CN102202677A - 治疗疼痛的活性剂和方法 - Google Patents

治疗疼痛的活性剂和方法 Download PDF

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Publication number
CN102202677A
CN102202677A CN2009801431948A CN200980143194A CN102202677A CN 102202677 A CN102202677 A CN 102202677A CN 2009801431948 A CN2009801431948 A CN 2009801431948A CN 200980143194 A CN200980143194 A CN 200980143194A CN 102202677 A CN102202677 A CN 102202677A
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CN
China
Prior art keywords
pain
peptide
tat
purposes
aforesaid right
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Pending
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CN2009801431948A
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English (en)
Chinese (zh)
Inventor
M·P·贝尔马里斯
J·D·加尔曼
P·S·卢
M·W·萨尔特
M·蒂米安斯基
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NoNO Inc
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NoNO Inc
Arbor Vita Corp
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Publication date
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Publication of CN102202677A publication Critical patent/CN102202677A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN2009801431948A 2008-09-03 2009-09-02 治疗疼痛的活性剂和方法 Pending CN102202677A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9402608P 2008-09-03 2008-09-03
US61/094,026 2008-09-03
PCT/US2009/055786 WO2010028089A2 (en) 2008-09-03 2009-09-02 Agents and methods for treatment of pain

Publications (1)

Publication Number Publication Date
CN102202677A true CN102202677A (zh) 2011-09-28

Family

ID=41797838

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801431948A Pending CN102202677A (zh) 2008-09-03 2009-09-02 治疗疼痛的活性剂和方法

Country Status (7)

Country Link
US (3) US8324168B2 (enExample)
EP (1) EP2334315B1 (enExample)
JP (1) JP5801197B2 (enExample)
CN (1) CN102202677A (enExample)
AU (1) AU2009288088B2 (enExample)
CA (1) CA2739416C (enExample)
WO (1) WO2010028089A2 (enExample)

Cited By (6)

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CN103012597A (zh) * 2012-12-31 2013-04-03 黑龙江大学 用于治疗骨质疏松症和止痛的OGP-CTx融合蛋白及编码该融合蛋白的核酸
CN107312071A (zh) * 2016-04-27 2017-11-03 拜西欧斯（北京）生物技术有限公司 兴奋性神经毒性相关损伤的治疗方法
CN109106942A (zh) * 2018-09-18 2019-01-01 北京大学深圳研究生院 一种可通过血脑屏障的多肽在制备药物中的应用
CN109106941A (zh) * 2012-11-28 2019-01-01 诺诺公司 Tat-nr2b9c的冻干制剂
US20190134150A1 (en) * 2016-04-27 2019-05-09 Biocells (Beijing) Biotech Co., Ltd. Therapeutic methods for excitatory neurotoxicity-related injuries
WO2020056990A1 (zh) * 2018-09-18 2020-03-26 深圳瑞健生物科技有限公司 改进型齐考诺肽在制备药物中的应用

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JP6005357B2 (ja) * 2008-05-16 2016-10-12 ノノ インコーポレイテッド てんかんの治療
AU2009288088B2 (en) 2008-09-03 2014-12-04 Nono Inc. Agents and methods for treatment of pain
AU2011307488B2 (en) * 2010-10-01 2015-08-20 Hoba Therapeutics Aps Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain
EP2852397B1 (en) * 2012-05-18 2022-02-16 Janssen Biotech, Inc. Huwentoxin-iv variants and methods of use
US10414808B2 (en) 2012-05-18 2019-09-17 Janssen Biotech, Inc. Huwentoxin-IV variants and methods of use
US10251935B2 (en) 2012-11-28 2019-04-09 Nono Inc. Lyophilized formulation comprising tat-NR2B9C, histidine and trehalose
ES2841173T3 (es) 2013-10-03 2021-07-07 Janssen Biotech Inc Variantes de Protoxina-II y métodos de uso
JP2017521044A (ja) * 2014-04-22 2017-08-03 キュー−ステート バイオサイエンシーズ， インコーポレイテッドＱ−Ｓｔａｔｅ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 疼痛及び感覚障害のための化合物の分析
MA41642A (fr) 2015-03-03 2018-01-09 Janssen Biotech Inc Variants de protoxine ii et méthodes d'utilisation
US10048275B2 (en) 2015-03-13 2018-08-14 Q-State Biosciences, Inc. Cardiotoxicity screening methods
MX2017012654A (es) 2015-04-02 2018-01-09 Janssen Biotech Inc Variantes de protoxina-ii y metodos de uso.
CN107913395B (zh) * 2016-10-10 2019-12-13 拜西欧斯（北京）生物技术有限公司 神经兴奋性损伤相关多肽在预防、缓解或治疗疼痛的用途
EA039314B1 (ru) * 2017-07-05 2022-01-12 Биоселз (Бейдзин) Биотек Ко., Лтд. Фармацевтически приемлемые соли полипептидов и их применение
WO2019061395A1 (zh) * 2017-09-30 2019-04-04 拜西欧斯（北京）生物技术有限公司 兴奋性神经毒性相关损伤的治疗肽组合物
CN109265557B (zh) * 2018-09-18 2019-12-24 深圳瑞健生物科技有限公司 一种齐考诺肽和tat肽的融合多肽在制备药物中的应用
CN109232745B (zh) * 2018-09-18 2020-02-28 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽
EP4393504A2 (en) * 2018-12-26 2024-07-03 Skinmed Co., Ltd. Acetylcholine receptor inhibitory peptides and uses thereof
CN111097037A (zh) * 2020-01-16 2020-05-05 刘成龙 一种psd95-pdz1/2结构域抑制剂及其应用
WO2024199436A1 (zh) * 2023-03-31 2024-10-03 青岛普美圣医药科技有限公司 具有延长的半衰期和提高的稳定性的多肽活性分子

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US20050164933A1 (en) * 2003-12-23 2005-07-28 Michael Tymianski Method of reducing injury to mammalian cells
EP1884521A1 (en) * 2006-07-31 2008-02-06 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal NMDA receptor (NMDAR) and NMDAR interacting proteins
CN101616682A (zh) * 2006-12-29 2009-12-30 雷文斯治疗公司 用源自hiv-tat的多肽片段稳定的肉毒杆菌毒素的组合物及其局部施用和透皮递送的方法

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US7760905B2 (en) 1999-06-29 2010-07-20 Digimarc Corporation Wireless mobile phone with content processing
US7510824B2 (en) 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
US7595297B2 (en) 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
US6759520B1 (en) 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US8003609B2 (en) * 2004-03-30 2011-08-23 The Hospital For Sick Children Method for ameliorating pain by modification of NMDA receptors through inhibition of Src
US20080227684A1 (en) 2005-12-30 2008-09-18 Belmares Michael P Small Molecule Inhibitors of PDZ Interactions
US8633160B2 (en) 2005-12-30 2014-01-21 Nono Inc. Small molecule inhibitors of PDZ interactions
GB0610868D0 (en) 2006-06-01 2006-07-12 Syntaxin Ltd Treatment of pain
US20100040609A1 (en) * 2006-07-07 2010-02-18 Gorman James R Methods for preventing, postponing or improving the outcome of invasive spinal procedures
US20080124698A1 (en) 2006-11-28 2008-05-29 Ebensberger Jason M Virtual coatings application system with structured training and remote instructor capabilities
EP2120987B1 (en) 2007-03-02 2014-01-15 NoNO Inc. Treating stroke and other diseases without inhibiting n-type calcium channels
CA2693256A1 (en) * 2007-04-06 2008-10-16 Kai Pharmaceuticals, Inc. Methods of use of gamma inhibitor compounds for the attenuation of pain
US20100204100A1 (en) * 2007-04-19 2010-08-12 The Johns Hopkins Univeristy Biological agents active in central nervous system
US8008253B2 (en) 2007-07-03 2011-08-30 Andrew Tasker Treatment for anxiety
US8080518B2 (en) 2007-12-05 2011-12-20 Arbor Vita Corporation Co-administration of an agent linked to an internalization peptide with an anti-inflammatory
JP6005357B2 (ja) 2008-05-16 2016-10-12 ノノ インコーポレイテッド てんかんの治療
AU2009288088B2 (en) 2008-09-03 2014-12-04 Nono Inc. Agents and methods for treatment of pain
WO2011072275A2 (en) 2009-12-11 2011-06-16 Nono, Inc. Agents and methods for treating ischemic and other diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050164933A1 (en) * 2003-12-23 2005-07-28 Michael Tymianski Method of reducing injury to mammalian cells
EP1884521A1 (en) * 2006-07-31 2008-02-06 Xigen S.A. Fusion peptide for inhibiting interaction of neuronal NMDA receptor (NMDAR) and NMDAR interacting proteins
CN101616682A (zh) * 2006-12-29 2009-12-30 雷文斯治疗公司 用源自hiv-tat的多肽片段稳定的肉毒杆菌毒素的组合物及其局部施用和透皮递送的方法

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109106941A (zh) * 2012-11-28 2019-01-01 诺诺公司 Tat-nr2b9c的冻干制剂
CN103012597A (zh) * 2012-12-31 2013-04-03 黑龙江大学 用于治疗骨质疏松症和止痛的OGP-CTx融合蛋白及编码该融合蛋白的核酸
CN107312071A (zh) * 2016-04-27 2017-11-03 拜西欧斯（北京）生物技术有限公司 兴奋性神经毒性相关损伤的治疗方法
CN107312071B (zh) * 2016-04-27 2018-11-06 拜西欧斯（北京）生物技术有限公司 兴奋性神经毒性相关损伤的治疗方法
US20190134150A1 (en) * 2016-04-27 2019-05-09 Biocells (Beijing) Biotech Co., Ltd. Therapeutic methods for excitatory neurotoxicity-related injuries
CN109106942A (zh) * 2018-09-18 2019-01-01 北京大学深圳研究生院 一种可通过血脑屏障的多肽在制备药物中的应用
WO2020056990A1 (zh) * 2018-09-18 2020-03-26 深圳瑞健生物科技有限公司 改进型齐考诺肽在制备药物中的应用
WO2020056988A1 (zh) * 2018-09-18 2020-03-26 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽在制备药物中的应用

Also Published As

Publication number Publication date
JP5801197B2 (ja) 2015-10-28
AU2009288088A1 (en) 2010-03-11
US20100062985A1 (en) 2010-03-11
US20130137641A1 (en) 2013-05-30
JP2012501973A (ja) 2012-01-26
CA2739416C (en) 2017-10-31
US9365620B2 (en) 2016-06-14
CA2739416A1 (en) 2010-03-11
US8324168B2 (en) 2012-12-04
WO2010028089A2 (en) 2010-03-11
EP2334315B1 (en) 2023-01-18
EP2334315A4 (en) 2012-08-15
WO2010028089A3 (en) 2010-04-29
US8748387B2 (en) 2014-06-10
AU2009288088B2 (en) 2014-12-04
EP2334315A2 (en) 2011-06-22
US20150018283A1 (en) 2015-01-15

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Owner name: NUONUO CORP.

Free format text: FORMER OWNER: ARBOR VITA CORP;NONO INC.

Effective date: 20130319

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Address after: Ontario

Applicant after: NoNo Inc.

Address before: American California

Applicant before: Arbor Vita Corp.

Applicant before: NoNo Inc.

RJ01 Rejection of invention patent application after publication

Application publication date: 20110928

RJ01 Rejection of invention patent application after publication