CN109464545A - A kind of Chinese medicine composition and the preparation method and application thereof for treating chronic gastritis - Google Patents
A kind of Chinese medicine composition and the preparation method and application thereof for treating chronic gastritis Download PDFInfo
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- CN109464545A CN109464545A CN201811441290.8A CN201811441290A CN109464545A CN 109464545 A CN109464545 A CN 109464545A CN 201811441290 A CN201811441290 A CN 201811441290A CN 109464545 A CN109464545 A CN 109464545A
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- radix aucklandiae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses a kind of Chinese medicine compositions and the preparation method and application thereof for treating chronic gastritis.The Chinese medicine composition is by including that the Chinese medicine of following parts by weight is made: 6-10 parts of rhizoma nardostachyos, 4-8 parts of radix aucklandiae, 3-7 parts of fingered citron, 1-5 parts of Divine Comedy, 1-4 parts of myrobalan.The present invention passes through the mutual compatibility of said medicine, regulating qi-flowing for relieving pain is played altogether, soothing liver and harmonizing stomach, disperse accumulation is except full function, it cures mainly because of diseases such as liver-stomach disharmony, the stomachache of stagnation of QI due to depression of the liver, feeling of fullness, is used for chronic superficial gastritis, atrophic gastritis symptoms include epigastric discomfort, pain, abdominal distension, pantothenic acid, heartburn, anorexia, nausea person.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for treating chronic gastritis and its preparation side
Method and application.
Background technique
Chronic gastritis (Chronic Gastritis, CG) is the chronic inflammation lesion of gastric mucosa, can be by a variety of different
The cause of disease causes, and gastric mucosa inflammatory cell infiltration, reconstruction are shown as in histology, finally can lead to the atrophy of the intrinsic body of gland of mucous membrane,
Even disappear.It is at present to be divided into superficial gastritis, atrophic gastritis and specific type gastritis three classes more.
It is adult almost 100% to suffer from this disease in China, there is symptom and the person of being examined accounts for about 60%, high year group disease incidence is 80%,
And atrophic gastritis incidence increases with the age.And atrophic gastritis is classified as disease before Stomach Carcinomas by WHO, changing into gastric cancer rate is
5%-10%.Therefore the therapeutic intervention that superficial gastritis is converted to atrophic gastritis turns blocking atrophic gastritis to gastric cancer
Become significant.
The Western medicine of chronic gastritis is treated at this stage there are commonly Amoxicillin, Omeprazole, clarithromycin, metronidazole etc.,
Wherein antibiotic is in the majority, and effect is mostly related with elimination helicobacter pylori (Hp), it is seen that eliminating and eradicating helicobacter pylori (Hp) is west
The essential therapeutic arsenals of doctor, but antibiotic medicine has stronger drug resistance, and is harmful to the human body, side effect is more, answers for a long time
With that certainly will impact to the health of the mankind, nowadays each hospital has all made further specification to the use of antibiotic.
For Western medicine, traditional Chinese medicine has higher safety.The TCM Culture in China is with a long history, middle medical knowledge
The cause of disease of chronic gastritis mainly has the reasons such as liver-stomach disharmony, stagnation of liver-QI with deficiency of the spleen, weakness of the spleen and the stomach, damp heat in the spleen and the stomach, deficiency of stomach-Yin in,
Highest clinical incidence is liver-stomach disharmony, stagnation of liver-QI with deficiency of the spleen.As that studies chronic gastritis gradually gos deep into, traditional Chinese medicine treatment is slow
Property gastritis show its unique advantage, have vast potential for future development.
In view of this, the present invention is specifically proposed.
Summary of the invention
It is an object of that present invention to provide a kind of Chinese medicine compositions and the preparation method and application thereof for treating chronic gastritis.This hair
Bright research discovery is by rhizoma nardostachyos, radix aucklandiae, fingered citron, Divine Comedy, myrobalan.Manufactured Chinese medicine composition is aobvious for the therapeutic effect of chronic gastritis
It writes, there is synergistic function, which cures mainly because of diseases such as liver-stomach disharmony, the stomachache of stagnation of QI due to depression of the liver, feeling of fullness, for slow
Property superficial gastritis, atrophic gastritis symptoms include epigastric discomfort, pain, abdominal distension, pantothenic acid, heartburn, anorexia, nausea person.
Specifically, the present invention provides a kind of Chinese medicine composition for treating chronic gastritis, by including in following parts by weight
Medicine is made: 6-10 parts of rhizoma nardostachyos, 4-8 parts of radix aucklandiae, 3-7 parts of fingered citron, 1-5 parts of Divine Comedy, 1-4 parts of myrobalan.
Preferably, the Chinese medicine composition by include following parts by weight Chinese medicine be made: 7-9 parts of rhizoma nardostachyos, 5-7 parts of radix aucklandiae,
4-6 parts of fingered citron, 2-4 parts of Divine Comedy, 1-3 parts of myrobalan.
Preferably, the Chinese medicine composition is by including that the Chinese medicine of following parts by weight is made: 8 parts of rhizoma nardostachyos, 7 parts of radix aucklandiae, fingered citron 6
Part, 2 parts of Divine Comedy, 1 part of myrobalan.
Further, the active constituent of Chinese medicine composition of the present invention is by rhizoma nardostachyos, radix aucklandiae, fingered citron, Divine Comedy, myrobalan
It is made.
Preferably to play curative effect, the present invention also provides the preparation methods of above-mentioned Chinese medicine composition, comprising the following steps:
1) rhizoma nardostachyos, radix aucklandiae, fingered citron, Divine Comedy, myrobalan are taken according to the ratio；
2) rhizoma nardostachyos is extracted with water, amount of water is generally 8-15 times of rhizoma nardostachyos weight, and extraction time is generally 10-15h；Water
Steam distillation method is extracted to obtain volatile oil, will volatilize oily beta-cyclodextrin inclusion compound, obtains Spikenard volatile oil Benexate Hydrochloride；
Aqueous extract is concentrated under reduced pressure, rhizoma nardostachyos medicinal extract is obtained；It can be generally concentrated into relative density 1.25-1.30 (60-70 DEG C),
3) radix aucklandiae of formula ratio 40-60% is crushed respectively with Divine Comedy, crosses 80-100 mesh, obtains medicinal material powder；
4) surplus radix aucklandiae is mixed with fingered citron, myrobalan, with the extraction of 55%-65% ethyl alcohol, (general ethanol consumption is medicinal material weight
8-15 times of amount extracts 1-3 times, and each time is 1-3h)；Extracting solution is concentrated to give medicinal material medicinal extract；It can generally be concentrated into opposite
Density 1.25-1.30 (60-70 DEG C),
Spikenard volatile oil Benexate Hydrochloride produced above, rhizoma nardostachyos medicinal extract, medicinal material powder and medicinal material medicinal extract are mixed, system
At Chinese medicine composition.Pharmaceutically acceptable auxiliary material, which is further added, can be made into Chinese materia medica preparation.
Generally, conventional method in that art can be used by Spikenard volatile oil beta-cyclodextrin inclusion compound, inclusion compound is made.
In a specific embodiment of the invention, the preparation method of above-mentioned Chinese medicine composition includes:
1) rhizoma nardostachyos, radix aucklandiae, fingered citron, Divine Comedy, myrobalan are taken according to the ratio；
2) 10 times of weight waters of rhizoma nardostachyos are extracted into 10h, extraction by steam distillation obtains volatile oil, will volatilize oil β-ring
Dextrin inclusion, obtains Spikenard volatile oil Benexate Hydrochloride；Aqueous extract is concentrated under reduced pressure, relative density 1.25- is concentrated into
When 1.30 (60 DEG C), rhizoma nardostachyos medicinal extract is obtained；
3) radix aucklandiae of formula ratio 50% is crushed respectively with Divine Comedy, crosses 80 meshes, obtains medicinal material powder；
4) surplus radix aucklandiae is mixed with fingered citron, myrobalan, with 10 times of 60% ethanol solution extraction times of weight 2 times, extract when
Between 2 hours, extracting solution merge filtering, be concentrated into relative density 1.20-1.30 (60 DEG C), obtain medicinal material medicinal extract；
Spikenard volatile oil Benexate Hydrochloride produced above, rhizoma nardostachyos medicinal extract, medicinal material powder and medicinal material medicinal extract are mixed, system
At Chinese medicine composition.
Various Chinese materia medica preparations can be made in pharmaceutical composition of the present invention by conventional method in that art, and preferred dosage form is
Tablet, capsule, granule or pill.
In Chinese materia medica preparation provided by the invention, pharmaceutically acceptable auxiliary material is the customary adjuvant in Chinese materia medica preparation, is such as collapsed
Agent, lubricant, adhesive etc. are solved, but acceptable auxiliary material is not limited thereto in Chinese pharmacology of the present invention, those skilled in the art
Think that feasible customary adjuvant is within the scope of the present invention, the present invention is it is not limited here.
In the present invention, the preparation method of Chinese materia medica preparation is conventional preparation method.In the present invention, the present invention is provided
Chinese medicine composition mixed with pharmaceutically acceptable auxiliary material needed for different dosage forms, be made using routine techniques common oral
Preparation, those skilled in the art think that feasible preparation method is within the scope of the present invention, and the present invention is not done herein
It limits.
The answering in the drug of preparation treatment chronic gastritis the invention also includes above-mentioned Chinese medicine composition or Chinese materia medica preparation
With.
In the traditional chinese medicine composition of the invention, rhizoma nardostachyos is monarch drug in a prescription；" collected statements on the herbal foundation " is said: rhizoma nardostachyos, the medicine for smooth stomach of being amusing；Its fragrance
Row dissipates, warming spleen and stomach for dispelling cold, and energy regulating qi-flowing for relieving pain opens strongly fragrant be amusing.Radix aucklandiae and fingered citron are ministerial drug.Radix aucklandiae can manage it Liver Channel, and promoting qi circulation and relieving pain is good for
Spleen helps digestion." book on Chinese herbal medicine " says that the total medicine for controlling gas, the unified inside and outside all gas lower with it of pipe solely push away its function." book on Chinese herbal medicine is looked for the truth " speech: radix aucklandiae, under
During gas is wide, therefore all deficiency-cold in spleen and stomach stagnate, and see vomiting and diarrhoea and stop eating；The liver cold of insufficiency type enters, and sees the obstruction of the circulation of vital energy circulation of vital energy in the wrong direction, takes this pungent fragrance hardship, then can
Lower gas and in width, rhizoma nardostachyos promoting the circulation of qi can be helped.Fingered citron, dispersing stagnated hepatoqi, protecting the stomach and relieve the pain." the southern regions of the Yunnan Province book on Chinese herbal medicine ": tonifying liver warm stomach, anti-nausea,
The stomach cold that disappears phlegm, controls stomach Qi pain." book on Chinese herbal medicine is new again ": controlling the easypro liver of gas, and stomach function regulating resolving sputum breaks product, can help rhizoma nardostachyos soothing liver and harmonizing stomach.Divine Comedy and
Myrobalan is adjuvant.Divine Comedy, Appetizing spleen-tonifying, helping digestion disperse accumulation.Myrobalan, relieving diarrhea with astringents, lower gas dissipate-swelling." herbal row justice ": though this object
Puckery intestines, and lose heart；Tang Materia Medica: main cold air trusted subordinate turgor, lower place object.Regulating qi-flowing for relieving pain, soothing liver and harmonizing stomach are played altogether by full side, and disperse accumulation is removed
Full function cures mainly because of diseases such as liver-stomach disharmony, the stomachache of stagnation of QI due to depression of the liver, feeling of fullness, is used for chronic superficial gastritis, atrophic stomach
Inflammation is shown in epigastric discomfort, pain, abdominal distension, pantothenic acid, heartburn, anorexia, nausea person.
The traditional chinese medicine composition of the invention treats chronic gastritis curative effect height, convenient to take, and curative effect is stable, cures thoroughly, and is applicable in
In various gastritis, have no toxic side effect.
Specific embodiment
With reference to embodiment, the embodiment of the present invention is furthur described in detail.Following embodiment is used for
Illustrate the present invention, but is not intended to limit the scope of the invention.Each raw material of following embodiment is conventional commercial product.
Embodiment 1
A kind of Chinese medicine composition for treating chronic gastritis, is made of following Chinese medicine material: 8 parts of rhizoma nardostachyos, 7 parts of radix aucklandiae, fingered citron 6
Part, 2 parts of Divine Comedy, 1 part of myrobalan.
The preparation method of the present embodiment Chinese medicine composition, comprising the following steps:
1) rhizoma nardostachyos, radix aucklandiae, fingered citron, Divine Comedy, myrobalan are taken according to the ratio；
2) 10 times of weight waters of rhizoma nardostachyos are extracted into 10h, extraction by steam distillation obtains volatile oil, will volatilize oil β-ring
Dextrin inclusion, obtains Spikenard volatile oil Benexate Hydrochloride；Aqueous extract is concentrated under reduced pressure, relative density 1.25 is concentrated into
When (60 DEG C), rhizoma nardostachyos medicinal extract is obtained；
3) radix aucklandiae of formula ratio 50% is crushed respectively with Divine Comedy, crosses 80 meshes, obtains medicinal material powder；
4) surplus radix aucklandiae is mixed with fingered citron, myrobalan, with 10 times of 60% ethanol solution extraction times of weight 2 times, extract when
Between 2 hours, extracting solution merge filtering, be concentrated into relative density 1.20 (60 DEG C), obtain medicinal material medicinal extract；
Spikenard volatile oil Benexate Hydrochloride produced above, rhizoma nardostachyos medicinal extract, medicinal material powder and medicinal material medicinal extract are mixed, system
At Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition for treating chronic gastritis, is made of following Chinese medicine material: 8 parts of rhizoma nardostachyos, 6 parts of radix aucklandiae, fingered citron 6
Part, 4 parts of Divine Comedy, 2 parts of myrobalan.
The preparation method of the present embodiment Chinese medicine composition is same as Example 1.
Embodiment 3
A kind of Chinese medicine composition for treating chronic gastritis, is made of following Chinese medicine material: 9 parts of rhizoma nardostachyos, 7 parts of radix aucklandiae, fingered citron 6
Part, 4 parts of Divine Comedy, 3 parts of myrobalan.
The preparation method of the present embodiment Chinese medicine composition is same as Example 1.
Embodiment 4
A kind of Chinese medicine composition for treating chronic gastritis, is made of following Chinese medicine material: 9 parts of rhizoma nardostachyos, 8 parts of radix aucklandiae, fingered citron 5
Part, 4 parts of Divine Comedy, 2 parts of myrobalan.
The preparation method of the present embodiment Chinese medicine composition is same as Example 1.
Embodiment 5
Tablet, capsule, granule is made by conventional method in that art in Chinese medicine composition prepared by embodiment 1-4 respectively
Or pill.
1 zoopery of experimental example
Laboratory sample: Chinese medicine composition prepared by embodiment 1.MOLUO DAN, Handan Pharmaceutical Co., Ltd, lot number 161003.
Experimental method:
SD rat 60 are taken, male, 150 ± l0g of weight is randomly divided into 6 groups, every group 10.(1) distilled water control group
(distilled water 10mLkg-1·bw)；(2) chronic gastritis model group (distilled water l0mLkg-1·bw)；(3) positive drug MOLUO DAN
Group (90.0gkg-1·bw)；(4) pharmaceutical composition low dose group (0.9gkg-1·bw)；(5) pharmaceutical composition middle dosage
Group (1.8gkg-1·bw)；(6) pharmaceutical composition high dose group (3.6gkg-1·bw)。
Except distilled water control group, (2)-(6) group rat is primary every 5 days 60% ethyl alcohol of stomach-filling, and each 2ml/, and with
63% sodium deoxycholate solution (pH7.0-7.8) is arbitrarily drunk as beverage by rat, and continuous 3 months.Start within four month,
Ethyl alcohol with 63% sodium deoxycholate solution and 30% is that (2)-(6) organize rat beverage, primary every rotation in 7 days, any to drink
With continuous 5 months.It is drinking the l days and the 5th day in NaTDC 7 days, it is each that (2)-(6) organize 60% ethyl alcohol of rat oral gavage
Once, 2mL/.Cause it is scorching after, test medicine is administered in each group rat oral gavage, once a day, capacity 2ml/l00g, continuous 2
Month.Experiment terminates the previous day, and each group rat is unified fasting (can't help water), and eyeball blood sampling, 3500rpm centrifugation are extractd after 18h
25min, radioimmunoassays survey serum gastrin content, and subsequent cervical dislocation puts to death rat, abdomen is opened under aseptic condition, ligature cardia
And pylorus, full stomach is taken out, 0.3ml gastric juice is collected after splitting, and dilute 10 times of with distilled water (pH7.0) and take 10 times of dilutions, with
(1.0 grams of phenolphthalein are dissolved in for support Freund solution (0.5 gram be dissolved in methyl- aniline 95% l00mL ethyl alcohol) and phenolphthalein solution
95% l00mL ethyl alcohol) it is indicator, titration surveys gastric juice free acid and total acid content；Take 10 times of dilutions, wheat spy's capillary glass
Tube method surveys pepsin activity: taking 10 times of dilution lml, adds 1% A Xinlan solution 0.1mL, adds the Acidum Citricum phosphoric acid of pH5.8 slow
Fliud flushing 3.3mL, then plus distilled water to 5.6mL.It mixes, after incubating for 24 hours, 2500rpm is centrifuged l0min, takes supernatant 615nm wavelength
Colorimetric, find out with the protein bound A Xinlan amount of gastric mucus, mucus amount is indicated with A Xinlan amount, the results are shown in Table 1, t examine system
Count processing.
Influence (x ± s, n=10) of the table 1 to Rat Experimental chronic gastritis
Compared with chronic gastritis model group, * P < 0.05, * * P < 0.01.
The results showed that each dosage group rat gastric juice of medicinal composition tablets is free compared with chronic gastritis model group
Acidity, total acidity and serum gastrin value increase, and high dose group gastric mucus amount then reduces.And each index and model group are poor
Different significant (P < 0.05 or P < 0.01).Illustrate, for rat chronic gastritis caused by long-term stomach-filling NaTDC and ethyl alcohol, originally
Invention pharmaceutical composition has preventive and therapeutic effect.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.
Claims (9)
1. a kind of Chinese medicine composition for treating chronic gastritis, which is characterized in that be made of the Chinese medicine for including following parts by weight: rhizoma nardostachyos
6-10 parts, 4-8 parts of radix aucklandiae, 3-7 parts of fingered citron, 1-5 parts of Divine Comedy, 1-4 parts of myrobalan.
2. Chinese medicine composition according to claim 1, which is characterized in that be made of the Chinese medicine for including following parts by weight: sweet
7-9 parts loose, 5-7 parts of radix aucklandiae, 4-6 parts of fingered citron, 2-4 parts of Divine Comedy, 1-3 parts of myrobalan.
3. Chinese medicine composition according to claim 1, which is characterized in that be made of the Chinese medicine for including following parts by weight: sweet
Loose 8 parts, 7 parts of radix aucklandiae, 6 parts of fingered citron, 2 parts of Divine Comedy, 1 part of myrobalan；
Or the Chinese medicine by including following parts by weight is made: 8 parts of rhizoma nardostachyos, 6 parts of radix aucklandiae, 6 parts of fingered citron, 4 parts of Divine Comedy, 2 parts of myrobalan；
Or the Chinese medicine by including following parts by weight is made: 9 parts of rhizoma nardostachyos, 7 parts of radix aucklandiae, 6 parts of fingered citron, 4 parts of Divine Comedy, 3 parts of myrobalan；
Or the Chinese medicine by including following parts by weight is made: 9 parts of rhizoma nardostachyos, 8 parts of radix aucklandiae, 5 parts of fingered citron, 4 parts of Divine Comedy, 2 parts of myrobalan.
4. the preparation method of any one of the claim 1-3 Chinese medicine composition, which comprises the following steps:
1) rhizoma nardostachyos, radix aucklandiae, fingered citron, Divine Comedy, myrobalan are taken according to the ratio；
2) rhizoma nardostachyos is extracted with water, extraction by steam distillation obtains volatile oil, will volatilize oily beta-cyclodextrin inclusion compound, obtains sweet
Loose volatile oil beta cyclodextrin inclusion complex；Aqueous extract is concentrated under reduced pressure, rhizoma nardostachyos medicinal extract is obtained；
3) radix aucklandiae of formula ratio 40-60% is crushed respectively with Divine Comedy, crosses 80-100 mesh, obtains medicinal material powder；
4) surplus radix aucklandiae is mixed with fingered citron, myrobalan, is extracted with 55%-65% ethyl alcohol；Extracting solution is concentrated to give medicinal material medicinal extract；
Spikenard volatile oil Benexate Hydrochloride produced above, rhizoma nardostachyos medicinal extract, medicinal material powder and medicinal material medicinal extract are mixed, are made
Drug composition；Or pharmaceutically acceptable auxiliary material is further added, Chinese materia medica preparation is made.
5. the preparation method according to claim 4, which comprises the following steps:
1) rhizoma nardostachyos, radix aucklandiae, fingered citron, Divine Comedy, myrobalan are taken according to the ratio；
2) 10 times of weight waters of rhizoma nardostachyos are extracted into 10h, extraction by steam distillation obtains volatile oil, will volatilize oil beta-cyclodextrin
Inclusion, obtains Spikenard volatile oil Benexate Hydrochloride；Aqueous extract is concentrated under reduced pressure, relative density 1.25-1.30 is concentrated into
When, obtain rhizoma nardostachyos medicinal extract；
3) radix aucklandiae of formula ratio 50% is crushed respectively with Divine Comedy, crosses 80 meshes, obtains medicinal material powder；
4) surplus radix aucklandiae is mixed with fingered citron, myrobalan, it is small with 10 times of 60% ethanol solution extraction times of weight 2 times, extraction time 2
When, extracting solution merges filtering, is concentrated into relative density 1.20-1.30, obtains medicinal material medicinal extract；
Spikenard volatile oil Benexate Hydrochloride produced above, rhizoma nardostachyos medicinal extract, medicinal material powder and medicinal material medicinal extract are mixed, are made
Drug composition.
6. claim 4 or the Chinese medicine composition of 5 the methods preparation.
7. a kind of Chinese materia medica preparation for treating chronic gastritis, which is characterized in that by any one of claim 1-3,6 Chinese traditional medicine composition
Object is made with pharmaceutically acceptable auxiliary material.
8. Chinese materia medica preparation according to claim 7, which is characterized in that its dosage form includes tablet, capsule, granule or ball
Agent.
9. any one of claim 1-3,6 Chinese medicine composition or the Chinese materia medica preparation of claim 7 or 8 are slow in preparation treatment
Application in the drug of property gastritis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000060612A (en) * | 1999-03-18 | 2000-10-16 | 한영복 | Pharmaceutical composition comprising mixed-extract of phellodendron cortex and anemarrhena rhizoma for alalgesic and anti-inflammation |
| CN1799617A (en) * | 2005-04-08 | 2006-07-12 | 王智森 | Chinese medicine for treating chronic gastritis and gastroduodenal ulcer and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000060612A (en) * | 1999-03-18 | 2000-10-16 | 한영복 | Pharmaceutical composition comprising mixed-extract of phellodendron cortex and anemarrhena rhizoma for alalgesic and anti-inflammation |
| CN1799617A (en) * | 2005-04-08 | 2006-07-12 | 王智森 | Chinese medicine for treating chronic gastritis and gastroduodenal ulcer and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 宁红建 等: "六味能消胶囊治疗腹胀患者血浆胃动素水平的变化", 《中国中医药信息杂志》 * |
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Application publication date: 20190315 |