CN101637527A - Application method of amur cork for preparing digestive ulcer medicament - Google Patents
Application method of amur cork for preparing digestive ulcer medicament Download PDFInfo
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- CN101637527A CN101637527A CN200910127572A CN200910127572A CN101637527A CN 101637527 A CN101637527 A CN 101637527A CN 200910127572 A CN200910127572 A CN 200910127572A CN 200910127572 A CN200910127572 A CN 200910127572A CN 101637527 A CN101637527 A CN 101637527A
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- cortex phellodendri
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Abstract
The invention relates to an application method of amur cork for preparing digestive ulcer medicament.
Description
Technical field
The present invention relates to traditional Chinese medicine technology, be specifically related to the new purposes of Cortex Phellodendri in preparation anti-peptic ulcer ulcer medicine.
Background information
Peptic ulcer (hereinafter to be referred as Peptic Ulcers) is commonly encountered diseases, frequently-occurring disease, whole mankind's sickness rate about 10%.Because of the generation of Peptic Ulcers is gained the name with gastric acid-pepsic digestion is relevant with formation.The symptom of their early stage is similar to functional dyspepsia disease, and stomachache, melena, hematemesis etc. then appear in severe patient afterwards.Now the pathogeny that medical circle is concrete also in research is discussed, thinks that at present its defense factor disequilibrium with attack factor that causes ulcer and mucosa is relevant, the bile that attack factor comprises gastric acid, pepsin, backflow etc.; Defense factor comprises mucus barrier, mucosa repair function etc.Causing the factor of peptic ulcer to mainly contain work strain, fatigue, diet does not have rule, takes the medicine in too much stimulating gastrointestinal road, living habit and mental status etc.
The medicine of treatment peptic ulcer mainly contains proton pump inhibitor, H2 receptor blocking agent, mucosa protective agent, antacid at present.
Generally believe that now helicobacter pylori is the main cause of peptic ulcer, and good antiulcerative proton pump inhibitor can not the suppressing and killing helicobacter spirillum, and antacids etc. can only suppress helicobacter pylori indirectly.So multiple medicines share and is expected to obtain better efficacy, use more convenient, economic antiulcerative.Understand according to the applicant, the useful omeprazole that known multiple medicines share adds levofloxacin and adds furazolidone triple therapy and bismuth and add metronidazole and add tetracycline capsule.Other still have the use clinically of multifunctional compound preparation (as bismuth aluminate compound, SIDASHU, SANJIU WEITAI, WEIKANGLING etc.).The shortcoming of this method is to take multiple medicine simultaneously, has both increased the drug administration amount, has improved compatibility of drugs again and has used difficulty; The financial burden that this had both increased the weight of the patient uses also inconvenient.There is the potential demand of comparing more convenient economy with the anti-ulcer medicament of present use clinically for antiulcerative.The purpose of this invention is to provide a kind of with in the past known to antiulcer drug different, more convenient economy.
Summary of the invention
The present inventor is used for the raw material process of antiulcerative in exploration, finds that Chinese herbal medicine---Cortex Phellodendri or its extract can satisfy this purpose.
Cortex Phellodendri (being the bark of rutaceae Cortex Phellodendri or wampee) nature and flavor hardship, cold.Function cures mainly heat clearing away.Dampness, pathogenic fire purging, detoxifcation.Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid are had blood in stool, also under the leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.
Modern pharmacological research proves: 1. Cortex Phellodendri contain, alkaloid such as jateorhizine, magnoflorine, phellodendrine, candicine, palmatine, Dauricine; Other contains obacunone, obakulactone, Dictamnolide, obacunonic acid, blue or green fluorescent acid, 7-dehydrogenation stigmasterol, cupreol, campesterol.Root bark contains berberine, jateorhizine, phellodendrine, candicine.Timber also contains berberine.Fresh leaf contains amurensin, amurensin, phellatin, phellavin.Dried leaves contains hyperin, does not contain amurensin.2. the wampee bark contains multiple alkaloid such as berberine, magnoflorine, phellodendrine, palmatine and lactone, sterol, phlegmatic temperament etc.3. bald leaf wampee bark contains N-1, tetrahydropalmatine, tetrahydrojatrorrhizine, phellodendrine, magnoflorine and cupreol.
Pharmacological action:
1, contained berberine has antibiotic, antiinflammatory action.It also has local anaesthesia, calmness, analgesia, antiulcer, choleretic effect
2, Cortex Phellodendri powder can strengthen the gastrointestinal amplitude, and obacunone can strengthen its tension force and amplitude; Obakulactone then suppresses intestinal tube.Cortex Phellodendri has the effect that promotes pancreatic secretion.
Cortex Phellodendri also finds to have the effect of treatment cardiovascular disease recently except being used as antibacterial treatment inflammatory diseases, eczema, skin ulcer (external); Perhaps as heat clearing away.Dampness, pathogenic fire purging, detoxifcation at the treatment hematodiarrhoea, is had loose bowels, quenches one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid are had blood in stool, leucorrhea with red and white discharge, the hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, the Chinese medicine of sore swollen toxin is directly used or is used as capsule.But, up to now, also do not know the new purposes of Cortex Phellodendri at the preparation antiulcer drug.Here, what deserves to be mentioned is, Cortex Phellodendri mucus be the impurity of generally acknowledging tried every means separate the back reject, discover that according to the applicant Cortex Phellodendri mucus is a kind of natural gastrointestinal tract mucous protective agent, has good ulcer defencive function.
Its inventive features is, Cortex Phellodendri is in the new purposes of preparation digestive ulcer medicament:
1, contained berberine of Cortex Phellodendri and furazolidone furazolidone are the jljl isomers, have the effect of suppressing and killing helicobacter spirillum.In addition, berberine also has antiinflammatory, analgesia, antiulcer, choleretic effect; Contained phlegmatic temperament is a kind of natural gastrointestinal mucosa protective agent; The berberine obacunone can strengthen gastrointestinal tension force and amplitude; Obakulactone then suppresses the intestinal tube motion, and gastrointestinal tract is had dual regulation.Cortex Phellodendri promptly is collection suppressing and killing helicobacter spirillum, protection mucosa (ulcer surface), promotes (gastrointestinal) motion, analgesic antiulcerative.
1.1 the effective ingredient among the present invention: 1. can be Cortex Phellodendri (one or more in relationship or the close relative's edge plant) the direct processed goods of crude drug; Also can be medicinal monomer and or the combination in any of composite parts.Raw material can be fresh or exsiccant, also can be how to pay no attention to its extraction means.2. being used for these compositions of the present invention can be extract, also can be arbitrary similar substance that the synthetic way obtains.
1.2 the present invention can make capsule according to purpose, any dosage forms such as powder, honeyed pill, drop pill, oral liquid.
1.3 the present invention can suitably add with various adjuvants such as buffer agent according to purpose, synergist, antiseptic, excipient etc.
Embodiment
Simple embodiment supplementary notes are provided below:
The first step is produced the Cortex Phellodendri powder
It is longer to strip the age in the end of spring and the beginning of summer, the Cortex Phellodendri master Cortex Phellodendri or the root bark of riotous growth.With skin depth, phlegmatic temperament is many, yellow is dark, the bitter in the mouth person is good.Taking advantage of wets peels off outer rough skin, dries.Cut into coarse pulverization for the first time behind the fritter, get fine powder with 40 mesh sieves, discard thick slag (being mainly cellulose), pulverize again with 120 mesh sieve mistakes, rough Cortex Phellodendri powder---mainly contain the Cortex Phellodendri phlegmatic temperament (be the very high a kind of heavy-gravity jelly of content in the bark of amur corktree, translucent.Colourless or slightly yellow.PH value is 6～7, is a kind of natural ulcer surface protective agent) berberine, effective ingredient such as Radix Berberidis Amurensis ammonium need not to purify again.
Digestive tract hemorrhage, pain because Peptic Ulcers often occurs together can suitably add Radix Notoginseng to strengthen the hemostatic analgesia effect; Rotten for anti-medicine, add Cortex Cinnamomi etc.
Second step preparation packing
Get above-mentioned Cortex Phellodendri powder and add adjuvant.Mix thoroughly.Sterilization.Encapsulated (1#).Sterilization.Specification is 0.3g/S.After the sterilization.Bottle or carry out other standard packs and get final product.
[preservation] Cortex Cinnamomi has very strong antifungal activity, need not to add other antiseptic again.Can preserve for 1～3 year.
[character] yellowish-brown powder, bitter, Gan Wen; Fragrance is arranged.Meet water and be gelatin, little yellow, the sticking aqueous vapor flavor nothing of meeting of matter changes.PH value 6～7.
[function] is antibiotic, antiinflammatory, analgesia, antiulcer.
[curing mainly] peptic ulcer.Other can also treat gastritis, enteritis, dysentery, stomachache, diarrhoea.
[usage and dosage] oral 0.60～1.20/ next day/4 time child's consumption cuts down according to the circumstance
[drug effect signal] oral this product had belch in 10～20 minutes, passwinds, borborygmus, sensation that ambition is happy.Minority has slight kecking, and diarrhoea all belongs to normal phenomenon.
[toxicity] 1, this product are to be that raw material develops with the natural Chinese medicinal herb, and toxicity is low, the little green safety of side effect.
2, more than do not have incompatibility between each composition.
3, use amount is little: this product maximum dose level is (with Cortex Phellodendri crude drug dry product 24g/d, Radix Notoginseng 1.6g/d, 0.8g/ meter of Cortex Cinnamomi) also littler more at every turn than the clinical minimum using dosage (taking minimum use amount 5gd, Radix Notoginseng 2.5g/d, Cortex Cinnamomi orally 1.0g/ time) of same medicine in Cortex Phellodendri.
Control and test
The present invention is the applicant through research repeatedly, by through more than ten years routine clinical verifications up to a hundred:
See the following form
| The pain name | Case load | Effectively | Invalid | Effective percentage % | Remarks |
| Peptic ulcer | ????83 | ????80 | ????3 | ??96.38％ | The County Hospital inspection is identified and is as the criterion |
| Gastritis | ????6 | ????6 | ????0 | ??100％ | The same |
| Abdominal pain diarrhea | ????14 | ????14 | ????0 | ??100％ | Clinical symptoms |
The result
Through clinical verification: stable curative effect.More convenient to use, economical.
Claims (1)
1, according to claim, it is characterized in that, Cortex Phellodendri the preparation digestive ulcer medicament new purposes:
1.1 according to claim, or 1 is described, it is characterized in that, the contained berberine of Cortex Phellodendri has the effect of suppressing and killing helicobacter spirillum and antiinflammatory, analgesia, antiulcer, choleretic effect; Contained phlegmatic temperament is a kind of natural gastrointestinal mucosa protective agent; Obacunone can strengthen gastrointestinal tension force and amplitude; Obakulactone then suppresses the intestinal tube motion, and gastrointestinal tract is had dual regulation.Thereby Cortex Phellodendri promptly is collection suppressing and killing helicobacter spirillum, protection mucosa (ulcer surface), promotes (gastrointestinal) motion, analgesic antiulcerative.
1.2 according to claim, or 1～1.2 is described, it is characterized in that the effective ingredient among the present invention: 1. can be Cortex Phellodendri (one or more in relationship or the close relative's edge plant) the direct processed goods of crude drug; Also can be medicinal monomer and or the combination in any of composite parts.Raw material can be fresh or exsiccant, also can be how to pay no attention to its extraction means.2. being used for these compositions of the present invention can be extract, also can be the similar substance that the synthetic way obtains.
1.3 according to claim, or 1～1.3 is described, it is characterized in that, among the present invention, can make capsule according to purpose, any dosage forms such as powder, honeyed pill, drop pill, oral liquid.
1.4 according to claim, or 1～1.4 is described, it is characterized in that the present invention can be suitably with various adjuvants such as buffer agent according to purpose, synergist, antiseptic, excipient etc.
1.5 according to claim, or 1～1.5 is described, it is characterized in that being used for " bitterly ", " rushing down " is the multiple treatment of diseases of cardinal symptom, so, have another name called " pain is rushed down spirit ".
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910127572A CN101637527A (en) | 2009-01-09 | 2009-01-09 | Application method of amur cork for preparing digestive ulcer medicament |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910127572A CN101637527A (en) | 2009-01-09 | 2009-01-09 | Application method of amur cork for preparing digestive ulcer medicament |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910003530A Division CN101653501A (en) | 2008-07-28 | 2009-01-09 | Chinese herbal medicine compound for treating peptic ulcer disease |
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| CN101637527A true CN101637527A (en) | 2010-02-03 |
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| CN200910127572A Pending CN101637527A (en) | 2009-01-09 | 2009-01-09 | Application method of amur cork for preparing digestive ulcer medicament |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142740A (en) * | 2013-03-12 | 2013-06-12 | 熊烈 | Chinese herbal medicine mixture for treating abdominal pain and diarrhea and preparation method thereof |
| CN109575010A (en) * | 2018-12-29 | 2019-04-05 | 西南大学 | Method, high-purity methyl jamaicin prepared therefrom and the application that methyl jamaicin is extracted in mother liquor are extracted from the coptis |
-
2009
- 2009-01-09 CN CN200910127572A patent/CN101637527A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142740A (en) * | 2013-03-12 | 2013-06-12 | 熊烈 | Chinese herbal medicine mixture for treating abdominal pain and diarrhea and preparation method thereof |
| CN103142740B (en) * | 2013-03-12 | 2015-03-18 | 熊烈 | Chinese herbal medicine mixture for treating abdominal pain and diarrhea and preparation method thereof |
| CN109575010A (en) * | 2018-12-29 | 2019-04-05 | 西南大学 | Method, high-purity methyl jamaicin prepared therefrom and the application that methyl jamaicin is extracted in mother liquor are extracted from the coptis |
| CN109575010B (en) * | 2018-12-29 | 2021-07-20 | 西南大学 | Method for extracting methyl berberine from coptis chinensis extraction mother liquor, high-purity methyl berberine prepared by method and application of high-purity methyl berberine |
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Open date: 20100203 |