CN102058832A - Medicine composition preparation and preparation method thereof - Google Patents
Medicine composition preparation and preparation method thereof Download PDFInfo
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- CN102058832A CN102058832A CN200910237567XA CN200910237567A CN102058832A CN 102058832 A CN102058832 A CN 102058832A CN 200910237567X A CN200910237567X A CN 200910237567XA CN 200910237567 A CN200910237567 A CN 200910237567A CN 102058832 A CN102058832 A CN 102058832A
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine composition preparation and a preparation method thereof. The medicine composition preparation comprises the following 15 material medicines: calculus bovis artifactus, pulvis fellis suis, baikal skullcap root, tuber of aromatic turmeric, cape jasmine fruit, borneol, goldthread, pearl, ocher, realgar, cinnabar, menthol crystal, gypsum, buffalo horn concentrated powder and mother-of-pearl. The preparation method of the medicine composition comprises the following steps of: firstly grouping the material medicines and respectively preparing into intermediates and medicine powder; mixing and processing with a conventional process; and finally adding conventional auxiliary materials and preparing into a preparation form which is acceptable pharmaceutically. Pharmacodynamic experiments prove that the medicine composition prepared with the method disclosed in the invention has the effects of clearing heat, resisting inflammation and thrombopoiesis and reducing blood pressure.
Description
Technical field
The present invention relates to a kind of drug combination preparation and preparation method thereof.
Background technology
Annaowan bolus is the prescriptions of Chinese medicine that is recorded in the 13 77 pages in the Sanitation Ministry medicine standard Chinese traditional patent formulation preparation, standard is numbered WS3-B-2517-97, and the prescription of having put down in writing Annaowan bolus in the standard comprises: artificial Calculus Bovis, Pulvis Fellis Suis, Cinnabaris, Borneolum Syntheticum, Pulvis Cornus Bubali Concentratus, Margarita, Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Realgar, Radix Curcumae, Gypsum Fibrosum, Haematitum, Concha Margaritifera and Mentholum; The patent No. is the prescription consumption proportion relation that 93100258.3 patent applications disclose Annaowan bolus, and conventional preparation technology; The open Annaowan bolus of available data has heat-clearing and toxic substances removing, refreshment and tranquilization, eliminates phlegm for resuscitation, the relieving convulsion effect that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and nowadays is hyperpyrexia, the delirious clinical application that a kind of treatment acute inflammation commonly used causes.
Yet, Annaowan bolus has existed for many years as the honeyed pill dosage form, by the simple and regular preparation technology that pulverizing, water fly, step such as refined honey is formed can't solve this prescription products all the time and have that potential toxic and side effects, wastage of material are more, dosage form is original causes fully being absorbed, taking by human body problems such as inconvenience, the problems referred to above exert an influence to the market prospect of this prescription products in the environment that nowadays tradition is write out a prescription and high-tech is combined closely, and simplifying prescription, improveing dosage form, improve preparation technology all is problem demanding prompt solutions that Annaowan bolus faces.
Summary of the invention
The objective of the invention is to disclose a kind of drug combination preparation, the present invention also aims to the preparation method of open said preparation.
The present invention seeks to be achieved by the following scheme.
The crude drug of drug combination preparation of the present invention consists of:
The crude drug composition of drug combination preparation of the present invention is preferably:
The crude drug composition of drug combination preparation of the present invention is preferably:
The crude drug composition of drug combination preparation of the present invention is preferably:
The preparation method of drug combination preparation of the present invention is following method:
Technology 1: form by following steps A, B, C, D and E
Steps A: preparation intermediate compound I
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution reclaims ethanol, concentrates, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Step B: preparation intermediate II
B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add the 3-10% dilute hydrochloric acid, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filters, and filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaim ethanol, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add the 3-10% dilute hydrochloric acid respectively, consumption is the 5-15 times of weight, make into suspension, left standstill 12-48 hour, and filtered, filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and gets the extract of Pulvis Cornus Bubali Concentratus powder, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;
Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder,, add the 3-10% dilute hydrochloric acid respectively, consumption is the 5-15 times of weight, makes into suspension, leaves standstill 12-48 hour, filter, filtrate transfers pH value to 3-5 with 10-20% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 8-10 times of weight in the concentrated solution, leave standstill, get supernatant, reclaim ethanol, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, reclaim ethanol, concentrate, get the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;
Step C: preparation intermediate III
C1: get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 3-5% sodium hydroxide 4-8 times of weight, left standstill 12-48 hour, filter, filtrate transfers pH value to 3-5, concentrates, and adds 30-80% ethanol 8-15 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get intermediate III; Or after the drying the powder of intermediate III;
Or C2: get Pulvis Fellis Suis and be broken into fine powder, add 3-5% sodium hydroxide 4-8 times of weight, left standstill 12-48 hour, filter, filtrate transfers pH value to 3-5, concentrates, and adds 30-80% ethanol 8-15 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, adding 4-8 times of weight 5-10% hydrochloric acid left standstill 8-24 hour, filtered, and filtrate transfers pH value to 3-5, concentrates, and adding is washed to colourless, promptly gets Realgar extract, or gets the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, intermediate III or the powder of intermediate III;
Step D: preparation medicated powder
D1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or D2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder;
Step e: preparation
The powder of intermediate compound I, II, III or intermediate compound I, II, III is mixed with medicated powder, technology routinely, add conventional adjuvant and make pharmaceutically acceptable dosage form, as powder, granule, tablet, capsule, dispersible tablet, drop pill, watered pill, honey pill agent, pellet, concentrated pill, soft capsule, slow releasing agent, oral liquid or injection.
Wherein steps A is preferably as follows method:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Wherein step B is preferably as follows method:
B1: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B2: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, is concentrated into relative density 1-1.2, and centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II;
Or B3: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and gets the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II;
Or B4: respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leave standstill, get supernatant, reclaim ethanol, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, reclaim ethanol, concentrate, get the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.
Wherein step C is preferably as follows method:
C1: get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get intermediate III; Or after the drying the powder of intermediate III;
Or C2: get Pulvis Fellis Suis and be broken into fine powder, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 6 times of weight, 8% hydrochloric acid, left standstill 24 hours, filter, filtrate is transferred pH value to 4, concentrates, and adding is washed to colourless, promptly gets Realgar extract, or gets the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, intermediate III or the powder of intermediate III.
Wherein step D is preferably as follows method:
D1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or D2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Wherein, above-mentioned any step all can be substituted by conventional method.
Wherein, above-mentioned macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.
The preparation method of drug combination preparation of the present invention can also be following method:
Technology 2: form by following steps A, B, C and D
Steps A: preparation intermediate compound I
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution reclaims ethanol, concentrates, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Step B: preparation intermediate II
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add the 30-80% ethanol of 4-10 times of weight, 40-60 ℃ warm macerating 12-48 hour, filter, get filtrate, reclaim ethanol, concentrate, promptly get intermediate II; Or after the drying the powder of intermediate II;
Step C: preparation medicated powder
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder;
Step D: preparation
The powder of intermediate compound I, II or intermediate compound I, II is mixed with medicated powder, technology routinely, add conventional adjuvant and make pharmaceutically acceptable dosage form, as powder, granule, tablet, capsule, dispersible tablet, drop pill, watered pill, honey pill agent, pellet, concentrated pill, soft capsule, slow releasing agent, oral liquid or injection.
Wherein steps A is preferably as follows method:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Wherein step B is preferably as follows method:
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrate, reclaim ethanol, concentrate, and promptly get intermediate II; Or after the drying the powder of intermediate II.
Wherein step C is preferably as follows method:
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Wherein, above-mentioned any step all can be substituted by conventional method.
Wherein, above-mentioned macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.
By pharmacodynamic experiment, that the pharmaceutical composition that shows the method for the invention preparation has is analgesic, antiinflammatory, antithrombotic forms and the effect of blood pressure lowering.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The medicinal composition powders of the present invention that the described extracting method of experimental example 1 embodiment of the invention 1-48 is made is to the hypertensive influence of rat experiment
Laboratory animal: healthy male Waster rat, body weight 190g～210g;
Experiment equipment: RBP-1 type rat blood pressure meter;
Experimental drug and reagent: modeling agent: androlin; Get the medicinal composition powders of the present invention that the described extracting method of embodiment of the invention 1-48 is made, be mixed with 100mg/ml, 4-5 ℃ of preservation with normal saline.
Experimental technique: get healthy rat, be divided into 28 groups at random, 8 every group, survey normotensive value and continuous measurement 3 days.After the METHOD FOR CONTINUOUS DETERMINATION 3 days, subcutaneous injection androlin 25mg/kg/ day, each group gavages the powder that the different preparation methoies of equivalent (1g/kg) the present invention are made, continuous 10 days respectively.Measure animal blood pressure on time, observe its blood pressure, the results are shown in Table 1.
The pharmaceutical composition of table 1 the inventive method preparation to the hypertensive influence of rat test (n=8, mmHg,
)
Table 1 shows that optimum extracting method is embodiment 23,24,35,36 among the embodiment 1-48, the described scheme of 41-48.
The medicinal composition powders of the present invention that the described extracting method of experimental example 2 embodiment of the invention 1-48 is made is to the analgesic and antiinflammatory action of inflammatory rat
Laboratory animal: healthy male Waster rat, body weight 190g～210g;
Experiment equipment: pointer electron temperature indicator.
Pyrogen: 1% carrageenin.
Experimental technique: take by weighing carrageenin 100mg, add sterile saline 10ml, mixing, in 4 ℃ of refrigerators, take out morning next day, is inverted to make suspension even for several times, standby; Get the medicinal composition powders of the present invention that the described extracting method of embodiment of the invention 1-48 is made, be mixed with 100mg/ml with normal saline respectively, 4 ℃ of preservations are standby; Healthy rat every day is surveyed axil temperature 2 times (upper and lower noon each 1 time) with the electronics temperature indicator, continuous 3 days, chooses the body temperature rat that is no more than 0.3 ℃ of fluctuating and is divided into 28 groups at random, 10 every group.Every group gavages the powder 1g/kg that the different preparation methoies of the present invention are made, and after this administration measures its axil temperature simultaneously in rat rear foot ripple plantar subcutaneous injection 1% carrageenin suspension 0.1ml/ pawl on time, the results are shown in Table 2.
The influence of rat fever due to the pharmaceutical composition on Carrageenan of table 2 distinct methods preparation of the present invention (℃,
)
Table 2 shows that the best approach is embodiment 23,24,35,36, the described scheme of 41-48 among the embodiment 1-48.
Following embodiment all can realize the described effect of above-mentioned experimental example.
The specific embodiment
Crude drug described in the following embodiment forms 1:
Described crude drug forms 2:
Described crude drug forms 3:
Described technology 1 steps A 1 is:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, get the powder of intermediate compound I after the drying.
Described technology 1 steps A 2 is:
Crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Described technology 1 steps A 3 is:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Described technology 1 steps A 4 is:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Described technology 1 step B1 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II.
Described technology 1 step B2 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, mix; Add 6% dilute hydrochloric acid, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, is concentrated into relative density 1-1.2, and centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrates, and promptly gets intermediate II; Or after the drying the powder of intermediate II.
Described technology 1 step B3 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leaves standstill, and gets supernatant, reclaims ethanol, concentrates, and gets the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly gets intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.
Described technology 1 step B4 is:
Respectively Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera are ground into fine powder, add 6% dilute hydrochloric acid respectively, consumption is 10 times of weight, makes into suspension, leaves standstill 24 hours, filters, and filtrate is transferred pH value to 4 with 15% sodium hydroxide (or other alkali liquor); Filter, filtrate is concentrated into thick paste, adds the ethanol of 9 times of weight in the concentrated solution, leave standstill, get supernatant, reclaim ethanol, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, reclaim ethanol, concentrate, get the extract of Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita and Concha Margaritifera respectively, promptly get intermediate II after the mixing; Or behind the combination drying the powder of intermediate II.
Described technology 1 step C1 is:
Get Pulvis Fellis Suis and Realgar is broken into fine powder, mix, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get intermediate III; Or after the drying the powder of intermediate III.
Described technology 1 step C2 is:
Get Pulvis Fellis Suis and be broken into fine powder, add 4% sodium hydroxide, 6 times of weight, left standstill 24 hours, filter, filtrate is transferred pH value to 4, concentrates, and adds 50% ethanol, 12 times of weight; Get supernatant, reclaim ethanol, concentrate, promptly get ketone ibuprofen extract, or get the ketone ibuprofen extract powder after the drying; Get Realgar powder and be broken into fine powder, add 6 times of weight, 8% hydrochloric acid, left standstill 24 hours, filter, filtrate is transferred pH value to 4, concentrates, and adding is washed to colourless, promptly gets Realgar extract, or gets the Realgar extract powder after the drying; Ketone ibuprofen extract is mixed with Realgar extract, intermediate III or the powder of intermediate III.
Described technology 1 step D1 is:
Respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder.
Described technology 1 step D2 is:
Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Described technology 2 steps A 1 are:
Crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Described technology 2 steps A 2 are:
Crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Described technology 2 steps A 3 are:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Described technology 2 steps A 4 are:
Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
Described technology 2 step B1 are:
Crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrate, reclaim ethanol, concentrate, and promptly get intermediate II; Or after the drying the powder of intermediate II.
Described technology 2 step C1 are:
Respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or mix medicated powder.
Described technology 2 step C2 are:
Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
Embodiment 1: powder
Crude drug forms 1
Processing step is steps A 1, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 2: powder
Crude drug forms 2
Processing step is steps A 2, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 3: powder
Crude drug forms 3
Processing step is steps A 3, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 4: granule
Crude drug forms 1
Processing step is steps A 4, B1, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes granule routinely.
Embodiment 5: granule
Crude drug forms 2
Processing step is steps A 1, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes granule routinely.
Embodiment 6: granule
Crude drug forms 3
Processing step is steps A 2, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes granule routinely.
Embodiment 7: tablet
Crude drug forms 1
Processing step is steps A 3, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes tablet routinely.
Embodiment 8: tablet
Crude drug forms 2
Processing step is steps A 4, B2, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes tablet routinely.
Embodiment 9: tablet
Crude drug forms 3
Processing step is steps A 1, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes tablet routinely.
Embodiment 10: capsule
Crude drug forms 1
Processing step is steps A 2, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes capsule routinely.
Embodiment 11: capsule
Crude drug forms 2
Processing step is steps A 3, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes capsule routinely.
Embodiment 12: capsule
Crude drug forms 3
Processing step is steps A 4, B3, C1, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes capsule routinely.
Embodiment 13: dispersible tablet
Crude drug forms 1
Processing step is steps A 1, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes dispersible tablet routinely.
Embodiment 14: dispersible tablet
Crude drug forms 2
Processing step is steps A 2, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes dispersible tablet routinely.
Embodiment 15: dispersible tablet
Crude drug forms 3
Processing step is steps A 3, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes dispersible tablet routinely.
Embodiment 16: drop pill
Crude drug forms 1
Processing step is steps A 4, B4, C2, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes drop pill routinely.
Embodiment 17: drop pill
Crude drug forms 2
Processing step is steps A 1, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes drop pill routinely.
Embodiment 18: drop pill
Crude drug forms 3
Processing step is steps A 2, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes drop pill routinely.
Embodiment 19: the watered pill
Crude drug forms 1
Processing step is steps A 3, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes the watered pill routinely.
Embodiment 20: the watered pill
Crude drug forms 2
Processing step is steps A 4, B1, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes the watered pill routinely.
Embodiment 21: the watered pill
Crude drug forms 3
Processing step is steps A 1, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes the watered pill routinely.
Embodiment 22: honeyed pill
Crude drug forms 1
Processing step is steps A 2, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes honeyed pill routinely.
Embodiment 23: powder
Crude drug forms 1
Processing step is steps A 3, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 24: powder
Crude drug forms 1
Processing step is steps A 4, B2, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 25: honeyed pill
Crude drug forms 1
Processing step is steps A 1, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes honeyed pill routinely.
Embodiment 26: honeyed pill
Crude drug forms 2
Processing step is steps A 2, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes honeyed pill routinely.
Embodiment 27: micropill
Crude drug forms 3
Processing step is steps A 3, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes micropill routinely.
Embodiment 28: micropill
Crude drug forms 1
Processing step is steps A 4, B3, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes micropill routinely.
Embodiment 29: concentrated pill
Crude drug forms 2
Processing step is steps A 1, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes concentrated pill routinely.
Embodiment 30: concentrated pill
Crude drug forms 3
Processing step is steps A 2, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes concentrated pill routinely.
Embodiment 31: soft capsule
Crude drug forms 1
Processing step is steps A 3, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes soft capsule routinely.
Embodiment 32: soft capsule
Crude drug forms 2
Processing step is steps A 4, B4, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes soft capsule routinely.
Embodiment 33: slow releasing agent
Crude drug forms 3
Processing step is steps A 1, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes slow releasing agent routinely.
Embodiment 34: slow releasing agent
Crude drug forms 1
Processing step is steps A 2, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes slow releasing agent routinely.
Embodiment 35: powder
Crude drug forms 1
Processing step is steps A 3, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 36: powder
Crude drug forms 1
Processing step is steps A 4, B3, C1, the D2 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 37: oral liquid
Crude drug forms 1
Processing step is steps A 1, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes oral liquid routinely.
Embodiment 38: oral liquid
Crude drug forms 2
Processing step is steps A 2, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes oral liquid routinely.
Embodiment 39: powder
Crude drug forms 3
Processing step is steps A 3, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 40: powder
Crude drug forms 1
Processing step is steps A 4, B4, C2, the D1 in the technology 1, and the powder of intermediate compound I, II, III is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 41: powder
Crude drug forms 1
Processing step is steps A 1, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 42: powder
Crude drug forms 1
Processing step is steps A 2, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 43: powder
Crude drug forms 1
Processing step is steps A 3, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 44: powder
Crude drug forms 1
Processing step is steps A 4, B1, the C1 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 45: powder
Crude drug forms 1
Processing step is steps A 1, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 46: powder
Crude drug forms 1
Processing step is steps A 2, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 47: powder
Crude drug forms 1
Processing step is steps A 3, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Embodiment 48: powder
Crude drug forms 1
Processing step is steps A 4, B1, the C2 in the technology 2, and the powder of intermediate compound I, II is mixed with medicated powder, and technology adds conventional adjuvant and makes powder routinely.
Claims (10)
1. drug combination preparation, the crude drug of said preparation consists of:
It is characterized in that said preparation is prepared by following method:
Steps A: preparation intermediate compound I
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution reclaims ethanol, concentrates, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Step B: preparation intermediate II
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add the 30-80% ethanol of 4-10 times of weight, 40-60 ℃ warm macerating 12-48 hour, filter, get filtrate, reclaim ethanol, concentrate, promptly get intermediate II; Or after the drying the powder of intermediate II;
Step C: preparation medicated powder
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder;
Step D: preparation
The powder of intermediate compound I, II or intermediate compound I, II is mixed with medicated powder, technology routinely, add conventional adjuvant and make pharmaceutically acceptable dosage form, as powder, granule, tablet, capsule, dispersible tablet, drop pill, watered pill, honey pill agent, pellet, concentrated pill, soft capsule, slow releasing agent, oral liquid or injection.
2. drug combination preparation as claimed in claim 1 is characterized in that the A step in the preparation method of said preparation is following method:
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added the hot water reflux, extract, 3 times jointly, each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, 50% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into thick paste; Add 50% ethanol of 7 times of weight in the thick paste, left standstill 24 hours, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added the hot water reflux, extract, earlier 3 times, and each 1.5 hours, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 3 times, and each 1.5 hours, merge decocting liquid, be concentrated into relative density 1-1.2, centrifugal, supernatant is crossed macroporous resin column, and 50% ethanol elution reclaims ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I.
3. drug combination preparation as claimed in claim 1 or 2 is characterized in that the B step in the preparation method of said preparation is following method:
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add 50% ethanol of 7 times of weight, 50 ℃ of warm macerating 24 hours filter, and get filtrate, reclaim ethanol, concentrate, and promptly get intermediate II; Or after the drying the powder of intermediate II.
4. as the arbitrary described drug combination preparation of claim 1-3, it is characterized in that the C step in the preparation method of said preparation is following method:
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, respectively or mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 6 times of weight water grind to pasty state, added entry by 1: 65 again and stir, leave standstill, inclining suspension, and sediment grinds again; As above method is 4 times repeatedly, merges each time suspension, leaves standstill, and gets and is deposited in 35 ℃ of airings, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder.
5. as the arbitrary described drug combination preparation of claim 1-4, it is characterized in that the arbitrary step in the preparation method of said preparation is replaced by conventional method.
6. as the arbitrary described drug combination preparation of claim 1-5, it is characterized in that the macroporous resin column model described in the preparation method of said preparation is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.
7. as the arbitrary described drug combination preparation of claim 1-6, it is characterized in that the crude drug of said preparation consists of:
Or
Or
8. as the preparation method of the arbitrary described drug combination preparation of claim 1-7, it is characterized in that this method is:
Steps A: preparation intermediate compound I
A1: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A2: crude drug Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Radix Curcumae and Gypsum Fibrosum are added hot water reflux, extract, 2-4 time jointly, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution, reclaim ethanol, concentrate, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A3: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, and each 0.5-2.5 hour, merge decocting liquid, be concentrated into thick paste; Add the 30%-80% ethanol of 4-10 times of weight in the thick paste, left standstill 12-48 hour, get supernatant and reclaim ethanol, concentrate, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Or A4: Radix Curcumae is added hot water reflux, extract, 2-4 time earlier, and each 0.5-2.5 hour, volatile oil was standby; Radix Curcumae medicinal residues and the common decocting of crude drug Radix Scutellariae, Rhizoma Coptidis, Gypsum Fibrosum and Fructus Gardeniae boil 2-4 time, each 0.5-2.5 hour, merge decocting liquid, be concentrated into relative density 1-1.0～1.4, centrifugal, supernatant is crossed macroporous resin column, the 30-80% ethanol elution reclaims ethanol, concentrates, spray into volatile oil, promptly get intermediate compound I; Or after the drying the powder of intermediate compound I;
Step B: preparation intermediate II
B1: crude drug Pulvis Cornus Bubali Concentratus, artificial Calculus Bovis, Margarita, Concha Margaritifera, Pulvis Fellis Suis and Realgar powder are broken into fine powder, mix, add the 30-80% ethanol of 4-10 times of weight, 40-60 ℃ warm macerating 12-48 hour, filter, get filtrate, reclaim ethanol, concentrate, promptly get intermediate II; Or after the drying the powder of intermediate II;
Step C: preparation medicated powder
C1: respectively Borneolum Syntheticum, Mentholum, Cinnabaris and Haematitum are prepared impalpable powder, mix medicated powder;
Or C2: Borneolum Syntheticum, Mentholum and Haematitum are prepared impalpable powder, Cinnabaris is added 5-8 times of weight water grind to pasty state, again by 1: 60--70 adds entry and stirs, and leaves standstill, and inclining suspension, and sediment grinds again; As above method is 3-6 time repeatedly, merges each time suspension, leaves standstill, and gets to be deposited in 25-45 ℃ of airing, and levigation promptly gets the Cinnabaris impalpable powder; With the impalpable powder of above-mentioned four kinds of crude drug mix medicated powder;
Step D: preparation
The powder of intermediate compound I, II or intermediate compound I, II is mixed with medicated powder, technology routinely, add conventional adjuvant and make pharmaceutically acceptable dosage form, as powder, granule, tablet, capsule, dispersible tablet, drop pill, watered pill, honey pill agent, pellet, concentrated pill, soft capsule, slow releasing agent, oral liquid or injection.
9. the preparation method of drug combination preparation as claimed in claim 8 is characterized in that the arbitrary step in this method is replaced by conventional method; Wherein said macroporous resin column model is: YPR-II, X5, AB-8, HPD-100, DX-5, D101, DA201, DM130, WLD-3 or NKA-9.
10. has application in the medicine of analgesic, antiinflammatory and hypotensive effect as the arbitrary described drug combination preparation of claim 1-7 in preparation.
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