CN112294878A - Traditional Chinese medicine composition for treating asthma and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating asthma and preparation method thereof Download PDF

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CN112294878A
CN112294878A CN202011139617.3A CN202011139617A CN112294878A CN 112294878 A CN112294878 A CN 112294878A CN 202011139617 A CN202011139617 A CN 202011139617A CN 112294878 A CN112294878 A CN 112294878A
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chinese medicine
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medicine composition
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帅放文
平措绕吉
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Liuyang Limei Hospital Co ltd
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Liuyang Limei Hospital Co ltd
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Abstract

The invention discloses a traditional Chinese medicine composition for treating asthma and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3.0-30 parts of rhodiola rosea, 0.2-20 parts of liquorice, 1.0-10 parts of Tibetan costustoot, 2.5-25 parts of eucommia bark, 4.0-40 parts of sea buckthorn, 1.0-10 parts of ramulus Uncariae cum uncis, 0.5-5 parts of alpine weathered anhydrite, 5-15 parts of loquat leaves, 5-20 parts of perilla seeds and at least one selected from 2-12 parts of honeysuckle, 0.1-10 parts of bulbus fritillariae cirrhosae, 1-15 parts of aleppo avens and 0.1-10 parts of rhododendron dauricum; pulverizing the above materials, sterilizing, mixing, and adding the crude drug powder; or extracting with suitable solvent, filtering, and concentrating to obtain dry extract; or pulverizing and extracting to obtain dry extract powder. The traditional Chinese medicine composition has reasonable formula and strong synergistic effect, and the prepared capsule has the effects of clearing heat and removing toxicity, eliminating phlegm and relieving cough, diminishing inflammation and relieving asthma and moistening lung, and can tonify lung and kidney and prevent and treat asthma attack after being taken for a long time.

Description

Traditional Chinese medicine composition for treating asthma and preparation method thereof
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating asthma.
Background
Asthma is also known as bronchial asthma. Bronchial asthma is a chronic airway inflammation involving various cells and cell components, which is accompanied by increased airway responsiveness, resulting in recurrent wheezing, shortness of breath, chest tightness and/or cough, which often occur during the night and/or early morning, with a wide and variable airflow obstruction that can be reversed either by itself or by therapy. According to the report of the world health organization: "the harm and economic burden of asthma to human health exceeds the sum of tuberculosis and AIDS". The morbidity and mortality of asthma are gradually increased year by year due to the increasing pollution degree of the ecological environment. At present, 1.5 to 2 hundred million people with asthma patients all over the world, more than 18 million people dying from asthma every year, the incidence rate of asthma in China is 1 to 5 percent, and about 3000 million patients with asthma exist.
The Tibetan medicine considers that asthma belongs to the category of the symptoms of the asthma and the ormidwa, and usually is caused by the internal exuberance of pathogenic qi, obstruction of essence transmission and collaterals dredging due to improper diet, external infection, overstrain and the like, or the obstruction of air passages due to lung deficiency cough and the like, so that asthma is caused. It can suddenly attack and stop, and has the characteristics of "wind moves well and changes gradually" and "wind is strong and spasm suddenly". Aiming at bronchial asthma, western medicine treatment mainly takes antiallergic drugs and anti-infective drugs, so that the diseases are difficult to be eradicated completely, and meanwhile, adverse reactions are generated, and the compliance is general. In addition, the prevention and treatment of bronchial asthma in China are not standard enough, hospitals do not carry out formal and reasonable lung function measurement, and long-term planning is not made during treatment, so that the due curative effect cannot be achieved finally. The Tibetan medicine has the main effects of relieving cough and asthma, clearing heat and benefiting lung, assists in regulating digestive system, and improves the immunologic function of patients so as to achieve the purpose of treatment. Long-term clinical practice shows that the Tibetan medicine has good curative effect on bronchial asthma and has no side effect. However, the Tibetan medicine treatment puts more importance on individuation, and the treatment units are difficult to unify the treatment scheme, so that the popularization of the application needs to be increased and the investment in various aspects is gradually improved.
The invention develops a traditional Chinese medicine composition for treating asthma based on Tibetan medicine theory. The traditional Chinese medicine composition has the advantages of regulating the immune function of an organism from the whole angle, inhibiting airway inflammation, improving airway remodeling, reducing airway reaction and regulating nerve imbalance, and plays an important role in improving lung function and preventing and treating asthma.
Disclosure of Invention
The invention aims to solve the defects of the prior art and provides the traditional Chinese medicine composition which is scientific and reasonable in proportion, exact in curative effect, safe in clinical use, low in adverse reaction, sufficient in medicine source, advanced in preparation method and convenient to take and the preparation method thereof. In order to achieve the above purpose, the invention adopts the technical scheme that:
the traditional Chinese medicine composition for treating asthma is characterized by comprising the following raw materials: rhodiola rosea, liquorice, Tibetan costus root, donkey-hide gelatin, sea buckthorn, ramulus Uncariae cum uncis, alpine weathered anhydrite, loquat leaves, perilla seeds and at least one selected from honeysuckle, bulbus fritillariae cirrhosae, aleppo avens and rhododendron dauricum.
Further, the weight parts of the raw materials are as follows: 3.0 to 30 parts of rhodiola rosea, 0.2 to 20 parts of liquorice, 1.0 to 10 parts of Tibet inula root, 2.5 to 25 parts of eucommia bark, 4.0 to 40 parts of sea buckthorn, 1.0 to 10 parts of ramulus Uncariae cum uncis, 0.5 to 5 parts of alpine weathered anhydrite, 5 to 15 parts of loquat leaf, 5 to 20 parts of perilla fruit and at least one selected from 2 to 12 parts of honeysuckle, 0.1 to 10 parts of bulbus fritillariae cirrhosae, 1 to 15 parts of aleppo avens and 0.1 to 10 parts of dahurian rhododendron leaf.
Further, the weight parts of the raw materials are as follows: 3.0 to 30 portions of rhodiola rosea, 0.2 to 20 portions of liquorice, 1.0 to 10 portions of Tibet inula root, 2.5 to 25 portions of eucommia bark, 4.0 to 40 portions of sea buckthorn, 1.0 to 10 portions of ramulus Uncariae cum uncis, 0.5 to 5 portions of alpine weathered anhydrite, 5 to 15 portions of loquat leaf, 5 to 20 portions of perilla fruit, 2 to 12 portions of honeysuckle, 0.1 to 10 portions of bulbus fritillariae cirrhosae, 1 to 15 portions of aleppo avens and 0.1 to 10 portions of dahurian rhododendron leaf.
Further, the weight parts of the raw materials are as follows: 3.0-20 parts of rhodiola rosea, 1-10 parts of liquorice, 2-8 parts of Tibetan costus root, 5-15 parts of eucommia bark, 10-30 parts of sea buckthorn, 2-8 parts of ramulus Uncariae cum uncis, 1-4 parts of alpine weathering anhydrite, 5-10 parts of loquat leaf, 8-15 parts of perilla fruit, 5-10 parts of honeysuckle, 1-6 parts of bulbus fritillariae cirrhosae, 2-10 parts of aleppo avens and 1-6 parts of rhododendron dauricum.
Further, the preparation method of the traditional Chinese medicine composition comprises the following steps: pulverizing the above materials, sterilizing, and mixing to obtain the composition.
Further, the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) soaking the medicinal materials in a prescription amount in a proper amount of solvent for 0.5-2h, and extracting for 1-5 times, wherein each extraction time is 0.5-2h, the solvent is water, ethanol or a mixture of water and ethanol, and the amount of the solvent is 1-20 times of the total amount of the medicinal materials;
(2) mixing extractive solutions, filtering, concentrating to obtain extract with relative density of 1.2-1.5, and drying to obtain dry extract with water content of 10% or less.
Further, the preparation method of the traditional Chinese medicine composition comprises the following steps:
(1) taking the formula amount of liquorice, ramulus Uncariae cum uncis, alpine weathered anhydrite, honeysuckle, bulbus fritilariae and perilla seeds, crushing by a crusher, sieving by a sieve of 80-120 meshes, and performing ultraviolet sterilization for 30-600 min;
(2) extracting medicinal materials: soaking the rest medicinal materials in the amount of the prescription in a proper amount of solvent for 1-5 times, wherein the solvent is water, ethanol or a mixture of water and ethanol, the amount of the solvent is 1-20 times of the total amount of the medicinal materials, and the extraction time is 0.5-2 hours each time; mixing the extracting solutions, filtering, and concentrating to obtain an extract with the relative density of 1.20-1.40; drying the obtained extract to obtain dry extract with water content not more than 10%, and pulverizing the dry extract for use;
(3) mixing: mixing the fine powder and the dry extract powder.
Further, the extraction method of Tibetan radix aucklandiae comprises the following steps: adding 65-95% ethanol 5-10 times the weight of the extract, performing ultrasonic continuous countercurrent extraction with ultrasonic power of 300-500W for 30-60 min, extracting for 1-3 times, mixing the extractive solutions, filtering, and concentrating under reduced pressure to obtain radix Inulae extract mainly containing volatile oil components, wherein the volatile oil is prepared into clathrate by saturated aqueous solution method, and the volatile oil is prepared by the following steps: beta-cyclodextrin: absolute ethyl alcohol =1:8-10:2.5-5, dissolving the volatile oil of the Tibetan radix aucklandiae in the absolute ethyl alcohol, adding the dissolved beta-cyclodextrin solution, keeping the temperature at 30-45 ℃, stirring for 0.5-1h, cooling, filtering, and carrying out solid-liquid separation to obtain the wet beta-cyclodextrin inclusion compound of the volatile oil of the Tibetan radix aucklandiae.
Further, any conventional dosage form is produced optionally with the addition of suitable pharmaceutically acceptable excipients, and the preparation is preferably an oral dosage form, and may be selected from powder, capsule, tablet, pill, decoction or spray in consideration of patient compliance and drug efficacy.
Further, the capsule shell adopted by the capsule can be a starch hollow capsule, a gelatin hollow capsule, a pullulan hollow capsule and a hydroxypropyl methylcellulose hollow capsule.
Furthermore, the traditional Chinese medicine composition has the effects of eliminating phlegm, relieving cough, diminishing inflammation and relieving asthma, and can tonify lung and kidney, and prevent and treat asthma attack after long-term administration.
The invention provides a traditional Chinese medicine composition for treating asthma, which is prepared by screening and composing according to Tibetan medicine theory dialectical treatment, and the formula comprises the following components in parts by weight:
rhodiola root: is the dried root and rhizome of rhodiola crenulata of Crassulaceae. Sweet, bitter and neutral in flavor. It enters lung and heart meridians. Has effects of invigorating qi, promoting blood circulation, dredging collaterals and relieving asthma, and can be used for treating qi deficiency and blood stasis, thoracic obstruction, cardiodynia, apoplexy, hemiplegia, listlessness and asthma. The main active component of the compound is salidroside, and the content of the compound is not less than 0.5 percent according to Chinese pharmacopoeia.
Licorice root: licorice, mild in nature, mild in temperature, sweet in taste; enter spleen, stomach, lung, heart and kidney meridians and enter twelve meridians. Has effects in invigorating spleen, invigorating qi, clearing away heat and toxic materials, expelling phlegm, relieving cough, relieving spasm, relieving pain, and harmonizing the drugs. The record of the herbal essentials records liquorice: "Weigan". The raw material is neutral in nature, and can tonify spleen and stomach deficiency to purge heart fire (in case of acute fire, it should be relieved). The moxibustion is warm in nature and can tonify the triple energizer's original qi to dissipate exterior cold. Indicating that the unprocessed gan Cao is cool in nature and can enter lung meridian to treat lung system diseases such as swollen sore throat and cough. Record "treating throat disease in Ben Cao Zheng Yao (Chinese materia medica): it is indicated for red swelling, and it is also indicated for clearing heat from throat. Wuyuanshen, Sheng Ma or Huang Lian. It is also used for putrefaction to remove toxicity. Used for Wuwu Qiyezhihua or jin Guo Yan. it is indicated for chronic and weak sore throat and is also tonifying. It is used for Wu Yu Zhu and Bei Sha Shen. It has actions of alleviating pain, detumescence and relieving spasm when entering throat-blowing herbs, so it is indicated for sores due to swelling and toxicity by using licorice root node instead of … … for treating abscess, furuncle and sore throat, which is good for swallowing and improving the herbs taste. "the treatment of pain in the pharynx with Licorice decoction from Han Dynasty" Shang Han Lun "and the treatment of pulmonary abscess with Licorice decoction from Jing nong Shu (longevity Shi Bao Yuan)" in Ming Dynasty "are both effective when Licorice enters lung meridian. Modern pharmacological research shows that glycyrrhizic acid in licorice is the active component of licorice with antiphlogistic effect, and glycyrrhizic acid salt have treating effect on respiratory tract inflammation. The liquorice specified in the Chinese pharmacopoeia contains not less than 0.5 percent of liquiritin and not less than 2.0 percent of glycyrrhizic acid.
Tibetan aucklandia root: the Tibetan language name "Manu" is the root of Tibetan radix aucklandiae of Compositae. Has aromatic and thick flavor, sweet, bitter and pungent taste, has effects of eliminating phlegm, descending qi, softening hard masses, and promoting diuresis, and can be used for treating swordlike process disease, bacon and red bar complications. The main active component is sesquiterpene volatile oil.
And A, Zhong: the plant Caryophyllaceae, Gansu flea, is decorated with whole plant of Arenaria kansuensis Maxim. Slightly sweet and bitter in taste and cold in nature. It belongs to liver, gallbladder and kidney channels, has effects of clearing heat, relieving cough, promoting diuresis, eliminating jaundice, eliminating arthralgia, and relieving pain, and can be used for treating fever due to exogenous pathogenic factor, cough due to lung heat, jaundice, stranguria with turbid urine, rheumatalgia, and hypertension. The main active ingredients are: alkaloids, triterpenes, saponins thereof, sterols and other compounds.
Sea-buckthorn: is a traditional Chinese medicine for Mongolian and Tibetan. Is dried mature fruit of Hippophae rhamnoides of Elaeagnaceae. Sour, astringent and warm. It enters spleen, stomach, lung and heart meridians. Has the functions of invigorating spleen, promoting digestion, relieving cough, promoting digestion, promoting blood circulation and removing blood stasis. Can be used for treating spleen deficiency, anorexia, abdominal pain due to dyspepsia, cough, excessive phlegm, thoracic obstruction, cardialgia, blood stasis, amenorrhea, traumatic injury, blood stasis, and swelling. The main active ingredients are flavone and isorhamnetin.
D, wood suspensor: the medicine has sweet, bitter and slightly pungent taste, has effects of clearing heat, pneumonia, influenza and detoxicating, and can be used for treating pyretic fever, bacon disease, edema, common cold, cough due to lung heat, asthma, and pulmonary diseases, and also can be used for treating febrile epidemic.
Weathered anhydrite in mountains: the product is divided into two products, the upper product is a genuine product, and the lower product is a substitute. The upper products are produced in places such as Makedus snow mountain, and are stones formed by accumulated snow for a long time, or snow-dissolved water drops on soil and stone dirt to form a bronze-shaped combination which is agglomerated into blocks like gypsum rubrum. White, slightly sweet and gritty when chewing. When the stone can not be found, two stones can be substituted: one is milky stone formed in a high and cool cave with the mountain shade facing north; one is the milky stone formed on the stone which can not be irradiated by the sun in summer and is attached to the stone surface or other objects in the deep mountains where the snow can not be disappeared in summer. Has astringent taste and cool, and has the effect of clearing liver heat.
Loquat leaf: the dry leaves of Eriobotrya japonica of Rosaceae family are bitter and slightly cold in taste. It enters lung and stomach meridians. Has effects of clearing lung-heat, relieving cough, lowering adverse flow of qi, and relieving vomit, and can be used for treating cough due to lung heat, asthma, vomiting due to stomach heat, dysphoria with smothery sensation, and thirst. The main active ingredients are oleanolic acid and ursolic acid.
Perilla seed: dried mature fruit of Perilla frutescens of Labiatae family. Pungent and warm in flavor. It enters lung meridian. Has the effects of lowering qi, reducing phlegm, relieving cough and asthma, and loosening bowel to relieve constipation. Can be used for treating phlegm stagnation and adverse flow of qi, cough, asthma, and constipation due to intestinal dryness.
Honeysuckle flower: is dried bud or flower of Lonicera japonica Thunb of Caprifoliaceae. Collected before blooming in summer and dried. Sweet and cold in nature, entering lung, heart and stomach meridians, has effects of clearing heat and detoxicating, and dispelling pathogenic wind and heat, and can be used for treating carbuncle, swelling, furuncle, pharyngitis, erysipelas, toxic heat, dysentery, wind heat common cold, and warm disease. The honeysuckle is rich in volatile oil, organic acid, iridoid, flavone, triterpenoid saponin and other effective components. Modern pharmacology indicates that the honeysuckle extract has the effects of resisting inflammation, bacteria, viruses and oxidation, and can be used for treating wind-heat type common cold, epidemic febrile disease and fever.
Bulbus Fritillariae Cirrhosae: dried bulb of Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Uninbracteatae, Bulbus Fritillariae Cirrhosae, Fritillaria Mimosoidis, Bulbus Fritillariae Taipaiensis or Bulbus Fritillariae Orobavatae of Liliaceae. Mainly contains alkaloid, and is bitter, sweet and slightly cold in taste. It enters lung and heart meridians. Has effects of clearing heat, moistening lung, eliminating phlegm, relieving cough, resolving hard mass, and resolving carbuncle. Can be used for treating cough due to lung heat, dry cough with little phlegm, cough due to yin deficiency, bloody sputum, and pulmonary abscess.
Blue cloth positive: dried whole plant of Rosaceae plant Geranium japonicum or Geranium japonicum. Sweet, bitter and cool. It enters liver, spleen and lung meridians. Has the functions of benefiting qi, invigorating spleen, replenishing blood, nourishing yin, moistening lung and eliminating phlegm. Can be used for treating deficiency of both qi and blood, cough due to consumptive disease, and leukorrhagia due to spleen deficiency.
Red dahurian rhododendron leaf: the product is dried leaf of Rhododendron dauricum of Ericaceae. Pungent and bitter in flavor and cold in nature. It enters lung and spleen meridians. Has the effects of relieving cough and eliminating phlegm, and is mainly used for treating cough, asthma and excessive phlegm.
The medicines are scientifically matched, can clear phlegm and phlegm qi in lung and disperse lung qi downward through combination, and can be used for treating lung paroxysmal diseases which are mainly manifested by sudden breathing, dyspnea and wheezing between throats. It also has effects in warming lung, dispelling cold, eliminating phlegm, and relieving asthma, and can be used for treating cold asthma (attack stage); clearing heat, ventilating lung, eliminating phlegm, lowering adverse qi, and treating heat asthma (in stage of attack); tonifying lung and strengthening wei, benefiting qi and relieving asthma, and can be used for treating lung deficiency (in remission stage); invigorating spleen, eliminating phlegm, lowering adverse qi, and relieving asthma, and can be used for treating spleen deficiency (in remission stage).
In the formula, the rhodiola rosea has the effects of tonifying qi and activating blood, and promoting blood circulation and relieving asthma, the sea-buckthorn has the effects of tonifying spleen, relieving cough, activating blood and removing blood stasis, and the two medicines are combined to be a pioneer of the effects of the medicines for completely resolving phlegm and relieving asthma, clearing heat and resolving masses, and expelling toxin and removing blood stasis, and the effects are primary and secondary, so the rhodiola rosea is a monarch medicine. The eucommia bark has the effects of clearing heat, relieving cough, eliminating arthralgia and relieving pain; tibet inula root has the effects of eliminating phlegm, descending qi, softening hard masses, promoting diuresis and the like; the loquat leaves have the effects of clearing away lung-heat, relieving cough, calming adverse-rising energy and preventing vomiting; fructus Perillae has effects of lowering qi, eliminating phlegm, relieving cough and asthma; the four medicines are matched to have the efficacies of clearing heat and ventilating lung, relieving cough, dissolving phlegm and descending qi, and are used as ministerial medicines for assisting the monarch medicines in ventilating lung qi, eliminating phlegm and relieving asthma and supplementing each other. Ramulus Uncariae cum uncis has effects in clearing away heat, pneumonia, influenza, and toxic materials; the alpine weathered anhydrite has the functions of clearing heat; the honeysuckle has the effects of clearing away heat and toxic materials and dispelling wind and heat; bulbus Fritillariae Cirrhosae has effects of clearing heat, moistening lung, eliminating phlegm, relieving cough, resolving hard mass, and resolving carbuncle; the blue cloth has the effects of tonifying qi and spleen, enriching blood and nourishing yin, moistening lung and reducing phlegm; folium Rhododendri Daurici enters lung and spleen channels, and has effects of relieving cough and eliminating phlegm. The six medicines are used together to have the functions of tonifying lung and spleen, clearing away heat and toxic materials, dissolving phlegm and dissipating heat, provide strong auxiliary effects for monarch and minister medicines, and are adjuvant medicines. The liquorice has the effects of tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, and is used as a guiding drug by harmonizing the medicines. The Chinese medicinal materials are scientifically matched and have the effects of reducing phlegm and relieving cough and ventilating and relieving asthma by combining.
Has the advantages that:
(1) the compatibility of the traditional Chinese medicine composition accords with the principle of 'monarch, minister, assistant and guide' of traditional Chinese medicine, and pharmacodynamics verifies that the traditional Chinese medicine composition has obvious effects of relieving asthma, eliminating phlegm and relieving cough.
(2) The preparation method of the traditional Chinese medicine composition for treating asthma provided by the invention is stable and reliable, the extraction process is designed according to the chemical properties of the active ingredients of each medicine, the content of the active ingredients is improved, wherein the volatile oil which is the main active ingredient of Tibet inula root is subjected to an ultrasonic continuous countercurrent extraction technology, the oil yield is high, the volatile oil is subjected to inclusion by beta-cyclodextrin, the volatilization loss of the volatile oil can be effectively prevented, the effect of the volatile oil is ensured to be stably exerted, and the quality of the traditional Chinese medicine composition is improved.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to limit the scope of the present invention in any way, and any modifications or alterations based on the present invention are within the scope of the present invention.
Example 1
3.0 parts of rhodiola rosea, 0.2 part of liquorice, 1.0 part of Tibetan costus root, 2.5 parts of eucommia bark, 4.0 parts of sea buckthorn, 1.0 part of ramulus Uncariae cum uncis, 0.5 part of alpine weathered anhydrite, 5 parts of loquat leaf, 5 parts of perilla fruit, 2 parts of honeysuckle, 0.1 part of bulbus fritillariae cirrhosae, 1 part of aleppo avens and 0.1 part of rhododendron dauricum, crushing by using a crusher, sterilizing after passing through an 80-mesh screen, loading into a disc with the thickness of 2mm, sterilizing by using an ultraviolet lamp of an ultraviolet sterilization box at the illuminance of 80uW/cm2 for 60min, and mixing to obtain the composition.
Example 2
(1) Pulverizing Glycyrrhrizae radix 20 parts, ramulus Uncariae cum uncis 10 parts, Gaoshan weathered anhydrite 5 parts, flos Lonicerae 12 parts, Bulbus Fritillariae Cirrhosae 10 parts, and fructus Perillae 20 parts into fine powder with pulverizer, sieving with 80 mesh sieve, sterilizing, placing into a tray with thickness of 3mm, and ultraviolet sterilizing box with ultraviolet lamp illumination of 100uW/cm2Sterilizing for 120 min;
(2) taking 10 parts of Tibetan radix aucklandiae, adding 10 times of 80% ethanol by weight, performing ultrasonic continuous countercurrent extraction with the ultrasonic power of 500W for 60 minutes, extracting for 3 times, combining the extracting solutions, filtering, and concentrating under reduced pressure to obtain a Tibetan radix aucklandiae extract which mainly contains volatile oil components, wherein the volatile oil is used for preparing a clathrate compound by a saturated aqueous solution method, and the volatile oil is prepared by the following steps: beta-cyclodextrin: absolute ethyl alcohol =1:10: 5, dissolving the volatile oil of the Tibetan radix aucklandiae in the absolute ethyl alcohol, adding the dissolved beta-cyclodextrin solution, keeping the temperature at 45 ℃, stirring for 1h, cooling, filtering, and performing solid-liquid separation to obtain the wet beta-cyclodextrin inclusion compound of the volatile oil of the Tibetan radix aucklandiae.
(3) Soaking 30 parts of rhodiola rosea, 25 parts of eucommia bark and 10 parts of rhododendron dauricum in 15 times of 60% ethanol water for 30min, extracting by ultrasonic waves, controlling the temperature at 45 ℃ and extracting for 50min at 300W; extracting for 2 times, mixing extractive solutions, filtering, removing residue, and collecting filtrate;
(4) soaking 40 parts of fructus Hippophae, 15 parts of folium Eriobotryae, and 15 parts of herba Gei, adding 12 times of 95% ethanol, soaking for 40min, extracting with ultrasonic wave at 40 deg.C and 350W for 40 min; extracting for 2 times, mixing extractive solutions, filtering, removing residue, mixing filtrate with the filtrate in step (3), concentrating under reduced pressure, drying to obtain dry extract with water content of no more than 10%, and pulverizing;
(5) uniformly mixing the crude drug powder in the step (1), the inclusion compound in the step (2) and the dry extract powder in the step (4), adding 20 parts of self-micropowder silica gel, mixing, adding a proper amount of ethanol water to prepare soft materials, granulating, drying at 50 ℃ for 2 hours, granulating to obtain dry granules, and filling the dry granules into starch hollow capsules to prepare capsules with the specification of 0.4 g/granule.
Example 3
(1) Pulverizing 1 part of Glycyrrhrizae radix, 5 parts of ramulus Uncariae cum uncis, and 3 parts of Gaoshan weathered anhydrite into fine powder with a pulverizer, and sterilizing;
(2) taking 5 parts of Tibetan radix aucklandiae, adding 8 times of 80% ethanol by weight, performing ultrasonic continuous countercurrent extraction with the ultrasonic power of 400W for 40 minutes, extracting for 2 times, combining the extracting solutions, filtering, and concentrating under reduced pressure to obtain a Tibetan radix aucklandiae extract which mainly contains volatile oil components, wherein the volatile oil is used for preparing an inclusion compound by a saturated aqueous solution method, and the volatile oil is prepared by the following steps: beta-cyclodextrin: absolute ethyl alcohol =1:9:3.5, dissolving the volatile oil of the Tibetan radix aucklandiae in the absolute ethyl alcohol, adding the dissolved beta-cyclodextrin solution, keeping the temperature at 30-45 ℃, stirring for 0.8h, cooling, filtering, and performing solid-liquid separation to obtain a wet beta-cyclodextrin inclusion compound of the volatile oil of the Tibetan radix aucklandiae;
(3) taking 15 parts of rhodiola rosea and 13 parts of eucommia ulmoides according to the proportion, adding 60 percent ethanol water with the weight being 12 times of that of the rhodiola rosea, soaking for 60min, extracting by ultrasonic waves, controlling the temperature to be 35 ℃ and extracting for 60min under 400W; extracting for 2 times, mixing extractive solutions, filtering, removing residue, and collecting filtrate;
(4) taking 20 parts of fructus Hippophae powder according to a certain proportion, adding 12 times of 95% ethanol, soaking for 40min, extracting with ultrasonic wave, controlling temperature at 38 deg.C, extracting at 350W for 40 min; extracting for 2 times, mixing extractive solutions, filtering, removing residue, mixing filtrate with the filtrate in step c, concentrating under reduced pressure, drying to obtain dry extract with water content of no more than 10%, and pulverizing;
(5) uniformly mixing the crude drug powder in the step (1), the inclusion compound in the step (2) and the dry extract powder in the step (4), adding 15 parts of pregelatinized hydroxypropyl starch, mixing, adding a proper amount of ethanol water to prepare a soft material, granulating, drying at 60 ℃ for 3h, granulating to obtain dry granules, and filling the dry granules into hydroxypropyl methylcellulose hollow capsules to prepare capsules with the specification of 0.4 g/granule.
Example 4
(1) Taking 20 parts of rhodiola rosea, 10 parts of liquorice, 8 parts of Tibetan costus root, 20 parts of eucommia bark, 30 parts of sea buckthorn, 8 parts of ramulus Uncariae cum uncis, 4 parts of alpine weathered anhydrite, 12 parts of loquat leaf, 15 parts of perilla fruit, 10 parts of honeysuckle, 8 parts of bulbus fritillariae cirrhosae, 13 parts of aleppo avens and 8 parts of rhododendron dauricum, adding 50% ethanol water, soaking for 1 hour, performing ultrasonic extraction, controlling the temperature to be 42 ℃, extracting for 1 hour at 350W, and extracting for 3 times;
(2) mixing extractive solutions, filtering, concentrating to obtain extract with relative density of 1.2, and drying to obtain dry extract with water content of no more than 10%.
Experimental example 5: the pharmacodynamics research of the composition provided by the invention
The treatment effect of the traditional Chinese medicine composition on asthma is examined:
(1) effect on the incubation period of asthma induced by egg protein in sensitized rats: healthy wistar rats with SPF grade and male body weight (190 +/-25) g and 60 animals are selected and randomly divided into 6 groups of a model group, a wheezin capsule group, a high-dose group and a low-dose group of the crude drug powder in the embodiment 1 of the invention, a high-dose group and a low-dose group of contents in the embodiment 2 and the like, and 10 animals are selected in each group. After 2mL of 5% egg protein normal saline is intraperitoneally injected for sensitization, the intragastric administration (administration volume: 20 mL/kg) is started on the 12 th day after sensitization, the same amount of normal saline is intragastric administered to the model group, and the high and low dose experimental groups of example 1 are respectively administered to example 1 (crude drug powder 4, 2g/kg, which is equivalent to 15, 7.5 times of the daily dosage of clinical adults), and the high and low dose experimental groups of example 2 are respectively administered to example 2 capsules (content 2, 1g/kg, which is equivalent to 15, 7.5 times of the daily dosage of clinical adults) and a capsule group of wheezin (content 0.81 g/kg), 1 time per day and 6 days continuously. Asthma induction was stimulated 1h after administration on days 14 and 17 after sensitization. When the rat is stimulated, the sensitized rat is placed into a self-made spray box, 1% egg protein normal saline is sprayed for 15s through ultrasonic atomization, the rat is placed in a closed spray box to continue inhaling until the rat contracts abdominal muscles, breathes like a nod, and the asthma latency is recorded.
The results are shown in Table 1, and compared with the model control group, the asthma latency of rats in each dose group of example 1 and each dose group of example 2 is obviously prolonged (P <0.05) and has stronger effect than the asthmatic capsule group.
TABLE 1 influence of examples 1 and 2 on the induction of asthma incubation period by egg protein in sensitized rats ()
Figure 199093DEST_PATH_IMAGE002
Comparison with model control group+ P < 0.05。
(2) Effect on mouse cough response by concentrated ammonia: 60 mice are taken and randomly divided into 6 groups, namely a model group, an albany capsule group, a crude drug powder high-dose group and a low-dose group in the embodiment 1 of the invention, a content high-dose group and a content low-dose group in the embodiment 2, and 10 mice are taken in each group. Respectively carrying out intragastric administration (administration volume: 20 mL/kg), carrying out intragastric administration with the same amount of normal saline in a model group, respectively carrying out intragastric administration with the same amount of normal saline in a high-dose experimental group and a low-dose experimental group in example 1 (crude drug powder is 2, 1g/kg, which is 15 and 7.5 times of the daily dosage of clinical adults), respectively carrying out intragastric administration with the same amount of normal saline in a high-dose experimental group and a low-dose experimental group in example 2 (content is 2 and 1g/kg, which is 15 and 7.5 times of the daily dosage of clinical adults) and carrying out intragastric administration with the same amount of normal saline in a high-dose experimental group and a low-dose experimental group in example 2 (content is 0, the mice are respectively placed in a self-made spray box, an atomizer is started to spray strong ammonia water into the box in a spray shape for 30s at a constant pressure of 18.9kPa, the mice are taken out and placed in a clean big beaker, and the cough latency period (the cough index is that the abdominal muscles of the mice contract the abdomen and open the mouth to spit the tongue) and the cough frequency within 3min are observed.
The results are shown in Table 2, and compared with the model control group, the cough frequency of mice in each dose group of example 1 and each dose group of example 2 is obviously reduced, and the cough latency period is obviously prolonged (P < 0.05）。
TABLE 2 influence of examples 1 and 2 on the cough response in mice with concentrated ammonia ()
Figure 116233DEST_PATH_IMAGE004
Comparison with model control group+ P < 0.05。
(3) Effect on the output of phenol red in the mouse airway: 60 mice are taken and randomly divided into 6 groups, namely a model group, a high-dose group and a low-dose group of the crude drug powder in the embodiment 1 of the invention, a high-dose group and a low-dose group of contents in the embodiment 2, and 10 mice in each group. After 2mL of 5% egg protein normal saline is used for intraperitoneal injection for sensitization, the intragastric administration (the administration volume: 20 mL/kg) is started on the 12 th day after sensitization, the intragastric administration is carried out on the model group by the same amount of normal saline, the high and low dose experimental groups in the example 1 are respectively the administration example 1 (crude drug powder 4, 2g/kg, which is equivalent to 15, 7.5 times of the daily dose of clinical adults), the example 2 is high, the low dose test group administered capsules of example 2 (content 2, 1g/kg, equivalent to 15, 7.5 times daily dose for clinical adults), 1 time daily for 6 days continuously, starving mice for 16h before the last administration, injecting 5% phenol red physiological saline 500mg/kg into abdominal cavity of mice for 1h after the last administration, killing mice after 30min, fixing back, separating trachea, cutting a small opening in trachea, inserting a 1ml syringe connected with 8-gauge needle. The airway was flushed 3 times with 1ml of physiological saline, 0.6ml of the flushed solution was placed in a test tube and 2ml of physiological saline was added, and 0.1ml of 1mol/l sodium hydroxide solution was added to make it alkaline. And (4) carrying out color comparison at 610nm of a model 752 ultraviolet spectrophotometer.
The results are shown in Table 3, the mice in each dose group of example 1 and each dose group of example 2 can increase the output of phenol red in the airway of the mice, and the difference is significant compared with the model control group (the difference is shown in the specification)P < 0.05）。
Table 3 influence of examples 1 and 2 on the amount of phenol red discharged from mouse airway ()
Figure 268209DEST_PATH_IMAGE006
Comparison with model control group+ P < 0.05。
From the pharmacodynamic test results, compared with the control group of each experimental model, the asthma latency of each dose group in the embodiment 1 and each dose group in the embodiment 2 of the invention is obviously prolonged, the cough frequency is obviously reduced, the cough latency is obviously prolonged, and the phenol red discharge in the airway is increased; the traditional Chinese medicine composition has certain effects of relieving asthma, relieving cough and reducing phlegm, and has a treatment effect on asthma.

Claims (9)

1. A traditional Chinese medicine composition for treating asthma is characterized by comprising the following raw materials: rhodiola rosea, liquorice, Tibetan costus root, donkey-hide gelatin, sea buckthorn, ramulus Uncariae cum uncis, alpine weathered anhydrite, loquat leaves, perilla seeds and at least one selected from honeysuckle, bulbus fritillariae cirrhosae, aleppo avens and rhododendron dauricum.
2. The traditional Chinese medicine composition for treating asthma according to claim 1, which is prepared from the following raw materials in parts by weight: 3.0 to 30 portions of rhodiola rosea, 0.2 to 20 portions of liquorice, 1.0 to 10 portions of Tibet inula root, 2.5 to 25 portions of eucommia bark, 4.0 to 40 portions of sea buckthorn, 1.0 to 10 portions of ramulus Uncariae cum uncis, 0.5 to 5 portions of alpine weathered anhydrite, 5 to 15 portions of loquat leaf, 5 to 20 portions of perilla fruit, and at least one selected from 2 to 12 portions of honeysuckle, 0.1 to 10 portions of bulbus fritillariae cirrhosae, 1 to 15 portions of aleppo avens and 0.1 to 10 portions of dahurian rhododendron leaf.
3. The traditional Chinese medicine composition for treating asthma as claimed in claim 1, and the preparation method thereof, is characterized in that the composition is obtained by pulverizing, sterilizing and mixing the prescribed amount of each medicinal material.
4. The traditional Chinese medicine composition for treating asthma and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps:
(1) soaking the medicinal materials in a prescription amount in a proper amount of solvent for 0.5-2h, and extracting for 1-5 times, wherein each extraction time is 0.5-2h, the solvent is water, ethanol or a mixture of water and ethanol, and the amount of the solvent is 1-20 times of the total amount of the medicinal materials;
(2) mixing extractive solutions, filtering, concentrating to obtain extract with relative density of 1.2-1.5, and drying to obtain dry extract with water content of 10% or less.
5. The traditional Chinese medicine composition for treating asthma and the preparation method thereof according to claim 1 are characterized in that the preparation method comprises the following steps:
(1) taking the formula amount of liquorice, ramulus Uncariae cum uncis, alpine weathered anhydrite, honeysuckle, bulbus fritilariae and perilla seeds, crushing by a crusher, sieving by a sieve of 80-120 meshes, and performing ultraviolet sterilization for 30-600 min;
(2) extracting medicinal materials: soaking the rest medicinal materials in the amount of the prescription in a proper amount of solvent for 1-5 times, wherein the solvent is water, ethanol or a mixture of water and ethanol, the amount of the solvent is 1-20 times of the total amount of the medicinal materials, and the extraction time is 0.5-2 hours each time; mixing the extracting solutions, filtering, and concentrating to obtain an extract with the relative density of 1.20-1.40; drying the obtained extract to obtain dry extract with water content not more than 10%, and pulverizing the dry extract for use;
(3) mixing: mixing the fine powder and the dry extract powder.
6. The Chinese medicinal composition and the preparation method thereof according to claim 5, wherein the extraction method of Tibet inula root comprises the following steps: adding 65-95% ethanol 5-10 times the weight of the extract, performing ultrasonic continuous countercurrent extraction with ultrasonic power of 300-500W for 30-60 min, extracting for 1-3 times, mixing the extractive solutions, filtering, and concentrating under reduced pressure to obtain radix Inulae extract mainly containing volatile oil components, wherein the volatile oil is prepared into clathrate by saturated aqueous solution method, and the volatile oil is prepared by the following steps: beta-cyclodextrin: absolute ethyl alcohol =1:8-10:2.5-5, dissolving the volatile oil of the Tibetan radix aucklandiae in the absolute ethyl alcohol, adding the dissolved beta-cyclodextrin solution, keeping the temperature at 30-45 ℃, stirring for 0.5-1h, cooling, filtering, and carrying out solid-liquid separation to obtain the wet beta-cyclodextrin inclusion compound of the volatile oil of the Tibetan radix aucklandiae.
7. The Chinese medicinal composition according to claim 1, optionally with suitable pharmaceutically acceptable excipients, produced in any conventional dosage form, preferably oral dosage form, optionally in the form of powder, granules, capsules, tablets, pills, decoctions or sprays, in view of patient compliance and efficacy.
8. The capsule according to claim 6, wherein the capsule shell can be starch hollow capsule, gelatin hollow capsule, pullulan hollow capsule and hypromellose hollow capsule.
9. The traditional Chinese medicine composition for treating asthma according to claim 1, wherein the traditional Chinese medicine composition has the effects of eliminating phlegm and relieving cough, diminishing inflammation and relieving asthma, and can tonify lung and kidney, and prevent and treat asthma attack after long-term administration.
CN202011139617.3A 2020-10-22 2020-10-22 Traditional Chinese medicine composition for treating asthma and preparation method thereof Pending CN112294878A (en)

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Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李永华等: "芩仙胶囊治疗支气管哮喘的主要药效学研究", 《中国实验方剂学杂志》 *

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