CN102216279A - 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途 - Google Patents

一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途 Download PDF

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CN102216279A
CN102216279A CN200980145293XA CN200980145293A CN102216279A CN 102216279 A CN102216279 A CN 102216279A CN 200980145293X A CN200980145293X A CN 200980145293XA CN 200980145293 A CN200980145293 A CN 200980145293A CN 102216279 A CN102216279 A CN 102216279A
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yue
diethyl
dihydro
oxopyrimidin
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CN102216279B (zh
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刘正
李剑峰
杨小军
王震
张金凤
朱毅
田广辉
金青
沈竞康
朱维良
蒋华良
沈敬山
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Suzhou Wangshan Wangshui Biopharmaceutical Co ltd
Shanghai Institute of Materia Medica of CAS
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Shandong Topharman Medical Raw Material Co ltd
Shanghai Institute of Materia Medica of CAS
Topharman Shanghai Co Ltd
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Abstract

本发明涉及一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途。更具体而言，本发明涉及一类如下式I所示的含有嘧啶酮苯基的化合物、其药学上可接受的盐或其溶剂化物，本发明还涉及该类化合物的药物组合物以及该类化合物的制备方法，本发明的式I所示化合物可有效地抑制V型磷酸二酯酶(PDE5)，从而可应用于男性勃起功能障碍、肺动脉高压等多种血管障碍性疾病的治疗。

Description

一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN200980145293.XA 2008-12-10 2009-12-10 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途 Active CN102216279B (zh)

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CN200810204368A CN101747282A (zh) 2008-12-10 2008-12-10 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
CN200980145293.XA CN102216279B (zh) 2008-12-10 2009-12-10 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
PCT/CN2009/001418 WO2010066111A1 (zh) 2008-12-10 2009-12-10 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途

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CN114344306A (zh) * 2022-01-24 2022-04-15 苏州旺山旺水生物医药有限公司 含苯基嘧啶酮盐酸盐的药物组合物，包含其的药物制剂，及其制备方法和用途

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BR112012021656A2 (pt) * 2010-03-04 2017-02-07 Merck Sharp & Dohme composto, uso do mesmo, e, composição farmacêutica
US9260413B2 (en) * 2010-03-04 2016-02-16 Merck Sharp & Dohme Corp. Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
CN103601686A (zh) * 2013-11-08 2014-02-26 大连九信生物化工科技有限公司 一锅法合成含氟的嘧啶类化合物的方法
TWI651310B (zh) * 2014-02-20 2019-02-21 日商日本煙草產業股份有限公司 三化合物及其醫藥用途
PE20180951A1 (es) * 2015-08-17 2018-06-11 Japan Tobacco Inc Compuestos de hidroxitriazina y usos medicos de los mismos
CN108137513B (zh) * 2015-10-29 2022-03-01 Aska 制药株式会社 嘧啶衍生物
CN109476610B (zh) * 2017-07-07 2022-05-24 中国科学院上海药物研究所 一种苯基嘧啶酮化合物的盐、多晶型物及其药物组合物和用途
CN115518058A (zh) * 2021-12-29 2022-12-27 河北医科大学 N-环烷基取代的芳甲胺类化合物在制备抗病毒药物中的用途及结构和制备方法
CN115785101B (zh) * 2022-11-23 2023-10-13 西安市食品药品检验所 一种含有苯基哌嗪结构的那非类化合物及其制备方法

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