CN102245584A - 溶血磷脂酶受体的拮抗剂 - Google Patents

溶血磷脂酶受体的拮抗剂 Download PDF

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Publication number
CN102245584A
CN102245584A CN2009801506164A CN200980150616A CN102245584A CN 102245584 A CN102245584 A CN 102245584A CN 2009801506164 A CN2009801506164 A CN 2009801506164A CN 200980150616 A CN200980150616 A CN 200980150616A CN 102245584 A CN102245584 A CN 102245584A
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phenyl
methyl
compound
biphenyl
isoxazol
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CN2009801506164A
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Chinese (zh)
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王博韦
约翰·霍华德·哈钦森
托马斯·乔恩·赛德尔斯
珍妮·M·阿鲁达
杰弗里·罗杰·罗普
蒂莫西·帕尔
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Amira Pharmaceuticals Inc
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Amira Pharmaceuticals Inc
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    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801506164A 2008-12-15 2009-12-15 溶血磷脂酶受体的拮抗剂 Pending CN102245584A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12256808P 2008-12-15 2008-12-15
US61/122,568 2008-12-15
PCT/US2009/068106 WO2010077883A2 (en) 2008-12-15 2009-12-15 Antagonists of lysophosphatidic acid receptors

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CN102245584A true CN102245584A (zh) 2011-11-16

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US (4) US20110301142A1 (enExample)
EP (1) EP2358688B1 (enExample)
JP (1) JP2012512178A (enExample)
KR (1) KR101323054B1 (enExample)
CN (1) CN102245584A (enExample)
AR (1) AR074676A1 (enExample)
AU (1) AU2009333275B2 (enExample)
BR (1) BRPI0923512A2 (enExample)
CA (1) CA2744221C (enExample)
EA (1) EA201100691A1 (enExample)
GB (1) GB2466121B (enExample)
IL (1) IL212779A (enExample)
MX (1) MX2011006407A (enExample)
SG (1) SG172163A1 (enExample)
TW (1) TWI415841B (enExample)
UY (1) UY32327A (enExample)
WO (2) WO2010077882A2 (enExample)
ZA (1) ZA201103945B (enExample)

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CN104411690A (zh) * 2012-06-20 2015-03-11 霍夫曼-拉罗奇有限公司 作为lpar拮抗剂的取代的吡唑化合物
CN104411692A (zh) * 2012-06-20 2015-03-11 霍夫曼-拉罗奇有限公司 作为lpar拮抗剂的n-烷基三唑化合物
CN104884447A (zh) * 2012-12-28 2015-09-02 宇部兴产株式会社 卤素取代杂环化合物
CN105061346A (zh) * 2009-06-03 2015-11-18 艾米拉医药股份有限公司 溶血磷脂酸受体的多环拮抗剂
CN115181069A (zh) * 2022-07-15 2022-10-14 天津医科大学眼科医院 一种防治近视的化合物
CN116236486A (zh) * 2023-03-30 2023-06-09 复旦大学附属中山医院 髓过氧化物酶抑制剂在制备心脏保护药物中的应用
CN117562896A (zh) * 2023-11-23 2024-02-20 中国人民解放军海军军医大学第二附属医院 Lpar拮抗剂在制备多发性骨髓瘤car t细胞联合治疗药物中的应用

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WO2010016590A1 (ja) 2008-08-07 2010-02-11 国立大学法人 長崎大学 全身性疼痛症候群の治療または予防薬
US8455499B2 (en) 2008-12-11 2013-06-04 Amira Pharmaceuticals, Inc. Alkyne antagonists of lysophosphatidic acid receptors
GB2466121B (en) 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
EP2462128B1 (en) 2009-08-04 2016-09-21 Amira Pharmaceuticals, Inc. Compounds as lysophosphatidic acid receptor antagonists
GB2474748B (en) * 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
GB2474120B (en) * 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
ES2530345T3 (es) 2010-09-02 2015-03-02 Merck Patent Gmbh Derivados de pirazolopiridinona como antagonistas del receptor del LPA
US9556133B2 (en) * 2010-12-07 2017-01-31 Bristol-Myers Squibb Company Polycyclic LPA1 antagonist and uses thereof
CA2820817A1 (en) * 2010-12-07 2012-06-14 Amira Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonists and uses thereof
WO2012100436A1 (en) * 2011-01-30 2012-08-02 Curegenix Inc. Compound as antagonist of lysophosphatidic acid receptor, composition, and use thereof
EP2694496A1 (en) 2011-04-05 2014-02-12 Amira Pharmaceuticals, Inc. 3- or 5 - bi phenyl - 4 - ylisoxazole - based compounds useful for the treatment of fibrosis, pain, cancer and respiratory, allergic, nervous system or cardiovascular disorders
PH12014500355A1 (en) 2011-08-15 2014-03-31 Intermune Inc Lysophosphatidic acid receptor antagonists
WO2013070879A1 (en) * 2011-11-10 2013-05-16 Bristol-Myers Squibb Company Methods for treating spinal cord injury with lpa receptor antagonists
MX2014006130A (es) 2011-11-22 2015-04-13 Intermune Inc Metodos de diagnostico y tratamiento de la fibrosis pulmonar idiopatica.
US20140329871A1 (en) * 2011-12-04 2014-11-06 Angion Biomedica Corp. Small molecule anti-fibrotic compounds and uses thereof
PT3929207T (pt) 2013-03-15 2024-10-21 Univ Texas Utilização do péptido fttftvt no tratamento de fibrose
BR112015023267B1 (pt) 2013-03-15 2023-01-31 Epigen Biosciences, Inc Composto, e medicamento para tratar um indivíduo com doença ou condição lisofosfatídica dependente de ácido
EP3089986B1 (en) * 2013-12-30 2019-06-26 Rxbio Inc. Crystalline salts of (z)-o-octadec-9-en-1-yl o,o-dihydrogen phosphorothioate
ES2824801T3 (es) * 2014-06-27 2021-05-13 Ube Industries Sal de compuesto heterocíclico sustituido con halógeno
AU2016270373A1 (en) 2015-06-05 2018-01-04 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
RU2018122224A (ru) * 2015-11-20 2019-12-25 Убе Индастриз, Лтд. Фармацевтическая композиция для лечения или предупреждения nash
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
WO2019041340A1 (en) 2017-09-04 2019-03-07 Eli Lilly And Company LYSOPHOSPHATIDE ACID RECEPTOR 1 RECEPTOR INHIBITORS (LPAR1)
JP7301840B2 (ja) 2017-12-19 2023-07-03 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのイソキサゾールｎ結合カルバモイルシクロヘキシル酸
EP3849580A4 (en) 2018-09-10 2022-06-15 Lung Therapeutics, Inc. Modified peptide fragments of cav-1 protein and the use thereof in the treatment of fibrosis
EP4058144A1 (en) 2019-11-15 2022-09-21 Gilead Sciences, Inc. Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof
TWI838626B (zh) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
AU2021282986B2 (en) 2020-06-03 2024-03-07 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
WO2022006470A1 (en) 2020-07-01 2022-01-06 Vanderbilt University Methods of treatment for a kidney disease
CA3191452A1 (en) * 2020-08-11 2022-02-17 Viva Star Biosciences Limited Triazole-pyridinyl substituted azacyclohexyl acetic acid compounds as lpa receptor antagonists
AU2022273631B2 (en) 2021-05-11 2025-04-17 Gilead Sciences, Inc. Lpa receptor antagonists and uses thereof
KR20240007233A (ko) 2021-05-13 2024-01-16 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도
JP7709612B2 (ja) 2021-12-08 2025-07-16 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
AR128613A1 (es) 2022-02-25 2024-05-29 Lhotse Bio Inc Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor de lpa
WO2025235487A1 (en) * 2024-05-06 2025-11-13 Ohio State Innovation Foundation Lpa receptor antagonist-derived lipid compounds and uses thereof

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