CN1022633C - 一种配位体的制造方法 - Google Patents

一种配位体的制造方法 Download PDF

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Publication number
CN1022633C
CN1022633C CN89102600A CN89102600A CN1022633C CN 1022633 C CN1022633 C CN 1022633C CN 89102600 A CN89102600 A CN 89102600A CN 89102600 A CN89102600 A CN 89102600A CN 1022633 C CN1022633 C CN 1022633C
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CN
China
Prior art keywords
general formula
groups
ligand
atoms
heart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN89102600A
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English (en)
Chinese (zh)
Other versions
CN1040373A (zh
Inventor
詹姆斯·邓肯·凯利
招国威
伊安·安德鲁·莱瑟姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
Amersham International PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10634927&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1022633(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amersham International PLC filed Critical Amersham International PLC
Publication of CN1040373A publication Critical patent/CN1040373A/zh
Application granted granted Critical
Publication of CN1022633C publication Critical patent/CN1022633C/zh
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/20—Esters of thiophosphoric acids containing P-halide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5027—Polyphosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN89102600A 1988-04-11 1989-04-06 一种配位体的制造方法 Expired - Lifetime CN1022633C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888808414A GB8808414D0 (en) 1988-04-11 1988-04-11 Ligands & cationic complexes thereof with technetium-99m
GB8808414.0 1988-04-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN93102336A Division CN1031828C (zh) 1988-04-11 1993-02-23 一种带有锝-99m的阳离子配合物的制造方法

Publications (2)

Publication Number Publication Date
CN1040373A CN1040373A (zh) 1990-03-14
CN1022633C true CN1022633C (zh) 1993-11-03

Family

ID=10634927

Family Applications (2)

Application Number Title Priority Date Filing Date
CN89102600A Expired - Lifetime CN1022633C (zh) 1988-04-11 1989-04-06 一种配位体的制造方法
CN93102336A Expired - Lifetime CN1031828C (zh) 1988-04-11 1993-02-23 一种带有锝-99m的阳离子配合物的制造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN93102336A Expired - Lifetime CN1031828C (zh) 1988-04-11 1993-02-23 一种带有锝-99m的阳离子配合物的制造方法

Country Status (14)

Country Link
US (1) US5045302A (enExample)
EP (1) EP0337654B1 (enExample)
JP (2) JP2690142B2 (enExample)
KR (1) KR0149439B1 (enExample)
CN (2) CN1022633C (enExample)
AT (1) ATE133956T1 (enExample)
CA (1) CA1336437C (enExample)
DE (1) DE68925594T2 (enExample)
DK (1) DK171416B1 (enExample)
ES (1) ES2082771T3 (enExample)
GB (1) GB8808414D0 (enExample)
HK (1) HK98097A (enExample)
IL (1) IL89779A (enExample)
TW (1) TW206231B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD291327A5 (de) * 1989-12-29 1991-06-27 �������@����@�K@��@��k�� Myokardgaengige technetium-komplexverbindungen und verfahren zu deren herstellung
US5338864A (en) * 1992-07-06 1994-08-16 Mallinckrodt Medical, Inc. Hexadentate ligands useful in radiographic imaging agents
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
US7575653B2 (en) * 1993-04-15 2009-08-18 3M Innovative Properties Company Melt-flowable materials and method of sealing surfaces
WO1996030056A1 (en) * 1995-03-29 1996-10-03 The Curators Of The University Of Missouri Hydroxyalkyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
AU6231699A (en) * 1998-09-30 2000-04-17 Atofina Vlissingen B.V. Fluorous phosphines and processes for their preparation
GB0427392D0 (en) * 2004-12-15 2005-01-19 Amersham Plc Stabilised 99mTc compositions
JP4863345B2 (ja) * 2005-03-18 2012-01-25 国立大学法人金沢大学 心筋用放射性画像診断剤又は放射性治療薬
CA2654369C (en) * 2006-06-21 2014-10-14 Ge Healthcare Limited Radiopharmaceutical products
JP5427483B2 (ja) * 2009-06-19 2014-02-26 株式会社化研 放射性医薬品およびその標識化合物原料としての放射性テクネチウムの濃縮および溶出回収方法、およびシステム
US9321095B2 (en) 2010-06-30 2016-04-26 General Electric Company Apparatuses and methods for cutting porous substrates
EP2899195A1 (en) 2014-01-28 2015-07-29 ROTOP Pharmaka AG Stabilized form of Tetrofosmin and its use
US10836781B2 (en) * 2017-03-08 2020-11-17 Jubilant Generics Limited Process for the preparation of tetrofosmin or acid salt thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2005790A1 (en) * 1968-04-08 1969-12-19 Toa Gosei Chemical Indus But-1-ene-2,3,4-tricarboxylic ester is prepared by reacting acrylic ester with maleic or fumaric ester in presence of phosphine-type catalyst. New cpds. a
US4451450A (en) * 1981-10-15 1984-05-29 New England Nuclear Corporation Cationic compounds useful for making radiodiagnostic agents
US4481184A (en) * 1983-02-14 1984-11-06 E. R. Squibb & Sons, Inc. Cationic technetium (I) complexes
US4526776A (en) * 1983-04-15 1985-07-02 E. I. Du Pont De Nemours & Company Cationic cyanato and thiocyanato complexes useful as radiodiagnostic agents
GB8723438D0 (en) * 1987-10-06 1987-11-11 Amersham Int Plc Cationic complexes of technetium-99m
JP3176489B2 (ja) * 1993-07-22 2001-06-18 中部電力株式会社 真空バルブ

Also Published As

Publication number Publication date
HK98097A (en) 1997-08-08
KR0149439B1 (ko) 1998-10-15
EP0337654A3 (en) 1991-04-24
JPH09328495A (ja) 1997-12-22
GB8808414D0 (en) 1988-05-11
DK163289D0 (da) 1989-04-05
CA1336437C (en) 1995-07-25
CN1040373A (zh) 1990-03-14
EP0337654A2 (en) 1989-10-18
CN1031828C (zh) 1996-05-22
IL89779A (en) 1995-01-24
TW206231B (enExample) 1993-05-21
ES2082771T3 (es) 1996-04-01
ATE133956T1 (de) 1996-02-15
KR900016237A (ko) 1990-11-13
US5045302A (en) 1991-09-03
IL89779A0 (en) 1989-09-28
JP2764037B2 (ja) 1998-06-11
CN1079746A (zh) 1993-12-22
DE68925594D1 (de) 1996-03-21
DK163289A (da) 1989-10-12
DE68925594T2 (de) 1996-06-20
EP0337654B1 (en) 1996-02-07
DK171416B1 (da) 1996-10-21
JP2690142B2 (ja) 1997-12-10
JPH0222286A (ja) 1990-01-25

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C56 Change in the name or address of the patentee

Owner name: GENERAL ELECTRIC HEALTH CARE CO., LTD.

Free format text: FORMER NAME OR ADDRESS: AMERSHAM INTERNATION PLC.

CP03 Change of name, title or address

Address after: Buckinghamshire

Patentee after: GE Healthcare Ltd.

Address before: England

Patentee before: Amersham Internation Plc.

C17 Cessation of patent right
CX01 Expiry of patent term