematitums 4 weight portion Realgars 6 weight portions
Cinnabaris 4 weight portion Mentholums 1 weight portion Gypsum Fibrosum 8 weight portions
Borneolum Syntheticum 2 weight portion Pulvis Cornus Bubali Concentratuss 13 weight portion Concha Margaritiferas 5 weight portions;
Or
Artificial Calculus Bovis's 0.7 weight portion Pulvis Fellis Suis 18 weight portion Rhizoma Coptidis 6 weight portions
Radix Scutellariae 14 weight portion Margaritas 2 weight portion Fructus Gardeniaes 14 weight portions
Radix Curcumae 6 weight portion Haematitums 5 weight portion Realgars 4 weight portions
Cinnabaris 5 weight portion Mentholums 0.7 weight portion Gypsum Fibrosum 11 weight portions
Borneolum Syntheticum 1 weight portion Pulvis Cornus Bubali Concentratus 18 weight portion Concha Margaritiferas 3 weight portions;
Or
Artificial Calculus Bovis's 1.8 weight portion Pulvis Fellis Suiss 9 weight portion Rhizoma Coptidis 14 weight portions
Radix Scutellariae 6 weight portion Margaritas 4 weight portion Fructus Gardeniaes 6 weight portions
Radix Curcumae 14 weight portion Haematitums 3 weight portion Realgars 8 weight portions
Cinnabaris 3 weight portion Mentholums 1.8 weight portion Gypsum Fibrosum 6 weight portions
Borneolum Syntheticum 3.5 weight portion Pulvis Cornus Bubali Concentratuss 9 weight portion Concha Margaritiferas 7 weight portions.
7. drug combination preparation as claimed in claim 3 is characterized in that the crude drug of said preparation consists of:
Artificial Calculus Bovis's 1 weight portion Pulvis Fellis Suis 13 weight portion Rhizoma Coptidis 10 weight portions
Radix Scutellariae 10 weight portion Margaritas 3 weight portion Fructus Gardeniaes 10 weight portions
Radix Curcumae 10 weight portion Haematitums 4 weight portion Realgars 6 weight portions
Cinnabaris 4 weight portion Mentholums 1 weight portion Gypsum Fibrosum 8 weight portions
Borneolum Syntheticum 2 weight portion Pulvis Cornus Bubali Concentratuss 13 weight portion Concha Margaritiferas 5 weight portions;
Or
Artificial Calculus Bovis's 0.7 weight portion Pulvis Fellis Suis 18 weight portion Rhizoma Coptidis 6 weight portions
Radix Scutellariae 14 weight portion Margaritas 2 weight portion Fructus Gardeniaes 14 weight portions
Radix Curcumae 6 weight portion Haematitums 5 weight portion Realgars 4 weight portions
Cinnabaris 5 weight portion Mentholums 0.7 weight portion Gypsum Fibrosum 11 weight portions
Borneolum Syntheticum 1 weight portion Pulvis Cornus Bubali Concentratus 18 weight portion Concha Margaritiferas 3 weight portions;
Or
Artificial Calculus Bovis's 1.8 weight portion Pulvis Fellis Suiss 9 weight portion Rhizoma Coptidis 14 weight portions
Radix Scutellariae 6 weight portion Margaritas 4 weight portion Fructus Gardeniaes 6 weight portions
Radix Curcumae 14 weight portion Haematitums 3 weight portion Realgars 8 weight portions
Cinnabaris 3 weight portion Mentholums 1.8 weight portion Gypsum Fibrosum 6 weight portions
Borneolum Syntheticum 3.5 weight portion Pulvis Cornus Bubali Concentratuss 9 weight portion Concha Margaritiferas 7 weight portions.
8. drug combination preparation as claimed in claim 4 is characterized in that the crude drug of said preparation consists of:
Artificial Calculus Bovis's 1 weight portion Pulvis Fellis Suis 13 weight portion Rhizoma Coptidis 10 weight portions
Radix Scutellariae 10 weight portion Margaritas 3 weight portion Fructus Gardeniaes 10 weight portions
Radix Curcumae 10 weight portion Haematitums 4 weight portion Realgars 6 weight portions
Cinnabaris 4 weight portion Mentholums 1 weight portion Gypsum Fibrosum 8 weight portions
Borneolum Syntheticum 2 weight portion Pulvis Cornus Bubali Concentratuss 13 weight portion Concha Margaritiferas 5 weight portions;
Or
Artificial Calculus Bovis's 0.7 weight portion Pulvis Fellis Suis 18 weight portion Rhizoma Coptidis 6 weight portions
Radix Scutellariae 14 weight portion Margaritas 2 weight portion Fructus Gardeniaes 14 weight portions
Radix Curcumae 6 weight portion Haematitums 5 weight portion Realgars 4 weight portions
Cinnabaris 5 weight portion Mentholums 0.7 weight portion Gypsum Fibrosum 11 weight portions
Borneolum Syntheticum 1 weight portion Pulvis Cornus Bubali Concentratus 18 weight portion Concha Margaritiferas 3 weight portions;
Or
Artificial Calculus Bovis's 1.8 weight portion Pulvis Fellis Suiss 9 weight portion Rhizoma Coptidis 14 weight portions
Radix Scutellariae 6 weight portion Margaritas 4 weight portion Fructus Gardeniaes 6 weight portions
Radix Curcumae 14 weight portion Haematitums 3 weight portion Realgars 8 weight portions
Cinnabaris 3 weight portion Mentholums 1.8 weight portion Gypsum Fibrosum 6 weight portions
Borneolum Syntheticum 3.5 weight portion Pulvis Cornus Bubali Concentratuss 9 weight portion Concha Margaritiferas 7 weight portions.
9. has the application in the medicine of analgesic, antiinflammatory and hypotensive effect like claim 1,2,5 arbitrary described drug combination preparations in preparation.
10. drug combination preparation as claimed in claim 3 has the application in the medicine of analgesic, antiinflammatory and hypotensive effect in preparation.
11. drug combination preparation as claimed in claim 4 has the application in the medicine of analgesic, antiinflammatory and hypotensive effect in preparation.
12. drug combination preparation as claimed in claim 6 has the application in the medicine of analgesic, antiinflammatory and hypotensive effect in preparation.
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|---|---|---|---|---|
| CN1074376A (en) * | 1993-01-13 | 1993-07-21 | 史月兰 | Annaowan bolus |
| CN101269204A (en) * | 2008-04-24 | 2008-09-24 | 张晴龙 | Cow-bezoar bolus for resurrection and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074376A (en) * | 1993-01-13 | 1993-07-21 | 史月兰 | Annaowan bolus |
| CN101269204A (en) * | 2008-04-24 | 2008-09-24 | 张晴龙 | Cow-bezoar bolus for resurrection and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 崔巍等.安脑丸的药效学研究.《中国中医药信息杂志》.1999,第6卷(第8期),第26-27页. * |
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Effective date of registration: 20141015 Address after: 150700, No. 6, Taishan Road, Chengxi Industrial Zone, Yanshou County, Heilongjiang, Harbin Patentee after: Harbin Pugongying Pharmaceutical Co., Ltd. Address before: 150700, No. 6, Taishan Road, Chengxi Industrial Park, Yanshou County, Heilongjiang, Harbin Patentee before: Liu Liying |