CN102317256A - 制备消旋卡多曲的方法 - Google Patents

制备消旋卡多曲的方法 Download PDF

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Publication number
CN102317256A
CN102317256A CN2010800079704A CN201080007970A CN102317256A CN 102317256 A CN102317256 A CN 102317256A CN 2010800079704 A CN2010800079704 A CN 2010800079704A CN 201080007970 A CN201080007970 A CN 201080007970A CN 102317256 A CN102317256 A CN 102317256A
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reaction
compound
racecadotril
solvent
preparation
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CN102317256B (zh
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刘玉忠
张卓
张铭锡
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BEIJING MEDIKING BIOHARM CO LTD
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BEIJING MEDIKING BIOHARM CO LTD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

一种制备消旋卡多曲的方法，该方法包括将苄基丙烯酸与硫代乙酸进行反应，并用二氯甲烷蒸馏除去未反应的硫代乙酸后，得到的产物在二氯甲烷存在下直接与甘氨酸苄酯对甲苯磺酸盐缩合，然后在醇类溶剂中结晶得到高纯度的消旋卡多曲。

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PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN2010800079704A 2010-03-22 2010-03-22 制备消旋卡多曲的方法 Active CN102317256B (zh)

Applications Claiming Priority (1)

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PCT/CN2010/000346 WO2011116490A1 (zh) 2010-03-22 2010-03-22 制备消旋卡多曲的方法

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CN102317256A true CN102317256A (zh) 2012-01-11
CN102317256B CN102317256B (zh) 2013-12-11

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WO (1) WO2011116490A1 (zh)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107129450A (zh) * 2017-06-05 2017-09-05 山东裕欣药业有限公司 一种消旋卡多曲晶体化合物及其制备方法
CN115583903A (zh) * 2022-09-13 2023-01-10 湖北广辰药业有限公司 一种快速制备消旋卡多曲的方法
CN115583903B (zh) * 2022-09-13 2024-05-28 湖北广辰药业有限公司 一种快速制备消旋卡多曲的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103755611A (zh) * 2014-01-16 2014-04-30 陕西汉江药业集团股份有限公司 一种消旋卡多曲的制备方法
CN107602406B (zh) * 2017-08-29 2019-08-20 陕西汉江药业集团股份有限公司 消旋卡多曲中作为外标物的两种杂质的制备方法及含量控制方法
CN109942468B (zh) * 2019-04-22 2020-09-29 大连万福制药有限公司 一种由3-苯基-1-丙炔制备卡多曲的工艺方法
CN110283109B (zh) * 2019-07-10 2021-01-08 陕西汉江药业集团股份有限公司 一种工业化制备消旋卡多曲的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513009A (en) * 1980-04-17 1985-04-23 Societe Civile Bioprojet Aminoacid derivatives and their therapeutic applications
US5786494A (en) * 1995-03-03 1998-07-28 Societe Civile Bioprojet Process for the synthesis of α-substituted acrylic acids and their application

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4513009A (en) * 1980-04-17 1985-04-23 Societe Civile Bioprojet Aminoacid derivatives and their therapeutic applications
US5786494A (en) * 1995-03-03 1998-07-28 Societe Civile Bioprojet Process for the synthesis of α-substituted acrylic acids and their application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
袁哲东等: "消旋卡多曲的合成", 《中国医药工业杂志》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107129450A (zh) * 2017-06-05 2017-09-05 山东裕欣药业有限公司 一种消旋卡多曲晶体化合物及其制备方法
CN107129450B (zh) * 2017-06-05 2019-05-03 山东裕欣药业有限公司 一种消旋卡多曲晶体化合物及其制备方法
CN115583903A (zh) * 2022-09-13 2023-01-10 湖北广辰药业有限公司 一种快速制备消旋卡多曲的方法
CN115583903B (zh) * 2022-09-13 2024-05-28 湖北广辰药业有限公司 一种快速制备消旋卡多曲的方法

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CN102317256B (zh) 2013-12-11
WO2011116490A1 (zh) 2011-09-29

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